BRPI0810402A2 - Derivados de pirrolidina como antagonistas duais dos receptores nk1/nk3 - Google Patents
Derivados de pirrolidina como antagonistas duais dos receptores nk1/nk3Info
- Publication number
- BRPI0810402A2 BRPI0810402A2 BRPI0810402-6A2A BRPI0810402A BRPI0810402A2 BR PI0810402 A2 BRPI0810402 A2 BR PI0810402A2 BR PI0810402 A BRPI0810402 A BR PI0810402A BR PI0810402 A2 BRPI0810402 A2 BR PI0810402A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- derivatives
- pyrolidine
- formula
- pyrolidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07106666 | 2007-04-20 | ||
| PCT/EP2008/054261 WO2008128891A1 (en) | 2007-04-20 | 2008-04-09 | Pyrrolidine derivatives as dual nk1/nk3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810402A2 true BRPI0810402A2 (pt) | 2014-11-04 |
Family
ID=39563424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810402-6A2A BRPI0810402A2 (pt) | 2007-04-20 | 2008-04-09 | Derivados de pirrolidina como antagonistas duais dos receptores nk1/nk3 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7893062B2 (pt) |
| EP (1) | EP2148857B1 (pt) |
| JP (1) | JP5203449B2 (pt) |
| KR (1) | KR101163847B1 (pt) |
| CN (1) | CN101657418B (pt) |
| AT (1) | ATE475645T1 (pt) |
| AU (1) | AU2008240804B2 (pt) |
| BR (1) | BRPI0810402A2 (pt) |
| CA (1) | CA2682506C (pt) |
| DE (1) | DE602008001983D1 (pt) |
| ES (1) | ES2348002T3 (pt) |
| IL (1) | IL201317A0 (pt) |
| MX (1) | MX2009011051A (pt) |
| WO (1) | WO2008128891A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5580741B2 (ja) | 2008-09-19 | 2014-08-27 | 武田薬品工業株式会社 | 含窒素複素環化合物およびその用途 |
| WO2010040663A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Pyrrolidine n-benzyl derivatives |
| US8022099B2 (en) * | 2008-11-03 | 2011-09-20 | Hoffmann-La Roche Inc. | N-benzyl pyrrolidine derivatives |
| US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
| US20110144081A1 (en) | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
| US20110152233A1 (en) | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
| US8507535B2 (en) | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| PL2712358T3 (pl) | 2011-05-13 | 2017-05-31 | Array Biopharma, Inc. | Związki mocznika pirolidynowego, tiomocznika pirolidynowego oraz guanidyny pirolidynowej jako inhibitory kinazy trka |
| WO2016021562A1 (ja) * | 2014-08-06 | 2016-02-11 | キッセイ薬品工業株式会社 | シアノチオフェン誘導体 |
| CN114306347A (zh) | 2015-05-18 | 2022-04-12 | 康堤医疗有限公司 | 用于治疗性激素依赖性疾病的双重nk-1/nk-3受体拮抗剂 |
| SG11202008226YA (en) | 2018-03-14 | 2020-09-29 | Kandy Therapeutics Ltd | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists |
| WO2020107189A1 (en) * | 2018-11-27 | 2020-06-04 | Legion Pharma Co. Ltd | Pyrrolidine compounds for the treatment of malaria |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU506399B2 (en) | 1975-12-30 | 1980-01-03 | Showa Denko Kabushiki Kaisha | 3-(2-aryl-2-propyl) ureas |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| ATE278687T1 (de) | 1993-12-29 | 2004-10-15 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als therapeutische mittel |
| TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
| US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| EP1192952A3 (en) | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
| US6531597B2 (en) | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
| MXPA06000192A (es) * | 2003-07-03 | 2006-04-11 | Hoffmann La Roche | Antagonistas duales del receptor nk1/nk3 para el tratamiento esquizofrenia. |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| JP2008509179A (ja) * | 2004-08-09 | 2008-03-27 | グラクソ グループ リミテッド | グルタミン酸受容体を強化する化合物および医学におけるその使用 |
| JP2007008913A (ja) * | 2004-09-17 | 2007-01-18 | Tanabe Seiyaku Co Ltd | ピペリジン化合物およびその製法 |
| KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법 |
-
2008
- 2008-04-09 CN CN2008800121653A patent/CN101657418B/zh not_active Expired - Fee Related
- 2008-04-09 AU AU2008240804A patent/AU2008240804B2/en not_active Ceased
- 2008-04-09 DE DE602008001983T patent/DE602008001983D1/de active Active
- 2008-04-09 KR KR1020097024085A patent/KR101163847B1/ko not_active IP Right Cessation
- 2008-04-09 BR BRPI0810402-6A2A patent/BRPI0810402A2/pt not_active IP Right Cessation
- 2008-04-09 CA CA2682506A patent/CA2682506C/en not_active Expired - Fee Related
- 2008-04-09 EP EP08735987A patent/EP2148857B1/en not_active Not-in-force
- 2008-04-09 MX MX2009011051A patent/MX2009011051A/es active IP Right Grant
- 2008-04-09 ES ES08735987T patent/ES2348002T3/es active Active
- 2008-04-09 AT AT08735987T patent/ATE475645T1/de active
- 2008-04-09 WO PCT/EP2008/054261 patent/WO2008128891A1/en active Application Filing
- 2008-04-09 JP JP2010503460A patent/JP5203449B2/ja not_active Expired - Fee Related
- 2008-04-14 US US12/102,121 patent/US7893062B2/en not_active Expired - Fee Related
-
2009
- 2009-10-01 IL IL201317A patent/IL201317A0/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5203449B2 (ja) | 2013-06-05 |
| CA2682506A1 (en) | 2008-10-30 |
| KR20090130317A (ko) | 2009-12-22 |
| CA2682506C (en) | 2016-05-24 |
| EP2148857A1 (en) | 2010-02-03 |
| ES2348002T3 (es) | 2010-11-26 |
| US7893062B2 (en) | 2011-02-22 |
| DE602008001983D1 (de) | 2010-09-09 |
| WO2008128891A1 (en) | 2008-10-30 |
| IL201317A0 (en) | 2010-05-31 |
| MX2009011051A (es) | 2009-10-30 |
| ATE475645T1 (de) | 2010-08-15 |
| CN101657418A (zh) | 2010-02-24 |
| KR101163847B1 (ko) | 2012-07-09 |
| US20080275021A1 (en) | 2008-11-06 |
| JP2010524880A (ja) | 2010-07-22 |
| AU2008240804B2 (en) | 2013-02-21 |
| CN101657418B (zh) | 2012-05-30 |
| EP2148857B1 (en) | 2010-07-28 |
| AU2008240804A1 (en) | 2008-10-30 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2509 DE 05-02-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |