BRPI0721369A2 - Péletes que compreendem uma matriz de substância ativa e um revestimento polimérico, e um método para produzir os referidos péletes - Google Patents

Péletes que compreendem uma matriz de substância ativa e um revestimento polimérico, e um método para produzir os referidos péletes

Info

Publication number
BRPI0721369A2
BRPI0721369A2 BRPI0721369-7A2A BRPI0721369A BRPI0721369A2 BR PI0721369 A2 BRPI0721369 A2 BR PI0721369A2 BR PI0721369 A BRPI0721369 A BR PI0721369A BR PI0721369 A2 BRPI0721369 A2 BR PI0721369A2
Authority
BR
Brazil
Prior art keywords
pellets
understanding
active substance
polymer coating
substance matrix
Prior art date
Application number
BRPI0721369-7A2A
Other languages
English (en)
Inventor
Andreas Gryczke
Hans-Ulrich Petereit
Christian Meier
Kathrin Nollenberger
Christian Brunnengraeber
Andreas Klosendorf
Reinhard Menzel
Original Assignee
Evonik Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of BRPI0721369A2 publication Critical patent/BRPI0721369A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0721369-7A2A 2007-02-22 2007-11-21 Péletes que compreendem uma matriz de substância ativa e um revestimento polimérico, e um método para produzir os referidos péletes BRPI0721369A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007009243A DE102007009243A1 (de) 2007-02-22 2007-02-22 Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets
PCT/EP2007/062603 WO2008101554A1 (de) 2007-02-22 2007-11-21 Pellets mit einer wirkstoff-matrix und einem polymerüberzug, sowie ein verfahren zur herstellung der pellets

Publications (1)

Publication Number Publication Date
BRPI0721369A2 true BRPI0721369A2 (pt) 2014-03-04

Family

ID=38983907

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0721369-7A2A BRPI0721369A2 (pt) 2007-02-22 2007-11-21 Péletes que compreendem uma matriz de substância ativa e um revestimento polimérico, e um método para produzir os referidos péletes

Country Status (11)

Country Link
US (1) US20080206324A1 (pt)
EP (1) EP2120955A1 (pt)
JP (1) JP5345557B2 (pt)
KR (1) KR101465819B1 (pt)
CN (1) CN101626769A (pt)
BR (1) BRPI0721369A2 (pt)
CA (1) CA2677727A1 (pt)
DE (1) DE102007009243A1 (pt)
IL (1) IL199817A0 (pt)
MX (1) MX2009008951A (pt)
WO (1) WO2008101554A1 (pt)

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CA2359812C (en) 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
CA2711473C (en) * 2008-01-10 2016-01-26 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced active substance release in the colon
WO2009086941A1 (en) * 2008-01-10 2009-07-16 Evonik Röhm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced pulsed active substance release
JP2011509266A (ja) * 2008-01-10 2011-03-24 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング 活性物質の制御放出が促進された、コーティングされた医薬製剤もしくはニュートラシューティカル製剤
TWI441658B (zh) 2008-03-11 2014-06-21 Takeda Pharmaceutical 口腔崩解固體製劑
CN101897674B (zh) * 2009-05-25 2012-12-19 范敏华 L-半胱氨酸片及其制备方法
SG176675A1 (en) 2009-06-08 2012-01-30 Ucl Business Plc Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate
US8822539B2 (en) * 2010-03-28 2014-09-02 Children's Medical Center Corporation Combination therapies: inhibitors of GABA transaminase and NKCC1
ITPN20100027A1 (it) * 2010-05-12 2011-11-13 Friulchem S P A Processo per la preparazione di cilindri e granuli utilizzabili nell'industria veterinaria e mangimistica contenenti principi farmacologicamente attivi, integratori, nutrienti, vitamine o microorganismi
CN101961324A (zh) * 2010-09-10 2011-02-02 武汉药谷生物工程有限公司 一种依托贝特缓释胶囊的处方及制备方法
MX341163B (es) * 2010-10-13 2016-08-10 Evonik Roehm Gmbh Proceso para preparar un copolimero de (met)acrilato que contiene grupos amino terciarios por polimerizacion por radicales libres en solucion.
CN102258478B (zh) * 2011-04-29 2013-02-27 武汉华扬动物药业有限责任公司 一种兽用甲磺酸培氟沙星微丸及其制备方法
CA2936748C (en) 2014-10-31 2017-08-08 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
SG11201708393UA (en) 2015-05-04 2017-11-29 Confluence Pharmaceuticals Llc Sprinkle formulations of acamprosate
MX2017015465A (es) 2015-06-05 2018-03-28 Evonik Roehm Gmbh Composicion farmaceutica o nutraceutica con resistencia contra la influencia del etanol.
CN104983692A (zh) * 2015-07-17 2015-10-21 江西博莱大药厂有限公司 一种阿莫西林缓释微丸及其制备方法
KR20180086431A (ko) * 2015-11-13 2018-07-31 오세라 테라퓨틱스, 아이엔씨. L-오르니틴 페닐아세테이트의 제제
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
CN108338978B (zh) * 2018-04-20 2020-09-18 广州白云山医药集团股份有限公司白云山制药总厂 一种s-羧甲基-l-半胱氨酸肠溶微丸胶囊
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
JP2022533610A (ja) * 2019-05-15 2022-07-25 エボニック オペレーションズ ゲーエムベーハー カプセル充填機を用いて、（メタ）アクリレートコポリマー系のコーティングを有する、充填されたハードシェルカプセルを製造する方法
US10792262B1 (en) * 2019-07-29 2020-10-06 Saol International Limited Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives
US11654124B2 (en) 2019-07-29 2023-05-23 Amneal Pharmaceuticals Llc Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives

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Also Published As

Publication number Publication date
DE102007009243A1 (de) 2008-09-18
CN101626769A (zh) 2010-01-13
US20080206324A1 (en) 2008-08-28
IL199817A0 (en) 2010-04-15
KR101465819B1 (ko) 2014-11-27
EP2120955A1 (de) 2009-11-25
MX2009008951A (es) 2009-08-31
JP5345557B2 (ja) 2013-11-20
WO2008101554A1 (de) 2008-08-28
CA2677727A1 (en) 2008-08-28
JP2010519228A (ja) 2010-06-03
KR20090112718A (ko) 2009-10-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Ipc: A61K 9/16 (2006.01), A61K 9/50 (2006.01), A61K 31/