CA1341396C - Cyclosporin crystal form, processes for its production pharmaceutical compositions containing it and its use - Google Patents

Cyclosporin crystal form, processes for its production pharmaceutical compositions containing it and its use Download PDF

Info

Publication number
CA1341396C
CA1341396C CA000586611A CA586611A CA1341396C CA 1341396 C CA1341396 C CA 1341396C CA 000586611 A CA000586611 A CA 000586611A CA 586611 A CA586611 A CA 586611A CA 1341396 C CA1341396 C CA 1341396C
Authority
CA
Canada
Prior art keywords
ciclosporin
crystal form
orthorhombic crystal
orthorhombic
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000586611A
Other languages
English (en)
French (fr)
Inventor
Danielle Giron
Martin List
Friedrich Richter
Yasuyuki Uike
Hans Peter Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of CA1341396C publication Critical patent/CA1341396C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CA000586611A 1987-12-21 1988-12-21 Cyclosporin crystal form, processes for its production pharmaceutical compositions containing it and its use Expired - Fee Related CA1341396C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US136,230 1987-12-21
US17261388A 1988-03-24 1988-03-24
US172,613 1988-03-24
US21254888A 1988-06-28 1988-06-28
US212,548 1988-06-28

Publications (1)

Publication Number Publication Date
CA1341396C true CA1341396C (en) 2002-11-05

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000586611A Expired - Fee Related CA1341396C (en) 1987-12-21 1988-12-21 Cyclosporin crystal form, processes for its production pharmaceutical compositions containing it and its use

Country Status (27)

Country Link
JP (1) JPH0791316B2 (sv)
KR (1) KR100188305B1 (sv)
AT (1) AT403163B (sv)
AU (1) AU626274B2 (sv)
BE (1) BE1002665A4 (sv)
CA (1) CA1341396C (sv)
CH (1) CH677926A5 (sv)
CY (1) CY1799A (sv)
DE (1) DE3843054C2 (sv)
DK (1) DK175220B1 (sv)
ES (1) ES2012580A6 (sv)
FI (1) FI89065C (sv)
FR (1) FR2624863B1 (sv)
GB (1) GB2211848B (sv)
GR (1) GR1002486B (sv)
HK (1) HK102894A (sv)
HU (1) HU203564B (sv)
IE (1) IE62006B1 (sv)
IL (1) IL88719A0 (sv)
IT (1) IT1235356B (sv)
LU (1) LU87409A1 (sv)
MY (1) MY103943A (sv)
NL (1) NL195096C (sv)
NO (1) NO177228C (sv)
NZ (1) NZ227384A (sv)
SE (1) SE503174C2 (sv)
SG (1) SG99494G (sv)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
US10017541B2 (en) 2011-11-15 2018-07-10 Allergan, Inc. Cyclosporin a form 2 and method of making same

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
WO1996014079A1 (de) 1994-11-03 1996-05-17 Arzneimittelwerk Dresden Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
PL190420B1 (pl) 1997-01-30 2005-12-30 Novartis Ag Twarda kapsułka żelatynowa zawierajaca kompozycjęfarmaceutyczną
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
WO2005072701A1 (en) 2004-01-20 2005-08-11 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
EP2714720B1 (en) * 2011-05-27 2018-12-26 Allergan, Inc. A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof
EP2779994B1 (en) 2011-11-15 2020-02-19 Allergan, Inc. Suspensions of cyclosporin a form 2
CN104039309B (zh) 2011-11-15 2018-03-06 阿勒根公司 环孢菌素形式2的持续作用型制剂
KR102015151B1 (ko) * 2011-11-15 2019-08-27 알러간, 인코포레이티드 사이클로스포린 a 제2형의 고압멸균처리 가능한 현탁액
WO2024085235A1 (ja) * 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (sv) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
US10017541B2 (en) 2011-11-15 2018-07-10 Allergan, Inc. Cyclosporin a form 2 and method of making same

Also Published As

Publication number Publication date
KR890009975A (ko) 1989-08-05
NO177228C (no) 1995-08-09
IE883779L (en) 1989-06-21
SE8804570L (sv) 1989-06-22
FI885869A0 (fi) 1988-12-19
NL8803125A (nl) 1989-07-17
BE1002665A4 (fr) 1991-04-30
HU203564B (en) 1991-08-28
NZ227384A (en) 1991-09-25
IT1235356B (it) 1992-06-30
LU87409A1 (fr) 1989-07-07
FI89065B (fi) 1993-04-30
DK705488D0 (da) 1988-12-19
HK102894A (en) 1994-09-30
GB8829556D0 (en) 1989-02-08
FR2624863A1 (fr) 1989-06-23
JPH01211598A (ja) 1989-08-24
GB2211848A (en) 1989-07-12
SE503174C2 (sv) 1996-04-15
ES2012580A6 (es) 1990-04-01
DE3843054A1 (de) 1989-07-27
JPH0791316B2 (ja) 1995-10-04
AU626274B2 (en) 1992-07-30
FI885869A (fi) 1989-06-22
DK175220B1 (da) 2004-07-12
AU2705588A (en) 1989-06-22
ATA309588A (de) 1997-04-15
CH677926A5 (sv) 1991-07-15
NL195096C (nl) 2004-02-09
NO177228B (no) 1995-05-02
KR100188305B1 (ko) 1999-06-01
SG99494G (en) 1994-10-28
NO885625D0 (no) 1988-12-19
GB2211848B (en) 1991-11-06
IE62006B1 (en) 1994-12-14
FR2624863B1 (fr) 1991-04-26
IT8848690A0 (it) 1988-12-20
SE8804570D0 (sv) 1988-12-19
FI89065C (sv) 1993-09-30
MY103943A (en) 1993-10-30
NO885625L (no) 1989-06-22
GR1002486B (el) 1996-12-09
GR880100850A (el) 1994-03-31
CY1799A (en) 1995-02-17
IL88719A0 (en) 1989-07-31
DK705488A (da) 1989-06-22
DE3843054C2 (de) 2003-08-21
AT403163B (de) 1997-11-25
HUT49893A (en) 1989-11-28

Similar Documents

Publication Publication Date Title
CA1341396C (en) Cyclosporin crystal form, processes for its production pharmaceutical compositions containing it and its use
US5756450A (en) Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
US5916589A (en) Pharmaceutical compositions comprising cyclosporins
US5342625A (en) Pharmaceutical compositions comprising cyclosporins
US6007840A (en) Pharmaceutical compositions comprising cyclosporins
HUT73664A (en) Pharmaceutically acceptable improved compositions containing an alcohol and a hydrophobic drug
JPH11505257A (ja) 親油性薬物の自己乳化性製剤
JP3090666B2 (ja) 薬理活性化合物および医薬賦形剤用可溶化剤としての水溶性モノエステル類
KR100256007B1 (ko) 사이클로스포린을 함유하는 약학 조성물
KR100267149B1 (ko) 사이클로스포린을 함유하는 약학 조성물
HU212727B (en) Process for producing pharmaceutical compositions in form of microemulsion-prae-concentrate or microemulsion containing cyclosporin(s) as active component
CZ279654B6 (cs) Způsob výroby cyklosporinu A

Legal Events

Date Code Title Description
MKLA Lapsed

Effective date: 20161107