BRPI0819541A2 - "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol" - Google Patents

"enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol"

Info

Publication number
BRPI0819541A2
BRPI0819541A2 BRPI0819541A BRPI0819541A BRPI0819541A2 BR PI0819541 A2 BRPI0819541 A2 BR PI0819541A2 BR PI0819541 A BRPI0819541 A BR PI0819541A BR PI0819541 A BRPI0819541 A BR PI0819541A BR PI0819541 A2 BRPI0819541 A2 BR PI0819541A2
Authority
BR
Brazil
Prior art keywords
enzyme
keto acid
acid reductoisomerase
evolution
reductoisomerase
Prior art date
Application number
BRPI0819541A
Other languages
English (en)
Inventor
P O'keefe Daniel
Liao Der-Ing
J Nelson Mark
Li Yougen
Original Assignee
Butamax Advanced Biofuels Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40385503&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819541(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Butamax Advanced Biofuels Llc filed Critical Butamax Advanced Biofuels Llc
Publication of BRPI0819541A2 publication Critical patent/BRPI0819541A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0819541A 2007-12-20 2008-12-18 "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol" BRPI0819541A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1534607P 2007-12-20 2007-12-20
US10929708P 2008-10-29 2008-10-29
PCT/US2008/087429 WO2009085953A2 (en) 2007-12-20 2008-12-18 Ketol-acid reductoisomerase using nadh

Publications (1)

Publication Number Publication Date
BRPI0819541A2 true BRPI0819541A2 (pt) 2017-05-23

Family

ID=40385503

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819541A BRPI0819541A2 (pt) 2007-12-20 2008-12-18 "enzima mutante cetoácido reductoisomerase, molécula de ácido nucléico, célula recombinante e métodos para evolução e a identificação de uma enzima cetoácido reductoisomerase e para a produção de isobutanol"

Country Status (6)

Country Link
US (3) US8129162B2 (pt)
EP (2) EP2677028B1 (pt)
BR (1) BRPI0819541A2 (pt)
CA (1) CA2709372A1 (pt)
ES (2) ES2553726T3 (pt)
WO (1) WO2009085953A2 (pt)

Families Citing this family (74)

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EP2677028B1 (en) 2007-12-20 2016-03-09 Butamax (TM) Advanced Biofuels LLC Ketol-acid reductoisomerase using NADH
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
US8828695B2 (en) * 2008-06-04 2014-09-09 Butamax Advanced Biofuels Llc Method for producing butanol using two-phase extractive fermentation
WO2009149270A2 (en) * 2008-06-04 2009-12-10 E. I. Du Pont De Nemours And Company A method for producing butanol using two-phase extractive fermentation
BRPI0913552B1 (pt) 2008-09-29 2020-09-29 Butamax Advanced Biofuels Llc Método para produção de isobutanol e método para conversão de 2,3-dihidroxi isovalerato
AU2009320163B2 (en) * 2008-10-27 2014-10-02 Butamax(Tm) Advanced Biofuels Llc Carbon pathway optimized production hosts for the production of isobutanol
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
US8557562B2 (en) * 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
US8795992B2 (en) * 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
US8455225B2 (en) * 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
CN102439162A (zh) * 2009-04-13 2012-05-02 布特马斯先进生物燃料有限责任公司 利用萃取发酵生产丁醇的方法
US20110020867A1 (en) * 2009-07-20 2011-01-27 Joule Unlimited, Inc. Constructs And Methods For Efficient Transformation Of Micro-Organisms For Production Of Carbon-Based Products Of Interest
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WO2011041415A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes
CN102712912A (zh) * 2009-09-29 2012-10-03 布特马斯先进生物燃料有限责任公司 在乳酸菌中改善流向乙酰乳酸来源产物的流量
WO2011041426A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved yeast production host cells
US20110195505A1 (en) * 2009-10-08 2011-08-11 Butamax(Tm) Advanced Biofuels Llc Bacterial strains for butanol production
AU2010321564A1 (en) * 2009-11-23 2012-05-10 Butamax(Tm) Advanced Biofuels Llc Method for producing butanol using extractive fermentation with electrolyte addition
CN102666867A (zh) * 2009-11-23 2012-09-12 布特马斯先进生物燃料有限责任公司 使用添加渗透物的萃取发酵生产丁醇的方法
US20120034666A1 (en) * 2009-11-24 2012-02-09 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
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NZ600585A (en) 2009-12-29 2014-07-25 Butamax Tm Advanced Biofuels Expression of hexose kinase in recombinant host cells
EP2536821B1 (en) 2010-02-17 2018-06-13 Butamax(TM) Advanced Biofuels LLC Improving activity of fe-s cluster requiring proteins
WO2011159894A1 (en) 2010-06-17 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Yeast production culture for the production of butanol
US9040263B2 (en) 2010-07-28 2015-05-26 Butamax Advanced Biofuels Llc Production of alcohol esters and in situ product removal during alcohol fermentation
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
CA2800542A1 (en) 2010-06-18 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Supplementation of fatty acids for improving alcohol productivity
US20110312053A1 (en) 2010-06-18 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Supplementation of fatty acids for improving alcohol productivity
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
EP3269806B1 (en) 2010-09-07 2020-05-27 Butamax (TM) Advanced Biofuels LLC Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
BR112013024328A2 (pt) * 2011-03-24 2020-08-25 Butamax (Tm) Advanced Biofuels Llc. Células hospedeiras recombinantes, métodos para produzir isobutanol, composiçãofermentativa, métodos para produzir uma célula hospedeira recombinante, para reduzir oueliminar a conversão de isobutiraldeído, polipeptídeos, polinucleqtídeo, método paraconverter acetolactato, leveduras recombinantes, métodos para produzir butanol, paraaumentar a atividade e para aumentar a produtividade da enzima karl
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US9238828B2 (en) 2011-07-28 2016-01-19 Butamax Advanced Biofuels Llc Keto-isovalerate decarboxylase enzymes and methods of use thereof
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WO2013102084A2 (en) 2011-12-30 2013-07-04 Butamax (Tm) Advanced Biofuels Llc Fermentative production of alcohols
MX2014008073A (es) 2011-12-30 2014-10-06 Butamax Advanced Biofuels Llc Cambios geneticos para la produccion de butanol.
AU2013235391A1 (en) 2012-03-23 2014-09-04 Butamax Advanced Biofuels Llc Acetate supplemention of medium for butanologens
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WO2014031831A1 (en) 2012-08-22 2014-02-27 Butamax Advanced Biofuels Llc Production of fermentation products
CN104919050A (zh) 2012-09-12 2015-09-16 布特马斯先进生物燃料有限责任公司 用于生产发酵产物的工艺和***
US9840724B2 (en) 2012-09-21 2017-12-12 Butamax Advanced Biofuels Llc Production of renewable hydrocarbon compositions
US9512408B2 (en) 2012-09-26 2016-12-06 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
CA2884876A1 (en) 2012-09-28 2014-04-03 Butamax Advanced Biofuels Llc Production of fermentation products
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
AU2013329024A1 (en) 2012-10-11 2015-03-12 Butamax Advanced Biofuels Llc Processes and systems for the production of fermentation products
WO2014106107A2 (en) 2012-12-28 2014-07-03 Butamax (Tm) Advanced Biofuels Llc Dhad variants for butanol production
WO2014105840A1 (en) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Fermentative production of alcohols
US9523104B2 (en) 2013-03-12 2016-12-20 Butamax Advanced Biofuels Llc Processes and systems for the production of alcohols
HUE045200T2 (hu) 2013-03-14 2019-12-30 Du Pont Glicerin-3-foszfát dehidrogenáz butanol elõállítására
WO2014144643A1 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Method for producing butanol using extractive fermentation
WO2014151190A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Dhad variants and methods of screening
WO2014151645A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Process for maximizing biomass growth and butanol yield by feedback control
BR112015020685A2 (pt) 2013-03-15 2017-07-18 Butamax Advanced Biofuels Llc método para a recuperação do butanol, composição, métodos para a extração de álcool e de secagem
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
JP5845210B2 (ja) * 2013-06-13 2016-01-20 トヨタ自動車株式会社 組換え酵母、及びそれを用いたエタノールの製造方法
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EP2677028B1 (en) 2007-12-20 2016-03-09 Butamax (TM) Advanced Biofuels LLC Ketol-acid reductoisomerase using NADH

Also Published As

Publication number Publication date
WO2009085953A3 (en) 2009-09-03
US20130072394A1 (en) 2013-03-21
US8895307B2 (en) 2014-11-25
EP2677028B1 (en) 2016-03-09
EP2677028A1 (en) 2013-12-25
WO2009085953A2 (en) 2009-07-09
CA2709372A1 (en) 2009-07-09
EP2222841B1 (en) 2015-08-26
US20120115197A1 (en) 2012-05-10
US20090163376A1 (en) 2009-06-25
US8222017B2 (en) 2012-07-17
EP2222841A2 (en) 2010-09-01
US8129162B2 (en) 2012-03-06
ES2553726T3 (es) 2015-12-11
ES2575413T3 (es) 2016-06-28

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