BRPI0600194A - composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas - Google Patents
composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmasInfo
- Publication number
- BRPI0600194A BRPI0600194A BRPI0600194-7A BRPI0600194A BRPI0600194A BR PI0600194 A BRPI0600194 A BR PI0600194A BR PI0600194 A BRPI0600194 A BR PI0600194A BR PI0600194 A BRPI0600194 A BR PI0600194A
- Authority
- BR
- Brazil
- Prior art keywords
- docetaxel
- degradation inhibitor
- pharmaceutical compositions
- containing pharmaceutical
- obtaining same
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSIçõES FARMACêUTICAS CONTENDO DOCETAXEL E UM INIBIDOR DE DEGRADAçãO E PROCESSO DE OBTENçãO DAS MESMAS Composição Farmacêutica contendo um ácido orgânico com pKa entre 2,5-4,5 utilizado como inibidor de degradação, polissorbato 80 e docetaxel anidro (I) ou o seu triidrato. As composições obtidas são estéreis e estáveis até 30 meses quando armazenadas a temperatura ambiente, Correspondente à faixa de 15 a 30<198>C, ± 1<198>C, e apresentam baixos teores de 7-epi--docetaxel (II).
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0600194-7A BRPI0600194A (pt) | 2006-01-30 | 2006-01-30 | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
MX2008009705A MX2008009705A (es) | 2006-01-30 | 2006-02-09 | Composiciones farmaceuticas que contienen docetaxel, un inhibidor de degradacion y un proceso para obtener el mismo. |
PCT/BR2006/000016 WO2007085067A1 (en) | 2006-01-30 | 2006-02-09 | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same. |
EP06721578A EP1978953A1 (en) | 2006-01-30 | 2006-02-09 | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same. |
RU2008131308/15A RU2408362C2 (ru) | 2006-01-30 | 2006-02-09 | Фармацевтическая композиция, содержащая доцетаксель и ингибитор деградации, и способ ее получения |
CA002640950A CA2640950A1 (en) | 2006-01-30 | 2006-02-09 | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same |
CNA2006800540696A CN101415416A (zh) | 2006-01-30 | 2006-02-09 | 含多西他赛和降解抑制剂的药物组合物及其制备方法 |
US12/162,772 US20090221688A1 (en) | 2006-01-30 | 2006-02-09 | Pharmaceutical compositions containing docetaxel and a degradation inhibitor and a process for obtaining the same |
JP2008554552A JP2009524700A (ja) | 2006-01-30 | 2006-02-09 | ドセタキセルと分解阻害剤を含む医薬組成物およびその医薬組成物の製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0600194-7A BRPI0600194A (pt) | 2006-01-30 | 2006-01-30 | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0600194A true BRPI0600194A (pt) | 2007-10-23 |
Family
ID=38603030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0600194-7A BRPI0600194A (pt) | 2006-01-30 | 2006-01-30 | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
Country Status (9)
Country | Link |
---|---|
US (1) | US20090221688A1 (pt) |
EP (1) | EP1978953A1 (pt) |
JP (1) | JP2009524700A (pt) |
CN (1) | CN101415416A (pt) |
BR (1) | BRPI0600194A (pt) |
CA (1) | CA2640950A1 (pt) |
MX (1) | MX2008009705A (pt) |
RU (1) | RU2408362C2 (pt) |
WO (1) | WO2007085067A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR054215A1 (es) * | 2006-01-20 | 2007-06-13 | Eriochem Sa | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
BRPI0600194A (pt) | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
KR100878455B1 (ko) * | 2007-04-10 | 2009-01-13 | 한미약품 주식회사 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
FR2917088B1 (fr) * | 2007-06-08 | 2009-09-04 | Aventis Pharma Sa | Dissolution directe du docetaxel dans un solvant dans le polysorbate 80 |
CN101396354B (zh) * | 2007-09-30 | 2010-12-01 | 江苏恒瑞医药股份有限公司 | 一种稳定的塔三烷类化合物液体组合物及其制备方法和其应用 |
KR101053780B1 (ko) * | 2008-02-29 | 2011-08-02 | 동아제약주식회사 | 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물 |
US8686165B2 (en) * | 2009-11-04 | 2014-04-01 | Emcure Pharmaceuticals Limited | Process for preparation of taxane derivatives |
CN101708177B (zh) * | 2009-11-23 | 2012-09-05 | 浙江万马药业有限公司 | 一种含多西他赛的药物组合物及其制备方法 |
CN109745287A (zh) | 2010-05-03 | 2019-05-14 | 帝国制药美国公司 | 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法 |
CN103906747A (zh) | 2011-10-31 | 2014-07-02 | 台湾神隆股份有限公司 | 卡巴他赛及其中间体的制备方法 |
CN103159705B (zh) * | 2011-12-12 | 2015-05-27 | 福建南方制药股份有限公司 | 卡巴他赛中间体的制备方法 |
JP2013194009A (ja) * | 2012-03-21 | 2013-09-30 | Nipro Corp | ドセタキセル製剤 |
DK2875814T3 (en) * | 2012-07-19 | 2018-11-12 | Fujifilm Corp | LIQUID COMPOSITION CONTAINING TAXAN-BASED ACTIVE INGREDIENT, PROCEDURE FOR PREPARING IT AND LIQUID PHARMACEUTICAL COMPOSITION |
JO3685B1 (ar) * | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
EP2777691A1 (en) * | 2013-03-14 | 2014-09-17 | Pharmachemie B.V. | Taxoid - Purification of Liquid Excipients |
EA024176B1 (ru) * | 2014-03-05 | 2016-08-31 | Республиканское Унитарное Производственное Предприятие "Белмедпрепараты" (Руп "Белмедпрепараты") | Способ получения противоопухолевого препарата на основе доцетаксела |
TWI715636B (zh) | 2015-09-30 | 2021-01-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
JP6292267B2 (ja) * | 2016-09-13 | 2018-03-14 | ニプロ株式会社 | ドセタキセル製剤 |
JP2018115178A (ja) * | 2018-03-15 | 2018-07-26 | ニプロ株式会社 | ドセタキセル製剤 |
CN111557934A (zh) * | 2020-06-10 | 2020-08-21 | 四川汇宇制药股份有限公司 | 一种含多西他赛的药物组合物及其制备方法和用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2678833B1 (fr) | 1991-07-08 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes. |
CA2149150C (en) * | 1992-11-27 | 2000-08-01 | David R. Carver | Injectable taxol composition with improved stability |
FR2698543B1 (fr) | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
CA2240595A1 (en) * | 1995-12-21 | 1997-07-03 | Bijan Almassian | Taxane composition and method |
US6071952A (en) * | 1998-12-02 | 2000-06-06 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
EP1315484A1 (en) * | 2000-03-24 | 2003-06-04 | Baker Norton Pharmaceuticals, Inc. | Taxane-based compositions and methods of use |
EP1374864A1 (en) * | 2002-06-26 | 2004-01-02 | Munich Biotech AG | Amphiphilic taxane compositions |
CN1241561C (zh) * | 2002-12-16 | 2006-02-15 | 天津大学 | 紫杉烷类的注射药制剂 |
US20040171560A1 (en) * | 2002-12-23 | 2004-09-02 | Dabur Research Foundation | Stabilized pharmaceutical composition |
EP1510206A1 (en) * | 2003-08-29 | 2005-03-02 | Novagali Pharma SA | Self-nanoemulsifying oily formulation for the administration of poorly water-soluble drugs |
DE602004020506D1 (de) * | 2003-12-12 | 2009-05-20 | Quiral Quimica Do Brasil | Verfahren zur herstellung von wasserfreien und hydratisierten pharmazeutischen wirkstoffen (apis); aus diesen hergestellte stabile pharmazeutische zusammensetzungen und anwendungen für diese zusammensetzungen |
EP1867699B1 (en) | 2005-03-31 | 2018-10-10 | Mitsubishi Chemical Corporation | Deterioration preventing agent |
JP2008543789A (ja) * | 2005-06-17 | 2008-12-04 | ホスピラ オーストラリア ピーティーワイ エルティーディー | ドセタキセルの液体薬学的処方物 |
US8034765B2 (en) | 2005-08-31 | 2011-10-11 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
CN100408032C (zh) | 2006-01-18 | 2008-08-06 | 深圳万乐药业有限公司 | 一种稳定的多西他赛注射剂 |
BRPI0600194A (pt) | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
-
2006
- 2006-01-30 BR BRPI0600194-7A patent/BRPI0600194A/pt not_active IP Right Cessation
- 2006-02-09 EP EP06721578A patent/EP1978953A1/en not_active Ceased
- 2006-02-09 RU RU2008131308/15A patent/RU2408362C2/ru not_active IP Right Cessation
- 2006-02-09 CA CA002640950A patent/CA2640950A1/en not_active Abandoned
- 2006-02-09 CN CNA2006800540696A patent/CN101415416A/zh active Pending
- 2006-02-09 US US12/162,772 patent/US20090221688A1/en not_active Abandoned
- 2006-02-09 JP JP2008554552A patent/JP2009524700A/ja active Pending
- 2006-02-09 MX MX2008009705A patent/MX2008009705A/es not_active Application Discontinuation
- 2006-02-09 WO PCT/BR2006/000016 patent/WO2007085067A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2007085067A1 (en) | 2007-08-02 |
CN101415416A (zh) | 2009-04-22 |
EP1978953A1 (en) | 2008-10-15 |
CA2640950A1 (en) | 2007-08-02 |
MX2008009705A (es) | 2008-10-08 |
US20090221688A1 (en) | 2009-09-03 |
JP2009524700A (ja) | 2009-07-02 |
RU2008131308A (ru) | 2010-03-10 |
RU2408362C2 (ru) | 2011-01-10 |
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