CA2285457A1 - Method for oral delivery of proteins - Google Patents

Method for oral delivery of proteins Download PDF

Info

Publication number
CA2285457A1
CA2285457A1 CA002285457A CA2285457A CA2285457A1 CA 2285457 A1 CA2285457 A1 CA 2285457A1 CA 002285457 A CA002285457 A CA 002285457A CA 2285457 A CA2285457 A CA 2285457A CA 2285457 A1 CA2285457 A1 CA 2285457A1
Authority
CA
Canada
Prior art keywords
composition
insulin
hydrogels
maa
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002285457A
Other languages
English (en)
French (fr)
Inventor
Mariko Morishita
Tsuneji Nagai
Nicholas A. Peppas
Anthony M. Lowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2285457A1 publication Critical patent/CA2285457A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002285457A 1997-04-02 1998-04-02 Method for oral delivery of proteins Abandoned CA2285457A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US60/042,280 1997-04-02
US6136797P 1997-10-08 1997-10-08
US60/061,367 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
CA2285457A1 true CA2285457A1 (en) 1998-10-08

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002285457A Abandoned CA2285457A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Country Status (14)

Country Link
EP (1) EP0975328A1 (ko)
JP (1) JP2002512607A (ko)
KR (1) KR20010005952A (ko)
CN (1) CN1259045A (ko)
AU (1) AU727053B2 (ko)
BR (1) BR9808466A (ko)
CA (1) CA2285457A1 (ko)
IL (1) IL132176A0 (ko)
NO (1) NO994757L (ko)
NZ (1) NZ500075A (ko)
PL (1) PL335974A1 (ko)
TR (1) TR199903240T2 (ko)
WO (1) WO1998043615A1 (ko)
YU (1) YU49699A (ko)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (de) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
CA2479751C (en) 2002-03-20 2008-06-03 Trent Poole Inhalation apparatus
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
ES2560240T5 (es) 2005-07-29 2022-11-08 Stichting Groningen Centre For Drug Res Sistema de suministro pulsátil controlado por pH, métodos para la preparación y uso del mismo
CN101232899A (zh) * 2005-08-01 2008-07-30 曼金德公司 维持产胰岛素细胞功能的方法
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
JP2010500917A (ja) 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
US8470035B2 (en) 2007-12-21 2013-06-25 Microvention, Inc. Hydrogel filaments for biomedical uses
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN104491962B (zh) 2008-06-13 2018-10-23 曼金德公司 干粉吸入器和用于药物输送的***
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US8734845B2 (en) 2009-06-12 2014-05-27 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
WO2011038291A1 (en) 2009-09-24 2011-03-31 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
AU2010313530B2 (en) 2009-10-26 2015-12-17 Microvention, Inc. Embolization device constructed from expansile polymer
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
EP2582421A1 (en) 2010-06-21 2013-04-24 MannKind Corporation Dry powder drug delivery system and methods
SG10201606220QA (en) 2011-04-01 2016-09-29 Mannkind Corp Blister package for pharmaceutical cartridges
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
JP6312262B2 (ja) 2012-07-12 2018-04-18 マンカインド コーポレイション 乾燥粉末薬物送達システム
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
SG11201507564PA (en) 2013-03-15 2015-10-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
AU2014290438B2 (en) 2013-07-18 2019-11-07 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
WO2024130101A1 (en) * 2022-12-16 2024-06-20 Wake Forest University Health Sciences Hydrogel compositions and methods of making and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
DE1617393C2 (de) * 1966-01-06 1982-11-11 Československá akademie věd, Praha Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (fr) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie

Also Published As

Publication number Publication date
IL132176A0 (en) 2001-03-19
NO994757D0 (no) 1999-09-30
KR20010005952A (ko) 2001-01-15
AU6880998A (en) 1998-10-22
WO1998043615A1 (en) 1998-10-08
NZ500075A (en) 2001-03-30
JP2002512607A (ja) 2002-04-23
AU727053B2 (en) 2000-11-30
EP0975328A1 (en) 2000-02-02
PL335974A1 (en) 2000-06-05
TR199903240T2 (xx) 2000-05-22
NO994757L (no) 1999-11-29
CN1259045A (zh) 2000-07-05
YU49699A (sh) 2002-12-10
BR9808466A (pt) 2001-08-07

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Legal Events

Date Code Title Description
FZDE Discontinued