CA1102809A - 5-aroyl-1,2-dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxylic acid derivatives and process for the production thereof - Google Patents

5-aroyl-1,2-dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxylic acid derivatives and process for the production thereof

Info

Publication number
CA1102809A
CA1102809A CA282,599A CA282599A CA1102809A CA 1102809 A CA1102809 A CA 1102809A CA 282599 A CA282599 A CA 282599A CA 1102809 A CA1102809 A CA 1102809A
Authority
CA
Canada
Prior art keywords
pyrrole
dihydro
pyrrolo
prepared
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA282,599A
Other languages
English (en)
French (fr)
Inventor
Joseph M. Muchowski
Arthur F. Kluge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1102809(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of CA1102809A publication Critical patent/CA1102809A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA282,599A 1976-07-14 1977-07-12 5-aroyl-1,2-dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxylic acid derivatives and process for the production thereof Expired CA1102809A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US704,909 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US771,286 1985-08-30

Publications (1)

Publication Number Publication Date
CA1102809A true CA1102809A (en) 1981-06-09

Family

ID=27107410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA282,599A Expired CA1102809A (en) 1976-07-14 1977-07-12 5-aroyl-1,2-dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxylic acid derivatives and process for the production thereof

Country Status (27)

Country Link
JP (1) JPS539788A (it)
AR (1) AR224997A1 (it)
CA (1) CA1102809A (it)
CH (3) CH641458A5 (it)
CS (1) CS204954B2 (it)
DE (2) DE2731678A1 (it)
DK (1) DK151886C (it)
ES (2) ES460706A1 (it)
FI (1) FI63406C (it)
FR (2) FR2358406A1 (it)
GB (1) GB1554075A (it)
GR (1) GR61111B (it)
HK (1) HK15981A (it)
HU (1) HU174224B (it)
IE (1) IE45253B1 (it)
IL (2) IL52493A (it)
IT (1) IT1117313B (it)
MX (1) MX163202B (it)
MY (1) MY8100357A (it)
NL (2) NL186318C (it)
NO (1) NO147564C (it)
NZ (1) NZ184610A (it)
PL (4) PL124444B1 (it)
PT (1) PT66780B (it)
SE (1) SE434643B (it)
SU (1) SU695558A3 (it)
YU (1) YU40816B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
DK0612521T3 (da) * 1991-11-11 2000-01-17 Hisamitsu Pharmaceutical Co Keterolacholdigt varmt omslag
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置

Also Published As

Publication number Publication date
NO772494L (no) 1978-01-17
AU513384B2 (en) 1980-11-27
IL52493A (en) 1982-02-28
DE2731678C2 (it) 1989-06-08
DK151886C (da) 1988-06-06
NZ184610A (en) 1979-03-28
NL186318C (nl) 1990-11-01
MY8100357A (en) 1981-12-31
GR61111B (en) 1978-09-12
ES470214A1 (es) 1979-09-16
FI63406B (fi) 1983-02-28
NL7707651A (nl) 1978-01-17
PL124444B1 (en) 1983-01-31
MX163202B (es) 1992-02-20
AR224997A1 (es) 1982-02-15
JPS539788A (en) 1978-01-28
IE45253B1 (en) 1982-07-14
DE2760330C2 (it) 1989-06-15
IL52493A0 (en) 1977-10-31
JPS6254109B2 (it) 1987-11-13
GB1554075A (en) 1979-10-17
CH641458A5 (en) 1984-02-29
NO147564C (no) 1983-05-18
NO147564B (no) 1983-01-24
SU695558A3 (ru) 1979-10-30
HU174224B (hu) 1979-11-28
PL124711B1 (en) 1983-02-28
YU172177A (en) 1983-09-30
DK151886B (da) 1988-01-11
CH646973A5 (en) 1984-12-28
AU2697577A (en) 1979-01-18
FI63406C (fi) 1983-06-10
FR2358406B1 (it) 1981-04-17
YU40816B (en) 1986-06-30
SE434643B (sv) 1984-08-06
CH646972A5 (en) 1984-12-28
FR2358406A1 (fr) 1978-02-10
FI772153A (it) 1978-01-15
CS204954B2 (en) 1981-04-30
PT66780A (fr) 1977-08-01
HK15981A (en) 1981-05-01
PL124445B1 (en) 1983-01-31
PT66780B (fr) 1978-12-18
DE2731678A1 (de) 1978-03-16
FR2375234B1 (it) 1980-11-07
DK307577A (da) 1978-01-15
NL930021I2 (nl) 1997-03-03
NL186318B (nl) 1990-06-01
ES460706A1 (es) 1978-12-01
IL58779A0 (en) 1980-02-29
NL930021I1 (nl) 1993-05-03
FR2375234A1 (fr) 1978-07-21
IT1117313B (it) 1986-02-17
SE7708141L (sv) 1978-01-15
PL199603A1 (pl) 1978-04-24
PL109390B1 (en) 1980-05-31
IE45253L (en) 1978-01-14

Similar Documents

Publication Publication Date Title
US4089969A (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
CA1113938A (en) 5-(2-pyrroyl)-1,2-dihydro-3h-pyrrolo¬1,2-a|- pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
US4087539A (en) 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
CA1102809A (en) 5-aroyl-1,2-dihydro-3h-pyrrolo ¬1,2-a|-pyrrole-1- carboxylic acid derivatives and process for the production thereof
US4344943A (en) 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
NO874834L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tienopyridinoner.
CA1127165A (en) Dibenzothiepin derivatives and a process for producing the same
US4560699A (en) 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
US3652569A (en) Ergonine ergoptine and the 1-methyl and 9 10-dihydro derivatives thereof
US4011328A (en) Derivatives of pyridine-3-acetic acid, process for their preparation and applications thereof
CA1100140A (en) 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3- thenoyl)-1,2-dihydro-3h-pyrrolo ¬1,2-a|pyrrole-1- carboxylic acid derivatives and process for the production thereof
US4410534A (en) 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors
US3931286A (en) Novel benzoylphenylacetic acid derivatives
US4130654A (en) Novel 4-(8X-6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl)-4-oxobutyric acids, methods of preparation, compositions and uses thereof
US4134894A (en) Pyrrolo[1,2-a]indole compounds
US4000308A (en) 6,11-Dihydrodibenzo-thiepin-11-ones, compositions and uses thereof
US5153217A (en) Pyrrolealdehyde derivative
GB1576841A (en) Substituted n-acyl phenylamine compounds having hypolipidaemic activity
IE45702B1 (en) New pyridobenzodiazepinones, processes for their preparation and pharmaceutical compositions containing them
US4810722A (en) 1-styrenesulphonyl-2-oxo-5-hydroxy pyrrolidines and their use for memory restoration after electoshock treatment
US4051149A (en) 6,11-Dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile
DK151335B (da) Analogifremgangsmaade til fremstilling af (dl)- eller (l)-5-benzoyl-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyreestere eller salte
EP0005055A2 (en) 6,11-Dihydrodibenzo-thiepin-11-ones and their S-oxides, methods for their preparation and pharmaceutical compositions containing them
JPH02108684A (ja) ベンゾピラン誘導体の製造法

Legal Events

Date Code Title Description
MKEX Expiry