BRPI0510123A - modelos transgênicos de doença de alzheimer e seu uso no tratamento de uma variedade de doenças neurodegenerativas - Google Patents
modelos transgênicos de doença de alzheimer e seu uso no tratamento de uma variedade de doenças neurodegenerativasInfo
- Publication number
- BRPI0510123A BRPI0510123A BRPI0510123-9A BRPI0510123A BRPI0510123A BR PI0510123 A BRPI0510123 A BR PI0510123A BR PI0510123 A BRPI0510123 A BR PI0510123A BR PI0510123 A BRPI0510123 A BR PI0510123A
- Authority
- BR
- Brazil
- Prior art keywords
- alzheimer
- disease
- treatment
- neurodegenerative diseases
- variety
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 3
- 230000004770 neurodegeneration Effects 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 238000012301 transgenic model Methods 0.000 title abstract 3
- 238000003776 cleavage reaction Methods 0.000 abstract 3
- 230000035772 mutation Effects 0.000 abstract 3
- 230000007017 scission Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 206010003694 Atrophy Diseases 0.000 abstract 1
- 102000011727 Caspases Human genes 0.000 abstract 1
- 108010076667 Caspases Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000037444 atrophy Effects 0.000 abstract 1
- 239000002981 blocking agent Substances 0.000 abstract 1
- 230000000971 hippocampal effect Effects 0.000 abstract 1
- 230000007505 plaque formation Effects 0.000 abstract 1
- 230000007470 synaptic degeneration Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
Abstract
MODELOS TRANSGêNICOS DE DOENçA DE ALZHEIMER E SEU USO NO TRATAMENTO DE UMA VARIEDADE DE DOENçAS NEURODEGENERATIVAS. A presente invenção, refere-se a mutações selecionadas tais como uma mutação Asp<242> Ala (D664A) na APP (que impede a clivagem no sítio de clivagem da caspase), que impedem tanto a perda sináptica do hipocampo quanto a atrofia do giro dentado, mesmo embora tais mutações não interferem com a produção de A<225> ou a formação de placas de amilóide em um modelo transgênico de doença de Alzheimer. Conseqüentemente, em vista desta descoberta, métodos foram desenvolvidos para a identificação de agentes que bloqueiam a clivagem na Asp664 da APP, incluindo animais transgênicos que são úteis para tal propósito, assim como métodos para o seu uso para o tratamento de doenças neurodegenerativas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/830,713 US7544855B2 (en) | 2004-04-23 | 2004-04-23 | Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664 |
PCT/US2005/013761 WO2005115136A2 (en) | 2004-04-23 | 2005-04-22 | Transgenic models of alzheimer’s disease and uses thereof in the treatment of a variety of neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510123A true BRPI0510123A (pt) | 2007-09-25 |
Family
ID=35137988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510123-9A BRPI0510123A (pt) | 2004-04-23 | 2005-04-22 | modelos transgênicos de doença de alzheimer e seu uso no tratamento de uma variedade de doenças neurodegenerativas |
Country Status (9)
Country | Link |
---|---|
US (1) | US7544855B2 (pt) |
EP (1) | EP1744762A4 (pt) |
JP (1) | JP2007534323A (pt) |
CN (1) | CN1964720A (pt) |
AU (1) | AU2005247312A1 (pt) |
BR (1) | BRPI0510123A (pt) |
CA (1) | CA2563926A1 (pt) |
MX (1) | MXPA06012302A (pt) |
WO (1) | WO2005115136A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040192889A1 (en) * | 2001-03-30 | 2004-09-30 | Dale Bredesen | Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof |
US9480658B2 (en) | 2005-12-09 | 2016-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptic maintenance |
WO2007070375A2 (en) | 2005-12-09 | 2007-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptic maintenance |
US20110023152A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Genome editing of cognition related genes in animals |
CN102058619A (zh) * | 2010-12-08 | 2011-05-18 | 山西医科大学 | 一种阿尔茨海默病复合动物模型的制备方法 |
WO2012149607A1 (en) * | 2011-05-03 | 2012-11-08 | Commonwealth Scientific And Industrial Research Organisation | Method for detection of a neurological disease |
FI3019240T3 (fi) | 2013-07-09 | 2024-05-30 | Annexon Inc | Anti-komplementtitekijä c1q -vasta-aineita ja niiden käyttöjä |
KR101514282B1 (ko) | 2013-09-16 | 2015-04-23 | 한국생명공학연구원 | Ptprt 및 신탁신―결합 단백질 1을 이용한 시냅스 형성 조절제의 스크리닝 방법 |
JP6951246B2 (ja) | 2014-11-05 | 2021-10-20 | アネクソン,インコーポレーテッド | ヒト化抗補体因子C1q抗体及びその使用 |
EP3224380A1 (en) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Clonal haematopoiesis |
EP3224381B1 (en) | 2014-11-25 | 2019-09-04 | The Brigham and Women's Hospital, Inc. | Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease |
GB201518910D0 (en) | 2015-10-26 | 2015-12-09 | Rieke Packaging Systems Ltd | Dispensers |
IL296130A (en) | 2015-11-24 | 2022-11-01 | Annexon Inc | Anti-complement factor c1q fab fragments and their uses |
CN105494263B (zh) * | 2015-12-25 | 2018-11-30 | 哈尔滨医科大学 | 一种产生ho-1/app/psen1三转基因阿尔茨海默病小鼠模型的方法 |
CA3063061A1 (en) * | 2016-05-12 | 2017-11-16 | Ohio State Innovation Foundation | Peptides and methods for treating neurodegenerative disorders |
JP6870852B2 (ja) * | 2017-05-19 | 2021-05-12 | 国立研究開発法人国立長寿医療研究センター | 遺伝子組換え無脊椎動物アルツハイマー病モデルおよびその利用 |
CN110232679A (zh) * | 2019-05-24 | 2019-09-13 | 潘丹 | 一种阿尔茨海默症遗传生物标志物确定方法及*** |
CN110679549B (zh) * | 2019-11-05 | 2021-08-20 | 南通大学 | 一种阿尔茨海默病小鼠模型的构建方法 |
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GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
US4701521A (en) * | 1978-07-17 | 1987-10-20 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
US5144011A (en) * | 1981-06-26 | 1992-09-01 | Boston University | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
US4631190A (en) * | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
WO1989001034A1 (en) | 1987-07-24 | 1989-02-09 | The Regents Of The University Of Michigan | Encapsulation of biological materials in semi-permeable membranes |
US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
US5149796A (en) * | 1989-08-31 | 1992-09-22 | City Of Hope | Chimeric DNA-RNA catalytic sequences |
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US5225347A (en) * | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Therapeutic ribozyme compositions and expression vectors |
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US5268164A (en) * | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
CA2085127C (en) * | 1990-06-15 | 2002-12-10 | Barbara Cordell | Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease |
US5246921A (en) * | 1990-06-26 | 1993-09-21 | The Wistar Institute Of Anatomy And Biology | Method for treating leukemias |
WO1992013069A1 (en) * | 1991-01-21 | 1992-08-06 | Imperial College Of Science, Technology & Medicine | Test and model for alzheimer's disease |
US5222982A (en) * | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
EP0620849B1 (en) * | 1992-01-07 | 2003-06-25 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
US5455169A (en) * | 1992-06-04 | 1995-10-03 | Alzheimer's Institute Of America, Inc. | Nucleic acids for diagnosing and modeling Alzheimer's disease |
DE69426571T2 (de) * | 1993-10-27 | 2001-08-09 | Elan Pharm Inc | TRANSGENE TIERE, DIE APP Allele mit der schwedischen Mutation beherbergen |
US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
US5716614A (en) * | 1994-08-05 | 1998-02-10 | Molecular/Structural Biotechnologies, Inc. | Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
ATE394481T1 (de) * | 1996-07-24 | 2008-05-15 | Novartis Pharma Gmbh | Transgentier-modell für die krankheit von alzheimer |
AU4589297A (en) | 1996-10-07 | 1998-05-05 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
PT1268425E (pt) * | 2000-03-29 | 2008-04-01 | Vertex Pharma | Inibidores de caspase do grupo do carbamato e as suas utilizações |
ES2262662T3 (es) * | 2000-06-20 | 2006-12-01 | The Governing Council Of The University Of Toronto | Modelo de animal transgenico que presenta desordenes neurodegenerativos. |
EP1392340A4 (en) | 2001-03-30 | 2006-04-26 | Buck Inst | CYTOTOXIC PEPTIDES, PEPTIDOMIMETICS BASED ON THESE PEPTIDES, AND METHODS OF USE |
US20040192889A1 (en) * | 2001-03-30 | 2004-09-30 | Dale Bredesen | Cytotoxic peptides and peptidomimetics based thereon, and methods for use thereof |
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2004
- 2004-04-23 US US10/830,713 patent/US7544855B2/en active Active
-
2005
- 2005-04-22 BR BRPI0510123-9A patent/BRPI0510123A/pt not_active IP Right Cessation
- 2005-04-22 CA CA002563926A patent/CA2563926A1/en not_active Abandoned
- 2005-04-22 AU AU2005247312A patent/AU2005247312A1/en not_active Abandoned
- 2005-04-22 CN CNA2005800180200A patent/CN1964720A/zh active Pending
- 2005-04-22 MX MXPA06012302A patent/MXPA06012302A/es unknown
- 2005-04-22 EP EP05780036A patent/EP1744762A4/en not_active Ceased
- 2005-04-22 WO PCT/US2005/013761 patent/WO2005115136A2/en active Application Filing
- 2005-04-22 JP JP2007509665A patent/JP2007534323A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1964720A (zh) | 2007-05-16 |
JP2007534323A (ja) | 2007-11-29 |
WO2005115136A3 (en) | 2006-09-14 |
EP1744762A2 (en) | 2007-01-24 |
AU2005247312A1 (en) | 2005-12-08 |
CA2563926A1 (en) | 2005-12-08 |
US7544855B2 (en) | 2009-06-09 |
WO2005115136A2 (en) | 2005-12-08 |
US20050241008A1 (en) | 2005-10-27 |
EP1744762A4 (en) | 2010-07-28 |
MXPA06012302A (es) | 2007-04-12 |
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