CA1236834A - Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols, preparation, and use thereof - Google Patents

Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols, preparation, and use thereof

Info

Publication number
CA1236834A
CA1236834A CA000435880A CA435880A CA1236834A CA 1236834 A CA1236834 A CA 1236834A CA 000435880 A CA000435880 A CA 000435880A CA 435880 A CA435880 A CA 435880A CA 1236834 A CA1236834 A CA 1236834A
Authority
CA
Canada
Prior art keywords
hydrogen
compound
alkyl
halogen
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000435880A
Other languages
English (en)
French (fr)
Inventor
William E. Kreighbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Application granted granted Critical
Publication of CA1236834A publication Critical patent/CA1236834A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000435880A 1982-09-03 1983-09-01 Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols, preparation, and use thereof Expired CA1236834A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41474882A 1982-09-03 1982-09-03
US414,748 1982-09-03

Publications (1)

Publication Number Publication Date
CA1236834A true CA1236834A (en) 1988-05-17

Family

ID=23642783

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000435880A Expired CA1236834A (en) 1982-09-03 1983-09-01 Substituted 1-pyridyloxy-3-indolylalkylamino-2- propanols, preparation, and use thereof

Country Status (28)

Country Link
JP (1) JPS5965087A (de)
KR (1) KR870001019B1 (de)
AT (1) AT387385B (de)
AU (4) AU567112B2 (de)
BE (1) BE897671A (de)
CA (1) CA1236834A (de)
CH (2) CH668593A5 (de)
CY (1) CY1521A (de)
DE (1) DE3331612A1 (de)
DK (1) DK399783A (de)
ES (4) ES525243A0 (de)
FI (1) FI79709C (de)
FR (1) FR2543952B1 (de)
GB (1) GB2126230B (de)
GR (1) GR79061B (de)
HK (1) HK17490A (de)
HU (2) HU194164B (de)
IE (1) IE56201B1 (de)
IL (1) IL69618A (de)
IT (1) IT1169459B (de)
LU (1) LU84986A1 (de)
NL (1) NL8303038A (de)
NO (1) NO161258C (de)
NZ (1) NZ205466A (de)
PT (1) PT77282B (de)
SE (2) SE460419B (de)
YU (2) YU45150B (de)
ZA (1) ZA836469B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543952B1 (fr) * 1982-09-03 1986-02-21 Bristol Myers Co Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
DE3721260A1 (de) * 1987-06-27 1989-01-12 Beiersdorf Ag Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5030640A (en) * 1989-01-05 1991-07-09 Merck & Co., Inc. Novel β-adrenergic agonists and pharmaceutical compositions thereof
BR0114884A (pt) * 2000-10-25 2004-07-06 Smithkline Beecham Corp Compostos calcilìticos
KR100457857B1 (ko) * 2002-05-23 2004-11-18 (주) 비엔씨바이오팜 2-[2-(3-인돌릴)에틸아미노]피리딘 유도체, 그 제조방법및 이를 포함하는 항바이러스용 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
FR2543952B1 (fr) * 1982-09-03 1986-02-21 Bristol Myers Co Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
CA1241660A (en) * 1984-06-25 1988-09-06 Yvan Guindon Indole-2-alkanoic acids

Also Published As

Publication number Publication date
DE3331612A1 (de) 1984-03-08
AU567112B2 (en) 1987-11-12
AU1859283A (en) 1984-03-08
YU224786A (en) 1987-10-31
CY1521A (en) 1990-11-16
YU44940B (en) 1991-04-30
ES8604930A1 (es) 1986-02-16
KR840006235A (ko) 1984-11-22
SE460419B (sv) 1989-10-09
IE832063L (en) 1984-03-03
FI833102A (fi) 1984-03-04
GB2126230A (en) 1984-03-21
AU613589B2 (en) 1991-08-08
AU8055887A (en) 1988-02-18
AU8055787A (en) 1988-02-18
HK17490A (en) 1990-03-16
NL8303038A (nl) 1984-04-02
NZ205466A (en) 1986-12-05
NO833128L (no) 1984-03-05
SE8802265L (sv) 1988-06-16
FI833102A0 (fi) 1983-08-31
SE8304751L (sv) 1984-03-04
ES547111A0 (es) 1986-02-16
YU45150B (en) 1992-03-10
DK399783A (da) 1984-03-04
FR2543952B1 (fr) 1986-02-21
KR870001019B1 (ko) 1987-05-23
NO161258B (no) 1989-04-17
IT1169459B (it) 1987-05-27
PT77282B (en) 1986-04-28
HU192862B (en) 1987-07-28
ES547110A0 (es) 1986-02-16
SE8802265D0 (sv) 1988-06-16
IL69618A0 (en) 1983-12-30
ZA836469B (en) 1984-04-25
IL69618A (en) 1987-02-27
IT8322765A0 (it) 1983-09-02
AU609067B2 (en) 1991-04-26
PT77282A (en) 1983-10-01
SE8304751D0 (sv) 1983-09-02
IE56201B1 (en) 1991-05-22
BE897671A (fr) 1984-03-02
GB8323641D0 (en) 1983-10-05
JPS5965087A (ja) 1984-04-13
ES8507537A1 (es) 1985-09-01
ES8505200A1 (es) 1985-05-16
LU84986A1 (fr) 1984-04-24
AU8055987A (en) 1988-02-18
CH668593A5 (fr) 1989-01-13
FI79709B (fi) 1989-10-31
HU194164B (en) 1988-01-28
FI79709C (fi) 1990-02-12
YU180383A (en) 1988-06-30
ES531872A0 (es) 1985-05-16
FR2543952A1 (fr) 1984-10-12
NO161258C (no) 1989-07-26
CH661512A5 (fr) 1987-07-31
AU609068B2 (en) 1991-04-26
DK399783D0 (da) 1983-09-01
GB2126230B (en) 1987-01-14
ES8604931A1 (es) 1986-02-16
ATA315583A (de) 1988-06-15
ES525243A0 (es) 1985-09-01
AT387385B (de) 1989-01-10
GR79061B (de) 1984-10-02

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Legal Events

Date Code Title Description
MKEX Expiry