BRPI0515530A - compostos de piperidinilamino-tieno[2,3-d]pirimidina - Google Patents
compostos de piperidinilamino-tieno[2,3-d]pirimidinaInfo
- Publication number
- BRPI0515530A BRPI0515530A BRPI0515530-4A BRPI0515530A BRPI0515530A BR PI0515530 A BRPI0515530 A BR PI0515530A BR PI0515530 A BRPI0515530 A BR PI0515530A BR PI0515530 A BRPI0515530 A BR PI0515530A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- piperidinylamino
- novel
- hypertension
- piperidinylaminothieno
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"COMPOSTOS DE PIPERIDINILAMINO-TIENO {2,3-D!PIRIMIDINA". A presente invenção refere-se aos moduladores de receptores de 5-HT, particularmente a antagonistas 5-HT~ 2B.~ os novos compostos de piperidinilamino-tieno¢2,3-d!pirimidina, e os usos dos mesmos para tratar condições que incluem hipertensão arterial pulmonar, insuficiência cartdíaca congestiva, hipertensão, distúrbios do sistema nervoso central tais como enxaqueca, distúrbios do trato gastrointestinal, restenose, asma, doenã obstrutiva das vias aéreas,hiperplasia prostática e priapismo, ansiedade, depressão, esquizofrenia, lesão neural e acidente vascular cerebral. Métodos de preparação e novos intermediários e sais farmacêuticos dos mesmos são também fornecidos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/947,995 US20050222175A1 (en) | 2004-03-31 | 2004-09-23 | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US11/075,565 US7612078B2 (en) | 2003-03-31 | 2005-03-08 | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
PCT/US2005/034862 WO2006034511A1 (en) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thieno[2,3-d] pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515530A true BRPI0515530A (pt) | 2008-07-29 |
Family
ID=35528225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515530-4A BRPI0515530A (pt) | 2004-09-23 | 2005-09-23 | compostos de piperidinilamino-tieno[2,3-d]pirimidina |
Country Status (21)
Country | Link |
---|---|
US (2) | US7612078B2 (pt) |
EP (1) | EP1797099B1 (pt) |
JP (1) | JP2008514643A (pt) |
KR (1) | KR20070057970A (pt) |
CN (1) | CN101048412A (pt) |
AR (1) | AR054982A1 (pt) |
AT (1) | ATE477257T1 (pt) |
AU (1) | AU2005287898A1 (pt) |
BR (1) | BRPI0515530A (pt) |
CA (1) | CA2581175A1 (pt) |
DE (1) | DE602005022897D1 (pt) |
DK (1) | DK1797099T3 (pt) |
HR (1) | HRP20100607T1 (pt) |
IL (1) | IL182099A0 (pt) |
MX (1) | MX2007003026A (pt) |
NO (1) | NO20072037L (pt) |
NZ (1) | NZ553886A (pt) |
PL (1) | PL1797099T3 (pt) |
PT (1) | PT1797099E (pt) |
TW (1) | TW200628472A (pt) |
WO (1) | WO2006034511A1 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
EP1856075A1 (en) | 2005-01-25 | 2007-11-21 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
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WO2007056208A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc. | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
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CN101820882A (zh) * | 2007-09-04 | 2010-09-01 | Epix特拉华公司 | 用于治疗纤维变性的哌啶基氨基噻吩并[2,3-d]嘧啶类化合物 |
US8114894B2 (en) * | 2008-12-03 | 2012-02-14 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
US8618116B2 (en) * | 2009-08-03 | 2013-12-31 | Daljit Singh Dhanoa | Deuterium-enriched pyrimidine compounds and derivatives |
JP6042331B2 (ja) * | 2010-07-23 | 2016-12-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | プロテアソーム活性を向上させる三環系化合物 |
KR101401496B1 (ko) * | 2011-05-12 | 2014-06-11 | 한국화학연구원 | 티에노피리미딘 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨 관련 질환의 예방 또는 치료용 약학적 조성물 |
EP2806875B1 (en) | 2012-01-25 | 2017-07-19 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
CN105188705A (zh) * | 2013-03-13 | 2015-12-23 | 密歇根大学董事会 | 包含噻吩并嘧啶和噻吩并吡啶化合物的组合物及其使用方法 |
USRE49687E1 (en) | 2014-09-09 | 2023-10-10 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
HRP20230537T1 (hr) | 2016-03-16 | 2023-08-04 | Kura Oncology, Inc. | Supstituirani derivati tieno[2,3-d]pirimidina kao inhibitori za menin-mll i postupci za uporabu |
JP7000333B2 (ja) | 2016-03-16 | 2022-02-10 | クラ オンコロジー,インク. | メニン-mllの架橋された二環式阻害剤及びその使用方法 |
DK3512857T3 (da) | 2016-09-14 | 2021-05-10 | Janssen Pharmaceutica Nv | Spiro-bicykliske inhibitorer af menin-mll-interaktion |
AU2017326485B2 (en) * | 2016-09-14 | 2021-04-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
AU2017376599B2 (en) | 2016-12-15 | 2021-10-07 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-MLL interaction |
EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
CN110075109B (zh) * | 2019-03-28 | 2021-07-27 | 中国人民解放军军事科学院军事医学研究院 | 一种促进干细胞因子合成和分泌的化合物及其用途 |
CN114560843B (zh) * | 2022-04-02 | 2023-04-18 | 河南维诺生物科技有限公司 | 一种作为荧光探针的化合物及其合成方法和应用 |
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2005
- 2005-03-08 US US11/075,565 patent/US7612078B2/en not_active Expired - Fee Related
- 2005-09-23 AU AU2005287898A patent/AU2005287898A1/en not_active Abandoned
- 2005-09-23 KR KR1020077009078A patent/KR20070057970A/ko not_active Application Discontinuation
- 2005-09-23 CA CA002581175A patent/CA2581175A1/en not_active Abandoned
- 2005-09-23 CN CNA2005800360646A patent/CN101048412A/zh active Pending
- 2005-09-23 PL PL05800014T patent/PL1797099T3/pl unknown
- 2005-09-23 DE DE602005022897T patent/DE602005022897D1/de active Active
- 2005-09-23 PT PT05800014T patent/PT1797099E/pt unknown
- 2005-09-23 TW TW094133175A patent/TW200628472A/zh unknown
- 2005-09-23 JP JP2007533765A patent/JP2008514643A/ja active Pending
- 2005-09-23 EP EP05800014A patent/EP1797099B1/en active Active
- 2005-09-23 MX MX2007003026A patent/MX2007003026A/es unknown
- 2005-09-23 AT AT05800014T patent/ATE477257T1/de active
- 2005-09-23 NZ NZ553886A patent/NZ553886A/en unknown
- 2005-09-23 WO PCT/US2005/034862 patent/WO2006034511A1/en active Application Filing
- 2005-09-23 BR BRPI0515530-4A patent/BRPI0515530A/pt not_active IP Right Cessation
- 2005-09-23 DK DK05800014.2T patent/DK1797099T3/da active
- 2005-09-26 AR ARP050103996A patent/AR054982A1/es unknown
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2007
- 2007-03-21 IL IL182099A patent/IL182099A0/en unknown
- 2007-04-20 NO NO20072037A patent/NO20072037L/no not_active Application Discontinuation
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2009
- 2009-10-30 US US12/609,470 patent/US20100113485A1/en not_active Abandoned
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TW200628472A (en) | 2006-08-16 |
WO2006034511A1 (en) | 2006-03-30 |
EP1797099A1 (en) | 2007-06-20 |
US20050222176A1 (en) | 2005-10-06 |
AR054982A1 (es) | 2007-08-01 |
DK1797099T3 (da) | 2010-11-29 |
CA2581175A1 (en) | 2006-03-30 |
PL1797099T3 (pl) | 2011-07-29 |
NZ553886A (en) | 2010-11-26 |
AU2005287898A1 (en) | 2006-03-30 |
MX2007003026A (es) | 2007-12-04 |
EP1797099B1 (en) | 2010-08-11 |
HRP20100607T1 (hr) | 2011-03-31 |
JP2008514643A (ja) | 2008-05-08 |
CN101048412A (zh) | 2007-10-03 |
PT1797099E (pt) | 2010-11-18 |
US20100113485A1 (en) | 2010-05-06 |
IL182099A0 (en) | 2007-07-24 |
NO20072037L (no) | 2007-06-21 |
ATE477257T1 (de) | 2010-08-15 |
KR20070057970A (ko) | 2007-06-07 |
US7612078B2 (en) | 2009-11-03 |
DE602005022897D1 (de) | 2010-09-23 |
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