BRPI0516453A - derivados de benzoimidazol úteis como agentes antiproliferativos - Google Patents
derivados de benzoimidazol úteis como agentes antiproliferativosInfo
- Publication number
- BRPI0516453A BRPI0516453A BRPI0516453-2A BRPI0516453A BRPI0516453A BR PI0516453 A BRPI0516453 A BR PI0516453A BR PI0516453 A BRPI0516453 A BR PI0516453A BR PI0516453 A BRPI0516453 A BR PI0516453A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives useful
- antiproliferative agents
- benzoimidazole derivatives
- formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
DERIVADOS de BENZOIMIDAZOL úTEIS COMO AGENTES ANTIPROLIFERATIVOS. A invenção se refere a compostos substancialmente puros da fórmula (1) e a sais farmaceuticamente aceitáveis pró-drogas e solvatos destes, em que R, R¹, R² , R³ , R¬ 4¬ , e R¬ 5¬ são como definidos aqui. A invenção da mesma forma se refere à composições farmacêuticas compreendendo os compostos da fórmula (1) e métodos de tratar crescimento celular anormal, tal como câncer, em mamíferos administrando-se tais formulações farmacêuticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61697804P | 2004-10-07 | 2004-10-07 | |
PCT/IB2005/003034 WO2006038111A1 (en) | 2004-10-07 | 2005-10-03 | Benzoimidazole derivatives useful as antiproliferative agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516453A true BRPI0516453A (pt) | 2008-09-02 |
Family
ID=35520072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516453-2A BRPI0516453A (pt) | 2004-10-07 | 2005-10-03 | derivados de benzoimidazol úteis como agentes antiproliferativos |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100016353A1 (pt) |
EP (1) | EP1799670A1 (pt) |
JP (1) | JP2008515872A (pt) |
BR (1) | BRPI0516453A (pt) |
CA (1) | CA2582479C (pt) |
MX (1) | MX2007004183A (pt) |
WO (1) | WO2006038111A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8051425B2 (en) * | 2004-10-29 | 2011-11-01 | Emc Corporation | Distributed system with asynchronous execution systems and methods |
US8055711B2 (en) * | 2004-10-29 | 2011-11-08 | Emc Corporation | Non-blocking commit protocol systems and methods |
US7917474B2 (en) * | 2005-10-21 | 2011-03-29 | Isilon Systems, Inc. | Systems and methods for accessing and updating distributed data |
US7551572B2 (en) * | 2005-10-21 | 2009-06-23 | Isilon Systems, Inc. | Systems and methods for providing variable protection |
US7756898B2 (en) * | 2006-03-31 | 2010-07-13 | Isilon Systems, Inc. | Systems and methods for notifying listeners of events |
FR2901135B1 (fr) * | 2006-05-22 | 2017-12-08 | Oreal | Utilisation de modulateurs de la glycolyse comme agents diminuant la proliferation des keratinocytes |
US7899800B2 (en) * | 2006-08-18 | 2011-03-01 | Isilon Systems, Inc. | Systems and methods for providing nonlinear journaling |
US7590652B2 (en) * | 2006-08-18 | 2009-09-15 | Isilon Systems, Inc. | Systems and methods of reverse lookup |
US7822932B2 (en) * | 2006-08-18 | 2010-10-26 | Isilon Systems, Inc. | Systems and methods for providing nonlinear journaling |
US7680836B2 (en) * | 2006-08-18 | 2010-03-16 | Isilon Systems, Inc. | Systems and methods for a snapshot of data |
US20080155191A1 (en) * | 2006-12-21 | 2008-06-26 | Anderson Robert J | Systems and methods for providing heterogeneous storage systems |
US8286029B2 (en) | 2006-12-21 | 2012-10-09 | Emc Corporation | Systems and methods for managing unavailable storage devices |
PT2137184E (pt) | 2007-04-03 | 2013-08-01 | Array Biopharma Inc | Compostos imidazo[1,2-a]piridina como inibidores do receptor de tirosina quinase |
US7779048B2 (en) | 2007-04-13 | 2010-08-17 | Isilon Systems, Inc. | Systems and methods of providing possible value ranges |
US7966289B2 (en) * | 2007-08-21 | 2011-06-21 | Emc Corporation | Systems and methods for reading objects in a file system |
HU230637B1 (hu) * | 2007-10-12 | 2017-05-29 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Eljárás rosuvastatin intermedierek előállítására |
HU230981B1 (hu) * | 2007-10-12 | 2019-08-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Eljárás rosuvastatin só előállítására |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
MY165585A (en) | 2010-06-24 | 2018-04-05 | Takeda Pharmaceuticals Co | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors |
TWI570122B (zh) * | 2011-06-22 | 2017-02-11 | 武田藥品工業股份有限公司 | 稠合雜環化合物之結晶 |
WO2014031445A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel benzimidazole tetrahydropyran derivatives |
KR101738063B1 (ko) * | 2012-09-21 | 2017-05-19 | 아로그 파마슈티칼스, 인코퍼레이티드 | 구조적으로 활성인 인산화된 flt3 키나제의 억제 방법 |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
JP2023536920A (ja) * | 2020-08-05 | 2023-08-30 | ザ ジェネラル ホスピタル コーポレイション | 塩誘導性キナーゼ阻害剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
JP2007516168A (ja) * | 2003-06-24 | 2007-06-21 | ファイザー・プロダクツ・インク | 1−[2−(ベンゾイミダゾル−1−イル)キノリン−8−イル]−ピペリジン−4−イルアミン誘導体の製造方法 |
-
2005
- 2005-10-03 MX MX2007004183A patent/MX2007004183A/es unknown
- 2005-10-03 EP EP05791733A patent/EP1799670A1/en not_active Withdrawn
- 2005-10-03 CA CA2582479A patent/CA2582479C/en not_active Expired - Fee Related
- 2005-10-03 WO PCT/IB2005/003034 patent/WO2006038111A1/en active Application Filing
- 2005-10-03 JP JP2007535268A patent/JP2008515872A/ja active Pending
- 2005-10-03 BR BRPI0516453-2A patent/BRPI0516453A/pt not_active IP Right Cessation
- 2005-10-03 US US11/718,115 patent/US20100016353A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2582479C (en) | 2011-07-12 |
EP1799670A1 (en) | 2007-06-27 |
JP2008515872A (ja) | 2008-05-15 |
US20100016353A1 (en) | 2010-01-21 |
WO2006038111A1 (en) | 2006-04-13 |
CA2582479A1 (en) | 2006-04-13 |
MX2007004183A (es) | 2007-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |