BRPI1009189A2 - método para melhorar o rendimento de um polipetídeo - Google Patents

método para melhorar o rendimento de um polipetídeo

Info

Publication number
BRPI1009189A2
BRPI1009189A2 BRPI1009189A BRPI1009189A BRPI1009189A2 BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2 BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A BRPI1009189 A BR PI1009189A BR PI1009189 A2 BRPI1009189 A2 BR PI1009189A2
Authority
BR
Brazil
Prior art keywords
polypeptide
yield
improving
Prior art date
Application number
BRPI1009189A
Other languages
English (en)
Inventor
Alrik Pieter Los
Herman Jan Pel
Jan Metske Van Der Laan
Johannes Andries Roubos
Liang Wu
Lucie Parenicova
Noel Nicolaas Maria Elisabeth Van Peij
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI1009189A2 publication Critical patent/BRPI1009189A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI1009189A 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo BRPI1009189A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (1)

Publication Number Publication Date
BRPI1009189A2 true BRPI1009189A2 (pt) 2015-09-15

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1009189A BRPI1009189A2 (pt) 2009-03-10 2010-03-08 método para melhorar o rendimento de um polipetídeo

Country Status (11)

Country Link
US (1) US9181573B2 (pt)
EP (1) EP2406386B1 (pt)
JP (1) JP2012520064A (pt)
CN (1) CN102741421B (pt)
AU (1) AU2010223354A1 (pt)
BR (1) BRPI1009189A2 (pt)
CA (1) CA2754851A1 (pt)
DK (1) DK2406386T3 (pt)
EA (1) EA021205B1 (pt)
MX (1) MX346700B (pt)
WO (1) WO2010102982A1 (pt)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
CA2803222A1 (en) 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
DK2683732T3 (en) 2011-03-11 2016-12-12 Dsm Ip Assets Bv Vector-host-system
CN105308171B (zh) 2012-07-19 2019-03-08 帝斯曼知识产权资产管理有限公司 Agse缺陷菌株
US9951339B2 (en) 2012-09-19 2018-04-24 Dsm Ip Assets B.V. Cell modification method using essential genes as markers and optionally recycling these
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
MX370305B (es) 2013-12-02 2019-12-09 Dsm Ip Assets Bv Proteína estructurante de hielo.
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR102105352B1 (ko) * 2014-11-03 2020-04-29 메르크 파텐트 게엠베하 생체분자를 정제하기 위한 가용성 인테인 융합 단백질 및 방법
US11396665B2 (en) 2015-01-06 2022-07-26 Dsm Ip Assets B.V. CRISPR-CAS system for a filamentous fungal host cell
WO2016110511A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a lipolytic yeast host cell
US20180103650A1 (en) 2015-04-10 2018-04-19 Dsm Ip Assets B.V. Method for preparing a dough
US20180160695A1 (en) * 2015-06-02 2018-06-14 Dsm Ip Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
CN109689856A (zh) 2016-07-13 2019-04-26 帝斯曼知识产权资产管理有限公司 用于海藻宿主细胞的CRISPR-Cas***
CN109715804A (zh) 2016-09-23 2019-05-03 帝斯曼知识产权资产管理有限公司 用于宿主细胞的指导rna表达***
WO2018166943A1 (en) 2017-03-13 2018-09-20 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
US20200032252A1 (en) 2017-04-06 2020-01-30 Dsm Ip Assets B.V. Self-guiding integration construct (sgic)
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
EP3728603A2 (en) 2017-12-20 2020-10-28 DSM IP Assets B.V. A method for genome editing in a host cell
EP3790969A1 (en) 2018-05-09 2021-03-17 DSM IP Assets B.V. Crispr transient expression construct (ctec)
EP3891281A1 (en) 2018-12-05 2021-10-13 DSM IP Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
DK3715464T3 (da) 2019-03-28 2021-07-26 Dsm Ip Assets Bv Drivhusgasforbedret fermentering
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

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ATE238425T1 (de) 1993-07-23 2003-05-15 Dsm Nv Selektionmarker-genfreie rekombinante stämme: verfahren zur ihrer herstellung und die verwendung dieser stämme
US5888773A (en) * 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
CA2229043C (en) * 1995-08-18 2016-06-07 Morphosys Gesellschaft Fur Proteinoptimierung Mbh Protein/(poly)peptide libraries
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
WO1998046772A2 (en) 1997-04-11 1998-10-22 Dsm N.V. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
ES2287989T3 (es) 1997-12-22 2007-12-16 Dsm Ip Assets B.V. Clonacion de expresion en hongos filamentosos.
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
CN1195058C (zh) 1999-02-22 2005-03-30 诺维信公司 草酰乙酸水解酶缺陷型真菌宿主细胞
WO2001021779A2 (en) 1999-09-17 2001-03-29 Dsm N.V. Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
DK1354056T3 (en) * 2000-10-10 2015-02-23 Danisco Us Inc IMPROVED secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
DE602005023427D1 (de) 2004-04-02 2010-10-21 Dsm Ip Assets Bv Filamentöse pilzmutanten mit verbesserter homologer rekombinationseffizienz
WO2005100573A2 (en) 2004-04-16 2005-10-27 Dsm Ip Assets B.V. Fungal promoters for expressing a gene in a fungal cell
EP1799827A2 (en) 2004-10-12 2007-06-27 DSMIP Assets B.V. Fungal transcriptional activators useful in methods for producing a polypeptide
EP2410048B1 (en) * 2005-01-24 2016-08-10 DSM IP Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
ES2534282T3 (es) 2006-06-29 2015-04-21 Dsm Ip Assets B.V. Un método para lograr la expresión polipeptídica mejorada
AU2007333485A1 (en) * 2006-10-31 2008-06-19 Immunogen, Inc. Methods for improving antibody production
DK3216802T3 (da) * 2007-08-20 2021-01-04 Glaxo Group Ltd Produktionsfremgangsmåde

Also Published As

Publication number Publication date
AU2010223354A1 (en) 2011-09-08
EP2406386A1 (en) 2012-01-18
CN102741421A (zh) 2012-10-17
WO2010102982A1 (en) 2010-09-16
US9181573B2 (en) 2015-11-10
CN102741421B (zh) 2015-03-25
CA2754851A1 (en) 2010-09-16
MX346700B (es) 2017-03-28
EA201101306A1 (ru) 2012-02-28
EP2406386B1 (en) 2019-01-23
DK2406386T3 (en) 2019-04-23
MX2011009059A (es) 2011-11-18
US20110318752A1 (en) 2011-12-29
JP2012520064A (ja) 2012-09-06
EA021205B1 (ru) 2015-04-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time