BRPI0511952A - receptor solúvel isolado, anticorpo ou fragmento de anticorpo, e, métodos de reduzir inflamação induzida por il-17a ou induzida por il-17f, de tratar um mamìfero afetado com uma doença inflamatória, e uma condição patológica em um indivìduo associada com atividade de zcytor14 - Google Patents

receptor solúvel isolado, anticorpo ou fragmento de anticorpo, e, métodos de reduzir inflamação induzida por il-17a ou induzida por il-17f, de tratar um mamìfero afetado com uma doença inflamatória, e uma condição patológica em um indivìduo associada com atividade de zcytor14

Info

Publication number
BRPI0511952A
BRPI0511952A BRPI0511952-9A BRPI0511952A BRPI0511952A BR PI0511952 A BRPI0511952 A BR PI0511952A BR PI0511952 A BRPI0511952 A BR PI0511952A BR PI0511952 A BRPI0511952 A BR PI0511952A
Authority
BR
Brazil
Prior art keywords
induced
antibody
reducing
methods
treating
Prior art date
Application number
BRPI0511952-9A
Other languages
English (en)
Inventor
Scott R Presnell
Steven K Burkhead
Steven D Levin
Rolf E Kuestner
Zeren Gao
Stephen R Jaspers
Janine Bilsborough
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of BRPI0511952A publication Critical patent/BRPI0511952A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

RECEPTOR SOLUVEL ISOLADO, ANTICORPO OU FRAGMENTO DE ANTICORPO, E, MéTODOS DE REDUZIR INFLAMAçãO INDUZIDA POR IL-17A OU INDUZIDA POR IL-17F, DE TRATAR UM MAMìFERO AFETADO COM UMA DOENçA INFLAMATóRIA, E UMA CONDIçãO PATOLóGICA EM UM INDIVìDUO ASSOCIADA COM ATIVIDADE DE ZCYTORl4 presente invenção refere-se ao bloqueio, inibição, redução, antagonização ou neutralização da atividade de moléculas de polipeptídeo IL-l7F, IL-17A, ou tanto IL-17A como IL-17F. IL-17A e IL-17F são citocinas que estão envolvidas em processos inflamatórios e doença humana. ZcytoRl4 é um receptor comum para IL- 1 7A e IL- 1 7F. A presente invenção inclui ZcytoRl4 solúvel, anticorpos anti-ZcytoRl4, e parceiros de ligação, assim como métodos para antagonizar IL- 1 7F, IL- 1 7A, ou tanto IL- 1 7A como IL-17F, usando estes receptores solúveis, anticorpos e parceiros de ligação.
BRPI0511952-9A 2004-06-10 2005-06-10 receptor solúvel isolado, anticorpo ou fragmento de anticorpo, e, métodos de reduzir inflamação induzida por il-17a ou induzida por il-17f, de tratar um mamìfero afetado com uma doença inflamatória, e uma condição patológica em um indivìduo associada com atividade de zcytor14 BRPI0511952A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57880504P 2004-06-10 2004-06-10
PCT/US2005/020521 WO2005123778A2 (en) 2004-06-10 2005-06-10 Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation

Publications (1)

Publication Number Publication Date
BRPI0511952A true BRPI0511952A (pt) 2008-01-29

Family

ID=35407029

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511952-9A BRPI0511952A (pt) 2004-06-10 2005-06-10 receptor solúvel isolado, anticorpo ou fragmento de anticorpo, e, métodos de reduzir inflamação induzida por il-17a ou induzida por il-17f, de tratar um mamìfero afetado com uma doença inflamatória, e uma condição patológica em um indivìduo associada com atividade de zcytor14

Country Status (11)

Country Link
US (4) US7910540B2 (pt)
EP (1) EP1765865A2 (pt)
JP (1) JP4903703B2 (pt)
CN (1) CN101001871A (pt)
AU (1) AU2005254998B2 (pt)
BR (1) BRPI0511952A (pt)
CA (1) CA2569867A1 (pt)
IL (2) IL179356A (pt)
MX (1) MXPA06014465A (pt)
NO (1) NO20070153L (pt)
WO (1) WO2005123778A2 (pt)

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Also Published As

Publication number Publication date
JP4903703B2 (ja) 2012-03-28
US20070048257A1 (en) 2007-03-01
US20110177083A1 (en) 2011-07-21
CN101001871A (zh) 2007-07-18
NO20070153L (no) 2007-03-09
EP1765865A2 (en) 2007-03-28
MXPA06014465A (es) 2007-05-16
IL179356A (en) 2011-07-31
IL208859A0 (en) 2011-01-31
JP2008509227A (ja) 2008-03-27
WO2005123778A2 (en) 2005-12-29
IL179356A0 (en) 2007-03-08
WO2005123778A3 (en) 2006-02-09
CA2569867A1 (en) 2005-12-29
US7910540B2 (en) 2011-03-22
IL208859A (en) 2013-01-31
US8268773B2 (en) 2012-09-18
US20070048826A1 (en) 2007-03-01
AU2005254998B2 (en) 2011-10-27
US20060002925A1 (en) 2006-01-05
AU2005254998A1 (en) 2005-12-29

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