CA2166989A1 - Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines - Google Patents

Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines

Info

Publication number
CA2166989A1
CA2166989A1 CA002166989A CA2166989A CA2166989A1 CA 2166989 A1 CA2166989 A1 CA 2166989A1 CA 002166989 A CA002166989 A CA 002166989A CA 2166989 A CA2166989 A CA 2166989A CA 2166989 A1 CA2166989 A1 CA 2166989A1
Authority
CA
Canada
Prior art keywords
formula
alkali metal
process according
dicyanoethylene
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002166989A
Other languages
English (en)
French (fr)
Inventor
Jean-Marie Assercq
Heinz Peter Schwemlein
Jeffrey William Perine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2166989A1 publication Critical patent/CA2166989A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002166989A 1993-07-26 1994-07-14 Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines Abandoned CA2166989A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9714193A 1993-07-26 1993-07-26
US21098094A 1994-03-21 1994-03-21
US08/097,141 1994-03-21
US08/210,980 1994-03-21

Publications (1)

Publication Number Publication Date
CA2166989A1 true CA2166989A1 (en) 1995-02-02

Family

ID=26792702

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166989A Abandoned CA2166989A1 (en) 1993-07-26 1994-07-14 Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines

Country Status (15)

Country Link
EP (1) EP0711285A1 (fi)
JP (1) JPH09500632A (fi)
CN (1) CN1128024A (fi)
AU (1) AU7385994A (fi)
BG (1) BG100366A (fi)
BR (1) BR9407024A (fi)
CA (1) CA2166989A1 (fi)
CZ (1) CZ22496A3 (fi)
FI (1) FI960332A (fi)
HU (1) HUT73357A (fi)
IL (1) IL110425A0 (fi)
LV (1) LV11463B (fi)
NO (1) NO960307D0 (fi)
SK (1) SK10396A3 (fi)
WO (1) WO1995003282A2 (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2297112C (en) * 1997-08-27 2009-04-07 Novartis Ag Dicyclanil polymorphs and hydrates and their preparation
KR101132590B1 (ko) * 2007-04-19 2012-04-10 닛뽕소다 가부시키가이샤 Ｎ-(2-아미노-1,2-디시아노비닐)이미데이트류의 제조 방법
CN102250017A (zh) * 2011-06-15 2011-11-23 扬州天和药业有限公司 地昔尼尔的一种合成方法
CN102399193A (zh) * 2011-12-15 2012-04-04 连云港市亚晖医药化工有限公司 4,6-二氨基-2-环丙胺基-5-腈基嘧啶的制备方法
CN104130197A (zh) * 2014-07-29 2014-11-05 华中农业大学 2,4,6-三氨基-5-氰基嘧啶的化学合成方法
CN104649982B (zh) * 2015-02-26 2016-12-07 齐鲁晟华制药有限公司 一种地昔尼尔的制备方法
CN107056655B (zh) * 2017-01-22 2018-12-04 营口三征新科技化工有限公司 一种1-氨基-1-氰氨基-2,2-二氰乙烯钠盐的制备方法
CN106966922B (zh) * 2017-03-28 2020-10-27 中国科学院大学 一种功能化取代的二氰基乙烯类化合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135913B (de) * 1960-11-08 1962-09-06 Bayer Ag Verfahren zur Herstellung von 2-Methyl-4-amino-5-cyanpyrimidin
US3226424A (en) * 1962-10-03 1965-12-28 Hoffmann La Roche Process for preparing 2-lower alkoxy-1,1-dicyanoethylene and 2-amino-1,1-dicyanoethylene
US4783468A (en) * 1986-04-30 1988-11-08 Ciba-Geigy Corporation Insecticidal 5-pyrimidine carbonitriles

Also Published As

Publication number Publication date
BR9407024A (pt) 1996-09-10
LV11463A (lv) 1996-08-20
NO960307L (no) 1996-01-25
NO960307D0 (no) 1996-01-25
IL110425A0 (en) 1994-10-21
BG100366A (en) 1996-07-31
WO1995003282A3 (en) 1995-04-13
WO1995003282A2 (en) 1995-02-02
AU7385994A (en) 1995-02-20
SK10396A3 (en) 1996-09-04
HUT73357A (en) 1996-07-29
EP0711285A1 (en) 1996-05-15
CZ22496A3 (en) 1996-04-17
HU9503959D0 (en) 1996-03-28
FI960332A0 (fi) 1996-01-24
CN1128024A (zh) 1996-07-31
JPH09500632A (ja) 1997-01-21
LV11463B (en) 1996-12-20
FI960332A (fi) 1996-01-24

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Legal Events

Date Code Title Description
FZDE Discontinued