BRPI0517672A - modalidades de formação de imagens para seleção terapêutica de doença de alzheimer - Google Patents
modalidades de formação de imagens para seleção terapêutica de doença de alzheimerInfo
- Publication number
- BRPI0517672A BRPI0517672A BRPI0517672-7A BRPI0517672A BRPI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A BR PI0517672 A BRPI0517672 A BR PI0517672A
- Authority
- BR
- Brazil
- Prior art keywords
- alzheimer
- disease
- imaging modalities
- therapeutic selection
- therapeutic
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biomedical Technology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
MODALIDADES DE FORMAçãO DE IMAGENS PARA SELEçãO TERAPêUTICA DE DOENçA DE ALZHEIMER. A presente invenção refere-se a uso de modelos animais de distúrbios neurodegenerativos para estabelecimento de índices diagnósticos pré-clínicos e terapêuticos, e para métodos de seleção para identificar terapias pré-clínicas eficazes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62516204P | 2004-11-05 | 2004-11-05 | |
PCT/US2005/039865 WO2006052691A2 (en) | 2004-11-05 | 2005-11-03 | Pet and magnetic resonance for screening alzheimer's disease therapeutics |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517672A true BRPI0517672A (pt) | 2008-10-14 |
Family
ID=36129750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517672-7A BRPI0517672A (pt) | 2004-11-05 | 2005-11-03 | modalidades de formação de imagens para seleção terapêutica de doença de alzheimer |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060117397A1 (pt) |
EP (1) | EP1807119A2 (pt) |
JP (1) | JP2008519282A (pt) |
CN (1) | CN101072591A (pt) |
AU (1) | AU2005304931A1 (pt) |
BR (1) | BRPI0517672A (pt) |
CA (1) | CA2586220A1 (pt) |
MX (1) | MX2007005317A (pt) |
WO (1) | WO2006052691A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
NZ563888A (en) * | 2005-05-17 | 2009-11-27 | Satori Pharmaceuticals Inc | Compounds isolated from black cohosh root that are useful for treating neurodegenerative disorders by inhibiting amyloid-beta peptide production |
US8150629B2 (en) * | 2005-11-10 | 2012-04-03 | In Silico Biosciences | Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases |
JP5153114B2 (ja) * | 2006-10-12 | 2013-02-27 | 知宏 千葉 | 新規のアルツハイマー病検出方法 |
JP5319121B2 (ja) * | 2007-01-30 | 2013-10-16 | 株式会社東芝 | 診療支援システム及び診療支援装置 |
EP2120717A1 (en) * | 2007-03-12 | 2009-11-25 | National Institute of Radiological Sciences | Pet visualization of amyloid-associated neuroinflammation in the brain |
WO2008140779A2 (en) * | 2007-05-10 | 2008-11-20 | Trustees Of Columbia University In The City Of New York | Methods for diagnosing diseases and evaluating treatments therefor using pet |
US20090099783A1 (en) * | 2007-06-08 | 2009-04-16 | Barry Reisberg | Stage Specific Prognostic In Vivo Markers of Brain Aging and Dementia |
CL2007002908A1 (es) | 2007-10-09 | 2008-05-30 | Univ Concepcion | Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg |
US8450466B2 (en) * | 2008-03-21 | 2013-05-28 | The General Hosptial Corporation | Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders |
EP2265174B1 (en) * | 2008-04-04 | 2018-06-06 | The Regents of The University of California | Functionalized magnetic nanoparticles and methods of use thereof |
US8593141B1 (en) | 2009-11-24 | 2013-11-26 | Hypres, Inc. | Magnetic resonance system and method employing a digital squid |
CA2795651A1 (en) * | 2010-04-13 | 2011-10-20 | Baxter International Inc. | Use of ventricular enlargement rate in intravenous immunoglobulin treatment of alzheimer's disease |
US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
DE102012209059B4 (de) * | 2012-05-30 | 2024-05-02 | Siemens Healthineers Ag | Verfahren und Vorrichtung zur Bestimmung einer zeitlichen Änderung eines Biomarkers in einem Untersuchungsgebiet |
US10203388B2 (en) | 2016-01-04 | 2019-02-12 | Toshiba Medical Systems Corporation | Magnetic resonance imaging apparatus and magnetic resonance imaging method |
CN114587323A (zh) * | 2020-12-04 | 2022-06-07 | 安影科技(北京)有限公司 | 一种阿尔茨海默病脑血流灌注异常的测量方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE971033T1 (de) * | 1991-01-21 | 2001-05-03 | Imperial College Of Science, Technology & Medicine | Prüfung und Modell für Alzheimers-Krankheit |
DE1001019T1 (de) * | 1993-10-27 | 2001-01-11 | Athena Neurosciences Inc | Transgene Tiere, die APP Allele mit der schwedischen Mutation beherbergen |
JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
US6717031B2 (en) * | 1995-06-07 | 2004-04-06 | Kate Dora Games | Method for selecting a transgenic mouse model of alzheimer's disease |
US5894078A (en) * | 1996-02-26 | 1999-04-13 | Advanced Bioconcept, Inc. | Transgenic mouse expressing C-100 app |
US5849999A (en) * | 1996-10-16 | 1998-12-15 | The Mclean Hospital Corporation | Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior |
US5898094A (en) * | 1996-10-21 | 1999-04-27 | University Of South Florida | Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes |
US6284944B1 (en) * | 1997-08-29 | 2001-09-04 | Cephalon, Inc, | Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring |
US6175057B1 (en) * | 1997-10-08 | 2001-01-16 | The Regents Of The University Of California | Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy |
US5846197A (en) * | 1998-03-16 | 1998-12-08 | Beth Israel Deaconess Medical Center | Compensating for magnetization transfer effects in multislice and three-dimensional MRI blood flow mapping studies |
US6664443B1 (en) * | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
JP3980833B2 (ja) * | 1998-08-20 | 2007-09-26 | リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | βアミロイド斑及び神経原線維変化の標識方法 |
AU4078900A (en) * | 1999-04-06 | 2000-10-23 | Harrington Arthritis Research Center | Methods for tracking the progression of alzheimer's disease and identifying treatments using transgenic mice |
US7371920B2 (en) * | 2000-06-20 | 2008-05-13 | The Governing Council Of The University Of Toronto | Transgenic mouse model of neurodegenerative disorders |
US6593516B1 (en) * | 2002-10-03 | 2003-07-15 | Rico Corp. | Holder for a musical instrument reed |
JP2006519609A (ja) * | 2003-03-12 | 2006-08-31 | サマリタン・ファーマシューティカルズ・インコーポレイテッド | 神経疾患擬態動物モデル |
-
2005
- 2005-11-03 CN CNA2005800416995A patent/CN101072591A/zh active Pending
- 2005-11-03 CA CA002586220A patent/CA2586220A1/en not_active Abandoned
- 2005-11-03 JP JP2007540047A patent/JP2008519282A/ja active Pending
- 2005-11-03 AU AU2005304931A patent/AU2005304931A1/en not_active Abandoned
- 2005-11-03 WO PCT/US2005/039865 patent/WO2006052691A2/en active Application Filing
- 2005-11-03 EP EP05821147A patent/EP1807119A2/en not_active Withdrawn
- 2005-11-03 MX MX2007005317A patent/MX2007005317A/es not_active Application Discontinuation
- 2005-11-03 BR BRPI0517672-7A patent/BRPI0517672A/pt not_active IP Right Cessation
- 2005-11-04 US US11/266,230 patent/US20060117397A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2006052691A2 (en) | 2006-05-18 |
CA2586220A1 (en) | 2006-05-18 |
AU2005304931A1 (en) | 2006-05-18 |
WO2006052691A3 (en) | 2007-05-10 |
US20060117397A1 (en) | 2006-06-01 |
JP2008519282A (ja) | 2008-06-05 |
EP1807119A2 (en) | 2007-07-18 |
MX2007005317A (es) | 2007-06-11 |
CN101072591A (zh) | 2007-11-14 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |