BRPI0519441A2 - composiÇÕes compreendendo uma epotilona, suas composiÇÕes farmacÊuticas e mÉtodos de produÇço - Google Patents

composiÇÕes compreendendo uma epotilona, suas composiÇÕes farmacÊuticas e mÉtodos de produÇço

Info

Publication number
BRPI0519441A2
BRPI0519441A2 BRPI0519441-5A BRPI0519441A BRPI0519441A2 BR PI0519441 A2 BRPI0519441 A2 BR PI0519441A2 BR PI0519441 A BRPI0519441 A BR PI0519441A BR PI0519441 A2 BRPI0519441 A2 BR PI0519441A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
epothilone
production
pharmaceutical compositions
Prior art date
Application number
BRPI0519441-5A
Other languages
English (en)
Inventor
Olaf Reer
Matthias Renz
Andreas Sachse
Claudia Sprenger
Anka Uffrecht
Jens Thomsen
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of BRPI0519441A2 publication Critical patent/BRPI0519441A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Silicon Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSIÇÕES COMPREENDENDO UMA EPOTILONA, SUAS COMPOSIÇÕES FARMACÊUTICAS E MÉTODOS DE PRODUÇçO. A presente invenção refere-se a métodos para produção de formulações farmacêuticas de Epotilona adequadas para serem administradas parenteralmente, tal como intravenosamente.
BRPI0519441-5A 2004-12-23 2005-12-20 composiÇÕes compreendendo uma epotilona, suas composiÇÕes farmacÊuticas e mÉtodos de produÇço BRPI0519441A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04090516A EP1674098A1 (en) 2004-12-23 2004-12-23 Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water
PCT/EP2005/013942 WO2006066949A1 (en) 2004-12-23 2005-12-20 Compositions comprising an epothilone and production methods

Publications (1)

Publication Number Publication Date
BRPI0519441A2 true BRPI0519441A2 (pt) 2009-01-20

Family

ID=34928859

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519441-5A BRPI0519441A2 (pt) 2004-12-23 2005-12-20 composiÇÕes compreendendo uma epotilona, suas composiÇÕes farmacÊuticas e mÉtodos de produÇço

Country Status (23)

Country Link
EP (3) EP1674098A1 (pt)
JP (1) JP2008525362A (pt)
KR (1) KR20070088802A (pt)
CN (1) CN101137364B (pt)
AR (1) AR052346A1 (pt)
AU (1) AU2005318353B2 (pt)
BR (1) BRPI0519441A2 (pt)
CA (1) CA2591997A1 (pt)
CR (1) CR9211A (pt)
GT (1) GT200500386A (pt)
HK (1) HK1114015A1 (pt)
IL (1) IL183937A0 (pt)
MX (1) MX2007007780A (pt)
NO (1) NO20073772L (pt)
NZ (1) NZ555989A (pt)
PA (1) PA8657901A1 (pt)
PE (2) PE20060839A1 (pt)
RU (1) RU2416407C2 (pt)
SG (1) SG161207A1 (pt)
TW (1) TWI367758B (pt)
UA (1) UA88182C2 (pt)
UY (1) UY29307A1 (pt)
WO (1) WO2006066949A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2210584A1 (en) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
WO2012146625A1 (en) 2011-04-28 2012-11-01 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
RS60068B1 (sr) 2012-10-26 2020-05-29 Oncopeptides Ab Liofilisani preparati melfalan flufenamida
CN107041886A (zh) 2016-02-06 2017-08-15 北京华昊中天生物技术有限公司 脱环氧埃坡霉素衍生物制剂、制备及其***的应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407079B1 (en) 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6380394B1 (en) 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19728914A1 (de) 1997-07-07 1999-01-14 Basf Ag Metallisch gefärbte Polyamide
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
PT1005465E (pt) 1997-08-09 2007-10-18 Bayer Schering Pharma Ag Novos derivados da epotilona, processo para a sua preparação e sua utilização farmacêutica
US6320045B1 (en) 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
SK287487B6 (sk) * 1998-02-05 2010-11-08 Novartis Ag Lyofilizovaná kompozícia a rekonštituovaná lyofilizovaná kompozícia
DE19820599A1 (de) 1998-05-08 1999-11-11 Biotechnolog Forschung Gmbh Epothilonderivate, Verfahren zu deren Herstellung und deren Verwendung
WO1999067253A2 (en) 1998-06-22 1999-12-29 Novartis Ag Desmethyl epothilones
SE517641C2 (sv) 1998-07-02 2002-07-02 Sca Hygiene Prod Ab Förfarande för att framställa ett materialskikt med barriärflikar samt ett ytskikt med sådana barriärflikar
CN1122668C (zh) 1998-12-22 2003-10-01 诺瓦提斯公司 环氧噻酮衍生物，其制备方法及其药物组合物
US6596875B2 (en) 2000-02-07 2003-07-22 James David White Method for synthesizing epothilones and epothilone analogs
CZ20012951A3 (cs) 1999-02-18 2001-11-14 Schering Aktiengesellschaft 16-Halogensubstituované deriváty epothilonu, způsoby jejich výroby a jejich farmaceutické pouľití
DE19908763A1 (de) 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19908760A1 (de) 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19907588A1 (de) 1999-02-22 2000-08-24 Biotechnolog Forschung Gmbh C-21 Modifizierte Epothilone
US20020058286A1 (en) 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
MXPA01009709A (es) * 1999-03-29 2002-05-14 Squibb Bristol Myers Co Proceso para la preparacion de aziridinil epotilonas a partir de oxiranil epotilonas.
PE20010116A1 (es) * 1999-04-30 2001-02-15 Schering Ag Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion
WO2001064650A2 (en) 2000-03-01 2001-09-07 Sloan-Kettering Institute For Cancer Research Center Synthesis of epothilones, intermediates thereto and analogues thereof
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
DE10020517A1 (de) * 2000-04-19 2001-10-25 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
AU2001266583A1 (en) 2000-05-26 2001-12-11 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
WO2002008440A2 (en) 2000-07-25 2002-01-31 Kosan Biosciences, Inc. Fermentation process for epothilones
EP1307579A2 (en) 2000-08-09 2003-05-07 Kosan Biosciences, Inc. Bio-intermediates for use in the chemical synthesis of polyketides
UA75365C2 (en) 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
WO2002030356A2 (en) 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
EP1358144B1 (de) 2000-10-16 2006-12-27 R&D-Biopharmaceuticals Epothilon-synthesebausteine i: unsymmetrisch substituierte acyloine und acyloinderivate, verfahren zu deren herstellung sowie deren verwendung zur herstellung von epothilonen und epothilonderivaten
AU2002245296B2 (en) * 2001-01-25 2006-12-21 Bristol-Myers Squibb Company Methods of administering epothilone analogs for the treatment of cancer
YU58203A (sh) * 2001-01-25 2006-08-17 Bristol-Myers Squibb Company Postupci primene epotilonskih analoga za lečenje kancera
MXPA03006485A (es) * 2001-01-25 2003-09-22 Bristol Myers Squibb Co Formulacion parenteral que contiene analogos de epotilona.
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
TW200403994A (en) * 2002-04-04 2004-03-16 Bristol Myers Squibb Co Oral administration of EPOTHILONES
WO2004032866A2 (en) * 2002-10-09 2004-04-22 Kosan Biosciences, Inc. Therapeutic formulations
EP1670487A4 (en) * 2003-10-09 2008-05-21 Kosan Biosciences Inc THERAPEUTIC FORMULATIONS
WO2006034147A2 (en) * 2004-09-16 2006-03-30 Abraxis Bioscience, Inc. Compositions and methods for the preparation and administration of poorly water soluble drugs

Also Published As

Publication number Publication date
TWI367758B (en) 2012-07-11
AU2005318353A1 (en) 2006-06-29
KR20070088802A (ko) 2007-08-29
HK1114015A1 (en) 2008-10-24
TW200635586A (en) 2006-10-16
SG161207A1 (en) 2010-05-27
EP1674098A1 (en) 2006-06-28
NZ555989A (en) 2010-12-24
UY29307A1 (es) 2006-07-31
AU2005318353B2 (en) 2011-09-29
RU2007128068A (ru) 2009-01-27
RU2416407C2 (ru) 2011-04-20
WO2006066949A1 (en) 2006-06-29
CN101137364A (zh) 2008-03-05
PA8657901A1 (es) 2007-01-17
IL183937A0 (en) 2007-10-31
GT200500386A (es) 2006-08-01
CR9211A (es) 2007-11-23
UA88182C2 (ru) 2009-09-25
CN101137364B (zh) 2011-11-16
PE20100240A1 (es) 2010-05-02
AR052346A1 (es) 2007-03-14
EP1827428A1 (en) 2007-09-05
CA2591997A1 (en) 2006-06-29
PE20060839A1 (es) 2006-09-15
JP2008525362A (ja) 2008-07-17
NO20073772L (no) 2007-09-21
MX2007007780A (es) 2007-08-14
EP2371365A1 (en) 2011-10-05

Similar Documents

Publication Publication Date Title
BRPI0923702B8 (pt) Composições inseticidas estáveis compreendendo spinosin e uma mistura esteroisomérica de sulfoxaflor, e seu método de produção
BR112012028291A2 (pt) composições farmacêuticas e métodos para sua produção
MX2010009646A (es) Agentes terapeuticos antivirales.
BRPI0518904A2 (pt) formulaÇÕes de nepafenac tàpicas
ECSP066883A (es) Derivados de heteroarilaminopirazol utiles para el tratamiento de la diabetes
AU2010233994A8 (en) Bispecific anti-ErbB-3/anti-c-Met antibodies
NO20083726L (no) Spiroindolinon derivater
BR112012011328A2 (pt) inibidores de akt
ECSP11011054A (es) Péptidos antivirales terapéuticos
EA200900282A1 (ru) Применение полиолов для получения устойчивых полиморфных форм рифаксимина
MA32979B1 (fr) Derives aminoesterifies d'alcaloides et composition medicinale les incluant
UA86731C2 (ru) Делимая галеновая форма модифицированного высвобождения активного ингредиента
EA201300990A1 (ru) Парентеральное введение тапентадола
WO2009115084A3 (de) Pyrrolopyrimidin-derivate und deren verwendungen
GT200600039A (es) Tiazolidinonas, su preparacion y su uso como medicamento
BRPI0519441A2 (pt) composiÇÕes compreendendo uma epotilona, suas composiÇÕes farmacÊuticas e mÉtodos de produÇço
WO2007115929A8 (de) Thiazolyl-dihydro-quinazoline
WO2009083664A8 (fr) Nouvelles compositions a base de taxoides
MX2009008249A (es) Composicion farmaceutica que comprende derivado de camptotecina.
CU24011B1 (es) Piperidinas 2-fenil-5-(1,2,4-oxadiazol-5-il) sustituidas
BRPI0408848B8 (pt) composições farmacêuticas de complexo de ciclodextrina-cladribina complexo, usos do referido complexo, bem como processos para a sua preparação
MX336359B (es) Composiciones farmaceuticas y metodos teraputicos que emplean una combinacion de un compuesto complejo de manganeso y una forma compleja no de manganeso del compuesto.
ATE552832T1 (de) Antidepressivum-propharmaka
BRPI0713343A2 (pt) Composições farmacêuticas contendo anticorpo monoclonal anti-idiolípico anti-ca-125 e alumínio
WO2009043577A3 (de) 19-nor-progesterone zur kontrazeption

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.