CA2277366A1 - Transdermal, acetylsalicylic acid-containing therapeutic system with reinforced resorption - Google Patents

Transdermal, acetylsalicylic acid-containing therapeutic system with reinforced resorption Download PDF

Info

Publication number: CA2277366A1
Authority: CA; Canada
Prior art keywords: limonene; acetylsalicylic acid; therapeutic system; dimethylisosorbide; transdermal therapeutic
Prior art date: 1997-01-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002277366A

Other languages

English (en)

French (fr)

Inventor

Michael Horstmann

Gerd Hoffmann

Heinrich Kindel

Theresa Maria Murphy

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

LTS Lohmann Therapie Systeme AG

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-15

Filing date

1998-01-03

Publication date

1998-07-23

1998-01-03 Application filed by Individual filed Critical Individual

1998-07-23 Publication of CA2277366A1 publication Critical patent/CA2277366A1/en

Status Abandoned legal-status Critical Current

Links

BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title claims abstract description 27
229960001138 acetylsalicylic acid Drugs 0.000 title claims abstract description 27
230000001225 therapeutic effect Effects 0.000 title claims abstract description 20
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims abstract description 44
229940087305 limonene Drugs 0.000 claims abstract description 22
235000001510 limonene Nutrition 0.000 claims abstract description 22
MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims abstract description 20
238000002156 mixing Methods 0.000 claims abstract description 8
239000010410 layer Substances 0.000 claims description 16
239000004480 active ingredient Substances 0.000 claims description 7
239000011159 matrix material Substances 0.000 claims description 7
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
239000011241 protective layer Substances 0.000 claims description 2
239000002356 single layer Substances 0.000 claims 1
239000013543 active substance Substances 0.000 abstract description 3
239000004744 fabric Substances 0.000 description 13
229920000728 polyester Polymers 0.000 description 8
239000000203 mixture Substances 0.000 description 7
239000000853 adhesive Substances 0.000 description 6
230000001070 adhesive effect Effects 0.000 description 6
229920001577 copolymer Polymers 0.000 description 5
229920000742 Cotton Polymers 0.000 description 4
WFDIJRYMOXRFFG-UHFFFAOYSA-N acetic acid anhydride Natural products CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000000654 additive Substances 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000001914 filtration Methods 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000002904 solvent Substances 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
238000006460 hydrolysis reaction Methods 0.000 description 2
229940070721 polyacrylate Drugs 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000005809 transesterification reaction Methods 0.000 description 2
101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 description 1
101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 description 1
229920002367 Polyisobutene Polymers 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000000202 analgesic effect Effects 0.000 description 1
230000001754 anti-pyretic effect Effects 0.000 description 1
229940127218 antiplatelet drug Drugs 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
239000003435 antirheumatic agent Substances 0.000 description 1
150000001733 carboxylic acid esters Chemical class 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000012907 medicinal substance Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000012466 permeate Substances 0.000 description 1
239000000106 platelet aggregation inhibitor Substances 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005573 silicon-containing polymer Polymers 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000007858 starting material Substances 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
229920005992 thermoplastic resin Polymers 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA002277366A 1997-01-15 1998-01-03 Transdermal, acetylsalicylic acid-containing therapeutic system with reinforced resorption Abandoned CA2277366A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19701059.8		1997-01-15
DE19701059A DE19701059C2 (de)	1997-01-15	1997-01-15	Acetylsalicylsäure enthaltendes transdermales therapeutisches System mit Resorptionsverstärkung
PCT/EP1998/000013 WO1998031348A1 (de)	1997-01-15	1998-01-03	Acetylsalicylsäure enthaltendes transdermales therapeutisches system mit resorptionsverstärkung

Publications (1)

Publication Number	Publication Date
CA2277366A1 true CA2277366A1 (en)	1998-07-23

Family

ID=7817375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002277366A Abandoned CA2277366A1 (en)	1997-01-15	1998-01-03	Transdermal, acetylsalicylic acid-containing therapeutic system with reinforced resorption

Country Status (8)

Country	Link
EP (1)	EP1023053A1 (no)
JP (1)	JP2001508069A (no)
KR (1)	KR20000070228A (no)
AU (1)	AU726094B2 (no)
CA (1)	CA2277366A1 (no)
DE (1)	DE19701059C2 (no)
NO (1)	NO993435D0 (no)
WO (1)	WO1998031348A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19949252B4 (de) *	1999-10-13	2004-02-12	Lts Lohmann Therapie-Systeme Ag	Verwendung eines superfiziellen therapeutischen Systems zur topischen Applikation von Acetylsalicylsäure zur Behandlung von Akne-Erkrankungen und Verfahren zu seiner Herstellung
DE19949202A1 (de) *	1999-10-13	2001-05-03	Lohmann Therapie Syst Lts	Transdermales therapeutisches System zur Abgabe von Acetylsalicylsäure und/oder Salicylsäure
DE19959913A1 (de) *	1999-12-11	2001-06-28	Lohmann Therapie Syst Lts	Acetylsalicylsäure enthaltendes transdermales System zur Behandlung von Migräne
KR100448469B1 (ko) *	2001-10-26	2004-09-13	신풍제약주식회사	항염증제의 경피 조성물 및 장치
JP4837892B2 (ja)	2001-11-01	2011-12-14	ネクターセラピューティクス	粉末バッチを製造する方法
DE10338162B3 (de) †	2003-08-20	2005-06-02	Haldex Brake Products Gmbh	Verfahren zum Betreiben einer Druckluftbeschaffungsanlage eines Kraftfahrzeuges sowie Druckluftaufbereitungseinrichtung
DE102005033543A1 (de) *	2005-07-14	2007-01-18	Grünenthal GmbH	Ein einen Duftstoff aufweisendes transdermales therapeutisches System
DE102005050431A1 (de) *	2005-10-21	2007-04-26	Lts Lohmann Therapie-Systeme Ag	Transdermales therapeutisches System zur Verabreicherung lipophiler und/oder wenig hautpermeabler Wirkstoffe
IT202000014578A1 (it) *	2020-06-18	2021-12-18	Poli Md S R L	Dispositivo medicale comprendente acido acetil salicilico

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4228162A (en) *	1979-07-09	1980-10-14	Research Corporation	Dimethyl isosorbide in liquid formulation of aspirin
US5164416A (en) *	1989-02-03	1992-11-17	Lintec Corporation	Transdermal therapeutic formulation containing a limonene
DE4332094C2 (de) *	1993-09-22	1995-09-07	Lohmann Therapie Syst Lts	Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung
DE4332093C2 (de) *	1993-09-22	1995-07-13	Lohmann Therapie Syst Lts	Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung

1997
- 1997-01-15 DE DE19701059A patent/DE19701059C2/de not_active Expired - Fee Related
1998
- 1998-01-03 WO PCT/EP1998/000013 patent/WO1998031348A1/de not_active Application Discontinuation
- 1998-01-03 JP JP53137698A patent/JP2001508069A/ja active Pending
- 1998-01-03 KR KR1019997006454A patent/KR20000070228A/ko not_active Application Discontinuation
- 1998-01-03 AU AU59862/98A patent/AU726094B2/en not_active Ceased
- 1998-01-03 EP EP98902976A patent/EP1023053A1/de not_active Withdrawn
- 1998-01-03 CA CA002277366A patent/CA2277366A1/en not_active Abandoned
1999
- 1999-07-12 NO NO993435A patent/NO993435D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1023053A1 (de)	2000-08-02
AU5986298A (en)	1998-08-07
AU726094B2 (en)	2000-11-02
DE19701059A1 (de)	1998-07-16
JP2001508069A (ja)	2001-06-19
KR20000070228A (ko)	2000-11-25
WO1998031348A1 (de)	1998-07-23
DE19701059C2 (de)	2000-12-21
NO993435L (no)	1999-07-12
NO993435D0 (no)	1999-07-12

Legal Events

Date	Code	Title	Description
2001-04-02	EEER	Examination request
2003-01-03	FZDE	Discontinued
2023-10-24	FZDE	Discontinued	Effective date: 20030103

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RU2212232C2 (ru)	2003-09-20	Пластырь местного действия с нестероидными антиревматическими средствами, содержащими кислотную группу
DE4020144C2 (no)	1993-07-29
CA2125662C (en)	2006-10-17	Transdermally administered system containing acetylsalicylic acid for thrombosis therapy and cancer prophylaxis
JP2000517343A (ja)	2000-12-26	医薬の塩を経皮送達するための感圧接着剤マトリックスパッチ
US5518734A (en)	1996-05-21	Transdermal delivery system for estradiol and process for manufacturing said device
JP2638635B2 (ja)	1997-08-06	経皮吸収製剤
CA2200189C (en)	2008-06-17	Scopolamine plaster
JPS6049601B2 (ja)	1985-11-02	治療デバイス
AU726094B2 (en)	2000-11-02	Acetylsalicylic acid-containing transdermal therapeutic system with absorption enhancement
CA2552679C (en)	2012-12-11	Tulobuterol adhesive patch
JP2869167B2 (ja)	1999-03-10	徐放性貼付製剤
US5705185A (en)	1998-01-06	Transdermal delivery of estradiol and process for manufacturing said device
JP4943643B2 (ja)	2012-05-30	経皮吸収製剤
JPS63307818A (ja)	1988-12-15	経皮吸収貼付剤
JPS5835112A (ja)	1983-03-01	複合製剤
SK22097A3 (en)	1997-07-09	Transdermal therapeutic system and a method for producing same
MXPA99006584A (es)	2000-04-24	Sistema terapeutico percutaneo que contiene acidoacetilsalicilico con refuerzo de resorcion
JPS5835113A (ja)	1983-03-01	複合製剤
JPH0999050A (ja)	1997-04-15	貼付剤
JPH0474119A (ja)	1992-03-09	貼付製剤
JPH1179980A (ja)	1999-03-23	経皮吸収型製剤
JP3229171B2 (ja)	2001-11-12	貼付剤
AU2007202273B2 (en)	2009-11-05	Transdermal therapeutic system containing fentanyl or related substance
JPH0853347A (ja)	1996-02-27	経皮吸収製剤
JPS60184010A (ja)	1985-09-19	経皮投与用医薬製剤