BRPI0513075A - moduladores gama-opióides tricìclicos - Google Patents
moduladores gama-opióides tricìclicosInfo
- Publication number
- BRPI0513075A BRPI0513075A BRPI0513075-1A BRPI0513075A BRPI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A
- Authority
- BR
- Brazil
- Prior art keywords
- modulators
- tricyclic
- opioid
- opioid modulators
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
MODULADORES GAMA-OPIóIDES TRICìCLICOS. A presente invenção refere-se a moduladores de receptar deita opióides. Mais especificamente, a invenção refere-se a moduladores <sym>-opióides tricíclicos. São também descritas composições farmacêuticas e veterinárias e métodos de tratar dor branda à severa e várias doenças empregando-se compostos da invenção.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59913104P | 2004-08-05 | 2004-08-05 | |
PCT/US2005/027568 WO2007030089A1 (en) | 2004-08-05 | 2005-08-02 | Tricyclic delta- opioid modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0513075A true BRPI0513075A (pt) | 2008-04-22 |
Family
ID=37075386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513075-1A BRPI0513075A (pt) | 2004-08-05 | 2005-08-02 | moduladores gama-opióides tricìclicos |
Country Status (17)
Country | Link |
---|---|
US (2) | US7553850B2 (pt) |
EP (1) | EP1910353A1 (pt) |
JP (1) | JP2008529971A (pt) |
KR (1) | KR20080027216A (pt) |
CN (1) | CN101039940A (pt) |
AR (1) | AR050198A1 (pt) |
AU (1) | AU2005335481A1 (pt) |
BR (1) | BRPI0513075A (pt) |
CA (1) | CA2574768A1 (pt) |
EA (1) | EA200700403A1 (pt) |
EC (1) | ECSP077230A (pt) |
IL (1) | IL181120A0 (pt) |
NI (1) | NI200700030A (pt) |
NO (1) | NO20071208L (pt) |
TW (1) | TW200621767A (pt) |
WO (1) | WO2007030089A1 (pt) |
ZA (1) | ZA200701875B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004253898A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
AU2005335481A1 (en) | 2004-08-05 | 2007-04-19 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
MX2007007626A (es) * | 2004-12-22 | 2008-01-28 | Johnson & Johnson | Moduladores delta-opioides triciclicos. |
US7589104B2 (en) * | 2004-12-22 | 2009-09-15 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators |
WO2006069275A1 (en) * | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
CA2594347A1 (en) * | 2005-01-06 | 2006-07-13 | Janssen Pharmaceutica N.V. | Tricyclic d-opioid modulators |
ATE490251T1 (de) * | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
EP2266959B1 (en) | 2005-07-21 | 2013-05-01 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents |
WO2013003720A1 (en) | 2011-06-29 | 2013-01-03 | Alkermes, Inc. | Peripherally acting opioid compounds |
JP7096817B2 (ja) | 2016-11-04 | 2022-07-06 | オークランド ユニサービシーズ リミティド | 三環式複素環式誘導体及びその使用 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
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US2368006A (en) | 1943-10-07 | 1945-01-23 | Searle & Co | Heterocyclic tertiary amines |
FR1159125A (fr) | 1953-03-27 | 1958-06-23 | Promonta Chem Fab | Procédé pour préparer des dérivés de la phényl-thiazine présentant comme substituant basique un noyau hétérocyclique contenant un atome d'azote |
US2901478A (en) | 1957-02-11 | 1959-08-25 | Promonta Chem Fab | Phenothiazine compounds |
US3179665A (en) | 1959-12-16 | 1965-04-20 | Wander Ag Dr A | 9-(n-ethyl and n-propyl piperidyl-3'-methyl)-thioxanthenes |
DE1159954B (de) | 1961-11-25 | 1963-12-27 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze |
DE1670118A1 (de) | 1966-07-22 | 1970-11-05 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung neuer Derivate des 6,11-Dihydro-dibenz[b,e]oxepins und ihrer Salze |
US3470188A (en) | 1967-01-05 | 1969-09-30 | Smithkline Corp | 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes |
NL6818027A (pt) | 1968-01-09 | 1969-07-11 | ||
US3987042A (en) | 1969-03-03 | 1976-10-19 | Claude Gueremy | Phenothiazine derivative |
GB1250534A (pt) | 1969-03-03 | 1971-10-20 | ||
US3931232A (en) | 1974-06-24 | 1976-01-06 | Smithkline Corporation | 3-Alkyl xanthene compounds |
ZA756550B (en) | 1974-11-06 | 1976-09-29 | Smithkline Corp | Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms |
US4086350A (en) | 1974-11-06 | 1978-04-25 | Smithkline Corporation | Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms |
US4285956A (en) | 1978-05-12 | 1981-08-25 | Kefalas A/S | Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith |
US4356184A (en) | 1980-06-04 | 1982-10-26 | G. D. Searle & Co. | Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines |
US4666907A (en) | 1983-10-05 | 1987-05-19 | Merck Frosst Canada, Inc. | Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors |
US4777177A (en) | 1984-10-19 | 1988-10-11 | Ciba-Geigy Corporation | Pesticidal thioxanthen-9-ylidenepiperidines |
FR2689013B1 (fr) | 1992-03-30 | 1995-05-05 | Rhone Poulenc Rorer Sa | Nouvelle application thérapeutique des dérivés de la phénothiazine. |
ZA978792B (en) | 1996-10-04 | 1998-04-06 | Novo Nordisk As | N-substituted azaheterocyclic compounds. |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
EP0991633A1 (en) | 1997-06-25 | 2000-04-12 | Novo Nordisk A/S | Novel heterocyclic compounds |
US6040318A (en) | 1997-06-25 | 2000-03-21 | Novo Nordisk A/S | Tricycle substituted with azaheterocyclic carboxylic acids |
AU2009799A (en) | 1997-12-24 | 1999-07-19 | Ortho-Mcneil Pharmaceutical, Inc. | 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor |
US7307990B2 (en) * | 1999-01-19 | 2007-12-11 | Cisco Technology, Inc. | Shared communications network employing virtual-private-network identifiers |
AU2063601A (en) | 1999-12-22 | 2001-07-03 | Ortho-Mcneil Pharmaceutical, Inc. | 4-(aryl(8-azabicyclo(3.2.1)octan-3-yl))aminobenzoic acid derivatives |
US20030181447A1 (en) * | 2001-02-22 | 2003-09-25 | Boyd Robert E. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
AU2001241676A1 (en) * | 2000-03-03 | 2001-09-17 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives |
AU2001249250A1 (en) | 2000-03-29 | 2001-10-08 | Research Triangle Institute | Selective ligands for the delta opioid receptor |
ES2572332T3 (es) | 2000-10-31 | 2016-05-31 | Rensselaer Polytech Inst | 2,6-metano-3-benzazocinas sustituidas en posición 8 y morfinanos sustituidos en posición 3 como ligandos de receptores opioides |
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US6601009B2 (en) | 2001-07-12 | 2003-07-29 | Yahoo Inc | Method and system of automatic bandwidth detection |
EP1306376A1 (en) | 2001-10-25 | 2003-05-02 | Biofrontera Pharmaceuticals AG | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
US7060711B2 (en) | 2001-10-25 | 2006-06-13 | Biofrontera Bioscience Gmbh | Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist |
EP1321169A1 (en) | 2001-12-18 | 2003-06-25 | Biofrontera Pharmaceuticals AG | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament |
CN1681388A (zh) | 2002-09-18 | 2005-10-12 | Fmc有限公司 | 三环衍生物杀虫剂 |
AU2003301299A1 (en) | 2002-10-15 | 2004-05-04 | Janssen Pharmaceutica, N.V. | Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators |
EP1615920A1 (en) | 2003-04-15 | 2006-01-18 | Pfizer Products Inc. | 3-benzhydrylidene-8-aza-bicyclo [3.2.1] octane derivatives with opioid receptor activity |
AU2004253898A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
AU2005335481A1 (en) | 2004-08-05 | 2007-04-19 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
MX2007007626A (es) | 2004-12-22 | 2008-01-28 | Johnson & Johnson | Moduladores delta-opioides triciclicos. |
WO2006069275A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
US7589104B2 (en) * | 2004-12-22 | 2009-09-15 | Janssen Pharmaceutica Nv | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators |
CA2594347A1 (en) | 2005-01-06 | 2006-07-13 | Janssen Pharmaceutica N.V. | Tricyclic d-opioid modulators |
ATE490251T1 (de) * | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
-
2005
- 2005-08-02 AU AU2005335481A patent/AU2005335481A1/en not_active Abandoned
- 2005-08-02 EP EP05782009A patent/EP1910353A1/en not_active Withdrawn
- 2005-08-02 CN CNA2005800336613A patent/CN101039940A/zh active Pending
- 2005-08-02 EA EA200700403A patent/EA200700403A1/ru unknown
- 2005-08-02 CA CA002574768A patent/CA2574768A1/en not_active Abandoned
- 2005-08-02 KR KR1020077005142A patent/KR20080027216A/ko not_active Application Discontinuation
- 2005-08-02 US US11/195,231 patent/US7553850B2/en not_active Expired - Fee Related
- 2005-08-02 BR BRPI0513075-1A patent/BRPI0513075A/pt not_active IP Right Cessation
- 2005-08-02 JP JP2007546634A patent/JP2008529971A/ja not_active Withdrawn
- 2005-08-02 WO PCT/US2005/027568 patent/WO2007030089A1/en active Application Filing
- 2005-08-04 AR ARP050103253A patent/AR050198A1/es not_active Application Discontinuation
- 2005-08-04 TW TW094126456A patent/TW200621767A/zh unknown
-
2007
- 2007-02-01 IL IL181120A patent/IL181120A0/en unknown
- 2007-02-02 NI NI200700030A patent/NI200700030A/es unknown
- 2007-02-07 EC EC2007007230A patent/ECSP077230A/es unknown
- 2007-03-02 ZA ZA200701875A patent/ZA200701875B/en unknown
- 2007-03-05 NO NO20071208A patent/NO20071208L/no not_active Application Discontinuation
-
2009
- 2009-05-22 US US12/470,675 patent/US20090291979A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008529971A (ja) | 2008-08-07 |
NO20071208L (no) | 2007-04-19 |
EP1910353A1 (en) | 2008-04-16 |
US20060030585A1 (en) | 2006-02-09 |
ZA200701875B (en) | 2008-07-30 |
AR050198A1 (es) | 2006-10-04 |
CA2574768A1 (en) | 2006-02-05 |
NI200700030A (es) | 2008-02-04 |
US20090291979A1 (en) | 2009-11-26 |
TW200621767A (en) | 2006-07-01 |
WO2007030089A8 (en) | 2007-05-31 |
US7553850B2 (en) | 2009-06-30 |
WO2007030089A1 (en) | 2007-03-15 |
AU2005335481A1 (en) | 2007-04-19 |
ECSP077230A (es) | 2007-04-26 |
AU2005335481A8 (en) | 2008-12-11 |
IL181120A0 (en) | 2008-03-20 |
CN101039940A (zh) | 2007-09-19 |
KR20080027216A (ko) | 2008-03-26 |
EA200700403A1 (ru) | 2007-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |