BRPI0918508A2 - orto-aminoanilidas para o tratamento de câncer - Google Patents
orto-aminoanilidas para o tratamento de câncerInfo
- Publication number
- BRPI0918508A2 BRPI0918508A2 BRPI0918508A BRPI0918508A BRPI0918508A2 BR PI0918508 A2 BRPI0918508 A2 BR PI0918508A2 BR PI0918508 A BRPI0918508 A BR PI0918508A BR PI0918508 A BRPI0918508 A BR PI0918508A BR PI0918508 A2 BRPI0918508 A2 BR PI0918508A2
- Authority
- BR
- Brazil
- Prior art keywords
- aminoanilides
- ortho
- cancer treatment
- cancer
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08164509 | 2008-09-17 | ||
| PCT/EP2009/061533 WO2010031708A2 (en) | 2008-09-17 | 2009-09-07 | Novel ortho-aminoanilides for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0918508A2 true BRPI0918508A2 (pt) | 2015-12-08 |
Family
ID=41716278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918508A BRPI0918508A2 (pt) | 2008-09-17 | 2009-09-07 | orto-aminoanilidas para o tratamento de câncer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8202866B2 (pt) |
| EP (1) | EP2334658A2 (pt) |
| JP (1) | JP2011526936A (pt) |
| KR (1) | KR20110043767A (pt) |
| CN (1) | CN102149678A (pt) |
| AR (1) | AR073513A1 (pt) |
| AU (1) | AU2009294668A1 (pt) |
| BR (1) | BRPI0918508A2 (pt) |
| CA (1) | CA2734349A1 (pt) |
| IL (1) | IL210066A0 (pt) |
| MX (1) | MX2011002574A (pt) |
| TW (1) | TWI378093B (pt) |
| WO (1) | WO2010031708A2 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010028192A1 (en) | 2008-09-03 | 2010-03-11 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| PT2680694T (pt) | 2011-02-28 | 2019-03-14 | Biomarin Pharm Inc | Inibidores de histona deacetilase |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8781041B2 (en) * | 2012-07-31 | 2014-07-15 | Hewlett-Packard Development Company, L.P. | Reducing noise in a sequence of data by linear and non-linear estimation |
| AU2014228344C1 (en) | 2013-03-15 | 2019-02-07 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1643264A1 (de) * | 1967-12-20 | 1971-06-09 | Basf Ag | Verfahren zur Herstellung von Aminoaniliden |
| IT1033046B (it) | 1970-10-31 | 1979-07-10 | Finotto Martino | Procedimento di fabbricazione di benzimidazoli sostituiti |
| KR20040048411A (ko) * | 2001-09-14 | 2004-06-09 | 메틸진, 인크. | 히스톤 데아세틸라아제의 억제제 |
| JP2009523726A (ja) | 2006-01-12 | 2009-06-25 | メルク エンド カムパニー インコーポレーテッド | ヒドロキシアルキルアリールアミド誘導体 |
| EP1991226B1 (en) * | 2006-02-28 | 2013-03-20 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
| CN101610996A (zh) * | 2006-12-19 | 2009-12-23 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂及其前体药物 |
| WO2008087514A2 (en) * | 2007-01-17 | 2008-07-24 | Orchid Research Laboratories Limited | Hdac inhibitors |
| MX2010008021A (es) * | 2008-01-29 | 2010-08-04 | Hoffmann La Roche | Nuevos derivados de n-(2-amino-fenil)-amida. |
| BRPI0912399A2 (pt) * | 2008-05-16 | 2016-01-12 | Hoffmann La Roche | n-(2-amino-fenil)-acrilamidas |
| JP2011150917A (ja) * | 2010-01-22 | 2011-08-04 | Nippon Soken Inc | ガス拡散層およびそれを備える燃料電池 |
-
2009
- 2009-08-19 US US12/543,527 patent/US8202866B2/en not_active Expired - Fee Related
- 2009-09-07 WO PCT/EP2009/061533 patent/WO2010031708A2/en active Application Filing
- 2009-09-07 JP JP2011517178A patent/JP2011526936A/ja active Pending
- 2009-09-07 AU AU2009294668A patent/AU2009294668A1/en not_active Abandoned
- 2009-09-07 CA CA2734349A patent/CA2734349A1/en not_active Abandoned
- 2009-09-07 BR BRPI0918508A patent/BRPI0918508A2/pt not_active IP Right Cessation
- 2009-09-07 CN CN2009801356932A patent/CN102149678A/zh active Pending
- 2009-09-07 MX MX2011002574A patent/MX2011002574A/es not_active Application Discontinuation
- 2009-09-07 KR KR1020117006073A patent/KR20110043767A/ko not_active Application Discontinuation
- 2009-09-07 EP EP09782677A patent/EP2334658A2/en not_active Withdrawn
- 2009-09-15 TW TW098131074A patent/TWI378093B/zh not_active IP Right Cessation
- 2009-09-15 AR ARP090103531A patent/AR073513A1/es not_active Application Discontinuation
-
2010
- 2010-12-16 IL IL210066A patent/IL210066A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010031708A2 (en) | 2010-03-25 |
| AR073513A1 (es) | 2010-11-10 |
| US20100069328A1 (en) | 2010-03-18 |
| CA2734349A1 (en) | 2010-03-25 |
| TWI378093B (en) | 2012-12-01 |
| MX2011002574A (es) | 2011-04-26 |
| EP2334658A2 (en) | 2011-06-22 |
| IL210066A0 (en) | 2011-02-28 |
| WO2010031708A3 (en) | 2010-08-05 |
| KR20110043767A (ko) | 2011-04-27 |
| JP2011526936A (ja) | 2011-10-20 |
| US8202866B2 (en) | 2012-06-19 |
| AU2009294668A1 (en) | 2010-03-25 |
| CN102149678A (zh) | 2011-08-10 |
| TW201014834A (en) | 2010-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |