BRPI0915405A2 - 7-sulfanilmetil-, 7-sulfinilmetil- e 7-sulfonilmetil-indóis substituídos e uso dos mesmos - Google Patents

7-sulfanilmetil-, 7-sulfinilmetil- e 7-sulfonilmetil-indóis substituídos e uso dos mesmos

Info

Publication number
BRPI0915405A2
BRPI0915405A2 BRPI0915405A BRPI0915405A BRPI0915405A2 BR PI0915405 A2 BRPI0915405 A2 BR PI0915405A2 BR PI0915405 A BRPI0915405 A BR PI0915405A BR PI0915405 A BRPI0915405 A BR PI0915405A BR PI0915405 A2 BRPI0915405 A2 BR PI0915405A2
Authority
BR
Brazil
Prior art keywords
sulfinylmethyl
sulfanylmethyl
sulfonylmethyl
indoles
substituted
Prior art date
Application number
BRPI0915405A
Other languages
English (en)
Inventor
Alexander Hillisch
Andreas Göller
Armin Kern
Astrid Brüns
Carsten Schmeck
Dieter Lang
Elisabeth Woltering
Holger Paulsen
Kai Thede
Karl-Heinz Schlemmer
Michael Gerisch
Olaf Prien
Peter Kolkhof
Rolf Grosser
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of BRPI0915405A2 publication Critical patent/BRPI0915405A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0915405A 2008-06-25 2009-06-16 7-sulfanilmetil-, 7-sulfinilmetil- e 7-sulfonilmetil-indóis substituídos e uso dos mesmos BRPI0915405A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008030207A DE102008030207A1 (de) 2008-06-25 2008-06-25 Substituierte 7-Sulfanylmethyl-, 7-Sulfinylmethyl- und 7-Sulfonylmethyl-Indole und ihre Verwendung
PCT/EP2009/004305 WO2009156072A1 (de) 2008-06-25 2009-06-16 Substituierte 7-sulfanylmethyl-, 7-sulfinylmethyl- und 7-sulfonylmethyl-indole und ihre verwendung

Publications (1)

Publication Number Publication Date
BRPI0915405A2 true BRPI0915405A2 (pt) 2015-11-03

Family

ID=41017186

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915405A BRPI0915405A2 (pt) 2008-06-25 2009-06-16 7-sulfanilmetil-, 7-sulfinilmetil- e 7-sulfonilmetil-indóis substituídos e uso dos mesmos

Country Status (24)

Country Link
US (2) US20110201564A1 (pt)
EP (1) EP2300423A1 (pt)
JP (1) JP2011525504A (pt)
KR (1) KR20110023895A (pt)
CN (1) CN102131776A (pt)
AR (1) AR072202A1 (pt)
AU (1) AU2009262582A1 (pt)
BR (1) BRPI0915405A2 (pt)
CA (1) CA2729048A1 (pt)
CL (1) CL2010001508A1 (pt)
CO (1) CO6321237A2 (pt)
CR (1) CR11869A (pt)
DE (1) DE102008030207A1 (pt)
DO (1) DOP2010000400A (pt)
EC (1) ECSP10010711A (pt)
IL (1) IL209718A0 (pt)
MA (1) MA32416B1 (pt)
MX (1) MX2010014447A (pt)
PE (1) PE20110331A1 (pt)
RU (1) RU2011102472A (pt)
SV (1) SV2010003773A (pt)
TW (1) TW201012800A (pt)
UY (1) UY31903A (pt)
WO (1) WO2009156072A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011137220A1 (en) * 2010-04-28 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Small molecule neuropeptide s antagonists for the treatment of addictive disorders, mood, anxiety and sleep disorders
AU2012208837B2 (en) 2011-01-20 2016-07-28 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
DE102011015126B4 (de) * 2011-03-25 2014-09-25 Airbus Operations Gmbh Flugzeugheckbereich mit einem in dem Flugzeugheckbereich installierten Kühlsystem
KR20170016754A (ko) * 2015-08-04 2017-02-14 씨제이헬스케어 주식회사 크로마논 유도체의 신규한 제조방법
KR101894091B1 (ko) 2018-01-23 2018-08-31 씨제이헬스케어 주식회사 크로마논 유도체의 신규한 제조방법
CN111039873B (zh) * 2019-12-20 2022-03-15 河北美荷药业有限公司 一种芬苯达唑亚砜的制备方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2778819A (en) 1950-08-21 1957-01-22 Bayer Ag 1-alkoxy-3 imino-isoindolenine derivatives
NL82464C (pt) 1952-01-05
US2765320A (en) 1954-09-03 1956-10-02 Pittsburgh Plate Glass Co Preparation of 2, 3-dimethylindole
JPH04501722A (ja) 1988-11-14 1992-03-26 ジ・アップジョン・カンパニー 抗―糖尿病、抗―肥満症および抗―アテローム性動脈硬化症薬として有用なα―アミノ―インドール―3―酢酸
GB9609641D0 (en) 1996-05-09 1996-07-10 Pfizer Ltd Compounds useful in therapy
US5808064A (en) 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
CN1084751C (zh) 1996-08-13 2002-05-15 麦克公司 钯催化的吲哚化反应
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
MXPA05007857A (es) 2003-01-22 2005-10-18 Lilly Co Eli Moduladores derivados de indol de receptores nucleares de hormonas esteroideas.
JP2007526304A (ja) 2004-03-03 2007-09-13 イーライ リリー アンド カンパニー 二環式置換インドール誘導体ステロイドホルモン核内受容体モジュレータ
ES2340180T3 (es) 2004-06-01 2010-05-31 F.Hoffmann-La Roche Ag 3-amino-1-arilpropil-indoles como inhibidores de reabsorcion de monoaminas.
CA2623154A1 (en) 2005-09-30 2007-04-12 Dainippon Sumitomo Pharma Co., Ltd. Novel fused pyrrole derivative
KR20080080593A (ko) 2005-11-30 2008-09-04 에프. 호프만-라 로슈 아게 3-아미노-1-아릴프로필 인돌의 합성 방법
EP1998766A2 (en) 2005-12-16 2008-12-10 Ironwood Pharmaceuticals, Inc. Useful indole compounds
EP2610244A1 (en) 2006-08-07 2013-07-03 Ironwood Pharmaceuticals, Inc. Indole compounds
US20090118503A1 (en) 2007-06-20 2009-05-07 Kevin Sprott Faah inhibitors

Also Published As

Publication number Publication date
US20110201564A1 (en) 2011-08-18
SV2010003773A (es) 2011-08-29
CL2010001508A1 (es) 2011-05-06
CA2729048A1 (en) 2009-12-30
MA32416B1 (fr) 2011-06-01
UY31903A (es) 2010-01-29
JP2011525504A (ja) 2011-09-22
AU2009262582A1 (en) 2009-12-30
US8063234B2 (en) 2011-11-22
MX2010014447A (es) 2011-01-21
TW201012800A (en) 2010-04-01
WO2009156072A1 (de) 2009-12-30
EP2300423A1 (de) 2011-03-30
DOP2010000400A (es) 2011-01-31
DE102008030207A1 (de) 2009-12-31
KR20110023895A (ko) 2011-03-08
PE20110331A1 (es) 2011-06-22
US20100105744A1 (en) 2010-04-29
AR072202A1 (es) 2010-08-11
CR11869A (es) 2011-05-10
CO6321237A2 (es) 2011-09-20
IL209718A0 (en) 2011-02-28
CN102131776A (zh) 2011-07-20
RU2011102472A (ru) 2012-07-27
ECSP10010711A (es) 2011-01-31

Similar Documents

Publication Publication Date Title
BRPI0907453A2 (pt) Compostos, uso e preparação dos mesmos
BRPI0815811A2 (pt) Derivados de indol substituído e métodos de uso dos mesmos
BRPI0918502A2 (pt) aminoindanos substituídos e análogos dos mesmos, e o uso farmacêutico dos mesmos
BR112012002349A2 (pt) composto,e, uso do mesmo
BRPI0821276A2 (pt) Produto, e, uso do produto
BRPI0918122A2 (pt) molécula de diaboy, diaboy, e mólecula dart
BRPI0821668A2 (pt) Uso
BRPI0813627A2 (pt) Peptídio antimicrobiano, composições e métodos de uso
BRPI0912198A2 (pt) anticorpos anti-fn14 e usos dos mesmos
BRPI0909770A2 (pt) Vacina, e, kit
BRPI1010024A2 (pt) derivados de aminopirrolidinona e uso dos mesmos
BRPI0811635A2 (pt) Compostos de arilazol-2-il cianoetilamino, métodos para fazê-los e métodos para o uso dos mesmos
BRPI0913188A2 (pt) moduladores de receptores 5-ht3, métodos de fabricação, e uso dos mesmos
BRPI0906936A2 (pt) Uso de canabinóide canabidiol e canabinóide tetraidrocanabivarina
BRPI0920927A2 (pt) derivados de azaquinolinona e usos dos mesmos
BRPI0907231A2 (pt) pirrolpirimidinas e pirrolpiridinas
DOP2010000260A (es) Derivado heterociclico fusionado y su uso
BRPI0819909A2 (pt) anticorpos antimesotelina e usos dos mesmos
CR20130360A (es) Compuesto heterocíclico y su uso
BRPI0906478A2 (pt) anticorpo anti-nr10 e uso do mesmo
BRPI0915086A2 (pt) detecção do uso de canabis
BRPI0823082A2 (pt) Uso derivados de sesquiterpeno
SMT201500218B (it) Composti aril-fenil-solfonammido-cicloalchile e loro uso
BRPI0920953A2 (pt) dispositivo de manutenção, e uso do mesmo.
BRPI0812909A2 (pt) Derivados de guanina policíclica e métodos de uso dos mesmos.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]