BRPI0507442B8 - método in vitro de diagnóstico de um indivíduo humano gestante como apresentando ou com uma propensão a desenvolver pré-eclâmpsia ou eclâmpsia - Google Patents
método in vitro de diagnóstico de um indivíduo humano gestante como apresentando ou com uma propensão a desenvolver pré-eclâmpsia ou eclâmpsiaInfo
- Publication number
- BRPI0507442B8 BRPI0507442B8 BRPI0507442A BRPI0507442A BRPI0507442B8 BR PI0507442 B8 BRPI0507442 B8 BR PI0507442B8 BR PI0507442 A BRPI0507442 A BR PI0507442A BR PI0507442 A BRPI0507442 A BR PI0507442A BR PI0507442 B8 BRPI0507442 B8 BR PI0507442B8
- Authority
- BR
- Brazil
- Prior art keywords
- eclampsia
- diagnosing
- propensity
- human subject
- vitro method
- Prior art date
Links
- 208000002296 eclampsia Diseases 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 201000011461 pre-eclampsia Diseases 0.000 title abstract 5
- 238000000338 in vitro Methods 0.000 title 1
- 101100372758 Danio rerio vegfaa gene Proteins 0.000 abstract 3
- 101100297639 Mus musculus Pigf gene Proteins 0.000 abstract 3
- 101150030763 Vegfa gene Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
Abstract
métodos de diagnóstico e tratamento de pré-eclampsia ou eclampsia. a presente invenção refere-se a métodos para o tratamento de pré-eclampsia ou eclampsia, que são divulgados aqui usando compostos que aumentam os níveis de vegf ou pigf ou compostos que diminuem os níveis de sfit-1. também são descritos aqui, métodos para o monitoramento do tratamento de pré-eclampsia ou eclampsia através de detecção dos níveis de sfit-1, vegf ou pigf. também são descritos aqui métodos para diagnóstico de pré-eclampsia e eclampsia através de detecção dos níveis de sfit-1, vegf e pigf em um indivíduo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/771,518 US7335362B2 (en) | 2002-07-19 | 2004-02-04 | Methods of treating pre-eclampsia or eclampsia |
US10/771,518 | 2004-02-04 | ||
US11/019,559 | 2004-12-21 | ||
US11/019,559 US7435419B2 (en) | 2002-07-19 | 2004-12-21 | Methods of diagnosing and treating pre-eclampsia or eclampsia |
PCT/US2005/003884 WO2005077007A2 (en) | 2004-02-04 | 2005-02-04 | Methods of diagnosing and treating pre-eclampsia or eclampsia |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0507442A BRPI0507442A (pt) | 2007-07-10 |
BRPI0507442B1 BRPI0507442B1 (pt) | 2021-02-23 |
BRPI0507442B8 true BRPI0507442B8 (pt) | 2021-05-25 |
Family
ID=34859793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507442A BRPI0507442B8 (pt) | 2004-02-04 | 2005-02-04 | método in vitro de diagnóstico de um indivíduo humano gestante como apresentando ou com uma propensão a desenvolver pré-eclâmpsia ou eclâmpsia |
Country Status (11)
Country | Link |
---|---|
US (2) | US7435419B2 (pt) |
EP (2) | EP1718334A4 (pt) |
JP (1) | JP4711972B2 (pt) |
KR (1) | KR20070001991A (pt) |
CN (1) | CN1946423A (pt) |
AU (1) | AU2005213493A1 (pt) |
BR (1) | BRPI0507442B8 (pt) |
CA (1) | CA2554971A1 (pt) |
ES (1) | ES2404295T3 (pt) |
HK (1) | HK1142535A1 (pt) |
WO (1) | WO2005077007A2 (pt) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7335362B2 (en) | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
ES2534926T3 (es) * | 2002-07-19 | 2015-04-30 | Beth Israel Deaconess Medical Center | Métodos para tratar la preeclampsia |
US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
US8273383B2 (en) * | 2004-05-04 | 2012-09-25 | Children's Medical Center Corporation | Methods and compositions for treatment of preeclampsia |
KR20130119506A (ko) | 2004-09-24 | 2013-10-31 | 베스 이스라엘 데코니스 메디칼 센터 | 임신성 합병증의 진단 및 치료 방법 |
US7740849B2 (en) * | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
WO2007053161A2 (en) | 2004-12-15 | 2007-05-10 | Beth Israel Deaconess Medical Center | Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy |
AU2006226891A1 (en) * | 2005-03-24 | 2006-09-28 | Beth Israel Deaconess Medical Center | Methods of diagnosing fetal trisomy 13 or a risk of fetal trisomy 13 during pregnancy |
DE102005022047A1 (de) * | 2005-05-09 | 2006-11-30 | Dade Behring Marburg Gmbh | Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung |
US8329175B2 (en) * | 2005-08-26 | 2012-12-11 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the treatment and diagnosis of endothelial cell disorders and angiogenic disorders |
CN101616927A (zh) * | 2005-09-15 | 2009-12-30 | 迪爱麦有限公司 | 诊断先兆子痫的方法 |
US20070111326A1 (en) * | 2005-11-14 | 2007-05-17 | Abbott Laboratories | Diagnostic method for proteinaceous binding pairs, cardiovascular conditions and preeclampsia |
GB0600916D0 (en) * | 2006-01-17 | 2006-02-22 | Perkinelmer Instr Las Inc | detecting and predicting pre-eclampsia |
US20090286271A1 (en) * | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
US20080071151A1 (en) * | 2006-06-30 | 2008-03-20 | Sogin David C | Method and Apparatus for Diagnosing Pre-eclampsia |
US20090104649A1 (en) * | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
WO2009083020A1 (en) * | 2007-12-28 | 2009-07-09 | F. Hoffmann-La Roche Ag | Assessment of physiological conditions |
RU2010133157A (ru) | 2008-01-07 | 2012-02-20 | Орто-Клиникал Дайэгностикс, Инк. (Us) | Определение комплекса sflt-1:ангиогенный фактор |
WO2009089271A1 (en) * | 2008-01-07 | 2009-07-16 | Ortho-Clinical Diagnostics, Inc. | Calibrator/control for simultaneous assay of proteins capable of complexing with one another |
JP2009162616A (ja) * | 2008-01-07 | 2009-07-23 | Univ Of Tokyo | オートタキシン測定による妊娠および妊娠高血圧症候群の検査方法および検査薬 |
ATE522815T1 (de) * | 2008-05-13 | 2011-09-15 | Hoffmann La Roche | Mittel und verfahren zur prognose von nierenversagen bei diabetikern auf basis des plazentalen wachstumsfaktors und löslichem flt-1 |
EP2300825A4 (en) * | 2008-06-18 | 2012-04-25 | Abbott Lab | P / GF 1 COMPARATIVE DIAGNOSTIC PROCEDURES AND PRODUCTS |
CN110187119B (zh) * | 2008-10-31 | 2022-07-29 | 耶鲁大学 | 子痫前期检测和治疗的方法和组合物 |
JP5753541B2 (ja) | 2009-12-21 | 2015-07-22 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 抗vegf治療によって治療された患者におけるタンパク尿の初期マーカー |
EP3248946B1 (en) | 2010-05-14 | 2021-02-24 | Beth Israel Deaconess Medical Center, Inc. | Extracorporeal devices and methods of treating complications of pregnancy |
KR20130091750A (ko) * | 2010-07-19 | 2013-08-19 | 에프. 호프만-라 로슈 아게 | 유방암의 치료를 위한 베바시주맙 병용 치료법을 위한 혈장 생체마커 |
KR20130091746A (ko) * | 2010-07-19 | 2013-08-19 | 에프. 호프만-라 로슈 아게 | 췌장암의 치료를 위한 베바시주맙 병용 치료법을 위한 혈장 생체마커 |
GB201013151D0 (en) * | 2010-08-04 | 2010-09-22 | Isis Innovation | Diagnostic method |
KR101230740B1 (ko) * | 2010-09-08 | 2013-02-07 | 인제대학교 산학협력단 | 자간전증의 조기 진단 및 예후 평가 방법 |
WO2012109282A2 (en) | 2011-02-07 | 2012-08-16 | Agamin Pharmaceuticals, Llc | Methods and systems for treating or preventing pregnancy-related hypertensive disorders |
CN103917875B (zh) * | 2011-11-09 | 2016-11-09 | 霍夫曼-拉罗奇有限公司 | SFlt-1或Endoglin/PlGF的比例动态用作危急的先兆子痫和/或HELLP综合征的指示物 |
KR20140114415A (ko) | 2012-01-13 | 2014-09-26 | 제넨테크, 인크. | Vegf 길항제로의 치료를 위한 환자를 확인하기 위한 생물학적 마커 |
RU2483311C1 (ru) * | 2012-06-15 | 2013-05-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздравсоцразви | Способ диагностики преэклампсии у беременных с хронической артериальной гипертензией |
KR101996123B1 (ko) * | 2012-06-27 | 2019-07-03 | 에프. 호프만-라 로슈 아게 | 특정 시기 내에 임신중독증의 개시를 배제하기 위한 sFlt-1/PlGF 또는 엔도글린/PlGF 비의 적용 수단 및 방법 |
KR101297886B1 (ko) * | 2012-10-02 | 2013-08-19 | 인제대학교 산학협력단 | 자간전증의 조기 진단 및 예후 평가 방법 |
EP2965088B1 (en) | 2013-03-04 | 2018-12-05 | IQ Products B.V. | Prognostic marker to determine the risk for early-onset preeclampsia |
CN105917233B (zh) * | 2014-01-24 | 2018-07-03 | 豪夫迈·罗氏有限公司 | 产后hellp综合征、产后子痫或产后子痫前期的预测 |
JP6822412B2 (ja) * | 2015-02-18 | 2021-01-27 | アストン ユニヴァーシティー | 妊娠高血圧腎症のための診断アッセイ及び治療 |
MX2017012831A (es) * | 2015-04-07 | 2018-05-04 | Shire Human Genetic Therapies | Anticuerpos anti receptor del factor de crecimiento endotelial vascular 1 (flt-1) en el tratamiento de displasia broncopulmonar. |
US10738123B2 (en) * | 2015-04-07 | 2020-08-11 | Shire Human Genetic Therapies, Inc. | Anti-FLT-1 antibodies in treating bronchopulmonary dysplasia |
CN115015552A (zh) | 2015-06-19 | 2022-09-06 | 赛拉预测公司 | 用于预测早产的生物标志物对 |
US11553892B2 (en) * | 2016-03-01 | 2023-01-17 | Koninklijke Philips N.V. | Automated ultrasonic measurement of nuchal fold translucency |
CA3022416A1 (en) * | 2016-04-27 | 2017-11-02 | Zietchick Research Institute, Llc | Method for monitoring fetus/preterm infant development, and for promoting the normal development of preterm infants |
CA3073192A1 (en) | 2017-08-18 | 2019-02-21 | Sera Prognostics, Inc | Pregnancy clock proteins for predicting due date and time to birth |
AU2018331400A1 (en) | 2017-09-13 | 2020-04-02 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
GB201806042D0 (en) * | 2018-04-12 | 2018-05-30 | Univ Oxford Innovation Ltd | Biomarkers and uses thereof |
WO2019217478A1 (en) * | 2018-05-09 | 2019-11-14 | Dermtech, Inc. | Novel gene classifiers and uses thereof in autoimmune diseases |
EP3880838A4 (en) * | 2018-11-15 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | COMPOSITIONS AND METHODS FOR PRODICTING AND CLASSIFICATION OF PREECLAMPIA |
MX2021009726A (es) * | 2019-02-14 | 2021-09-14 | Mirvie Inc | Metodos y sistemas para determinar un estado relacionado con el embarazo de un sujeto. |
WO2021113710A1 (en) * | 2019-12-04 | 2021-06-10 | Progenity, Inc. | Assessment of preeclampsia using assays for free and dissociated placental growth factor |
EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
RU2717942C1 (ru) * | 2019-12-20 | 2020-03-27 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Способ диагностики преэклампсии по аминокислотному профилю плазмы крови |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
WO1989009622A1 (en) | 1988-04-15 | 1989-10-19 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
WO1989009825A1 (en) | 1988-04-16 | 1989-10-19 | Celltech Limited | Method for producing recombinant dna proteins |
US5240848A (en) * | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
US5238819A (en) * | 1988-12-14 | 1993-08-24 | The Regents Of The University Of California | Diagnostic assay for the detection of preeclampsia |
US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5219739A (en) * | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5712395A (en) * | 1992-11-13 | 1998-01-27 | Yissum Research Development Corp. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5895783A (en) * | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
US6410322B1 (en) * | 1993-07-27 | 2002-06-25 | Hybridon Inc | Antisense oligonucleotide inhibition of vascular endothelial growth factor expression |
US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
US5861499A (en) * | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
US5543138A (en) * | 1994-03-10 | 1996-08-06 | Genetics Institute, Inc. | Methods of diagnosing and treating preeclampsia |
US6613757B1 (en) * | 1994-09-22 | 2003-09-02 | Board Of Regents, The University Of Texas System | Combination of prostacyclin with an estrogen or progestin for the prevention and treatment of atherosclerotic vascular disease including preeclampsia and for the treatment of hypertension, and for hormone replacement therapy |
GB9512994D0 (en) * | 1995-06-26 | 1995-08-30 | Brf International | Method for quantitative measurement of an enzyme linked immunosorbent assay |
US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US6399585B1 (en) * | 1996-05-15 | 2002-06-04 | Janet E. Larson | In Utero treatment of CFTR-related deficiencies |
EP0951298A1 (en) | 1996-12-23 | 1999-10-27 | Cambridge University Technical Services Limited | Diagnosis and treatment of pathological pregnancies |
US20010056068A1 (en) * | 1998-03-04 | 2001-12-27 | Kristof Chwalisz | Method of treatment and prevention of nitric oxide deficiency-related disorders with citrulline and citrulline derivatives |
US20030114407A1 (en) | 2001-12-06 | 2003-06-19 | Monia Brett P. | Antisense modulation of G protein-coupled receptor ETBR-LP-2 expression |
US6677300B1 (en) * | 1998-09-09 | 2004-01-13 | Scios, Inc. | Treatment of microvascular angiopathies |
US7030083B2 (en) * | 1998-09-09 | 2006-04-18 | University Of Washington | Treatment of eclampsia and preeclampsia |
EP1417971A3 (en) | 1998-09-09 | 2004-06-30 | Scios Inc. | Use of an angiogenic factor for the treatment of microvascular angiopathies |
US6245577B1 (en) * | 1998-09-11 | 2001-06-12 | Midland Bioproducts Corporation | IgG antibody testing method |
KR100638228B1 (ko) | 1998-09-28 | 2006-10-25 | 스켈레톤 테크놀로지스 에이지 | 다이아몬드 복합체 제조방법 및 이 방법에 의해 제조된복합체 |
EP1016726A1 (en) * | 1998-12-30 | 2000-07-05 | Introgene B.V. | Gene therapy to promote angiogenesis |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
GB0026823D0 (en) * | 2000-11-02 | 2000-12-20 | King S College London | Diagnosis of pre-eclampsia |
WO2002070535A1 (en) * | 2001-03-01 | 2002-09-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of recql5 expression |
ES2534926T3 (es) * | 2002-07-19 | 2015-04-30 | Beth Israel Deaconess Medical Center | Métodos para tratar la preeclampsia |
US7335362B2 (en) * | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
WO2005017192A2 (en) * | 2003-08-14 | 2005-02-24 | The General Hospital Corporation | Screening for gestational disorders |
US7344892B2 (en) * | 2003-09-23 | 2008-03-18 | Beth Israel Deaconess Medical Center, Inc. | Screening for gestational disorders |
US7740849B2 (en) | 2004-09-24 | 2010-06-22 | Beth Israel Deaconess Medical Center | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders |
WO2006069373A2 (en) | 2004-12-21 | 2006-06-29 | Yale University | Diagnosis of preeclampsia |
US8787344B2 (en) | 2006-08-30 | 2014-07-22 | Qualcomm Incorporated | Method and apparatus for ACKCH with repetition in orthogonal systems |
US8349325B2 (en) | 2008-12-23 | 2013-01-08 | Abbott Laboratories | Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making |
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2004
- 2004-12-21 US US11/019,559 patent/US7435419B2/en not_active Expired - Lifetime
-
2005
- 2005-02-04 CN CNA2005800121081A patent/CN1946423A/zh active Pending
- 2005-02-04 AU AU2005213493A patent/AU2005213493A1/en not_active Abandoned
- 2005-02-04 EP EP05722813A patent/EP1718334A4/en not_active Ceased
- 2005-02-04 BR BRPI0507442A patent/BRPI0507442B8/pt active IP Right Grant
- 2005-02-04 KR KR1020067017827A patent/KR20070001991A/ko not_active Application Discontinuation
- 2005-02-04 CA CA002554971A patent/CA2554971A1/en not_active Abandoned
- 2005-02-04 ES ES09014672T patent/ES2404295T3/es active Active
- 2005-02-04 JP JP2006552339A patent/JP4711972B2/ja active Active
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2008
- 2008-07-23 US US12/220,245 patent/US9518992B2/en active Active
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2010
- 2010-09-22 HK HK10109057.9A patent/HK1142535A1/xx unknown
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US7435419B2 (en) | 2008-10-14 |
CN1946423A (zh) | 2007-04-11 |
KR20070001991A (ko) | 2007-01-04 |
EP1718334A2 (en) | 2006-11-08 |
BRPI0507442A (pt) | 2007-07-10 |
US20050170444A1 (en) | 2005-08-04 |
BRPI0507442B1 (pt) | 2021-02-23 |
EP2172220A1 (en) | 2010-04-07 |
JP4711972B2 (ja) | 2011-06-29 |
HK1142535A1 (en) | 2010-12-10 |
US20090117588A1 (en) | 2009-05-07 |
EP2172220B1 (en) | 2013-01-23 |
WO2005077007A2 (en) | 2005-08-25 |
EP1718334A4 (en) | 2008-04-23 |
AU2005213493A1 (en) | 2005-08-25 |
CA2554971A1 (en) | 2005-08-25 |
WO2005077007A3 (en) | 2006-03-16 |
US9518992B2 (en) | 2016-12-13 |
JP2007522457A (ja) | 2007-08-09 |
ES2404295T3 (es) | 2013-05-27 |
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