BRPI0818457A2 - Derivados de oxadiazol - Google Patents
Derivados de oxadiazolInfo
- Publication number
- BRPI0818457A2 BRPI0818457A2 BRPI0818457A BRPI0818457A2 BR PI0818457 A2 BRPI0818457 A2 BR PI0818457A2 BR PI0818457 A BRPI0818457 A BR PI0818457A BR PI0818457 A2 BRPI0818457 A2 BR PI0818457A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxadiazol derivatives
- oxadiazol
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07117921 | 2007-10-04 | ||
US99825407P | 2007-10-09 | 2007-10-09 | |
PCT/EP2008/063180 WO2009043889A2 (en) | 2007-10-04 | 2008-10-01 | Oxadiazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0818457A2 true BRPI0818457A2 (pt) | 2015-04-14 |
Family
ID=38984441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0818457 BRPI0818457A2 (pt) | 2007-10-04 | 2008-10-01 | Derivados de oxadiazol |
Country Status (15)
Country | Link |
---|---|
US (1) | US8202865B2 (pt) |
EP (1) | EP2193125B1 (pt) |
JP (2) | JP6144450B2 (pt) |
KR (1) | KR20100075608A (pt) |
CN (1) | CN101970420B (pt) |
AR (1) | AR068731A1 (pt) |
AU (1) | AU2008306885B2 (pt) |
BR (1) | BRPI0818457A2 (pt) |
CA (1) | CA2696863C (pt) |
EA (1) | EA201070422A1 (pt) |
ES (1) | ES2622423T3 (pt) |
IL (1) | IL204521A0 (pt) |
MX (1) | MX2010003612A (pt) |
WO (1) | WO2009043889A2 (pt) |
ZA (2) | ZA201001121B (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL3345895T3 (pl) | 2003-04-11 | 2020-05-18 | Ptc Therapeutics, Inc. | Związek kwasu 1,2,4-oksadiazolobenzoesowego i jego zastosowanie do supresji mutacji nonsensownych i leczenia choroby |
SI2125797T1 (sl) | 2007-03-16 | 2014-03-31 | Actelion Pharmaceuticals Ltd. | Derivati amino-piridina kot agonisti receptorja s1p1/edg1 |
BRPI0817597A2 (pt) * | 2007-10-04 | 2015-04-07 | Merck Serono Sa | Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos |
AU2008340113B2 (en) * | 2007-12-21 | 2014-01-09 | Merck Serono S.A. | Triazole oxadiazoles derivatives |
CN102007107B (zh) | 2008-03-07 | 2014-07-23 | 埃科特莱茵药品有限公司 | 氨甲基苯衍生物 |
ES2405054T3 (es) | 2009-01-23 | 2013-05-30 | Bristol-Myers Squibb Company | Derivados de pirazol-1,2,4-oxadiazol como agonistas de esfingosina-1-fosfato |
US8354398B2 (en) | 2009-01-23 | 2013-01-15 | Bristol-Myers Squibb Company | Substituted isoxazole compounds |
JP2012515788A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置における、s1pアゴニストとしての置換オキサジアゾール誘導体 |
EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
JP2012530728A (ja) * | 2009-06-26 | 2012-12-06 | グラクソ グループ リミテッド | スフィンゴシン1−リン酸受容体アゴニストとして用いられる5員ヘテロアリール誘導体 |
GB0911130D0 (en) * | 2009-06-26 | 2009-08-12 | Glaxo Group Ltd | Novel compounds |
MY153617A (en) | 2009-07-16 | 2015-02-27 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
ES2759949T3 (es) | 2009-10-29 | 2020-05-12 | Bristol Myers Squibb Co | Compuestos heterocíclicos tricíclicos |
MX2012005281A (es) | 2009-11-05 | 2012-06-19 | Fibrostatin S L | Inhibicion de gpbp utilizando peptidomimeticos q2. |
US20130012491A1 (en) * | 2010-03-17 | 2013-01-10 | Glaxo Group Limited | Pyrimidine derivatives for use as sphingosine 1-phosphate 1 (s1p1) receptor agonists |
ES2548683T3 (es) | 2010-04-23 | 2015-10-20 | Bristol-Myers Squibb Company | Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1 |
TW201206429A (en) * | 2010-07-08 | 2012-02-16 | Merck Serono Sa | Substituted oxadiazole derivatives |
EP2595969B1 (en) | 2010-07-20 | 2015-04-22 | Bristol-Myers Squibb Company | Substituted 3-phenyl-1,2,4-oxadiazole compounds |
EP2619190B1 (en) | 2010-09-24 | 2015-08-12 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
WO2012061459A1 (en) | 2010-11-03 | 2012-05-10 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
CA2818751A1 (en) | 2010-11-22 | 2012-05-31 | Allergan, Inc. | Novel compounds as receptor modulators with therapeutic utility |
WO2012098505A1 (en) | 2011-01-19 | 2012-07-26 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
EP2511275A1 (en) * | 2011-04-12 | 2012-10-17 | Bioprojet | Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists |
CN102250035A (zh) * | 2011-06-10 | 2011-11-23 | 北京富卡生物技术有限公司 | 二芳基取代-1,3,4-噁二唑化合物的合成方法和其药物用途 |
TWI613182B (zh) | 2013-02-21 | 2018-02-01 | 必治妥美雅史谷比公司 | 雙環化合物 |
BR112015023161B1 (pt) | 2013-03-15 | 2022-11-16 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-4-ila |
EP2853532B1 (en) * | 2013-09-28 | 2020-12-09 | Instytut Farmakologii Polskiej Akademii Nauk | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III |
CA2942147C (en) | 2014-03-06 | 2022-12-13 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
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2008
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- 2008-10-01 US US12/675,235 patent/US8202865B2/en active Active
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- 2008-10-01 EA EA201070422A patent/EA201070422A1/ru unknown
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- 2008-10-01 EP EP08804970.5A patent/EP2193125B1/en active Active
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AU2008306885A1 (en) | 2009-04-09 |
WO2009043889A2 (en) | 2009-04-09 |
ZA201001121B (en) | 2011-10-26 |
CA2696863A1 (en) | 2009-04-09 |
EP2193125A2 (en) | 2010-06-09 |
WO2009043889A3 (en) | 2009-08-20 |
US8202865B2 (en) | 2012-06-19 |
AR068731A1 (es) | 2009-12-02 |
JP6144450B2 (ja) | 2017-06-07 |
EA201070422A1 (ru) | 2010-12-30 |
JP2015063571A (ja) | 2015-04-09 |
EP2193125B1 (en) | 2017-01-11 |
CN101970420A (zh) | 2011-02-09 |
CN101970420B (zh) | 2014-09-24 |
US20100240658A1 (en) | 2010-09-23 |
ZA201104423B (en) | 2012-03-28 |
IL204521A0 (en) | 2010-11-30 |
JP2010540592A (ja) | 2010-12-24 |
KR20100075608A (ko) | 2010-07-02 |
AU2008306885B2 (en) | 2013-12-05 |
JP6148263B2 (ja) | 2017-06-14 |
ES2622423T3 (es) | 2017-07-06 |
CA2696863C (en) | 2016-10-18 |
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