BRPI0807893A2 - Imidazoquinolinas como inibidores duais de lipídio quinase e mtor. - Google Patents

Imidazoquinolinas como inibidores duais de lipídio quinase e mtor.

Info

Publication number
BRPI0807893A2
BRPI0807893A2 BRPI0807893-9A2A BRPI0807893A BRPI0807893A2 BR PI0807893 A2 BRPI0807893 A2 BR PI0807893A2 BR PI0807893 A BRPI0807893 A BR PI0807893A BR PI0807893 A2 BRPI0807893 A2 BR PI0807893A2
Authority
BR
Brazil
Prior art keywords
imidazoquinolines
mtor inhibitors
lipid kinase
kinase
lipid
Prior art date
Application number
BRPI0807893-9A2A
Other languages
English (en)
Inventor
Saskia Maria Brachmann
Peter Finan
Christine Fritsch
Carlos Garcia-Echeverria
Sauveur-Michel Maira
Leon Murphy
Paul Leslie Nicklin
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0807893A2 publication Critical patent/BRPI0807893A2/pt

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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BRPI0807893-9A2A 2007-02-20 2008-02-19 Imidazoquinolinas como inibidores duais de lipídio quinase e mtor. BRPI0807893A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89064107P 2007-02-20 2007-02-20
PCT/US2008/054236 WO2008103636A1 (en) 2007-02-20 2008-02-19 Imidazoquinolines as dual lipid kinase and mtor inhibitors

Publications (1)

Publication Number Publication Date
BRPI0807893A2 true BRPI0807893A2 (pt) 2014-06-17

Family

ID=39495195

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0807893-9A2A BRPI0807893A2 (pt) 2007-02-20 2008-02-19 Imidazoquinolinas como inibidores duais de lipídio quinase e mtor.

Country Status (12)

Country Link
US (1) US9370508B2 (pt)
EP (1) EP2129379B1 (pt)
JP (3) JP2010519309A (pt)
KR (1) KR101472607B1 (pt)
CN (2) CN104758288A (pt)
AU (2) AU2008218806B2 (pt)
BR (1) BRPI0807893A2 (pt)
CA (1) CA2676786C (pt)
ES (1) ES2733822T3 (pt)
MX (1) MX2009008486A (pt)
RU (2) RU2478387C2 (pt)
WO (1) WO2008103636A1 (pt)

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US20150216870A1 (en) * 2012-08-16 2015-08-06 Novartis Ag Combination of PI3K Inhibitor and C-Met Inhibitor
CN103833752A (zh) * 2012-11-20 2014-06-04 北京富龙康泰生物技术有限公司 咪唑酮并喹啉类衍生物、其药物组合物和用途
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US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
CN113768881A (zh) * 2013-10-08 2021-12-10 人工智能治疗公司 用于治疗***平滑肌瘤病的雷帕霉素
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US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
BR112016022598A8 (pt) 2014-04-04 2021-06-29 Ai Therapeutics Inc composição aerossol farmacêutica na forma de um pó seco para liberação pulmonar, forma de dosagem unitária, pacote farmacêutico, kit e uso
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
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JP6865684B2 (ja) 2014-12-09 2021-04-28 チア タイ チオギン ファーマスーチカル グループ コーポレイテッド，リミテッド 非小細胞肺癌に対するキノリン誘導体
EP3828269B1 (en) 2015-03-06 2023-05-03 Korea Advanced Institute Of Science And Technology Composition for prevention or treatment of intractable epilepsy comprising mtor inhibitor
CN111747952A (zh) 2015-04-02 2020-10-09 默克专利股份公司 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
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CN114805352B (zh) 2015-07-11 2023-09-15 南京爱德程医药科技有限公司 作为pi3k/mtor抑制剂的吡咯并吡啶取代的稠合喹啉化合物
WO2017019828A1 (en) * 2015-07-30 2017-02-02 Bristol-Myers Squibb Company Aryl substituted bicyclic heteroaryl compounds
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CN107296811B (zh) 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
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