BRPI0510929A - derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer - Google Patents

derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer

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Publication number
BRPI0510929A
BRPI0510929A BRPI0510929-9A BRPI0510929A BRPI0510929A BR PI0510929 A BRPI0510929 A BR PI0510929A BR PI0510929 A BRPI0510929 A BR PI0510929A BR PI0510929 A BRPI0510929 A BR PI0510929A
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BR
Brazil
Prior art keywords
group
optionally substituted
substituted
hydrogen
aryl
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BRPI0510929-9A
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English (en)
Inventor
Weibo Wang
Paul A Barsanti
Yi Xi
Rustum S Boyce
Sabina Pecchi
Nathan Brammeier
Megan Phillips
Kelly Wayman
Liana Lagniton
Ryan Constantine
Elizabeth Mieuli
Savithri Ramurthy
Elisa Jazan
Anu Sharma
Jain Rama
Sharadha Sabramanian
Paul A Renhowe
Kenneth Bair
David Duhl
Annette Walter
Tinya Abrams
Kay Huh
Eric Martin
Mark Knapp
Vincent Le
Kris Mendenhall
Hong Yang
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Chiron Corp
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Application filed by Chiron Corp filed Critical Chiron Corp
Publication of BRPI0510929A publication Critical patent/BRPI0510929A/pt

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DERIVADOS DE N-(1-BENZIL-4FENIL-1H-IMIDAZOL-2-IL)-2,2-DIMETILPROPIL) BENZAMIDA E COMPOSTOS RELACIONADOS COMO INIBIDORES DA PROTEìNA CINESINA DO FUSO (KSP PARA O TRATAMENTO DE CáNCER Esta invenção é dirigida aos compostos imidazol substituídos que modulam a atividade de KSP são úteis para o tratamento de cãncer e são representados pela fórmula (I) em que: R¬ 1¬ é selecionado do grupo que consiste em aminoacil, acilamino, carboxil, éster carboxílico, aril e aquil opcionalmente substituído com hidroxi ou halo; R¬ 2¬ é selecionado do grupo que consiste em hidrogênio, alquil e aril; R¬ 3¬ é selecionado do grupo que consiste em hidrogênioe X-A, em que X é selecionado do grupo que consiste em C (O)-, -C(S)-, -S(O)~ 2~ e -S(O)~ 2~-N (R)-, em que R é hidrogênio ou alquil; e A é selecionado do grupo que consiste em hidrogênio, alquil opcionalmente substituído.alcoxi opcionalmente substituído,aril opcionalmente substituído, carboxil, éster carboxílico, aminoacil, heteroaril opcionalmente substituído, heterocíclico opcionalmente substituído e cicloalquil opcionalmente subistituído em que os grupos opcionalmente substituídos são substituídos com 1 a 4 substituintes; R¬ 5¬ é selecionado do grupo que consiste em L-A, em que L é selecionado do grupo que consiste em -S(O)<sym>-, em que q é um ou dois, e C~ 1~ a C~ 5~ alquileno opcionalmente substituído com hidroxi, halo ou acilamino;e A ¬ 1¬ é selecionado do grupo que consiste em aril, aril substituído,heteroaril, heteroaril substituído, heterocíclico, heterocíclico substituido, cicloaquil e cicloalquil subastituido e um de R¬ 6¬ ou R¬ 7¬ é selecionado do grupo que consiste em heterocíclico, abril e heteroaril, todos os quais podem ser opcionalmente substituídos com (R¬ 8¬)<sym> em que R¬ 8¬ e m é um número inteiro de 1 a 3 e o outro de R¬ 6¬ ou R¬ 7¬ é selecionado do grupo que consiste em hidrogêncio,halo e alquil, ou R¬ 6¬ e R¬ 7¬ são ambos hidrogênio; os outros substituintes são definidos nas reivinicações.
BRPI0510929-9A 2004-06-18 2005-06-20 derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer BRPI0510929A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58092704P 2004-06-18 2004-06-18
PCT/US2005/022062 WO2006002236A1 (en) 2004-06-18 2005-06-20 N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer

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BRPI0510929A true BRPI0510929A (pt) 2007-07-17

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ID=34980173

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BRPI0510929-9A BRPI0510929A (pt) 2004-06-18 2005-06-20 derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer

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US (3) US7576221B2 (pt)
EP (1) EP1765789B1 (pt)
JP (2) JP4836280B2 (pt)
KR (1) KR101170925B1 (pt)
CN (1) CN1993331A (pt)
AU (1) AU2005258135B2 (pt)
BR (1) BRPI0510929A (pt)
CA (1) CA2571002A1 (pt)
EC (1) ECSP077183A (pt)
ES (1) ES2409345T3 (pt)
IL (1) IL180147A0 (pt)
MA (1) MA28739B1 (pt)
MX (1) MXPA06014909A (pt)
NO (1) NO20070343L (pt)
NZ (1) NZ552510A (pt)
RU (1) RU2427572C2 (pt)
SG (1) SG153851A1 (pt)
TN (1) TNSN06419A1 (pt)
TW (1) TW200612958A (pt)
WO (1) WO2006002236A1 (pt)
ZA (1) ZA200700481B (pt)

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KR20070106961A (ko) 2007-11-06
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AU2005258135B2 (en) 2011-09-22
US20130017196A1 (en) 2013-01-17
US8735599B2 (en) 2014-05-27
ECSP077183A (es) 2007-02-28
JP2011256197A (ja) 2011-12-22
TW200612958A (en) 2006-05-01
MXPA06014909A (es) 2007-02-28
JP4836280B2 (ja) 2011-12-14
US20090258016A1 (en) 2009-10-15
EP1765789B1 (en) 2013-02-27
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US20060009472A1 (en) 2006-01-12
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