BRPI0512798A - molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse - Google Patents

molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse

Info

Publication number
BRPI0512798A
BRPI0512798A BRPI0512798-0A BRPI0512798A BRPI0512798A BR PI0512798 A BRPI0512798 A BR PI0512798A BR PI0512798 A BRPI0512798 A BR PI0512798A BR PI0512798 A BRPI0512798 A BR PI0512798A
Authority
BR
Brazil
Prior art keywords
interest
nucleic acid
polypeptides
expressing
protein
Prior art date
Application number
BRPI0512798-0A
Other languages
English (en)
Inventor
Arie Pieter Otte
Theodorus Hendrikus Jaco Kwaks
Richard George Antonius Sewalt
Henricus Johannes Mar Blokland
Original Assignee
Chromagenics Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971366&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0512798(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chromagenics Bv filed Critical Chromagenics Bv
Publication of BRPI0512798A publication Critical patent/BRPI0512798A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MOLéCULA DE áCIDO NUCLEICO RECOMBINANTE, CéLULA, MéTODO PARA PRODUZIR UMA PROTEìNA DE INTERESSE, USO DE UMA SEQüêNCIA DE áCIDO NUCLEICO TENDO ATIVIDADE ANTI-REPRESSORA, MéTODOS PARA GERAR UMA CéLULA HOSPEDEIRA EXPRESSANDO DOIS POLIPEPTìDIOS DE INTERESSE, E PARA EXPRESSAR DOIS POLIPEPTìDIOS DE INTERESSE. A invenção provê um novo elemento anti-repressor, que é útil para melhorar a expressão de ácido nucleico em células hospedeiras. Também são providos métodos usando o novo elemento anti-repressor para produzir uma proteína de interesse. A invenção também provê novas configurações de cassetes de expressão compreendendo elementos anti-repressores.
BRPI0512798-0A 2004-07-08 2005-07-07 molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse BRPI0512798A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58700704P 2004-07-08 2004-07-08
EP2004051405 2004-07-08
PCT/EP2005/053251 WO2006005718A2 (en) 2004-07-08 2005-07-07 Novel sequence for improving expression of nucleic acid

Publications (1)

Publication Number Publication Date
BRPI0512798A true BRPI0512798A (pt) 2008-04-08

Family

ID=34971366

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512798-0A BRPI0512798A (pt) 2004-07-08 2005-07-07 molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse

Country Status (20)

Country Link
US (1) US7825232B2 (pt)
JP (1) JP4805262B2 (pt)
KR (1) KR101188013B1 (pt)
CN (1) CN1981057B (pt)
AT (1) ATE378426T1 (pt)
AU (1) AU2005261699B2 (pt)
BR (1) BRPI0512798A (pt)
CA (1) CA2573022C (pt)
DE (1) DE602005003369T2 (pt)
DK (1) DK1763586T3 (pt)
EA (1) EA011747B1 (pt)
ES (1) ES2296201T3 (pt)
HK (1) HK1097004A1 (pt)
IL (1) IL180531A (pt)
MX (1) MXPA06014553A (pt)
NO (1) NO341862B1 (pt)
NZ (1) NZ551510A (pt)
PT (1) PT1763586E (pt)
WO (1) WO2006005718A2 (pt)
ZA (1) ZA200610470B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056986A2 (en) * 2002-12-20 2004-07-08 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors
DK1809750T3 (da) * 2004-11-08 2012-06-25 Chromagenics Bv Selektion af værtsceller, der udtrykker protein ved høje niveauer
US20060195935A1 (en) 2004-11-08 2006-08-31 Chromagenics B.V. Selection of host cells expressing protein at high levels
US20100136616A1 (en) * 2004-11-08 2010-06-03 Chromagenics B.V. Selection of Host Cells Expressing Protein at High Levels
PL1809750T3 (pl) * 2004-11-08 2012-08-31 Chromagenics Bv Selekcja komórki gospodarza eksprymującej białko na wysokich poziomach
US8999667B2 (en) 2004-11-08 2015-04-07 Chromagenics B.V. Selection of host cells expressing protein at high levels
US8039230B2 (en) 2004-11-08 2011-10-18 Chromagenics B.V. Selection of host cells expressing protein at high levels
DK2443239T3 (en) 2009-06-15 2016-02-15 Cellagenics B V New stringent selection markers
WO2011159157A1 (en) 2010-06-15 2011-12-22 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
WO2012030218A1 (en) 2010-09-01 2012-03-08 Cellagenics B.V. Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
CN110484563B (zh) * 2019-07-25 2023-04-07 新乡医学院 哺乳动物细胞组合表达载体、表达***、制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2344072T3 (es) 2001-07-04 2010-08-17 Chromagenics B.V. Secuencias de adn con actividad anti-represora.
JP4647309B2 (ja) * 2002-06-14 2011-03-09 クロマジェニックス ビー．ブイ． 複数のタンパク質の同時生産のための方法；そこで使用するためのベクター及び細胞
WO2004056986A2 (en) * 2002-12-20 2004-07-08 Chromagenics B.V. Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors

Also Published As

Publication number Publication date
HK1097004A1 (en) 2007-06-15
DE602005003369D1 (de) 2007-12-27
WO2006005718A3 (en) 2006-08-17
NZ551510A (en) 2009-10-30
AU2005261699B2 (en) 2009-07-23
WO2006005718A2 (en) 2006-01-19
ES2296201T3 (es) 2008-04-16
NO341862B1 (no) 2018-02-12
NO20070757L (no) 2007-02-08
MXPA06014553A (es) 2007-03-12
CN1981057B (zh) 2012-07-04
IL180531A0 (en) 2007-06-03
DK1763586T3 (da) 2008-03-17
EA011747B1 (ru) 2009-06-30
KR101188013B1 (ko) 2012-10-08
CA2573022C (en) 2012-03-06
JP2008505626A (ja) 2008-02-28
CN1981057A (zh) 2007-06-13
ZA200610470B (en) 2008-09-25
JP4805262B2 (ja) 2011-11-02
DE602005003369T2 (de) 2009-03-05
US20070212755A1 (en) 2007-09-13
US7825232B2 (en) 2010-11-02
CA2573022A1 (en) 2006-01-19
IL180531A (en) 2011-04-28
PT1763586E (pt) 2008-02-25
ATE378426T1 (de) 2007-11-15
KR20070042122A (ko) 2007-04-20
AU2005261699A1 (en) 2006-01-19
EA200700233A1 (ru) 2007-06-29

Similar Documents

Publication Publication Date Title
BRPI0512798A (pt) molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse
CY1112110T1 (el) Κυκλικο μοριο dna το οποιο διαθετει μια συμβατικη αφετηρια αντιγραφης, η διαδικασια παρασκευης του και η χρηση του στην γονιδιακη θεραπεια
ATE500331T1 (de) Verfahren zur gleichzeitigen herstellung von multiplen proteinen; vektoren und zellen, die hierfür verwendung finden
NO963371L (no) Hematopoietisk protein samt materialer og fremgangsmåter for fremstilling av det
BR0009206A (pt) Isolamento e análise de proteina
AR072680A1 (es) Axmi-115 axmi-113 axmi-005 axmi-163 y axmi-184 proteinas insecticidas y metodos de uso de las mismas
DE69942459D1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
EA201170635A1 (ru) Композиции, способы получения и применение каркаса на основе домена фибронектина типа iii
NO20065084L (no) Interferon-alfa polypeptider og konjugater
ATE500323T1 (de) Subtilisin-variante
ATE278024T1 (de) Methode zur herstellung von rekombinanten zellen
DE60041243D1 (de) Gebrauchsverfaheren eines neuen lysyloxidase-verwandten proteins
SI1675956T1 (sl) Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov
DK1082423T3 (da) Cyclin E2-gener og -proteiner
DE60235985D1 (de) Ntb-a, ein oberflächenmolekül impliziert in der aktivität natürlicher killerzellen (nk)
DE60139113D1 (de) 18477, eine menschliche proteinkinase und deren verwendung
ATE469920T1 (de) Herstellung von rekombinanten igm in den per.c6 zellen
WO2005079316A3 (en) Nucleic acid molecules encoding novel murine low-voltage activated calcium channel proteins, designated-alpha 1h, encoded proteins and methods of use thereof
DK1664097T3 (da) Piroplasmidvaccine
WO2003018804A1 (fr) Proteines pouvant commander la migration cellulaire et la mort cellulaire
WO2005094356A3 (en) Cngh0011 polynucleotides, polypeptides, antibodies, and compositions, and methods of production and use

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL