CA2161351A1 - Transgenic non-human animals capable of producing heterologous antibodies - Google Patents

Transgenic non-human animals capable of producing heterologous antibodies

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Publication number
CA2161351A1
CA2161351A1 CA002161351A CA2161351A CA2161351A1 CA 2161351 A1 CA2161351 A1 CA 2161351A1 CA 002161351 A CA002161351 A CA 002161351A CA 2161351 A CA2161351 A CA 2161351A CA 2161351 A1 CA2161351 A1 CA 2161351A1
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Prior art keywords
human
heavy chain
transgenic mouse
transgene
gene
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Granted
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CA002161351A
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French (fr)
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CA2161351C (en
Inventor
Nils Lonberg
Robert M. Kay
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Genpharm International Inc
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Individual
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Priority claimed from US08/053,131 external-priority patent/US5661016A/en
Priority claimed from US08/096,762 external-priority patent/US5814318A/en
Application filed by Individual filed Critical Individual
Publication of CA2161351A1 publication Critical patent/CA2161351A1/en
Application granted granted Critical
Publication of CA2161351C publication Critical patent/CA2161351C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to transgenic non-human animals capable of producing heterologous and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.

Claims (38)

1. A transgenic non-human animal comprising: a homozygous pair of functionally disrupted endogenous heavy chain alleles, a homozygous pair of functionally disrupted endogenous light chain alleles, at least one copy of a heterologous immunoglobulin heavy chain transgene, and at least one copy of a heterologous immunoglobulin heavy chain transgene, and wherein said animal makes an antibody response following immunization with an antigen.
2. A transgenic non-human animal of Claim 1, wherein said functionally disrupted endogenous heavy chain allele is a JH region homologous recombination knockout, said functionally disrupted endogenous light chain allele is a JK
region homologous recombination knockout, said heterologous immunoglobulin heavy chain transgene is the HC1 or HC2 human minigene transgene, said heterologous light chain transgene is the KC2 or KC1e human K transgene, and wherein said antigen is a human antigen.
3. A transgenic non-human animal of Claim 1, wherein the antibody response comprises a population of antibodies which comprise human µ chain-containing immunoglobulins and human .gamma. chain-containing immunoglobulins.
4. A transgenic non-human animal of Claim 2, wherein the heterologous antibodies comprise a population of heterologous immunoglobulins which bind specifically to human CD4 with an dissociation constant of approximately 8 x 107 M-1.
5. A transgenic animal of claim 2 wherein the animal comprises a transgenic mouse having a genotype selected from the group consisting of:
HC1-26+;JHD++;JKD++;KC2-1610++;
HC1-26+;JHD++;JKD++;KC2-1610+;
HC1-26+;JHD++;JKD++;KC1e-1527+; and HC1-26+;JHD++;JKD++;KC1e-1399+.
6. A transgenic animal of claim 5 wherein the animal comprises a transgenic mouse having a genotype selected from the group consisting of: HC1-26+;JHD++;
JKD++;KC1e-1527+ and HC1-26+;JHD++; JKD++;KC1e-1399+, wherein the antibody response comprises a population of antibodies which comprise human µ chain-containing immunoglobulins and human .gamma. chain-containing immunoglobulins.
7. A transgenic mouse comprising a genome comprising: (1) a homozygous functionally disrupted endogenous heavy chain locus comprising at least one murine constant region gene comprising a functional switch recombination sequence and capable of trans-switching, and (2) a human heavy chain transgene capable of rearranging to encode a functional human heavy chain variable region and containing a functional switch recombination sequence capable of undergoing trans-switching.
8. A transgenic mouse of claim 7, further comprising a human light chain transgene capable of rearranging to encode a functional human light chain variable region and expressing a human sequence light chain.
9. A transgenic mouse of claim 7, further comprising a homozygous functionally disrupted endogenous light chain locus.
10. A transgenic mouse of claim 9, further comprising a serum comprising an antibody comprising a chimeric heavy chain composed of a human sequence variable region encoded by a human transgene and a murine constant region sequence encoded by an endogenous murine heavy chain constant region gene.
11. A transgenic mouse comprising a serum having a detectable amount of a chimeric heavy chain encoded by a sequence produced by trans-switching between a human transgene and an endogenous murine heavy chain constant region gene.
12. A transgenic mouse comprising B cells which produce a human sequence heavy chain at a first timepoint and trans-switch to produce a chimeric heavy chain composed of a human variable region and a murine constant region at a second timepoint.
13. A transgenic mouse comprising B cells which produce a chimeric antibody comprising a chimeric heavy chain comprising a human sequence heavy chain variable region and a murine sequence heavy chain constant region.
14. A transgenic mouse of claim 13, wherein said chimeric antibody comprises a human sequence light chain.
15. A transgenic mouse of claim 14, wherein the chimeric antibody binds to a predetermined antigen (e.g., the immunogen) with an affinity of about at least 1 x 107 M-1.
16. A transgenic mouse of claim 15, wherein the predetermined antigen is human CD4 or human CEA.
17. A transgenic mouse having a genome comprising a human heavy chain transgene comprising two human VH gene segments, eight human D gene segments, six human JH
gene segments, a human J-µ enhancer, a human µ switch region, a complete human µ CH gene, a human sterile transcript promoter, a human .gamma. switch region, a complete human .gamma. CH gene, and a heavy chain 3' enhancer, and wherein said unrearranged human heavy chain transgene lacks mouse VB gene segments, mouse D
gene segments, mouse JH gene segments, mouse CH genes, mouse switch regions, and a mouse heavy chain enhancer, and wherein B
lymphocytes of said transgenic mouse rearrange said unrearranged human heavy chain transgene by V-D-J joining to produce a V-D-J gene joined in-frame encoding a heavy chain variable region expressed in polypeptide linkage to the constant region encoded by said complete human µ or complete human .gamma. CH gene on said transgene.
18. A transgenic mouse of claim 17, wherein said human heavy chain transgene comprises a 5.3 kb HindIII fragment of a human heavy chain gene locus containing the .gamma.1 switch region and the first exon of the preswitch sterile transcript, and wherein said B lymphocytes rearrange said human heavy chain transgene forming a V-D-J gene joined in-frame encoding a heavy chain variable region which is expressed as a human A or human chain in B lymphocytes of said transgenic mouse.
19. A transgenic mouse of claim 18, wherein said transgene further comprises a 0.7 kb XbaI/HindIII
fragment of a human heavy chain gene locus, said 0.7 kb XbaI/HindIII fragment consisting essentially of sequences immediately upstream of, and adjacent to, said 5.3 kb .gamma.1 fragment and further comprising a neighboring upstream 3.1 kb XbaI fragment of said human heavy chain gene locus.
20. A transgenic mouse of claim 19, wherein said human heavy chain transgene comprises a human .gamma.1 constant region including the associated switch region and sterile transcript associated exons, together with approximately 4 kb flanking sequences upstream of the sterile transcript initiation site, and a rat heavy chain 3' enhancer that can be PCR amplified with the following oligonucleotide primers: 5' CAG GAT CCA GAT ATC AGT ACC TGA AAC AGG GCT TGC 31 51 GAG CAT GCA CAG GAC CTG GAG CAC ACA CAG CCT TCC 3'.
21. A transgenic mouse of claim 20, wherein said human heavy chain transgene comprises a NotI
insert of pHC1.
22. A transgenic mouse of claim 21, wherein said transgenic mouse comprises one intact germline copy of said NotI insert of pHC1 and wherein said transgenic mouse expresses both human µ and human .gamma.1 chains in serum.
23. A transgenic mouse of claim 22, wherein said human heavy chain transgene undergoes isotype switching whereby said V-D-J gene joined in-frame encodes a human heavy chain variable region which is initially expressed in peptide linkage to a human µ constant region and subsequently expressed in peptide linkage to a human .gamma. constant region in B lymphocytes of said transgenic mouse.
24. A transgenic mouse comprising an intact integrated germline copy of a NotI insert of pHC1 or pIGM1, wherein said transgenic mouse expresses human µ and human .gamma.1 chains in serum, each human µ or human .gamma.1 chain comprising a variable region consisting essentially of a polypeptide sequence encoded by a human VH gene segment, a human D gene segment, and a human JH gene segment, joined in-frame as a VDJ gene.
25. A transgenic mouse of claim 17, wherein said transgenic mouse further comprises a functionally disrupted endogenous heavy chain locus which lacks mouse JH
gene segments.
26. A transgenic mouse having an intact integrated germline copy of a human heavy chain transgene consisting essentially of a NotI insert of pHC1, wherein said transgenic mouse expresses, in its serum, immunoglobulin chains encoded by said human heavy chain transgene and comprising human or human .gamma.1 constant regions.
27. A method for producing an antibody comprising a human immunoglobulin in serum of a transgenic mouse, said method comprising the step of immunizing with a predetermined antigen a transgenic mouse of claim 17 or claim 25, and collecting serum from said animal after a suitable period for a humoral immune response.
28. A hybridoma comprising a B cell of an transgenic mouse of claim 17 or claim 25 which has been immunized with a predetermined antigen, fused with a second cell capable of immortalizing said B cell, wherein the hybridoma produces a monoclonal antibody comprising a human heavy chain and wherein said monoclonal antibody binds to said predetermined antigen.
29. A hybridoma of Claim 28, wherein the predetermined antigen is a human antigen.
30. A hybridoma of Claim 29, wherein the human antigen is CEA, CD4, or NCA-2.
31. A hybridoma of Claim 28, wherein the monoclonal antibody binds to a human antigen with an affinity of at least 1 x 107 M-1.
32. A hybridoma of Claim 28, wherein the hybridoma comprises a functionally disrupted murine immunoglobulin allele.
33. A hybridoma of Claim 31, wherein the monoclonal antibody binds human CD4 with an affinity of approximately 8 x 107 M-1.
34. A human monoclonal antibody produced by a hybridoma of Claim 28.
35. A human monoclonal antibody of Claim 34, wherein said human antigen is CEA, CD4, or NCA-2.
36. An immunoglobulin heavy chain minilocus transgene that is expressed in B cells of a transgenic nonhuman animal containing at least one integrated copy of a polynucleotide comprising a DNA sequence of the formula:
(VH)x-(D)y-(JH)z-(SD)m-(C1)n-[(T)-(SA)P-(C2)]q wherein x, y, z, m, n, p, and q are integers and x is 2-100, n is 2-10, y is 2-8, p is 1-10, z is 1-50, q is 0-50, and m is 0-10 .
37. An immunoglobulin heavy chain transgene of claim 36, wherein said transgene is replicated in a mammalian genome.
38. A transgenic mouse of Claim 17 or Claim 25, wherein said heavy chain transgene is a minilocus.
CA2161351A 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies Expired - Lifetime CA2161351C (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US08/053,131 US5661016A (en) 1990-08-29 1993-04-26 Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US08/053,131 1993-04-26
US08/096,762 US5814318A (en) 1990-08-29 1993-07-22 Transgenic non-human animals for producing heterologous antibodies
US08/096,762 1993-07-22
US15530193A 1993-11-18 1993-11-18
US08/155,301 1993-11-18
US16173993A 1993-12-03 1993-12-03
US08/161,739 1993-12-03
US16569993A 1993-12-10 1993-12-10
US08/165,699 1993-12-10
US20974194A 1994-03-09 1994-03-09
US08/209,741 1994-03-09
PCT/US1994/004580 WO1994025585A1 (en) 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies

Publications (2)

Publication Number Publication Date
CA2161351A1 true CA2161351A1 (en) 1994-11-10
CA2161351C CA2161351C (en) 2010-12-21

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CA2161351A Expired - Lifetime CA2161351C (en) 1993-04-26 1994-04-25 Transgenic non-human animals capable of producing heterologous antibodies

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EP (1) EP0754225A4 (en)
JP (3) JPH08509612A (en)
AU (1) AU6819494A (en)
CA (1) CA2161351C (en)
WO (1) WO1994025585A1 (en)

Families Citing this family (721)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) * 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US7084260B1 (en) 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU4376400A (en) * 1995-04-27 2000-11-30 Abgenix, Inc. Human antibodies derived from immunized xenomice
EP1978033A3 (en) * 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
AU2008202860B9 (en) * 1995-04-27 2012-03-29 Amgen Fremont Inc. Human Antibodies Derived From Immunized Xenomice
CA2219486A1 (en) * 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
ES2227594T3 (en) * 1995-06-07 2005-04-01 Jacob N. Wohlstadter METHOD TO PROMOTE ENZYMATIC DIVERSITY.
US5914256A (en) * 1995-06-07 1999-06-22 Wohlstadter Jacob N Method for promoting enzyme diversity
US5919681A (en) * 1995-06-07 1999-07-06 Wohlstadter Jacob N Method for promoting enzyme diversity
ES2283005T3 (en) * 1995-07-21 2007-10-16 University Of Nebraska Board Of Regents COMPOSITIONS AND PROCEDURES FOR CATALIZING THE HYDROLYSIS OF GP 120 OF HIV.
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6497878B1 (en) 1996-04-23 2002-12-24 Chugai Seiyaku Kabushiki Kaisha Treatment of cerebral disorders by inhibition of IL-8 binding to receptor
AU719513B2 (en) * 1996-05-04 2000-05-11 Astrazeneca Ab Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system
ES2301183T3 (en) 1996-12-03 2008-06-16 Amgen Fremont Inc. COMPLETELY HUMAN ANTIBODY THAT JOINS THE EGFR RECEIVER.
AU2008200005B2 (en) * 1996-12-03 2012-05-17 Amgen Fremont Inc. Transgenic Mammals Having Human Ig Loci Including Plural Vh and Vk Regions and Antibodies Produced Therefrom
US6080910A (en) * 1997-02-20 2000-06-27 Case Western Reserve University Transgenic knockout animals lacking IgG3
ATE547119T1 (en) 1997-03-21 2012-03-15 Chugai Pharmaceutical Co Ltd PREVENTIVE OR THERAPEUTIC AGENT CONTAINING AN IL-6 ANTAGONIST AS AN ACTIVE INGREDIENTS FOR SENSITIZED T CELL-MEDIATED DISEASES
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
GB9711167D0 (en) * 1997-05-31 1997-07-23 Babraham The Inst Telomere-associated chromosome fragmentation
AU747883B2 (en) 1997-08-15 2002-05-30 Chugai Seiyaku Kabushiki Kaisha Preventives and/or remedies for systemic lupus erythematosus containing anti-IL-6 receptor antibody as the active ingredient
GB9823930D0 (en) * 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
JP4441121B2 (en) 1998-11-04 2010-03-31 中外製薬株式会社 A novel trypsin family serine protease
KR100856446B1 (en) 1998-12-23 2008-09-04 화이자 인크. Human monoclonal antibodies to ctla-4
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
JP4590107B2 (en) 1999-04-09 2010-12-01 中外製薬株式会社 New fetal gene
ATE455852T1 (en) 1999-06-02 2010-02-15 Chugai Pharmaceutical Co Ltd NEW HEMOPOIETIN RECEPTOR PROTEIN NR10
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
ES2307526T3 (en) 1999-08-23 2008-12-01 Chugai Seiyaku Kabushiki Kaisha POTENTIALS OF THE EXPRESSION OF THE ANTIGEN HM1.24.
ES2282133T3 (en) 1999-08-24 2007-10-16 Medarex, Inc. ANTIBODIES AGAINST HUMAN CTLA-4 AND ITS USES.
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
WO2001018200A1 (en) 1999-09-06 2001-03-15 Chugai Seiyaku Kabushiki Kaisha Tsg-like gene
WO2001019394A2 (en) * 1999-09-15 2001-03-22 Therapeutic Human Polyclonals, Inc. Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds
AU7317400A (en) 1999-09-21 2001-04-24 Chugai Research Institute For Molecular Medicine, Inc. Transporter genes oatp-b, c, d and e
SK4442002A3 (en) 1999-10-01 2003-04-01 Chugai Pharmaceutical Co Ltd Prevention and treatment of diseases associated with blood coagulation
CN100497624C (en) 2000-01-24 2009-06-10 杉山治夫 WT1-interacting protein WTIP
EP1987842A1 (en) 2000-04-28 2008-11-05 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitor
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
JP3597140B2 (en) 2000-05-18 2004-12-02 日本たばこ産業株式会社 Human monoclonal antibody against costimulatory molecule AILIM and pharmaceutical use thereof
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
UA81743C2 (en) 2000-08-07 2008-02-11 Центокор, Инк. HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6586251B2 (en) * 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PT1399483E (en) 2001-01-05 2010-07-20 Pfizer Antibodies to insulin-like growth factor i receptor
WO2002064159A1 (en) 2001-02-07 2002-08-22 Chugai Seiyaku Kabushiki Kaisha Remedies for tumor in hematopoietic organs
CA2437814C (en) 2001-02-12 2008-05-13 Medarex, Inc. Human monoclonal antibodies to fc alpha receptor (cd89)
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
KR20100120246A (en) 2001-11-14 2010-11-12 센토코 오르토 바이오테크 인코포레이티드 Anti-il-6 antibodies, compositions, methods and uses
WO2003047336A2 (en) 2001-11-30 2003-06-12 Abgenix, Inc. TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES
WO2003057881A1 (en) 2001-12-28 2003-07-17 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein
NZ534174A (en) 2002-01-09 2007-03-30 Medarex Inc An isolated human monoclonal antibody which binds to human CD30
EP3578168A1 (en) 2002-02-14 2019-12-11 Chugai Seiyaku Kabushiki Kaisha Formulation of antibody-containing solutions comprising a sugar as a stabilizer
DK1485477T3 (en) 2002-02-25 2009-08-10 Genentech Inc New type 1 cytokine receptor GLM-R
WO2003083116A1 (en) 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Emthod of screening transporter inhibitor
JP2005529873A (en) 2002-04-12 2005-10-06 メダレックス インコーポレイテッド Method of treatment using CTLA-4 antibody
US7217796B2 (en) * 2002-05-24 2007-05-15 Schering Corporation Neutralizing human anti-IGFR antibody
CA2488404C (en) 2002-06-06 2012-11-27 Oncotherapy Science, Inc. Genes and polypeptides relating to human colon cancers
CN101613405A (en) 2002-06-06 2009-12-30 肿瘤疗法科学股份有限公司 Gene relevant and polypeptide with human colon carcinoma
US20060058511A1 (en) 2002-08-27 2006-03-16 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing protein solution preparation
AU2002338020A1 (en) 2002-09-04 2004-03-29 Chugai Seiyaku Kabushiki Kaisha Antibody against blood-solubilized n-terminal peptide in gpc3
DK2261230T3 (en) 2002-09-11 2017-06-12 Chugai Pharmaceutical Co Ltd Method of Protein Purification.
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
TW200413539A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Genes and polypeptides relating to prostate cancers
CA2502552C (en) 2002-10-17 2019-02-12 Genmab A/S Human monoclonal antibodies against cd20
ATE492636T1 (en) 2002-10-22 2011-01-15 Eisai R&D Man Co Ltd GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINE-PRODUCING NEURONAL PRONECTOR CELLS
JPWO2004039981A1 (en) 2002-10-30 2006-03-02 中外製薬株式会社 Mast cell-derived membrane protein
ES2401136T3 (en) 2002-11-15 2013-04-17 Genmab A/S Human monoclonal antibodies against CD25
ES2347239T3 (en) 2002-12-02 2010-10-27 Amgen Fremont Inc. ANTIBODIES DIRECTED TO THE TUMOR NECROSIS FACTOR AND USES OF THE SAME.
ES2373947T3 (en) 2002-12-16 2012-02-10 Genmab A/S HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUCINE 8 (IL-8).
EP1613750B1 (en) 2003-03-19 2015-10-14 Amgen Fremont Inc. Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
EP1627916B1 (en) 2003-05-28 2009-11-25 Takeda Pharmaceutical Company Limited Anti-BAMBI antibodies or RNA for diagnosis and therapy of colon or liver cancer
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
EP2508608A1 (en) 2003-06-09 2012-10-10 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
EP2228445A1 (en) 2003-06-18 2010-09-15 Chugai Seiyaku Kabushiki Kaisha Fucose Transporter
CN104059147A (en) 2003-06-27 2014-09-24 艾默根佛蒙特有限公司 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof
WO2005047459A2 (en) 2003-08-04 2005-05-26 University Of Massachusetts Sars nucleic acids, proteins, antibodies, and uses thereof
EP2311468B1 (en) 2003-08-08 2014-01-15 Perseus Proteomics Inc. Gene overexpressed in cancer
EP1659918B1 (en) 2003-08-08 2009-01-14 Amgen Fremont Inc. Antibodies directed to parathyroid hormone (pth) and uses thereof
WO2005035753A1 (en) 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
AU2003271186A1 (en) 2003-10-14 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
EP1533617A1 (en) 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
US7642341B2 (en) 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
ATE512232T1 (en) 2003-12-03 2011-06-15 Chugai Pharmaceutical Co Ltd EXPRESSION SYSTEM WITH A MAMMAL BETA-ACTIN PROMOTER
ES2537163T3 (en) 2003-12-10 2015-06-03 E. R. Squibb & Sons, L.L.C. IP-10 antibodies and their uses
SI2418220T1 (en) 2003-12-10 2017-10-30 E. R. Squibb & Sons, L.L.C. Interferon alpha antibodies and their uses
US20080206229A1 (en) 2003-12-12 2008-08-28 Koichiro Ono Modified Antibodies Recognizing Receptor Trimers or Higher Multimers
NZ580828A (en) 2004-02-06 2011-09-30 Univ Massachusetts Antibodies against clostridium difficile toxin B and uses thereof
US20050260679A1 (en) 2004-03-19 2005-11-24 Sirid-Aimee Kellerman Reducing the risk of human anti-human antibodies through V gene manipulation
US7625549B2 (en) 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
ATE496142T1 (en) 2004-03-23 2011-02-15 Oncotherapy Science Inc METHOD FOR DIAGNOSING NON-SMALL CELL LUNG CANCER
SG172616A1 (en) 2004-04-13 2011-07-28 Hoffmann La Roche Anti-p-selectin antibodies
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
US9228008B2 (en) 2004-05-28 2016-01-05 Idexx Laboratories, Inc. Canine anti-CD20 antibodies
WO2005118642A2 (en) 2004-06-01 2005-12-15 Domantis Limited Bispecific fusion antibodies with enhanced serum half-life
KR101335079B1 (en) 2004-06-21 2013-12-12 메다렉스, 엘.엘.시. Interferon alpha receptor 1 antibodies and their uses
DK2287195T3 (en) 2004-07-01 2019-08-19 Innate Pharma PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND USE IN DIAGNOSTICS AND THERAPY
EP2898897A3 (en) 2004-07-09 2015-10-14 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody
US20080199437A1 (en) 2004-07-22 2008-08-21 Eisai Co., Ltd. Lrp4/Corin Dopaminergic Neuron Progenitor Cell Markers
TWI380996B (en) 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
US7790160B2 (en) 2004-10-01 2010-09-07 Medarex, Inc. Method of treating CD30 positive lymphomas
KR20070072608A (en) 2004-10-22 2007-07-04 레비비코르 인코포레이션 Ungulates with genetically modified immune systems
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
EP1824886B1 (en) 2004-11-17 2010-12-22 Amgen Inc. Fully human monoclonal antibodies to il-13
KR20070094909A (en) 2004-12-02 2007-09-27 도만티스 리미티드 Bispecific domain ant1bodies targeting serum albumin and glp-1 or pyy
ATE504602T1 (en) 2004-12-20 2011-04-15 Amgen Fremont Inc BINDING PROTEINS SPECIFIC TO HUMAN MATRIPTASE
RU2394839C2 (en) 2004-12-21 2010-07-20 Астразенека Аб Antibodies against angiopoietin-2 and use thereof
JPWO2006067847A1 (en) 2004-12-22 2008-06-12 中外製薬株式会社 Antibody production method using cells in which fucose transporter function is inhibited
EP1851245B1 (en) 2005-01-26 2012-10-10 Amgen Fremont Inc. Antibodies against interleukin-1 beta
CN101175862A (en) 2005-02-10 2008-05-07 肿瘤疗法科学股份有限公司 Method of diagnosing bladder cancer
RU2492186C2 (en) 2005-02-18 2013-09-10 Медарекс Ллс Isolated anti-cd30 antibody (versions); host cell, method of obtaining chimeric or humanised version of anti-cd30 antibodies (versions), method of inhibiting growth of cells cd30+ and method of inhibiting growth of tumour cells expressing cd30
TWI406870B (en) 2005-02-21 2013-09-01 Chugai Pharmaceutical Co Ltd A method of making a protein using hamster IGF-1
WO2006098464A1 (en) 2005-03-14 2006-09-21 Link Genomics, Inc. Method for diagnosis of prostate cancer
WO2007059082A1 (en) 2005-11-10 2007-05-24 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
SI2567976T1 (en) 2005-03-23 2017-11-30 Genmab A/S Antibodies against CD38 for treatment of multiple myeloma
EP2824183B1 (en) 2005-04-08 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Methods for producing bispecific antibodies
PE20061324A1 (en) 2005-04-29 2007-01-15 Centocor Inc ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES
CN109485727A (en) 2005-05-09 2019-03-19 小野药品工业株式会社 The human monoclonal antibodies of programmed death-1 (PD-1) and the method for carrying out treating cancer using anti-PD-1 antibody
KR101367544B1 (en) 2005-06-10 2014-02-26 추가이 세이야쿠 가부시키가이샤 Stabilizer for protein preparation comprising meglumine and use thereof
JP2009501006A (en) 2005-06-30 2009-01-15 セントカー・インコーポレーテツド Anti-IL-23 antibodies, compositions, methods and uses
MX2007015942A (en) 2005-07-01 2008-03-07 Medarex Inc Human monoclonal antibodies to programmed death ligand 1 (pd-l1).
EP1907859B1 (en) 2005-07-27 2011-03-02 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers
WO2007019865A2 (en) 2005-08-18 2007-02-22 Genmab A/S Therapy with cd4 binding peptides and radiation
ES2527961T3 (en) 2005-09-26 2015-02-02 Medarex, L.L.C. Human monoclonal antibodies to CD70
RU2396275C2 (en) 2005-09-29 2010-08-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. T cell adhesion molecule and antibody against said molecule
EP1941907B1 (en) 2005-10-14 2016-03-23 Fukuoka University Inhibitor of transplanted islet dysfunction in islet transplantation
EP2532677A1 (en) 2005-10-21 2012-12-12 Novartis AG Human antibodies against il13 and therapeutic uses
KR101239051B1 (en) 2005-10-21 2013-03-04 추가이 세이야쿠 가부시키가이샤 Agents for treating cardiopathy
KR20080068048A (en) 2005-10-28 2008-07-22 메이지 세이카 가부시키가이샤 Outer coat protein pa5158 of pseudomonas aeruginosa
US8128934B2 (en) 2005-11-14 2012-03-06 Ribomic, Inc. Method for treatment or prevention of disease associated with functional disorder of regulatory T cell
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization AGENTS TO DELETE INDUCTION OF CYTOTOXIC T LYMPHOCYTES
AR057941A1 (en) 2005-11-25 2007-12-26 Univ Keio THERAPEUTIC AGENTS FOR PROSTATE CANCER
CN101325971A (en) 2005-12-07 2008-12-17 米德列斯公司 CTLA-4 antibody dosage escalation regimens
CN101356195B (en) 2005-12-08 2013-04-03 米德列斯公司 Human monoclonal antibodies to fucosyl-GM1 and methods for using anti-fucosyl-GM1
CN105753983A (en) 2005-12-13 2016-07-13 阿斯利康(瑞典)有限公司 Binding Proteins Specific For Insulin-like Growth Factors And Uses Thereof
JP5231810B2 (en) 2005-12-28 2013-07-10 中外製薬株式会社 Antibody-containing stabilized preparation
CA2635849C (en) 2005-12-28 2017-05-09 Asubio Pharma Co., Ltd. An antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
AR056857A1 (en) 2005-12-30 2007-10-24 U3 Pharma Ag DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES
DK2463305T3 (en) 2006-01-12 2016-08-29 Alexion Pharma Inc Antibodies to OX-2 / CD200 and uses thereof
ES2396569T3 (en) 2006-01-17 2013-02-22 Medarex, Inc. Monoclonal antibodies against CD30 that lack fucosyl and xylosyl moieties
CN101370521A (en) 2006-01-27 2009-02-18 学校法人庆应义塾 Remedy for disease associated with choroidal angiogenesis
CA2645904A1 (en) 2006-03-30 2007-10-11 Meiji Seika Kaisha, Ltd. Pseudomonas aeruginosa outer membrane protein pa0427
US7910798B2 (en) 2006-03-31 2011-03-22 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
CA2648644C (en) 2006-04-07 2016-01-05 Osaka University Muscle regeneration promoter
BRPI0709481A2 (en) 2006-04-07 2011-07-19 Government Of The Us Secretary Dept Of Health And Human Services isolated monoclonal antibody, isolated human monoclonal antibody, pharmaceutical composition, isolated recombinant anti-igf-i and anti-igf-ii antibody or antigen-binding fragment thereof, method for detecting factor i and factor ii of human insulin growth in a sample , method for detecting human insulin growth factor i in a sample, isolated nucleic acid, recombinant cell, host cell, method for preparing an antibody, method for preparing an antibody, method for treating neoplastic disease in a mammalian individual, method for to diagnose neoplastic disease in a mammal and method to classify a drug candidate compound
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
EP2011513B1 (en) 2006-04-25 2016-10-19 The University of Tokyo Therapeutic agents for alzheimer's disease and cancer
AR061317A1 (en) 2006-06-08 2008-08-20 Chugai Pharmaceutical Co Ltd AGENTS TO PREVENT OR TREAT INFLAMMATORY DISEASES
KR20090021217A (en) 2006-06-14 2009-02-27 추가이 세이야쿠 가부시키가이샤 Hematopoietic stem cell proliferation promoter
CA2657385A1 (en) 2006-07-13 2008-01-17 Naoki Kimura Cell death inducer
US8025881B2 (en) 2006-07-21 2011-09-27 Chugai Seiyaku Kabushiki Kaisha BMP antibodies and methods of treating kidney disease using the same
CA2658612C (en) 2006-08-03 2015-11-17 Astrazeneca Ab Antibodies directed to .alpha.v.beta.6 and uses thereof
CL2007002225A1 (en) 2006-08-03 2008-04-18 Astrazeneca Ab SPECIFIC UNION AGENT FOR A RECEIVER OF THE GROWTH FACTOR DERIVED FROM PLATES (PDGFR-ALFA); NUCLEIC ACID MOLECULA THAT CODIFIES IT; VECTOR AND CELL GUESTS THAT UNDERSTAND IT; CONJUGADO UNDERSTANDING THE AGENT; AND USE OF THE AGENT OF A
JP5317697B2 (en) 2006-08-14 2013-10-16 中外製薬株式会社 Diagnosis and treatment of cancer using anti-Desmoglein3 antibody
KR20090088852A (en) 2006-09-05 2009-08-20 메다렉스, 인코포레이티드 Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
WO2008032833A1 (en) 2006-09-14 2008-03-20 Medical & Biological Laboratories Co., Ltd. Antibody having enhanced adcc activity and method for production thereof
SI2081595T1 (en) 2006-09-26 2019-10-30 Genmab As Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors
US8007797B2 (en) 2006-09-28 2011-08-30 Merck Serono S.A. Junctional adhesion molecule-C (JAM-C) binding compounds and methods of their use
HUE033630T2 (en) 2006-10-02 2017-12-28 Squibb & Sons Llc Human antibodies that bind CXCR4 and uses thereof
CA2665528C (en) 2006-10-12 2018-01-23 The University Of Tokyo Diagnosis and treatment of cancer using anti-ereg antibody
ES2388567T3 (en) 2006-10-19 2012-10-16 Csl Limited Anti-il-13r alpha 1 antibodies and uses thereof
EP3040347A3 (en) 2006-10-20 2016-09-21 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
WO2008047914A1 (en) 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Cancer therapeutic agent comprising anti-hb-egf antibody as active ingredient
CA2669921A1 (en) 2006-11-15 2008-06-26 Medarex, Inc. Human monoclonal antibodies to btla and methods of use
CN101626785A (en) 2006-11-17 2010-01-13 财团法人阪大微生物病研究会 Nerve elongation promoter and elongation inhibitor
ES2678060T3 (en) 2006-12-01 2018-08-08 E. R. Squibb & Sons, L.L.C. Antibodies, in particular, human antibodies, which bind to CD22 and uses thereof
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
MX2009006277A (en) 2006-12-14 2009-07-24 Medarex Inc Human antibodies that bind cd70 and uses thereof.
WO2008072723A1 (en) 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. ANTI-Claudin-3 MONOCLONAL ANTIBODY, AND TREATMENT AND DIAGNOSIS OF CANCER USING THE SAME
WO2008081942A1 (en) 2007-01-05 2008-07-10 The University Of Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
CN104524567A (en) 2007-01-16 2015-04-22 阿布维公司 Methods for treating psoriasis
CN101646459B (en) 2007-01-23 2014-02-12 国立大学法人信州大学 Chronic rejection inhibitor
EP2119777A4 (en) 2007-02-09 2011-05-25 Eisai R&D Man Co Ltd Gaba neuron progenitor cell marker 65b13
TW200900077A (en) 2007-02-15 2009-01-01 Univ Kyushu Nat Univ Corp Therapeutic agent for interstitial pulmonary disease comprising anti-HMGB-1 antibody
SI2129396T1 (en) 2007-02-16 2013-12-31 Merrimack Pharmaceuticals, Inc. Antibodies against erbb3 and uses thereof
PL2125889T3 (en) 2007-02-21 2014-06-30 Univ Massachusetts Human antibodies against hepatitis c virus (hcv) uses thereof
JP5374360B2 (en) 2007-02-27 2013-12-25 中外製薬株式会社 Pharmaceutical composition comprising anti-GRP78 antibody as an active ingredient
CL2008000719A1 (en) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO
PL2125894T3 (en) 2007-03-22 2019-08-30 Biogen Ma Inc. Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
NZ614857A (en) 2007-03-29 2015-04-24 Genmab As Bispecific antibodies and methods for production thereof
FI20075278A0 (en) 2007-04-20 2007-04-20 Biotie Therapies Corp Novel completely human anti-VAP-1 monoclonal antibodies
JP5117765B2 (en) 2007-05-28 2013-01-16 国立大学法人 東京大学 Tumor diagnostic agent for PET containing anti-ROBO1 antibody
WO2008145140A2 (en) 2007-05-31 2008-12-04 Genmab A/S Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
US20100267934A1 (en) 2007-05-31 2010-10-21 Genmab A/S Stable igg4 antibodies
CN101801407B (en) 2007-06-05 2013-12-18 耶鲁大学 Inhibitors of receptor tyrosine kinases and methods of use thereof
US8722858B2 (en) 2007-06-25 2014-05-13 Chugai Seiyaku Kabushiki Kaisha Anti-Prominin-1 antibody having ADCC activity or CDC activity
KR101560843B1 (en) 2007-06-27 2015-10-15 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 -17 cancer remedy containing antibody against peptide encoded by exon-17 of periostin
EP2186894A4 (en) 2007-07-10 2010-10-20 Shionogi & Co Monoclonal antibody having neutralizing activity against mmp13
JP5424330B2 (en) 2007-07-26 2014-02-26 国立大学法人大阪大学 A therapeutic agent for ocular inflammatory diseases comprising an interleukin 6 receptor inhibitor as an active ingredient
US8012474B2 (en) 2007-08-02 2011-09-06 Nov Immune S.A. Anti-RANTES antibodies
JP5588866B2 (en) 2007-08-10 2014-09-10 メダレックス エル．エル．シー． HCO 32 and HCO 27 and related examples
JP5555952B2 (en) 2007-08-20 2014-07-23 オンコセラピー・サイエンス株式会社 FOXM1 peptide and drug containing the same
CN101835892B (en) 2007-08-20 2013-11-06 肿瘤疗法科学股份有限公司 CDCA1 peptide and pharmaceutical agent comprising the same
CN104356225B (en) 2007-08-20 2018-02-13 肿瘤疗法科学股份有限公司 CDH3 peptides and the medicament containing CDH3 peptides
US8865875B2 (en) 2007-08-22 2014-10-21 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
EP2615113A3 (en) 2007-08-23 2013-11-13 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
JOP20080381B1 (en) 2007-08-23 2023-03-28 Amgen Inc Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9)
LT2769729T (en) 2007-09-04 2019-05-10 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
EP2207809B1 (en) 2007-09-26 2013-07-03 U3 Pharma GmbH Heparin-binding epidermal growth factor-like growth factor antigen binding proteins
KR101601986B1 (en) 2007-10-02 2016-03-17 추가이 세이야쿠 가부시키가이샤 Remedy for graft-versus-host disease comprising interleukin-6 receptor inhibitor as the active ingredient
AR068767A1 (en) 2007-10-12 2009-12-02 Novartis Ag ANTIBODIES AGAINST SCLEROSTIN, COMPOSITIONS AND METHODS OF USE OF THESE ANTIBODIES TO TREAT A PATHOLOGICAL DISORDER MEDIATIONED BY SCLEROSTIN
MX2010004007A (en) 2007-10-15 2010-06-15 Chugai Pharmaceutical Co Ltd Method for production of antibody.
EP2210901A4 (en) 2007-10-19 2012-04-25 Immunas Pharma Inc Antibody capable of specifically binding to a oligomer, and use thereof
BRPI0820327A2 (en) 2007-11-02 2020-10-06 Novartis Ag molecules and methods for protein modulation related to low density 6 lipoprotein receptor (lrp6)
EP2224954B1 (en) 2007-11-07 2014-01-08 Celldex Therapeutics, Inc. Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
ES2556214T3 (en) 2007-11-12 2016-01-14 U3 Pharma Gmbh AXL antibodies
CA2705509A1 (en) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-gpr49 antibody
CA2706549A1 (en) 2007-11-15 2009-05-22 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody capable of binding to anexelekto, and use thereof
BRPI0821110B8 (en) 2007-12-05 2021-05-25 Chugai Pharmaceutical Co Ltd anti-nr10/il31ra neutralizing antibody, pharmaceutical composition comprising said antibody and use thereof
TWI441649B (en) 2007-12-05 2014-06-21 Chugai Pharmaceutical Co Ltd Use of anti-NR10 monoclonal antibody with neutralizing activity against NR10 in the manufacture of prophylactic or therapeutic agents for pruritus
EP2241333A1 (en) 2007-12-12 2010-10-20 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
CN101945893B (en) 2007-12-14 2015-02-25 诺沃-诺迪斯克有限公司 Anti-human NKG2D monoclonal antibodies and use thereof
CN101970468A (en) 2007-12-25 2011-02-09 明治制果株式会社 Component protein pa1698 for type-iii secretion system of pseudomonas aeruginosa
PE20091174A1 (en) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT
BRPI0906810A2 (en) 2008-01-10 2019-10-01 Shionogi & Co pcrv antibody
EP4282428A3 (en) 2008-01-11 2024-03-20 The University of Tokyo Anti-cldn6 antibody
US8653020B2 (en) 2008-01-25 2014-02-18 Aarhus Universitet Selective exosite inhibition of PAPP-A activity against IGFBP-4
CA2714071A1 (en) 2008-02-05 2009-08-13 Bristol-Myers Squibb Company Alpha 5 - beta 1 antibodies and their uses
DK2246427T3 (en) 2008-02-08 2017-02-20 Immunas Pharma Inc Antibodies capable of binding specifically to amyloid-beta oligomers and their use
TW201513883A (en) 2008-03-18 2015-04-16 Abbvie Inc Methods for treating psoriasis
JPWO2009119794A1 (en) 2008-03-27 2011-07-28 タカラバイオ株式会社 Infectious disease prevention and treatment
CL2009000647A1 (en) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Pharmaceutical composition for treating or preventing liver cancer comprising a combination of a chemotherapeutic agent and an anti-glypican 3 antibody; agent for attenuating a side effect comprising said antibody; method of treating or preventing liver cancer of a subject.
WO2009147781A1 (en) 2008-06-02 2009-12-10 国立大学法人東京大学 Antitumor agent
WO2009148148A1 (en) 2008-06-05 2009-12-10 国立がんセンター総長が代表する日本国 Neuroinvasion inhibitor
CA2728473A1 (en) 2008-06-20 2009-12-23 National University Corporation Okayama University Antibody against oxidized ldl/.beta.2gpi complex and use of the same
JP5815403B2 (en) 2008-08-05 2015-11-17 ノバルティス アーゲー Compositions and methods relating to antibodies targeting complement protein C5
JP5692746B2 (en) 2008-08-07 2015-04-01 国立大学法人 長崎大学 Treatment or prevention of systemic pain syndrome
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
AR073060A1 (en) 2008-08-14 2010-10-13 Arana Therapeutic Ltd ANTI-BODIES ANTI-IL-12 / IL-23
US8192738B2 (en) 2008-09-19 2012-06-05 Medimmune, Llc Targeted antibodies directed to DLL4
CN102264762B (en) 2008-09-26 2018-03-27 达纳-法伯癌症研究公司 The anti-PD 1 of people, PD L1 and PD L2 antibody and its application
DK2346994T3 (en) 2008-09-30 2022-02-28 Ablexis Llc Knock-in mice for the production of chimeric antibodies
EP2348827B1 (en) 2008-10-27 2015-07-01 Revivicor, Inc. Immunocompromised ungulates
BRPI0921237A2 (en) 2008-11-10 2015-09-22 Alexion Pharma Inc methods and compositions for the treatment of complement-associated disorders
WO2010063785A2 (en) 2008-12-03 2010-06-10 Genmab A/S Antibody variants having modifications in the constant region
EP2373690B1 (en) 2008-12-08 2015-02-11 Compugen Ltd. Antibodies specific for tmem154
UA109633C2 (en) 2008-12-09 2015-09-25 HUMAN ANTIBODY AGAINST TISSUE FACTOR
CN112680475A (en) * 2008-12-18 2021-04-20 伊拉兹马斯大学鹿特丹医学中心 Non-human transgenic animals expressing humanized antibodies and uses thereof
EP2388320B1 (en) 2008-12-22 2017-02-15 Chugai Seiyaku Kabushiki Kaisha Anti-hs6st2 antibodies and uses thereof
EP2377921B1 (en) 2008-12-22 2016-04-13 Eisai R&D Management Co., Ltd. Method for obtaining pancreatic progenitor cell using neph3
AU2009331528A1 (en) 2008-12-23 2011-08-11 Astrazeneca Ab Targeted binding agents directed to alpha5beta1 and uses thereof
WO2010073694A1 (en) 2008-12-25 2010-07-01 国立大学法人東京大学 Diagnosis of treatment of cancer using anti-tm4sf20 antibody
MX2011006908A (en) 2008-12-26 2011-10-06 Univ Tokio Diagnosis and treatment of cancer using anti-lgr7 antibody.
JP5816558B2 (en) 2009-03-05 2015-11-18 メダレックス・リミテッド・ライアビリティ・カンパニーＭｅｄａｒｅｘ， Ｌ．Ｌ．Ｃ． Fully human antibody specific for CADM1
JP2010210772A (en) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd Method of manufacturing liquid crystal display device
EP2412825B8 (en) 2009-03-24 2018-01-10 Riken Leukemia stem cell markers
WO2010112034A2 (en) 2009-04-02 2010-10-07 Aarhus Universitet Compositions and methods for treatment and diagnosis of synucleinopathies
EP2416803B1 (en) 2009-04-08 2016-04-06 LipUm AB New methods for treatment of inflammatory diseases
EP2420515A4 (en) 2009-04-16 2013-08-28 Univ Tokyo Diagnosis and treatment of cancer using anti-tmprss11e antibody
EP2419447B1 (en) 2009-04-17 2017-08-23 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
US9062116B2 (en) 2009-04-23 2015-06-23 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
AU2010230311B9 (en) 2009-04-27 2012-09-20 Novartis Ag Composition and methods of use for therapeutic antibodies specific for the IL-12 receptore betal subunit
CA2993053A1 (en) 2009-04-27 2010-11-04 Novartis Ag Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
CA2760642A1 (en) 2009-05-01 2010-11-04 The University Of Tokyo Anti-cadherin antibody
AR076650A1 (en) 2009-05-04 2011-06-29 Pangenetics 110 B V ANTIBODIES AGAINST THE NERVOUS GROWTH FACTOR (NGF) WITH IMPROVED LIVE STABILITY
RU2605318C2 (en) 2009-05-05 2016-12-20 Новиммун С.А. Anti-il-17f antibodies and methods for use thereof
EP2436397B1 (en) 2009-05-29 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing antagonist of egf family ligand as component
US20120101262A1 (en) 2009-06-25 2012-04-26 Bristol-Myers Squibb Company Protein purification by caprylic acid (octanoic acid) precipitation
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
DK3241435T3 (en) 2009-07-08 2021-08-23 Kymab Ltd ANIMAL MODELS AND THERAPEUTIC MOLECULES
AU2010278067B2 (en) 2009-07-31 2016-10-27 Shin Maeda Cancer metastasis inhibitor
WO2011014438A1 (en) 2009-07-31 2011-02-03 N.V. Organon Fully human antibodies to btla
JP5769316B2 (en) 2009-08-06 2015-08-26 イムナス・ファーマ株式会社 Antibody specifically binding to Aβ oligomer and use thereof
US8613924B2 (en) 2009-08-06 2013-12-24 Immunas Pharma, Inc. Antibodies that specifically bind to A beta oligomers and use thereof
WO2011017294A1 (en) 2009-08-07 2011-02-10 Schering Corporation Human anti-rankl antibodies
AU2010285974A1 (en) 2009-08-17 2012-03-22 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient
WO2011021146A1 (en) 2009-08-20 2011-02-24 Pfizer Inc. Osteopontin antibodies
KR20140048229A (en) 2009-09-14 2014-04-23 애브비 인코포레이티드 Methods for treating psoriasis
US20120178910A1 (en) 2009-09-23 2012-07-12 Medarex, Inc. Cation exchange chromatography (methods)
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
AU2010314844B2 (en) 2009-11-09 2015-03-12 Alexion Pharmaceuticals, Inc. Reagents and methods for detecting PNH type II white blood cells and their identification as risk factors for thrombotic disorders
RS56741B1 (en) 2009-11-13 2018-03-30 Daiichi Sankyo Europe Gmbh Material and methods for treating or preventing her-3 associated diseases
EP3168232B1 (en) 2009-11-13 2021-09-29 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for the diagnosis, prognosis, monitoring, treatment and modulation of post-transplant lymphoproliferative disorders and hypoxia associated angiogenesis disorders using galectin-1
RS56484B1 (en) 2009-11-17 2018-01-31 Squibb & Sons Llc Methods for enhanced protein production
RS60033B1 (en) 2009-11-24 2020-04-30 Medimmune Ltd Targeted binding agents against b7-h1
WO2011067711A2 (en) 2009-12-01 2011-06-09 Compugen Ltd Novel heparanase splice variant
US9180186B2 (en) 2010-01-11 2015-11-10 Alexion Pharmaceuticals, Inc. Biomarkers of immunomodulatory effects in humans treated with anti-CD200 antibodies
TWI505838B (en) 2010-01-20 2015-11-01 Chugai Pharmaceutical Co Ltd Stabilized antibody
EP3907242A1 (en) 2010-01-29 2021-11-10 Chugai Seiyaku Kabushiki Kaisha Anti-dll3 antibody
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
ES2547142T5 (en) * 2010-02-08 2021-12-09 Regeneron Pharma Mouse common light chain
PL2535358T3 (en) 2010-02-10 2018-05-30 Fujifilm Ri Pharma Co., Ltd. Radioactive metal-labeled anti-cadherin antibody
MX341687B (en) 2010-02-10 2016-08-30 Immunogen Inc Cd20 antibodies and uses thereof.
US20120321557A1 (en) 2010-02-26 2012-12-20 Forerunner Pharma Research Co., Ltd. Anti-icam3 antibody and use thereof
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
EP3511342B1 (en) 2010-03-10 2024-01-17 Genmab A/S Monoclonal antibodies against c-met
US20110256135A1 (en) 2010-03-17 2011-10-20 Wolfgang Fraunhofer Anti-nerve growth factor (ngf) antibody compositions
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
CN107098958B (en) 2010-03-26 2021-11-05 达特茅斯大学理事会 VISTA regulatory T cell mediator protein, VISTA binding agent and uses thereof
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
EP4345164A2 (en) 2010-03-31 2024-04-03 Ablexis, LLC Genetic engineering of non-human animals for the production of chimeric antibodies
US9169325B2 (en) 2010-04-13 2015-10-27 Celldex Therapeutics, Inc. Antibodies that bind human CD27 and uses thereof
BR112012026766B1 (en) 2010-04-20 2021-11-03 Genmab A/S IN VITRO METHODS FOR GENERATING A HETERODIMERIC IGG ANTIBODY, FOR THE SELECTION OF A BISPECIFIC ANTIBODY, EXPRESSION VECTOR, HETERODIMERIC IGG ANTIBODY, PHARMACEUTICAL COMPOSITION, AND, USE OF A HETERODIMERIC IGG ANTIBODY
US9011852B2 (en) 2010-04-30 2015-04-21 Alexion Pharmaceuticals, Inc. Anti-C5a antibodies
KR20130060223A (en) 2010-05-04 2013-06-07 메리맥 파마슈티컬즈, 인크. Antibodies against epidermal growth factor receptor (egfr) and uses thereof
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
PE20130206A1 (en) 2010-05-06 2013-02-28 Novartis Ag MULTIVALENT ANTIBODIES ANTAGONISTS OF LRP6 (LOW DENSITY LIPOPROTEIN-RELATED PROTEIN 6) AND COMPOSITIONS
JP2013527762A (en) 2010-05-06 2013-07-04 ノバルティス アーゲー Therapeutic low density lipoprotein related protein 6 (LRP6) antibody compositions and methods of use
JP6082344B2 (en) 2010-05-27 2017-02-15 ゲンマブ エー／エス Monoclonal antibody against HER2 epitope
CN107253992B (en) 2010-05-27 2022-03-11 根马布股份公司 Monoclonal antibody against HER2
EP2578233B1 (en) 2010-05-28 2017-04-26 National Cancer Center Therapeutic agent for pancreatic cancer
HRP20221490T1 (en) 2010-05-28 2023-02-03 Chugai Seiyaku Kabushiki Kaisha Antitumor t cell response enhancer
LT2580243T (en) 2010-06-09 2020-01-27 Genmab A/S Antibodies against human cd38
CA2802782C (en) 2010-06-15 2018-03-13 Genmab A/S Human antibody drug conjugates against tissue factor
EP2585476A4 (en) 2010-06-22 2014-01-22 Neogenix Oncology Inc Colon and pancreas cancer specific antigens and antibodies
CA2803588A1 (en) 2010-06-22 2011-12-29 The Regents Of The University Of Colorado, A Body Corporate Antibodies to the c3d fragment of complement component 3
WO2012005076A1 (en) 2010-07-08 2012-01-12 本田技研工業株式会社 High frequency heating coil
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
RU2580017C2 (en) 2010-07-26 2016-04-10 Трианни, Инк. Transgenic animals and methods of use
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
US9516868B2 (en) 2010-08-02 2016-12-13 Regeneron Pharmaceuticals, Inc. Mice that make VL binding proteins
AU2011286407A1 (en) 2010-08-06 2013-02-21 Amgen Use of HER3 binding agents in prostate treatment
CN103080134B (en) 2010-08-20 2015-11-25 诺华股份有限公司 The antibody of EGF-R ELISA 3 (HER3)
AU2011301803A1 (en) 2010-09-17 2013-03-21 Baxalta GmbH Stabilization of immunoglobulins and other proteins through aqueous formulations with sodium chloride at weak acidic to neutral pH
US8999335B2 (en) 2010-09-17 2015-04-07 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
EP2622091B1 (en) 2010-09-23 2019-03-13 Precision Biologics, Inc. Colon and pancreas cancer peptidomimetics
US9675693B2 (en) 2010-09-30 2017-06-13 Riken Methods and drugs targeting Eva1 or Ceacam1 gene expression for treatment and diagnosing of glioma
EP2625203A1 (en) 2010-10-05 2013-08-14 Novartis AG Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders
KR20140014077A (en) 2010-10-25 2014-02-05 리전츠 오브 더 유니버스티 오브 미네소타 Therapeutic composition for treatment of glioblastoma
WO2012057328A1 (en) 2010-10-29 2012-05-03 株式会社ペルセウスプロテオミクス Anti-cdh3 antibody having high internalizing capability
TWI452136B (en) 2010-11-17 2014-09-11 中外製藥股份有限公司 A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
WO2012069466A1 (en) 2010-11-24 2012-05-31 Novartis Ag Multispecific molecules
EP2647706B1 (en) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
TWI638833B (en) 2010-11-30 2018-10-21 中外製藥股份有限公司 Cell damage induction treatment
US9085772B2 (en) 2010-12-27 2015-07-21 National University Corporation Nagoya University Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell
US9315566B2 (en) 2011-01-24 2016-04-19 National University Of Singapore Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins
AU2012212066A1 (en) 2011-02-03 2013-08-15 Alexion Pharmaceuticals, Inc. Use of an anti-CD200 antibody for prolonging the survival of allografts
EP2679681B2 (en) 2011-02-25 2023-11-15 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific FC antibody
JP5948683B2 (en) 2011-02-28 2016-07-06 国立研究開発法人国立循環器病研究センター Medicament for inhibiting malignant tumor metastasis
US8906635B2 (en) 2011-02-28 2014-12-09 Northshore University Healthsystem Methods of diagnosing Clostridium difficile infection
EP2698431B1 (en) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
US10059746B2 (en) 2011-04-04 2018-08-28 University Of Iowa Research Foundation Methods of improving vaccine immunogenicity
US8628773B2 (en) 2011-04-07 2014-01-14 Amgen Inc. Antigen binding proteins
WO2012136552A1 (en) 2011-04-08 2012-10-11 H. Lundbeck A/S ANTIBODIES SPECIFIC TO PYROGLUTAMATED Αβ
US9150644B2 (en) 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
RU2016147206A (en) 2011-04-15 2018-10-19 Компуджен Лтд. Polypeptides and polynucleotides and their use for the treatment of immunological disorders and cancer
EP2700652B1 (en) 2011-04-18 2018-12-19 The University of Tokyo Diagnosis and treatment of cancer using anti-itm2a antibody
CA2832389A1 (en) 2011-04-20 2012-10-26 Genmab A/S Bispecific antibodies against her2 and cd3
JP6177231B2 (en) 2011-04-20 2017-08-09 ゲンマブ エー／エス Bispecific antibody against HER2
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
JOP20200043A1 (en) 2011-05-10 2017-06-16 Amgen Inc Methods of treating or preventing cholesterol related disorders
US8846042B2 (en) 2011-05-16 2014-09-30 Fabion Pharmaceuticals, Inc. Multi-specific FAB fusion proteins and methods of use
TWI560200B (en) 2011-05-25 2016-12-01 Innate Pharma Sa Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
WO2012172495A1 (en) 2011-06-14 2012-12-20 Novartis Ag Compositions and methods for antibodies targeting tem8
EP2726503B1 (en) 2011-06-30 2019-09-04 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
EP4011913A1 (en) 2011-06-30 2022-06-15 Chugai Seiyaku Kabushiki Kaisha Heterodimerized polypeptide
PT2726099T (en) 2011-07-01 2018-11-13 Novartis Ag Method for treating metabolic disorders
EP2729496B8 (en) 2011-07-06 2017-10-18 Genmab A/S Modulation of complement-dependent cytotoxicity through modifications of the c-terminus of antibody heavy chains
UA117901C2 (en) 2011-07-06 2018-10-25 Ґенмаб Б.В. Antibody variants and uses thereof
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
WO2013012855A1 (en) 2011-07-18 2013-01-24 Amgen Inc. Apelin antigen-binding proteins and uses thereof
US9574005B2 (en) 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
EP2739652B1 (en) 2011-08-04 2017-04-05 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
PL3572517T3 (en) 2011-08-05 2021-10-04 Regeneron Pharmaceuticals, Inc. Humanized universal light chain mice
WO2013024517A1 (en) 2011-08-12 2013-02-21 国立感染症研究所 Method for testing for, preventing, and treating infectious disease aspergillus fumigatus; and composition
EP2749572A4 (en) 2011-08-23 2015-04-01 Chugai Pharmaceutical Co Ltd Novel anti-ddr1 antibody having anti-tumor activity
US10018630B2 (en) 2011-09-07 2018-07-10 Chugai Seiyaku Kabushiki Kaisha Cancer stem cell isolation
JP5813880B2 (en) * 2011-09-19 2015-11-17 カイマブ・リミテッド Antibodies, variable domains and chains made for human use
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
RU2732151C2 (en) 2011-09-30 2020-09-11 Чугаи Сейяку Кабусики Кайся Library of concentration-dependent binding molecules
US20140335089A1 (en) 2011-09-30 2014-11-13 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting elimination of antigens
CN110655578A (en) 2011-09-30 2020-01-07 中外制药株式会社 Antigen binding molecules that induce an immune response against a target antigen
EP2765192A4 (en) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for promoting clearance from plasma of antigen comprising saccharide chain receptor-binding domain
JP2014530816A (en) 2011-10-14 2014-11-20 ノバルティスアーゲー Antibodies and methods for Wnt pathway related diseases
US10246509B2 (en) 2011-10-17 2019-04-02 Regeneron Pharmaceuticals, Inc. Restricted immunoglobulin heavy chain mice
US10344050B2 (en) 2011-10-27 2019-07-09 Genmab A/S Production of heterodimeric proteins
WO2013062083A1 (en) 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド Cancer stem cell-specific molecule
EP2773664A1 (en) 2011-11-01 2014-09-10 Bionomics, Inc. Anti-gpr49 antibodies
JP2014533247A (en) 2011-11-01 2014-12-11 バイオノミクス インコーポレイテッド Antibodies and methods of treating cancer
ES2697674T3 (en) 2011-11-01 2019-01-25 Bionomics Inc Procedures to block the growth of cancer stem cells
AU2012332593B2 (en) 2011-11-01 2016-11-17 Bionomics, Inc. Anti-GPR49 antibodies
MX2014005957A (en) 2011-11-16 2015-02-04 Amgen Inc Methods of treating epidermal growth factor deletion mutant viii related disorders.
WO2013081143A1 (en) 2011-11-30 2013-06-06 中外製薬株式会社 Drug containing carrier into cell for forming immune complex
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
TW201328707A (en) 2011-12-05 2013-07-16 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3) directed to domain II of HER3
EP3590538A1 (en) 2011-12-05 2020-01-08 Novartis AG Antibodies for epidermal growth factor receptor 3 (her3)
US9051365B2 (en) 2011-12-21 2015-06-09 Novartis Ag Antibodies that bind factor P
TWI593705B (en) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
KR20140126357A (en) 2012-02-01 2014-10-30 컴퓨젠 엘티디. C1orf32 antibodies, and uses thereof for treatment of cancer
HUE13746964T2 (en) 2012-02-06 2020-01-28 Inhibrx Inc Cd47 antibodies and methods of use thereof
SG11201404751UA (en) 2012-02-09 2014-09-26 Chugai Pharmaceutical Co Ltd Modified fc region of antibody
CN107266564A (en) 2012-02-24 2017-10-20 中外制药株式会社 Promote the antigen binding molecules that antigen is eliminated via Fc γ IIB
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
EP2832856A4 (en) 2012-03-29 2016-01-27 Chugai Pharmaceutical Co Ltd Anti-lamp5 antibody and utilization thereof
CN104220595A (en) 2012-04-04 2014-12-17 株式会社英仙蛋白质科学 Conjugate of anti-CDH3 (P-cadherin) antibody and drug
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
EA039663B1 (en) 2012-05-03 2022-02-24 Амген Инк. Use of an anti-pcsk9 antibody for lowering serum cholesterol ldl and treating cholesterol related disorders
US9416189B2 (en) 2012-05-11 2016-08-16 Microbial Chemistry Research Foundation Anti-CXADR antibody
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
DK2857419T3 (en) 2012-05-30 2021-03-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for the elimination of aggregated antigens
CA2874721A1 (en) 2012-05-30 2013-12-05 Tomoyuki Igawa Target tissue-specific antigen-binding molecule
CN104582476B (en) * 2012-06-05 2017-03-08 瑞泽恩制药公司 The method preparing complete people bi-specific antibody using common light chain
BR112014031028A2 (en) 2012-06-11 2017-08-15 Amgen Inc ANTIGEN-BINDING PROTEIN ISOLATED, NUCLLEIC ACID ISOLATED, EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING AN ANTIGEN-BINDING PROTEIN, COMPOSITION, METHOD FOR REDUCING OR BLOCKING THE ACTIVITY OF MYOSTATIN, ACTIVIN A OR GDF-11, METHOD FOR ENHANCEMENT MUSCLE MASS FIRMNESS OR INCREASE THE MUSCLE MASS FIRMITY TO FAT MASS RATIO IN AN INDIVIDUAL IN NEED OF THE MENTIONED TREATMENT, METHOD FOR TREATMENT OR PREVENTION OF A HARMFUL DISEASE OF MUSCLE IN AN INDIVIDUAL SUFFERING FROM THE SAID DISORDER AND DUAL ANTAGONIST RECEPTOR ANTIBODY
NZ717848A (en) 2012-06-12 2019-03-29 Regeneron Pharma Humanized non-human animals with restricted immunoglobulin heavy chain loci
JP6628966B2 (en) 2012-06-14 2020-01-15 中外製薬株式会社 Antigen binding molecule containing an altered Fc region
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
CN104619722B (en) 2012-06-22 2022-10-04 达特茅斯大学理事会 Novel VISTA-IG constructs and use of VISTA-IG for treatment of autoimmune, allergic and inflammatory diseases
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
EP3632462A1 (en) 2012-07-06 2020-04-08 Genmab B.V. Dimeric protein with triple mutations
JP6519851B2 (en) 2012-07-06 2019-05-29 京都府公立大学法人 Ophthalmic cell differentiation markers and differentiation control
EP2869845B1 (en) 2012-07-06 2019-08-28 Genmab B.V. Dimeric protein with triple mutations
WO2014021339A1 (en) 2012-07-30 2014-02-06 国立大学法人名古屋大学 Monoclonal antibody against human midkine
BR112015001955A2 (en) 2012-08-24 2017-11-07 Chugai Pharmaceutical Co Ltd fcgamariib specific fc region variant
US11236168B2 (en) 2012-08-24 2022-02-01 Chugai Seiyaku Kabushiki Kaisha Mouse FcγammaRII-specific Fc antibody
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
JOP20200308A1 (en) 2012-09-07 2017-06-16 Novartis Ag IL-18 binding molecules
JP6368308B2 (en) 2012-09-07 2018-08-01 トラスティーズ・オブ・ダートマス・カレッジ VISTA modulators for cancer diagnosis and treatment
AU2013316441B2 (en) 2012-09-13 2018-08-09 Chugai Seiyaku Kabushiki Kaisha Gene knock-in non-human animal
EP2902489B9 (en) 2012-09-27 2018-02-07 Chugai Seiyaku Kabushiki Kaisha Fgfr3 fusion gene and pharmaceutical drug targeting same
RU2683933C2 (en) 2012-09-28 2019-04-03 Чугаи Сейяку Кабусики Кайся Method for evaluating reaction of blood coagulation
EP2917238A1 (en) 2012-11-08 2015-09-16 Eleven Biotherapeutics, Inc. Il-6 antagonists and uses thereof
HUE039920T2 (en) 2012-11-08 2019-02-28 Univ Miyazaki Antibody capable of specifically recognizing transferrin receptor
WO2014084859A1 (en) 2012-11-30 2014-06-05 Novartis Ag Molecules and methods for modulating tmem16a activities
MX368067B (en) 2012-12-05 2019-09-18 Novartis Ag Compositions and methods for antibodies targeting epo.
TW201427989A (en) 2012-12-18 2014-07-16 Novartis Ag Compositions and methods for long acting proteins
ES2876009T3 (en) 2012-12-27 2021-11-11 Chugai Pharmaceutical Co Ltd Heterodimerized polypeptide
CA2896723C (en) 2012-12-28 2024-02-13 Precision Biologics, Inc. Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer
AU2013372331A1 (en) 2013-01-10 2015-07-23 Genmab B.V. Human IgG1 Fc region variants and uses thereof
JO3519B1 (en) 2013-01-25 2020-07-05 Amgen Inc Antibody constructs for CDH19 and CD3
US9920121B2 (en) 2013-01-25 2018-03-20 Amgen Inc. Antibodies targeting CDH19 for melanoma
EP4137518A1 (en) 2013-02-06 2023-02-22 Inhibrx, Inc. Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
JP6357113B2 (en) 2013-02-08 2018-07-11 株式会社医学生物学研究所 Antibodies against human NRG1 protein
CU24300B1 (en) 2013-02-08 2017-12-08 Novartis Ag ANTI-IL-17A ANTIBODIES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
PT2840892T (en) 2013-02-20 2018-07-20 Regeneron Pharma Non-human animals with modified immunoglobulin heavy chain sequences
ES2673583T3 (en) 2013-02-28 2018-06-22 National Cancer Center Insoluble fibrin antibody
ES2811060T3 (en) 2013-03-08 2021-03-10 Univ Osaka Antibody against peptide encoded by exon-21 of periostin and pharmaceutical composition to prevent or treat diseases associated with inflammation that contain the same
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159239A2 (en) 2013-03-14 2014-10-02 Novartis Ag Antibodies against notch 3
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9505849B2 (en) 2013-03-15 2016-11-29 Amgen Research (Munich) Gmbh Antibody constructs for influenza M2 and CD3
AR095596A1 (en) 2013-03-15 2015-10-28 Amgen Res (Munich) Gmbh UNIQUE CHAIN UNION MOLECULES UNDERSTANDING N-TERMINAL ABP
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
WO2014163101A1 (en) 2013-04-02 2014-10-09 中外製薬株式会社 Fc region variant
WO2014174596A1 (en) 2013-04-23 2014-10-30 株式会社医学生物学研究所 Functional monoclonal antibody against heparin-binding epidermal growth factor-like growth factor
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
CN107095872A (en) 2013-05-16 2017-08-29 国立大学法人京都大学 Method for determining cancer prognosis
WO2014186877A1 (en) 2013-05-24 2014-11-27 Uger Marni Diane FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
AR096601A1 (en) 2013-06-21 2016-01-20 Novartis Ag ANTIBODIES OF LEXINED OXIDATED LDL RECEIVER 1 AND METHODS OF USE
CN105517571A (en) 2013-06-24 2016-04-20 中外制药株式会社 Therapeutic agent comprising humanized anti-epiregulin antibody as active ingredient for non-small-cell lung carcinoma excluding adenocarcinoma
AU2013396206B2 (en) 2013-06-28 2019-11-14 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
WO2015023851A1 (en) 2013-08-14 2015-02-19 The Governing Council Of The University Of Toronto Antibodies against frizzled proteins and methods of use thereof
US20160200818A1 (en) 2013-08-14 2016-07-14 Novartis Ag Methods of treating Sporadic Inclusion Body Myositis
CN105722527A (en) 2013-09-04 2016-06-29 国立大学法人大阪大学 DPP-4-targeting vaccine for treating diabetes
US20160229922A1 (en) 2013-09-20 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Treatment for hemorrhagic diseases by anti-protein-c antibody
NL2013554B1 (en) 2013-10-01 2016-01-08 Kymab Ltd Animal models and therapeutic molecules.
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20160264648A1 (en) 2013-11-06 2016-09-15 Osaka University Antibody having broad neutralization activity against group 1 influenza a viruses
EP3070168A4 (en) 2013-11-11 2017-06-28 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified antibody variable region
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
KR20220142539A (en) 2013-12-04 2022-10-21 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
DK3087098T3 (en) 2013-12-24 2020-06-08 Janssen Pharmaceutica Nv Anti-Vista antibodies and fragments
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
KR101836756B1 (en) 2013-12-27 2018-03-08 오사카 유니버시티 Vaccine targeting il-17a
TWI787590B (en) 2013-12-27 2022-12-21 日商中外製藥股份有限公司 Purification method of antibody with low isoelectric point
US10391081B2 (en) 2013-12-27 2019-08-27 Chugai Seiyaku Kabushiki Kaisha FGFR gatekeeper mutant gene and drug targeting same
WO2015121383A1 (en) 2014-02-12 2015-08-20 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
BR112016021679A2 (en) 2014-03-21 2018-12-04 Regeneron Pharmaceuticals, Inc. antigen binding protein, methods of producing an antigen binding protein and identifying one or more antigen binding proteins, hybridoma, nucleic acid, cell, and genetically modified non-human animal.
KR20210088756A (en) 2014-03-21 2021-07-14 리제너론 파마슈티칼스 인코포레이티드 Non-human animals that make single domain binding proteins
CN106459993A (en) 2014-03-31 2017-02-22 德彪药业国际股份公司 Fgfr fusions
CA2944649C (en) 2014-04-04 2022-06-21 Bionomics, Inc. Humanized antibodies that bind lgr5
TW201622746A (en) 2014-04-24 2016-07-01 諾華公司 Methods of improving or accelerating physical recovery after surgery for hip fracture
WO2015187835A2 (en) 2014-06-06 2015-12-10 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
CA2951885C (en) 2014-06-11 2023-07-04 Kathy A. Green Use of vista agonists and antagonists to suppress or enhance humoral immunity
TWI695011B (en) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 Monoclonal antibodies against her2 epitope and methods of use thereof
TWI831106B (en) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 Pharmaceutical compositions for the prevention and/or treatment of diseases that develop and/or progress due to reduced or deficient activity of coagulation factor VIII and/or activated coagulation factor VIII
WO2015198240A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
EP3161001A2 (en) 2014-06-25 2017-05-03 Novartis AG Antibodies specific for il-17a fused to hyaluronan binding peptide tags
WO2015198243A2 (en) 2014-06-25 2015-12-30 Novartis Ag Compositions and methods for long acting proteins
US10132818B2 (en) 2014-07-08 2018-11-20 New York University Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy
MX370807B (en) 2014-07-11 2020-01-08 Genmab As Antibodies binding axl.
MX2017001403A (en) 2014-07-31 2017-07-07 Amgen Res (Munich) Gmbh Bispecific single chain antibody construct with enhanced tissue distribution.
AR101669A1 (en) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh ANTIBODY CONSTRUCTS FOR CDH19 AND CD3
AU2015294834B2 (en) 2014-07-31 2021-04-29 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody constructs
WO2016016442A1 (en) 2014-08-01 2016-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) An anti-cd45rc antibody for use as drug
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
CU24453B1 (en) 2014-08-07 2019-11-04 Novartis Ag ANTI-PROTEIN ANTIBODIES SIMILAR TO ANGIOPOYETIN 4
EP3185004A4 (en) 2014-08-20 2018-05-30 Chugai Seiyaku Kabushiki Kaisha Method for measuring viscosity of protein solution
SG10201902924RA (en) 2014-10-03 2019-05-30 Massachusetts Inst Technology Antibodies that bind ebola glycoprotein and uses thereof
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
WO2016073401A1 (en) 2014-11-03 2016-05-12 Bristol-Myers Squibb Company Use of caprylic acid precipitation for protein purification
JP6951246B2 (en) 2014-11-05 2021-10-20 アネクソン，インコーポレーテッド Humanized anti-complement factor C1q antibody and its use
WO2016073894A1 (en) 2014-11-07 2016-05-12 Eleven Biotherapeutics, Inc. Therapeutic agents with increased ocular retention
PT3215530T (en) 2014-11-07 2019-11-21 Sesen Bio Inc Improved il-6 antibodies
BR112017010110A2 (en) 2014-11-21 2018-01-30 Bristol-Myers Squibb Company antibodies to cd73 and uses thereof
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
UY36449A (en) 2014-12-19 2016-07-29 Novartis Ag COMPOSITIONS AND METHODS FOR ANTIBODIES DIRECTED TO BMP6
PL3233912T3 (en) 2014-12-19 2021-12-27 Regenesance B.V. Antibodies that bind human c6 and uses thereof
UY36471A (en) 2014-12-23 2016-06-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware ANTIBODIES AGAINST THE IMMUNORRECEPTOR (TIGIT) OF T LYMPHOCYTES WITH IG DOMAINS AND REASONS FOR INHIBITION OF THE TYMOSINE-BASED IMMUNORRECEPTOR (ITIM)
EP4269440A3 (en) 2015-02-27 2024-02-28 Chugai Seiyaku Kabushiki Kaisha Composition for treating il-6-related diseases
AU2016233557B2 (en) 2015-03-13 2021-06-24 Bristol-Myers Squibb Company Use of alkaline washes during chromatography to remove impurities
CN107438622A (en) * 2015-03-19 2017-12-05 瑞泽恩制药公司 Non-human animal of the selection with reference to the light chain variable district of antigen
WO2016153978A1 (en) 2015-03-20 2016-09-29 Bristol-Myers Squibb Company Use of dextran to enhance protein purification by affinity chromatography
US20180105555A1 (en) 2015-03-20 2018-04-19 Bristol-Myers Squibb Company Use of dextran for protein purification
EP4276116A3 (en) 2015-04-17 2024-01-17 Amgen Research (Munich) GmbH Bispecific antibody constructs for cdh3 and cd3
BR112017016952A2 (en) 2015-04-17 2018-04-03 F. Hoffmann-La Roche Ag combination therapy with coagulation factors and multispecific antibodies
PE20230381A1 (en) 2015-04-28 2023-03-06 Mitsubishi Tanabe Pharma Corp RGMA BINDING PROTEIN
PE20180926A1 (en) 2015-05-29 2018-06-08 Bristol Myers Squibb Co ANTIBODIES AGAINST MEMBER 4 OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY (OX40) AND ITS USES
US10047155B2 (en) 2015-06-05 2018-08-14 Novartis Ag Antibodies targeting bone morphogenetic protein 9 (BMP9) and methods therefor
US11009509B2 (en) 2015-06-24 2021-05-18 Janssen Pharmaceutica Nv Anti-VISTA antibodies and fragments
US10479838B2 (en) 2015-06-29 2019-11-19 Bristol-Myers Squibb Company Antibodies to CD40 with enhanced agonist activity
ES2784685T3 (en) 2015-07-10 2020-09-29 Genmab As AXL-Specific Antibody-Drug Conjugates for Cancer Treatment
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Antibody constructs for flt3 and cd3
TWI744242B (en) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Antibody constructs for egfrviii and cd3
TWI717375B (en) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Antibody constructs for cd70 and cd3
TWI796283B (en) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Antibody constructs for msln and cd3
TWI793062B (en) 2015-07-31 2023-02-21 德商安美基研究（慕尼黑）公司 Antibody constructs for dll3 and cd3
WO2017021893A1 (en) 2015-08-03 2017-02-09 Novartis Ag Methods of treating fgf21-associated disorders
ES2954969T3 (en) 2015-08-13 2023-11-27 Univ New York Antibody-based molecules selective for the {p}Ser404 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
EP3334453A4 (en) 2015-08-13 2019-02-06 New York University Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy
AU2016320748B2 (en) 2015-09-09 2019-05-02 Novartis Ag Thymic stromal lymphopoietin (TSLP)-binding antibodies and methods of using the antibodies
CA2996635A1 (en) 2015-09-09 2017-03-16 Novartis Ag Thymic stromal lymphopoietin (tslp)-binding molecules and methods of using the molecules
US11649293B2 (en) 2015-11-18 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
WO2017086367A1 (en) 2015-11-18 2017-05-26 中外製薬株式会社 Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function
CA3005855A1 (en) 2015-11-19 2017-05-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
KR102630475B1 (en) 2015-11-30 2024-01-26 브리스톨-마이어스 스큅 컴퍼니 Anti-human IP-10 antibody and uses thereof
JP6983779B2 (en) 2015-11-30 2021-12-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California Tumor-specific payload delivery and immune activation using human antibodies targeting highly specific tumor cell surface antigens
US10813346B2 (en) 2015-12-03 2020-10-27 Trianni, Inc. Enhanced immunoglobulin diversity
UY37030A (en) 2015-12-18 2017-07-31 Novartis Ag ANTIBODIES DIRECTED TO CD32B AND METHODS OF USE OF THE SAME
EP3395835B1 (en) 2015-12-25 2021-02-03 Chugai Seiyaku Kabushiki Kaisha Antibody having enhanced activity, and method for modifying same
ES2847155T3 (en) 2016-01-21 2021-08-02 Novartis Ag Multispecific molecules targeting CLL-1
CR20180418A (en) 2016-02-03 2019-01-15 Amgen Res Munich Gmbh BISPECPIFYING ANTIBODY STRUCTURES FOR PSMA AND CD3 THAT ARE LINKED TO T-CELLS
MD3411402T2 (en) 2016-02-03 2022-05-31 Amgen Res Munich Gmbh BCMA and CD3 bispecific T cell engaging antibody constructs
EA039859B1 (en) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Bispecific antibody constructs binding egfrviii and cd3
KR20180104149A (en) 2016-02-04 2018-09-19 트리아니, 인코포레이티드 Increased production of immunoglobulins
TW202216201A (en) 2016-02-12 2022-05-01 比利時商楊森製藥公司 Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
AU2017228470A1 (en) 2016-03-04 2018-08-30 Bristol-Myers Squibb Company Combination therapy with anti-CD73 antibodies
SG11201807677YA (en) 2016-03-04 2018-10-30 Univ Rockefeller Antibodies to cd40 with enhanced agonist activity
RU2746754C2 (en) 2016-03-14 2021-04-20 Чугаи Сейяку Кабусики Кайся Cell damage inducing therapeutic medicinal product for anticancer therapy
CN109476756B (en) 2016-03-15 2022-05-31 埃泰美德(香港)有限公司 Multi-specificity Fab fusion protein and application thereof
US10947317B2 (en) 2016-03-15 2021-03-16 Mersana Therapeutics, Inc. NaPi2b-targeted antibody-drug conjugates and methods of use thereof
AU2017239038A1 (en) 2016-03-22 2018-10-04 Bionomics Inc Administration of an anti-LGR5 monoclonal antibody
CA3019164A1 (en) 2016-03-29 2017-10-05 Janssen Biotech, Inc. Method of treating psoriasis with increased interval dosing of anti-il12/23 antibody
WO2017175058A1 (en) 2016-04-07 2017-10-12 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
CN117562992A (en) 2016-04-15 2024-02-20 伊穆奈克斯特股份有限公司 Anti-human VISTA antibodies and uses thereof
BR112018071307A2 (en) 2016-04-18 2019-02-26 Celldex Therapeutics, Inc. human cd40 binding agonist antibodies and uses thereof
JOP20170091B1 (en) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia
KR102417687B1 (en) 2016-05-09 2022-07-07 브리스톨-마이어스 스큅 컴퍼니 TL1A antibodies and uses thereof
WO2017216724A1 (en) 2016-06-15 2017-12-21 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)
LT3484916T (en) 2016-07-12 2021-04-26 H. Lundbeck A/S Antibodies specific for hyperphosphorylated tau and methods of use thereof
JP7027401B2 (en) 2016-07-14 2022-03-01 ブリストル－マイヤーズ スクイブ カンパニー Antibodies to TIM3 and its use
WO2018029586A1 (en) 2016-08-07 2018-02-15 Novartis Ag Mrna-mediated immunization methods
WO2018031726A1 (en) 2016-08-12 2018-02-15 Bristol-Myers Squibb Company Methods of purifying proteins
WO2018044970A1 (en) 2016-08-31 2018-03-08 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus k envelope (herv-k) and uses thereof
TW201825674A (en) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 Oncolytic virus expressing bispecific engager molecules
EP3519049A4 (en) 2016-09-30 2020-05-27 Janssen Biotech, Inc. Safe and effective method of treating psoriasis with anti-il23 specific antibody
CU20210030A7 (en) 2016-10-13 2021-11-04 Massachusetts Inst Technology ANTIBODIES THAT BIND THE ZIKA VIRUS ENVELOPE PROTEIN
JP2020500020A (en) 2016-11-14 2020-01-09 ノバルティス アーゲー Compositions, methods, and therapeutic uses related to the fusogenic protein MINION
WO2018091444A1 (en) 2016-11-15 2018-05-24 H. Lundbeck A/S Agents, uses and methods for the treatment of synucleinopathy
MX2019005661A (en) 2016-11-16 2019-10-07 Janssen Biotech Inc Method of treating psoriasis with anti-il-23 specific antibody.
KR102533814B1 (en) 2016-11-28 2023-05-19 추가이 세이야쿠 가부시키가이샤 Ligand-binding molecules capable of tunable ligand-binding activity
US11325968B2 (en) 2016-12-16 2022-05-10 H. Lundbeck A/S Alpha-synuclein antibodies
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
JP7062669B2 (en) 2016-12-23 2022-05-06 ブリストル－マイヤーズ スクイブ カンパニー Design of therapeutic immunoglobulin G4 for improved bioanalytic and bioprocessing properties
EP3565836A1 (en) 2017-01-04 2019-11-13 H. Lundbeck A/S Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases
TW201833140A (en) 2017-01-09 2018-09-16 美商莫瑞麥克製藥公司 Anti-fgfr antibodies and methods of use
EP3573658A4 (en) 2017-01-30 2021-07-21 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis
JOP20190189A1 (en) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh Low ph pharmaceutical composition comprising t cell engaging antibody constructs
WO2018147915A1 (en) 2017-02-07 2018-08-16 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
MX2019009498A (en) 2017-02-08 2019-10-02 Novartis Ag Fgf21 mimetic antibodies and uses thereof.
WO2018151821A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
AU2018240938A1 (en) 2017-03-24 2019-10-10 Zenyaku Kogyo Co., Ltd. Anti-IgM/B cell surface antigen bispecific antibody
AU2018240117A1 (en) 2017-03-24 2019-09-19 Beth Israel Deaconess Medical Center, Inc. Methods for preventing and treating heart disease
WO2018183417A1 (en) 2017-03-30 2018-10-04 The Johns Hopkins University A supramolecular high affinity protein-binding system for purification of biomacromolecules
KR20190133230A (en) 2017-03-31 2019-12-02 고리츠다이가쿠호징 나라켕리츠 이카다이가쿠 Pharmaceutical composition for use in the prophylaxis and / or treatment of blood coagulation factor IX abnormalities containing multispecific antigen binding molecules that replace the function of blood coagulation factor VIII
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
WO2018199214A1 (en) 2017-04-27 2018-11-01 中外製薬株式会社 Coagulation factor ix with improved pharmacokinetics
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
CN110913904A (en) 2017-05-05 2020-03-24 美国安进公司 Pharmaceutical compositions comprising bispecific antibody constructs for improved storage and administration
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
EP3645564A1 (en) 2017-06-28 2020-05-06 Novartis AG Methods for preventing and treating urinary incontinence
US10894833B2 (en) 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
US11745165B2 (en) 2017-08-18 2023-09-05 The Johns Hopkins University Supramolecular filamentous assemblies for protein purification
TW201922780A (en) 2017-09-25 2019-06-16 美商健生生物科技公司 Safe and effective method of treating Lupus with anti-IL12/IL23 antibody
KR20200074160A (en) 2017-10-20 2020-06-24 가꼬우호우징 효고 이카다이가쿠 Pharmaceutical composition for inhibiting post-surgical adhesion containing anti-IL-6 receptor antibody
EP3700933A1 (en) 2017-10-25 2020-09-02 Novartis AG Antibodies targeting cd32b and methods of use thereof
US20210206845A1 (en) 2017-11-28 2021-07-08 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
US20210163592A1 (en) 2017-12-11 2021-06-03 Amgen Inc Continuous manufacturing process for bispecific antibody products
EP3498293A1 (en) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Treatment of monogenic diseases with an anti-cd45rc antibody
US11667713B2 (en) 2017-12-28 2023-06-06 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
UY38041A (en) 2017-12-29 2019-06-28 Amgen Inc CONSTRUCTION OF BIESPECFIC ANTIBODY DIRECTED TO MUC17 AND CD3
KR20200108870A (en) 2018-01-12 2020-09-21 브리스톨-마이어스 스큅 컴퍼니 Antibodies to TIM3 and uses thereof
CN111770936A (en) 2018-01-12 2020-10-13 百时美施贵宝公司 Combination therapy of anti-IL-8 and anti-PD-1 antibodies for the treatment of cancer
JP7458790B2 (en) 2018-01-31 2024-04-01 元一 加藤 Asthma therapeutic agent containing IL-6 inhibitor
EP3762015A4 (en) 2018-03-05 2022-04-27 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
AU2019236865A1 (en) 2018-03-23 2020-10-01 Bristol-Myers Squibb Company Antibodies against MICA and/or MICB and uses thereof
WO2019191416A1 (en) 2018-03-29 2019-10-03 Bristol-Myers Squibb Company Methods of purifying monomeric monoclonal antibodies
JP2021523158A (en) 2018-05-07 2021-09-02 ゲンマブ エー／エス Cancer treatment method using a combination of anti-PD-1 antibody and anti-tissue factor antibody-drug conjugate
BR112020022642A2 (en) 2018-05-07 2021-02-17 Genmab A/S method to treat cancer in an individual, and, kit
WO2019215701A1 (en) 2018-05-11 2019-11-14 Janssen Biotech, Inc. Methods of treating depression using il-23 antibodies
US20210196568A1 (en) 2018-05-21 2021-07-01 Chugai Seiyaku Kabushiki Kaisha Lyophilized formulation sealed in glass container
AR126019A1 (en) 2018-05-30 2023-09-06 Novartis Ag ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES
KR20210032412A (en) 2018-07-10 2021-03-24 미쓰비시 타나베 파마 코퍼레이션 Peripheral nerve disorder, peripheral nerve disorder, or a method of preventing or treating pain due to a disease recognized as a stellate cell disorder
JP2021530697A (en) 2018-07-18 2021-11-11 ヤンセン バイオテツク，インコーポレーテツド Sustained response predictor after treatment with anti-IL23 specific antibody
CN112771075A (en) 2018-07-30 2021-05-07 安进研发（慕尼黑）股份有限公司 Prolonged administration of bispecific antibody constructs that bind to CD33 and CD3
UY38326A (en) 2018-08-03 2020-01-31 Amgen Inc ANTIBODY CONSTRUCTS FOR CLDN18.2 AND CD3
MX2021002332A (en) 2018-08-27 2021-08-11 Affimed Gmbh Cryopreserved nk cells preloaded with an antibody construct.
JP2022502076A (en) 2018-09-18 2022-01-11 メリマック ファーマシューティカルズ インコーポレーティッド Anti-TNFR2 antibody and its use
PL3883606T3 (en) 2018-09-24 2023-11-27 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody
CA3114802A1 (en) 2018-10-11 2020-04-16 Amgen Inc. Downstream processing of bispecific antibody constructs
UY38407A (en) 2018-10-15 2020-05-29 Novartis Ag TREM2 STABILIZING ANTIBODIES
TW202034958A (en) 2018-10-30 2020-10-01 丹麥商珍美寶股份有限公司 Methods of treating cancer with a combination of an anti-vegf antibody and an anti-tissue factor antibody-drug conjugate
CN113316590A (en) 2018-11-16 2021-08-27 百时美施贵宝公司 anti-NKG 2A antibodies and uses thereof
CN113395979A (en) 2018-11-20 2021-09-14 詹森生物科技公司 Safe and effective methods for treating psoriasis with anti-IL-23 specific antibodies
WO2020128864A1 (en) 2018-12-18 2020-06-25 Janssen Biotech, Inc. Safe and effective method of treating lupus with anti-il12/il23 antibody
WO2020148651A1 (en) 2019-01-15 2020-07-23 Janssen Biotech, Inc. Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis
BR112021014106A2 (en) 2019-01-22 2021-10-13 Bristol-Myers Squibb Company ANTIBODIES AGAINST IL-7R ALPHA SUBUNIT AND USES THEREOF
CN113330031A (en) 2019-01-23 2021-08-31 詹森生物科技公司 anti-TNF antibody compositions for use in methods of treating psoriatic arthritis
JPWO2020153467A1 (en) 2019-01-24 2021-12-02 中外製薬株式会社 New cancer antigens and antibodies against those antigens
JP6821230B2 (en) 2019-02-04 2021-01-27 国立大学法人愛媛大学 How to make CAR library and scFv
CN113508140A (en) 2019-02-28 2021-10-15 学校法人顺天堂 Antibody binding to cleaved mutant Calreticulin and bone marrow proliferative tumor diagnostic, prophylactic or therapeutic agent
WO2020180712A1 (en) 2019-03-01 2020-09-10 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
US20220144934A1 (en) 2019-03-14 2022-05-12 Janssen Biotech, Inc. Methods for Producing Anti-TNF Antibody Compositions
JP2022525179A (en) 2019-03-14 2022-05-11 ヤンセン バイオテツク，インコーポレーテツド Production method for producing anti-TNF antibody composition
JP2022525145A (en) 2019-03-14 2022-05-11 ヤンセン バイオテツク，インコーポレーテツド A production method for producing an anti-IL12 / IL23 antibody composition.
CN113840837A (en) 2019-03-14 2021-12-24 詹森生物科技公司 Methods for producing anti-TNF antibody compositions
BR112021018441A2 (en) 2019-03-18 2023-02-28 Janssen Biotech Inc METHOD FOR TREATMENT OF PSORIASIS IN PEDIATRIC INDIVIDUALS WITH ANTI-IL12/IL23 ANTIBODY
CN113613676A (en) 2019-03-19 2021-11-05 中外制药株式会社 Antigen binding molecule comprising antigen binding domain whose binding activity to antigen is changed by MTA and library for obtaining the same
EP3948262A1 (en) 2019-03-29 2022-02-09 Bristol-Myers Squibb Company Methods of measuring hydrophobicity of chromatographic resins
AU2020273072A1 (en) 2019-04-10 2021-12-09 Chugai Seiyaku Kabushiki Kaisha Method for purifying Fc region-modified antibody
CA3135694A1 (en) 2019-04-17 2020-10-22 Hiroshima University Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination
AU2020279987A1 (en) 2019-05-23 2021-11-18 Janssen Biotech, Inc. Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
AU2020288404A1 (en) 2019-06-03 2022-02-03 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, and methods for the treatment of active Ankylosing Spondylitis
KR20220029593A (en) 2019-06-03 2022-03-08 얀센 바이오테크 인코포레이티드 Anti-TNF antibody compositions, and methods for the treatment of psoriatic arthritis
MX2021014433A (en) 2019-06-05 2022-03-11 Chugai Pharmaceutical Co Ltd Antibody cleavage site-binding molecule.
AU2020291821A1 (en) 2019-06-12 2022-01-06 Novartis Ag Natriuretic Peptide Receptor 1 antibodies and methods of use
TW202045711A (en) 2019-06-13 2020-12-16 美商安進公司 Automated biomass-based perfusion control in the manufacturing of biologics
CA3148591A1 (en) 2019-07-26 2021-02-04 Amgen Inc. Anti-il13 antigen binding proteins
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
AU2020345787A1 (en) 2019-09-10 2022-03-24 Amgen Inc. Purification method for bispecific antigen-binding polypeptides with enhanced protein L capture dynamic binding capacity
EP4031578A1 (en) 2019-09-18 2022-07-27 Novartis AG Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
TW202124446A (en) 2019-09-18 2021-07-01 瑞士商諾華公司 Combination therapies with entpd2 antibodies
IL292685A (en) 2019-11-04 2022-07-01 Seagen Inc Anti-cd30 antibody-drug conjugates and their use for the treatment of hiv infection
MX2022005222A (en) 2019-11-07 2022-06-08 Genmab As Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate.
TW202131954A (en) 2019-11-07 2021-09-01 丹麥商珍美寶股份有限公司 Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate
EP4058485A1 (en) 2019-11-13 2022-09-21 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
MX2022007688A (en) 2019-12-20 2022-07-19 Amgen Inc Mesothelin-targeted cd40 agonistic multispecific antibody constructs for the treatment of solid tumors.
US11396541B2 (en) 2019-12-20 2022-07-26 Novarock Biotherapeutics, Ltd. Anti-interleukin-23 P19 antibodies and methods of use thereof
AR120898A1 (en) 2019-12-26 2022-03-30 Univ Osaka AGENT TO TREAT OR PREVENT ACUTE NEUROMYELITIS OPTICA
AU2020414409A1 (en) 2019-12-27 2022-06-16 Affimed Gmbh Method for the production of bispecific FcyRIIl x CD30 antibody construct
CA3168209A1 (en) 2020-01-15 2021-07-22 Osaka University Prophylactic or therapeutic agent for dementia
EP4091632A1 (en) 2020-01-15 2022-11-23 Osaka University Agent for prevention or treatment of diabetic autonomic neuropathy
EP4093771A1 (en) 2020-01-22 2022-11-30 Amgen Research (Munich) GmbH Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
EP4118113A1 (en) 2020-03-12 2023-01-18 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
CN115427454A (en) 2020-03-19 2022-12-02 安进公司 Antibodies against mucin 17 and uses thereof
CN115335082A (en) 2020-03-27 2022-11-11 光爱科技公司 Medicinal product for killing tumor cells
CN115379858A (en) 2020-04-06 2022-11-22 光爱科技公司 Medicinal product for killing tumor cells
JP2023106635A (en) 2020-04-17 2023-08-02 中外製薬株式会社 Bispecific antigen binding molecules and compositions related thereto, uses, kits and methods for producing compositions
US20230242647A1 (en) 2020-05-01 2023-08-03 Novartis Ag Engineered immunoglobulins
US20230167193A1 (en) 2020-05-01 2023-06-01 Novartis Ag Immunoglobulin variants
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
EP4153633A1 (en) 2020-05-19 2023-03-29 Amgen Inc. Mageb2 binding constructs
EP4155405A1 (en) 2020-05-22 2023-03-29 Chugai Seiyaku Kabushiki Kaisha Antibody for neutralizing substance having coagulation factor viii (f.viii) function-substituting activity
EP4157874A2 (en) 2020-05-29 2023-04-05 Amgen Inc. Adverse effects-mitigating administration of a bispecific antibody construct binding to cd33 and cd3
WO2021261546A1 (en) 2020-06-24 2021-12-30 国立大学法人 東京大学 Photosensitizing dye
AU2021299947A1 (en) 2020-06-29 2022-12-22 Genmab A/S Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer
EP4183416A1 (en) 2020-07-17 2023-05-24 Mitsubishi Tanabe Pharma Corporation Agent for preventing or treating muscular disease
KR20230047397A (en) 2020-07-28 2023-04-07 추가이 세이야쿠 가부시키가이샤 Needle-added pre-filled syringe formulation with a needle shield containing a novel modified antibody
KR20230048059A (en) 2020-07-31 2023-04-10 추가이 세이야쿠 가부시키가이샤 Pharmaceutical composition comprising cells expressing chimeric receptors
KR20230066149A (en) 2020-08-07 2023-05-12 포티스 테라퓨틱스, 인크. Immunoconjugates targeting CD46 and methods of their use
AU2021331170A1 (en) 2020-08-27 2023-03-23 Juntendo Educational Foundation Anti-cleaved mutant calr-cd3 bispecific antibody and pharmaceutical composition
AU2021337687A1 (en) 2020-09-04 2023-03-23 Novarock Biotherapeutics, Ltd. Nectin-4 antibodies and uses thereof
EP4225792A1 (en) 2020-10-08 2023-08-16 Affimed GmbH Trispecific binders
KR20230104229A (en) 2020-11-06 2023-07-07 암젠 인크 Polypeptide constructs that bind CD3
CA3198064A1 (en) 2020-11-06 2022-05-12 Amgen Inc. Antigen binding domain with reduced clipping rate
MX2023005343A (en) 2020-11-06 2023-05-22 Amgen Res Munich Gmbh Polypeptide constructs selectively binding to cldn6 and cd3.
US20240002509A1 (en) 2020-11-06 2024-01-04 Novartis Ag ANTIBODY Fc VARIANTS
CA3200317A1 (en) 2020-11-06 2022-05-12 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
EP4247849A2 (en) 2020-11-17 2023-09-27 Seagen Inc. Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody
WO2022130182A1 (en) 2020-12-14 2022-06-23 Novartis Ag Reversal binding agents for anti-natriuretic peptide receptor 1 (npr1) antibodies and uses thereof
AR124914A1 (en) 2021-02-18 2023-05-17 Mitsubishi Tanabe Pharma Corp NEW ANTI-PAD4 ANTIBODY
KR20230156764A (en) 2021-03-12 2023-11-14 얀센 바이오테크 인코포레이티드 Method for treating psoriatic arthritis patients with inadequate response to TNF therapy by anti-IL23 specific antibody
AU2022233792A1 (en) 2021-03-12 2023-10-26 Janssen Biotech, Inc. Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody
KR20230156368A (en) 2021-03-12 2023-11-14 추가이 세이야쿠 가부시키가이샤 Pharmaceutical composition for the treatment or prevention of myasthenia gravis
WO2022212831A1 (en) 2021-04-02 2022-10-06 Amgen Inc. Mageb2 binding constructs
CA3217180A1 (en) 2021-05-06 2022-11-10 Amgen Research (Munich) Gmbh Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
KR20240034215A (en) 2021-07-09 2024-03-13 얀센 바이오테크 인코포레이티드 Manufacturing Methods for Producing Anti-IL12/IL23 Antibody Compositions
IL309996A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Manufacturing methods for producing anti-tnf antibody compositions
IL309997A (en) 2021-07-09 2024-03-01 Janssen Biotech Inc Manufacturing methods for producing anti-tnf antibody compositions
AU2022320948A1 (en) 2021-07-30 2024-01-18 Affimed Gmbh Duplexbodies
WO2023048231A1 (en) 2021-09-24 2023-03-30 株式会社PhotoQ3 Medicine for killing tumor cells
WO2023057871A1 (en) 2021-10-04 2023-04-13 Novartis Ag Surfactant stabilizers
WO2023058723A1 (en) 2021-10-08 2023-04-13 中外製薬株式会社 Method for preparing prefilled syringe formulation
CA3236735A1 (en) 2021-10-29 2023-05-04 Seagen Inc. Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-cd30 antibody-drug conjugate
CA3236779A1 (en) 2021-10-29 2023-05-04 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
AR127568A1 (en) 2021-11-03 2024-02-07 Affimed Gmbh CD16A BISPECIFIC LIGANDS
WO2023079493A1 (en) 2021-11-03 2023-05-11 Affimed Gmbh Bispecific cd16a binders
WO2023084488A1 (en) 2021-11-15 2023-05-19 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
US20230159633A1 (en) 2021-11-23 2023-05-25 Janssen Biotech, Inc. Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody
US20230312703A1 (en) 2022-03-30 2023-10-05 Janssen Biotech, Inc. Method of Treating Psoriasis with IL-23 Specific Antibody
WO2023209568A1 (en) 2022-04-26 2023-11-02 Novartis Ag Multispecific antibodies targeting il-13 and il-18
WO2023213960A1 (en) 2022-05-06 2023-11-09 Genmab A/S Methods of treating cancer with anti-tissue factor antibody-drug conjugates
TW202346368A (en) 2022-05-12 2023-12-01 德商安美基研究（慕尼黑）公司 Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
WO2023223265A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for evaluating and treating psoriatic arthritis with il23 antibody
WO2024013723A1 (en) 2022-07-15 2024-01-18 Pheon Therapeutics Ltd Antibody drug conjugates that bind cdcp1 and uses thereof
WO2024059675A2 (en) 2022-09-14 2024-03-21 Amgen Inc. Bispecific molecule stabilizing composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
WO1991000906A1 (en) * 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
SG48759A1 (en) * 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
EP0546073B1 (en) * 1990-08-29 1997-09-10 GenPharm International, Inc. production and use of transgenic non-human animals capable of producing heterologous antibodies
AU3328493A (en) * 1991-12-17 1993-07-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies

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