CA1120040A - .alpha.-FLUOROMETHYL-.alpha.-AMINO ALKANOIC ACIDS - Google Patents

.alpha.-FLUOROMETHYL-.alpha.-AMINO ALKANOIC ACIDS

Info

Publication number
CA1120040A
CA1120040A CA000304318A CA304318A CA1120040A CA 1120040 A CA1120040 A CA 1120040A CA 000304318 A CA000304318 A CA 000304318A CA 304318 A CA304318 A CA 304318A CA 1120040 A CA1120040 A CA 1120040A
Authority
CA
Canada
Prior art keywords
fluoromethyl
hcl
formula
tyrosine
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000304318A
Other languages
English (en)
French (fr)
Inventor
Janos Kollonitsch
Arthur A. Patchett
Stephen Marburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/802,391 external-priority patent/US4325961A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1120040A publication Critical patent/CA1120040A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CA000304318A 1977-06-01 1978-05-29 .alpha.-FLUOROMETHYL-.alpha.-AMINO ALKANOIC ACIDS Expired CA1120040A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80238977A 1977-06-01 1977-06-01
US05/802,391 US4325961A (en) 1977-06-01 1977-06-01 Fluorinated amino acids
US802,391 1977-06-01
US802,389 1985-11-27

Publications (1)

Publication Number Publication Date
CA1120040A true CA1120040A (en) 1982-03-16

Family

ID=27122442

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000304318A Expired CA1120040A (en) 1977-06-01 1978-05-29 .alpha.-FLUOROMETHYL-.alpha.-AMINO ALKANOIC ACIDS

Country Status (26)

Country Link
JP (1) JPS5416423A (no)
AR (1) AR223463A1 (no)
AT (1) AT360509B (no)
AU (1) AU518479B2 (no)
CA (1) CA1120040A (no)
CH (1) CH639639A5 (no)
DD (1) DD138651A5 (no)
DE (1) DE2824116A1 (no)
DK (1) DK149841C (no)
ES (1) ES470296A1 (no)
FI (1) FI66840C (no)
FR (1) FR2392958A1 (no)
GB (1) GB1602525A (no)
GR (1) GR64495B (no)
HK (1) HK18184A (no)
HU (1) HU181911B (no)
IE (1) IE46983B1 (no)
IT (1) IT1104709B (no)
LU (1) LU79750A1 (no)
NL (1) NL190485C (no)
NO (1) NO147382C (no)
NZ (1) NZ187377A (no)
PL (1) PL115731B1 (no)
PT (1) PT68102B (no)
SE (1) SE7806440L (no)
YU (1) YU129178A (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59481A0 (en) * 1977-07-11 1980-05-30 Merrell Toraude & Co -halomethyl amino acids
CA1091661A (en) * 1977-07-11 1980-12-16 Philippe Bey .alpha.-HALOMETHYL DERIVATIVES OF .alpha.-AMINO ACIDS
ZA783273B (en) * 1977-07-11 1979-06-27 Merrell Toraude & Co A-halomethyl amino acids
US4315095A (en) * 1977-07-28 1982-02-09 Merrell Toraude Et Compagnie α-Halomethyl derivatives of amino acids
DK309479A (da) * 1978-07-24 1980-02-19 Merck & Co Inc Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf
IE49522B1 (en) * 1979-04-26 1985-10-16 Merrell Toraude & Co Alpha-halomethylaminoacids
IL60591A (en) * 1979-07-26 1985-02-28 Merrell Toraude & Co Alkenyl fluoromethyl ketimine magnesium halides and process for their preparation
ZA813018B (en) * 1980-05-09 1982-05-26 Merrell Toraude & Co Fluoromethylated tyrosine methyl ester
PH16634A (en) * 1980-06-16 1983-12-05 Merrell Dow Pharma Method of inhibiting the growth of protozoa
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines

Also Published As

Publication number Publication date
FR2392958B1 (no) 1980-10-24
YU129178A (en) 1983-01-21
IT7849637A0 (it) 1978-05-31
ES470296A1 (es) 1979-09-16
AT360509B (de) 1981-01-12
CH639639A5 (en) 1983-11-30
NL190485C (nl) 1994-03-16
GR64495B (en) 1980-03-31
FI66840C (fi) 1984-12-10
ATA393278A (de) 1980-06-15
IT1104709B (it) 1985-10-28
FI781674A (fi) 1978-12-02
LU79750A1 (fr) 1979-02-02
AU518479B2 (en) 1981-10-01
SE7806440L (sv) 1978-12-02
AR223463A1 (es) 1981-08-31
DE2824116C2 (no) 1989-04-27
NZ187377A (en) 1981-05-15
FR2392958A1 (fr) 1978-12-29
JPS5416423A (en) 1979-02-07
PT68102A (en) 1978-06-01
GB1602525A (en) 1981-11-11
DK149841C (da) 1987-04-21
JPS641474B2 (no) 1989-01-11
DK237978A (da) 1979-01-19
DK149841B (da) 1986-10-13
PL207242A1 (pl) 1979-04-23
PL115731B1 (en) 1981-04-30
NO781892L (no) 1978-12-04
HK18184A (en) 1984-03-09
NO147382C (no) 1983-03-30
HU181911B (en) 1983-11-28
IE46983B1 (en) 1983-11-16
DD138651A5 (de) 1979-11-14
NO147382B (no) 1982-12-20
FI66840B (fi) 1984-08-31
NL190485B (nl) 1993-10-18
PT68102B (en) 1982-06-08
NL7805981A (nl) 1978-12-05
AU3658678A (en) 1979-12-06
DE2824116A1 (de) 1978-12-14
IE781078L (en) 1978-12-01

Similar Documents

Publication Publication Date Title
US4325961A (en) Fluorinated amino acids
CA1120040A (en) .alpha.-FLUOROMETHYL-.alpha.-AMINO ALKANOIC ACIDS
US4562263A (en) Process for producing 3-(3,4-dihydroxyphenyl) serine
JPH03176495A (ja) ドーパミン及びドーパミン誘導体の４―０―リン酸エステルの製造方法
US4695588A (en) Fluorinated amino acids
SU719498A3 (ru) Способ получени 1-нитро-9-алкиламиноалкиламиноакридинов или их солей
Bey et al. Stereospecific alkylation of the Schiff base ester of alanine with 2-substituted-(E)-and-(Z)-vinyl bromides. An efficient synthesis of 2-methyl-(E)-3, 4-didehydroglutamic acid, a potent substrate-induced irreversible inhibitor of L-glutamate-1-decarboxylase
US4013662A (en) Alkyl and benzyl 6,7-dialkoxy-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylates
US5451606A (en) Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment
EP0000034B1 (en) Fluorinated amines, compositions and process for preparing said compounds
US4288601A (en) Fluorination process
de Meijere et al. Convenient Syntheses of Novel α‐and β‐Amino Acids with Spiropentyl Groups
EP0000036B1 (en) Fluorinated alkylamines and process for preparing same
US4483870A (en) α-Difluoromethyl amino acids and hypertension treating compositions thereof
US4285935A (en) Dehydropeptide compounds, their production and their medical use
Kagan et al. A Novel Resolution of Pantolactone—The Synthesis of D (+)-Calcium Pantothenate1
EP0007600B1 (en) Alpha-difluoromethyl amino acids and pharmaceutical composition containing the same
US4347374A (en) Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives
US4045450A (en) Optical resolution of DL-pantolactone
US4215221A (en) Fluorination process
JPH07330732A (ja) 光学活性な３−アミノ−１−ベンジルピペリジン誘導体
US4411836A (en) Racemization of an α-methyl-β-acylthiopropionic acid
US4436740A (en) 3-Cycloalkylamino-2-OR-propoxycyanopyridines
Kemp et al. Peptide synthesis with benzisoxazolium salts—I: Properties of substituted 2-ethyl-benzisoxazolium salts
US4431817A (en) Fluorinated imidazolyl alkylamines

Legal Events

Date Code Title Description
MKEX Expiry