BRPI0817315A2 - Inibidores de quinase do tipo polo - Google Patents
Inibidores de quinase do tipo poloInfo
- Publication number
- BRPI0817315A2 BRPI0817315A2 BRPI0817315A BRPI0817315A2 BR PI0817315 A2 BRPI0817315 A2 BR PI0817315A2 BR PI0817315 A BRPI0817315 A BR PI0817315A BR PI0817315 A2 BRPI0817315 A2 BR PI0817315A2
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- type kinase
- polo type
- polo
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97512707P | 2007-09-25 | 2007-09-25 | |
US3730308P | 2008-03-17 | 2008-03-17 | |
PCT/US2008/077558 WO2009042711A1 (en) | 2007-09-25 | 2008-09-24 | Polo-like kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0817315A2 true BRPI0817315A2 (pt) | 2015-03-17 |
Family
ID=40219644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0817315 BRPI0817315A2 (pt) | 2007-09-25 | 2008-09-24 | Inibidores de quinase do tipo polo |
Country Status (27)
Country | Link |
---|---|
US (4) | US8026234B2 (pt) |
EP (3) | EP2205241B1 (pt) |
JP (2) | JP5372939B2 (pt) |
KR (2) | KR101444924B1 (pt) |
CN (2) | CN103122001A (pt) |
AR (1) | AR071729A1 (pt) |
AU (1) | AU2008304417B2 (pt) |
BR (1) | BRPI0817315A2 (pt) |
CA (2) | CA2699607A1 (pt) |
CL (1) | CL2008002852A1 (pt) |
CO (1) | CO6270231A2 (pt) |
CR (1) | CR11370A (pt) |
DO (1) | DOP2010000091A (pt) |
EA (1) | EA019487B1 (pt) |
EC (1) | ECSP10010129A (pt) |
ES (1) | ES2488966T3 (pt) |
GE (1) | GEP20125704B (pt) |
HK (1) | HK1145144A1 (pt) |
MA (1) | MA31763B1 (pt) |
MX (2) | MX2010003249A (pt) |
MY (1) | MY152283A (pt) |
NZ (1) | NZ584760A (pt) |
PE (1) | PE20090710A1 (pt) |
TN (1) | TN2010000131A1 (pt) |
TW (1) | TWI436769B (pt) |
WO (2) | WO2009042711A1 (pt) |
ZA (1) | ZA201002543B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5243970B2 (ja) | 2006-02-14 | 2013-07-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なジヒドロジアゼピン |
GEP20125704B (en) | 2007-09-25 | 2012-12-10 | Takeda Pharmaceuticals Co | Plk kinase inhibitors |
ES2585110T3 (es) * | 2007-09-28 | 2016-10-03 | Cyclacel Limited | Derivados de pirimidina como inhibidores de proteína cinasa |
JP2011527667A (ja) * | 2008-06-18 | 2011-11-04 | 武田薬品工業株式会社 | ハロ置換ピリミドジアゼピン |
US8049005B2 (en) | 2009-03-31 | 2011-11-01 | Arqule, Inc. | Substituted tetrahydropyrazolo-pyrido-azepine compounds |
CA2756568C (en) | 2009-04-06 | 2018-02-13 | University Health Network | Kinase inhibitors and method of treating cancer with same |
EP2480550B1 (en) | 2009-09-25 | 2016-02-10 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
WO2011038185A2 (en) * | 2009-09-25 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
US8445503B2 (en) | 2009-12-23 | 2013-05-21 | Elan Pharmaceuticals, Inc. | Inhibitors of polo-like kinase |
CN102892766B (zh) | 2010-04-06 | 2015-05-20 | 大学健康网络 | 激酶抑制剂和用其治疗癌症的方法 |
US8569331B2 (en) | 2010-11-01 | 2013-10-29 | Arqule, Inc. | Substituted benzo[f]lmidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds |
JP5986566B2 (ja) * | 2011-07-07 | 2016-09-06 | イハラケミカル工業株式会社 | ニトロベンゼン化合物の製造方法 |
WO2013058344A1 (ja) * | 2011-10-21 | 2013-04-25 | 武田薬品工業株式会社 | Plk1阻害剤の効果を予測する方法 |
HUE043194T2 (hu) | 2013-10-18 | 2019-08-28 | Univ Health Network | PLK-4 inhibitor sója és kristályformái |
CA2936865A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
EP3099693A4 (en) | 2014-01-31 | 2017-08-16 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
WO2017044849A1 (en) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
PE20181086A1 (es) | 2015-09-11 | 2018-07-05 | Dana Farber Cancer Inst Inc | Acetamida tienotrizolodiazepinas y usos de las mismas |
SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
TWI763668B (zh) * | 2016-05-05 | 2022-05-11 | 美商嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
KR102313753B1 (ko) | 2020-03-27 | 2021-10-19 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 바닐린 유도체 화합물 |
WO2022145989A1 (ko) * | 2020-12-31 | 2022-07-07 | (주) 업테라 | 선택적 plk1 억제제로서의 피리미도디아제핀 유도체 |
EP4289852A1 (en) * | 2021-02-08 | 2023-12-13 | Medshine Discovery Inc. | 5,6-dihydrothieno[3,4-h]quinazoline compound |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
EE200200140A (et) | 1999-09-15 | 2003-04-15 | Warner-Lambert Company | Pteridinoonid kui kinaasi inhibiitorid |
PL354241A1 (en) | 1999-09-17 | 2003-12-29 | Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg | Kinase inhibitors as therapeutic agents |
UA76512C2 (en) | 2001-09-04 | 2006-08-15 | Boehringer Ingelheim Pharma | Dihydropteridinones, a method for producing thereof and use thereof as medicament |
US6806272B2 (en) | 2001-09-04 | 2004-10-19 | Boehringer Ingelheim Pharma Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
EP1632493A1 (de) | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP1630163A1 (de) | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP1784406A1 (de) | 2004-08-27 | 2007-05-16 | Boehringer Ingelheim International GmbH | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
JP5243970B2 (ja) | 2006-02-14 | 2013-07-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なジヒドロジアゼピン |
JP2009537500A (ja) | 2006-05-19 | 2009-10-29 | アストラゼネカ アクチボラグ | 増殖抑制剤としてのジヒドロプテリジン化合物 |
TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
CN102746175B (zh) | 2007-03-22 | 2014-01-15 | 武田药品工业株式会社 | 可用作plk1抑制剂的取代的嘧啶并二氮杂* |
WO2009023269A2 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5h-pyrimido [4, 5-b[1, 4] diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases |
GEP20125704B (en) * | 2007-09-25 | 2012-12-10 | Takeda Pharmaceuticals Co | Plk kinase inhibitors |
ES2585110T3 (es) | 2007-09-28 | 2016-10-03 | Cyclacel Limited | Derivados de pirimidina como inhibidores de proteína cinasa |
JP2011527667A (ja) | 2008-06-18 | 2011-11-04 | 武田薬品工業株式会社 | ハロ置換ピリミドジアゼピン |
-
2008
- 2008-09-24 GE GEAP200811771A patent/GEP20125704B/en unknown
- 2008-09-24 US US12/237,306 patent/US8026234B2/en not_active Expired - Fee Related
- 2008-09-24 EP EP08834219.1A patent/EP2205241B1/en active Active
- 2008-09-24 MX MX2010003249A patent/MX2010003249A/es active IP Right Grant
- 2008-09-24 US US12/680,183 patent/US20110201818A1/en not_active Abandoned
- 2008-09-24 CN CN2012105686507A patent/CN103122001A/zh active Pending
- 2008-09-24 EP EP12189293.9A patent/EP2564850B1/en active Active
- 2008-09-24 KR KR1020107009029A patent/KR101444924B1/ko not_active IP Right Cessation
- 2008-09-24 MY MYPI20101261 patent/MY152283A/en unknown
- 2008-09-24 NZ NZ584760A patent/NZ584760A/en not_active IP Right Cessation
- 2008-09-24 AU AU2008304417A patent/AU2008304417B2/en not_active Ceased
- 2008-09-24 CA CA2699607A patent/CA2699607A1/en not_active Abandoned
- 2008-09-24 BR BRPI0817315 patent/BRPI0817315A2/pt not_active IP Right Cessation
- 2008-09-24 EA EA201070395A patent/EA019487B1/ru not_active IP Right Cessation
- 2008-09-24 ES ES08834219.1T patent/ES2488966T3/es active Active
- 2008-09-24 CN CN2008801169537A patent/CN101917995A/zh active Pending
- 2008-09-24 JP JP2010526067A patent/JP5372939B2/ja not_active Expired - Fee Related
- 2008-09-24 WO PCT/US2008/077558 patent/WO2009042711A1/en active Application Filing
- 2008-09-24 KR KR1020147017278A patent/KR20140097440A/ko not_active Application Discontinuation
- 2008-09-25 WO PCT/US2008/077746 patent/WO2009042806A1/en active Application Filing
- 2008-09-25 US US12/680,142 patent/US8202990B2/en not_active Expired - Fee Related
- 2008-09-25 EP EP08833760A patent/EP2197442B1/en not_active Not-in-force
- 2008-09-25 JP JP2010526073A patent/JP2010540464A/ja active Pending
- 2008-09-25 PE PE2008001672A patent/PE20090710A1/es not_active Application Discontinuation
- 2008-09-25 CL CL2008002852A patent/CL2008002852A1/es unknown
- 2008-09-25 CA CA2700295A patent/CA2700295A1/en not_active Abandoned
- 2008-09-25 TW TW097137049A patent/TWI436769B/zh not_active IP Right Cessation
- 2008-09-25 MX MX2010003244A patent/MX2010003244A/es active IP Right Grant
- 2008-09-25 AR ARP080104179A patent/AR071729A1/es unknown
-
2010
- 2010-03-22 TN TNP2010000131A patent/TN2010000131A1/fr unknown
- 2010-03-25 DO DO2010000091A patent/DOP2010000091A/es unknown
- 2010-04-08 MA MA32753A patent/MA31763B1/fr unknown
- 2010-04-09 CO CO10041197A patent/CO6270231A2/es active IP Right Grant
- 2010-04-12 ZA ZA2010/02543A patent/ZA201002543B/en unknown
- 2010-04-14 CR CR11370A patent/CR11370A/es unknown
- 2010-04-23 EC EC2010010129A patent/ECSP10010129A/es unknown
- 2010-12-07 US US12/962,557 patent/US8318727B2/en not_active Expired - Fee Related
- 2010-12-14 HK HK10111664.0A patent/HK1145144A1/xx not_active IP Right Cessation
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