ATE477257T1 - Piperidinylamino-thienoä2,3-dü- pyrimidinverbindungen - Google Patents
Piperidinylamino-thienoä2,3-dü- pyrimidinverbindungenInfo
- Publication number
- ATE477257T1 ATE477257T1 AT05800014T AT05800014T ATE477257T1 AT E477257 T1 ATE477257 T1 AT E477257T1 AT 05800014 T AT05800014 T AT 05800014T AT 05800014 T AT05800014 T AT 05800014T AT E477257 T1 ATE477257 T1 AT E477257T1
- Authority
- AT
- Austria
- Prior art keywords
- thienoä2
- piperidinylamino
- pyrimidine compounds
- pyrimidine
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/947,995 US20050222175A1 (en) | 2004-03-31 | 2004-09-23 | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US11/075,565 US7612078B2 (en) | 2003-03-31 | 2005-03-08 | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
PCT/US2005/034862 WO2006034511A1 (en) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thieno[2,3-d] pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE477257T1 true ATE477257T1 (de) | 2010-08-15 |
Family
ID=35528225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05800014T ATE477257T1 (de) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thienoä2,3-dü- pyrimidinverbindungen |
Country Status (21)
Country | Link |
---|---|
US (2) | US7612078B2 (de) |
EP (1) | EP1797099B1 (de) |
JP (1) | JP2008514643A (de) |
KR (1) | KR20070057970A (de) |
CN (1) | CN101048412A (de) |
AR (1) | AR054982A1 (de) |
AT (1) | ATE477257T1 (de) |
AU (1) | AU2005287898A1 (de) |
BR (1) | BRPI0515530A (de) |
CA (1) | CA2581175A1 (de) |
DE (1) | DE602005022897D1 (de) |
DK (1) | DK1797099T3 (de) |
HR (1) | HRP20100607T1 (de) |
IL (1) | IL182099A0 (de) |
MX (1) | MX2007003026A (de) |
NO (1) | NO20072037L (de) |
NZ (1) | NZ553886A (de) |
PL (1) | PL1797099T3 (de) |
PT (1) | PT1797099E (de) |
TW (1) | TW200628472A (de) |
WO (1) | WO2006034511A1 (de) |
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US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
CA2595607C (en) * | 2005-01-25 | 2014-07-15 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
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WO2007056214A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc | N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof |
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JP2010538078A (ja) * | 2007-09-04 | 2010-12-09 | エピックス デラウェア, インコーポレイテッド | 線維症を治療するためのピペリジニルアミノ−チエノ[2,3−d]ピリミジン化合物 |
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US8618116B2 (en) * | 2009-08-03 | 2013-12-31 | Daljit Singh Dhanoa | Deuterium-enriched pyrimidine compounds and derivatives |
WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
KR101401496B1 (ko) * | 2011-05-12 | 2014-06-11 | 한국화학연구원 | 티에노피리미딘 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨 관련 질환의 예방 또는 치료용 약학적 조성물 |
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CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
EP2968342B1 (de) * | 2013-03-13 | 2018-10-03 | The Regents of the University of Michigan | Zusammensetzungen mit thienopyrimidin- und thienopyridin-verbindungen und verfahren zur verwendung davon |
USRE49687E1 (en) | 2014-09-09 | 2023-10-10 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
EP3302057A4 (de) | 2015-06-04 | 2018-11-21 | Kura Oncology, Inc. | Verfahren und zusammensetzungen zur hemmung der interaktion von menin mit mll-proteinen |
TWI703150B (zh) * | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制menin及mll蛋白之交互作用的方法及組合物 |
EP4219449A3 (de) | 2016-03-16 | 2023-10-11 | Kura Oncology, Inc. | Substituierte indolderivate und deren herstellungsverfahren |
JP7000333B2 (ja) | 2016-03-16 | 2022-02-10 | クラ オンコロジー,インク. | メニン-mllの架橋された二環式阻害剤及びその使用方法 |
WO2018050684A1 (en) * | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-mll interaction |
EP3512857B1 (de) | 2016-09-14 | 2021-02-24 | Janssen Pharmaceutica NV | Spiro-bizyklische inhibitoren von menin-mll-wechselwirkung |
US10745409B2 (en) | 2016-12-15 | 2020-08-18 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-MLL interaction |
US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
CN110075109B (zh) * | 2019-03-28 | 2021-07-27 | 中国人民解放军军事科学院军事医学研究院 | 一种促进干细胞因子合成和分泌的化合物及其用途 |
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-
2005
- 2005-03-08 US US11/075,565 patent/US7612078B2/en not_active Expired - Fee Related
- 2005-09-23 PL PL05800014T patent/PL1797099T3/pl unknown
- 2005-09-23 KR KR1020077009078A patent/KR20070057970A/ko not_active Application Discontinuation
- 2005-09-23 AT AT05800014T patent/ATE477257T1/de active
- 2005-09-23 CA CA002581175A patent/CA2581175A1/en not_active Abandoned
- 2005-09-23 TW TW094133175A patent/TW200628472A/zh unknown
- 2005-09-23 JP JP2007533765A patent/JP2008514643A/ja active Pending
- 2005-09-23 AU AU2005287898A patent/AU2005287898A1/en not_active Abandoned
- 2005-09-23 NZ NZ553886A patent/NZ553886A/en unknown
- 2005-09-23 DE DE602005022897T patent/DE602005022897D1/de active Active
- 2005-09-23 MX MX2007003026A patent/MX2007003026A/es unknown
- 2005-09-23 BR BRPI0515530-4A patent/BRPI0515530A/pt not_active IP Right Cessation
- 2005-09-23 PT PT05800014T patent/PT1797099E/pt unknown
- 2005-09-23 CN CNA2005800360646A patent/CN101048412A/zh active Pending
- 2005-09-23 DK DK05800014.2T patent/DK1797099T3/da active
- 2005-09-23 WO PCT/US2005/034862 patent/WO2006034511A1/en active Application Filing
- 2005-09-23 EP EP05800014A patent/EP1797099B1/de active Active
- 2005-09-26 AR ARP050103996A patent/AR054982A1/es unknown
-
2007
- 2007-03-21 IL IL182099A patent/IL182099A0/en unknown
- 2007-04-20 NO NO20072037A patent/NO20072037L/no not_active Application Discontinuation
-
2009
- 2009-10-30 US US12/609,470 patent/US20100113485A1/en not_active Abandoned
-
2010
- 2010-11-11 HR HR20100607T patent/HRP20100607T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP1797099B1 (de) | 2010-08-11 |
US20100113485A1 (en) | 2010-05-06 |
CN101048412A (zh) | 2007-10-03 |
WO2006034511A1 (en) | 2006-03-30 |
EP1797099A1 (de) | 2007-06-20 |
PL1797099T3 (pl) | 2011-07-29 |
AR054982A1 (es) | 2007-08-01 |
IL182099A0 (en) | 2007-07-24 |
DK1797099T3 (da) | 2010-11-29 |
BRPI0515530A (pt) | 2008-07-29 |
US20050222176A1 (en) | 2005-10-06 |
KR20070057970A (ko) | 2007-06-07 |
AU2005287898A1 (en) | 2006-03-30 |
TW200628472A (en) | 2006-08-16 |
CA2581175A1 (en) | 2006-03-30 |
NZ553886A (en) | 2010-11-26 |
DE602005022897D1 (de) | 2010-09-23 |
PT1797099E (pt) | 2010-11-18 |
MX2007003026A (es) | 2007-12-04 |
HRP20100607T1 (hr) | 2011-03-31 |
JP2008514643A (ja) | 2008-05-08 |
US7612078B2 (en) | 2009-11-03 |
NO20072037L (no) | 2007-06-21 |
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