BRPI0509598A - cepas de lêvedo que produzem colesterol e suas aplicações - Google Patents
cepas de lêvedo que produzem colesterol e suas aplicaçõesInfo
- Publication number
- BRPI0509598A BRPI0509598A BRPI0509598-0A BRPI0509598A BRPI0509598A BR PI0509598 A BRPI0509598 A BR PI0509598A BR PI0509598 A BRPI0509598 A BR PI0509598A BR PI0509598 A BRPI0509598 A BR PI0509598A
- Authority
- BR
- Brazil
- Prior art keywords
- cholesterol
- applications
- yeast strains
- relates
- present
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 10
- 235000012000 cholesterol Nutrition 0.000 title abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 241000233866 Fungi Species 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000000004 low energy electron diffraction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
CEPAS DE LêVEDO QUE PRODUZEM COLESTEROL E SUAS APLICAçõES. A presente invenção refere-se à produção de colesterol em organismos do reino dos Fungi. Mas particularmente, a presente invenção refere-se a Fungus geneticamente modificados que produzem, de maneira autónoma, colesterol a partir de uma fonte de carbono simples. A presente invenção refere-se igualmente à utilização de Fungus de acordo com a invenção para a produção de colesterol não marcado e marcado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0404890A FR2869914B1 (fr) | 2004-05-06 | 2004-05-06 | Souches de levure produisant du cholesterol et leurs applications |
| PCT/FR2005/001090 WO2005121315A1 (fr) | 2004-05-06 | 2005-05-02 | Souches de levure produisant du cholesterol et leurs applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0509598A true BRPI0509598A (pt) | 2007-10-16 |
| BRPI0509598B1 BRPI0509598B1 (pt) | 2016-12-06 |
| BRPI0509598B8 BRPI0509598B8 (pt) | 2021-05-25 |
Family
ID=34946597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0509598A BRPI0509598B8 (pt) | 2004-05-06 | 2005-05-02 | cepa de levedura que produz colesterol, processo de produção de colesterol, de sua mistura isotópica, de um de seus sais de intermediários metabólicos, ou de uma mistura de esteróis marcada no 13c ou no 14c e uso de um organismo para a produção do referido colesterol |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8211676B2 (pt) |
| EP (2) | EP1745123B1 (pt) |
| JP (2) | JP5053838B2 (pt) |
| KR (1) | KR101252304B1 (pt) |
| CN (1) | CN1981029B (pt) |
| AR (1) | AR048938A1 (pt) |
| AU (1) | AU2005252401B2 (pt) |
| BR (1) | BRPI0509598B8 (pt) |
| CA (1) | CA2562773C (pt) |
| CY (2) | CY1113174T1 (pt) |
| DK (2) | DK1745123T3 (pt) |
| ES (2) | ES2662971T3 (pt) |
| FR (1) | FR2869914B1 (pt) |
| HK (1) | HK1107117A1 (pt) |
| HR (2) | HRP20120806T1 (pt) |
| HU (1) | HUE036218T2 (pt) |
| IL (2) | IL178741A (pt) |
| LT (1) | LT2354218T (pt) |
| MA (1) | MA28570B1 (pt) |
| ME (1) | ME01455B (pt) |
| MX (1) | MXPA06012840A (pt) |
| NO (2) | NO341207B1 (pt) |
| NZ (1) | NZ551057A (pt) |
| PL (2) | PL1745123T3 (pt) |
| PT (2) | PT1745123E (pt) |
| RS (2) | RS56952B1 (pt) |
| RU (1) | RU2397245C2 (pt) |
| SG (3) | SG185179A1 (pt) |
| SI (1) | SI2354218T1 (pt) |
| WO (1) | WO2005121315A1 (pt) |
| ZA (1) | ZA200609162B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262274C (zh) * | 2000-11-14 | 2006-07-05 | 生命健康科学有限公司 | 磷酸盐衍生物复合物 |
| FR2869914B1 (fr) * | 2004-05-06 | 2012-11-09 | Aventis Pharma Sa | Souches de levure produisant du cholesterol et leurs applications |
| DE102009022772A1 (de) | 2009-05-21 | 2010-11-25 | Organobalance Gmbh | Mikroorganismus zur Expression eines humanen Membranproteins |
| EP2507368B1 (en) | 2009-12-03 | 2016-03-30 | DSM IP Assets B.V. | Production of non-yeast sterols by yeast |
| FR2961218A1 (fr) | 2010-06-10 | 2011-12-16 | Sanofi Aventis | Methode de detection de composes modulateurs du metabolisme du cholesterol |
| WO2012095816A1 (en) | 2011-01-14 | 2012-07-19 | Sanofi | Method for detecting the biological activity of alpha-synuclein |
| FR2976949B1 (fr) | 2011-06-21 | 2015-08-28 | Sanofi Sa | Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre |
| EP2856142A1 (en) * | 2012-05-25 | 2015-04-08 | Health Diagnostic Laboratory, Inc. | Rapid and high-throughput analysis of sterols/stanols or derivatives thereof |
| JP6533747B2 (ja) * | 2014-01-17 | 2019-06-19 | 協和発酵バイオ株式会社 | ７デヒドロコレステロール及びビタミンｄ３の製造法 |
| US10329250B2 (en) | 2014-10-08 | 2019-06-25 | Kyowa Hakko Bio Co., Ltd. | Process for producing 7-dehydrocholesterol and vitamin D3 |
| CN104805027B (zh) * | 2015-05-27 | 2018-04-27 | 天津大学 | 一种重组耶氏解脂酵母菌株及其构建方法和应用 |
| US11466303B2 (en) * | 2015-12-23 | 2022-10-11 | Dsm Ip Assets B.V. | Production of sterols in modified yeast |
| CN106754993B (zh) * | 2017-02-17 | 2020-06-30 | 天津大学 | 一种基因、重组酿酒酵母菌株及其构建方法与应用 |
| JP6909466B2 (ja) * | 2017-07-25 | 2021-07-28 | 大陽日酸株式会社 | 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット |
| CN112626159B (zh) * | 2021-01-07 | 2022-08-05 | 华东理工大学 | 利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法 |
| CN114577925B (zh) * | 2021-12-29 | 2024-02-02 | 西南大学 | 一种水样中粪甾醇类物质快速检测方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB613778A (en) | 1946-07-02 | 1948-12-02 | United Domestic Ind Ltd | Improvements in or relating to the production of cholesterol |
| US2650929A (en) | 1948-02-27 | 1953-09-01 | Hewett Colin Leslie | Process for isolation of cholesterol from wool wax alcohols |
| GB646227A (en) | 1948-02-27 | 1950-11-15 | Organon Labor Ltd | Process for isolation of cholesterol from wool wax alcohols |
| GB690879A (en) | 1950-07-21 | 1953-04-29 | Organon Labor Ltd | Process for the isolation of cholesterol from wool-wax alcohols |
| US2688623A (en) | 1950-07-21 | 1954-09-07 | Organon Labor Ltd | Process for the isolation of cholesterol from wool-wax alcohols |
| CN1017820B (zh) * | 1988-12-01 | 1992-08-12 | 韦斯普里米森本亚克 | 地下空间特别是矿区的排水方法 |
| US5460949A (en) * | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| IL162476A (en) * | 1995-02-15 | 2005-12-18 | Aventis Pharma Sa | Arabidopsis thaliana proteins having delta -5,7- sterol - delta -7- reductase activity |
| FR2774393B1 (fr) | 1998-02-05 | 2000-03-24 | Hoechst Marion Roussel Inc | Souches de levure ayant le gene atf2 interrompu et leurs applications |
| FR2820145B1 (fr) | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
| JP2004141125A (ja) * | 2002-08-28 | 2004-05-20 | Mitsubishi Chemicals Corp | 代謝工学的に改変されている真菌類およびそれを用いるステロール類の製造法 |
| FR2869914B1 (fr) * | 2004-05-06 | 2012-11-09 | Aventis Pharma Sa | Souches de levure produisant du cholesterol et leurs applications |
-
2004
- 2004-05-06 FR FR0404890A patent/FR2869914B1/fr not_active Expired - Lifetime
-
2005
- 2005-05-02 BR BRPI0509598A patent/BRPI0509598B8/pt active IP Right Grant
- 2005-05-02 ME MEP-2012-114A patent/ME01455B/me unknown
- 2005-05-02 SI SI200532198T patent/SI2354218T1/en unknown
- 2005-05-02 HU HUE10186024A patent/HUE036218T2/hu unknown
- 2005-05-02 RS RS20180308A patent/RS56952B1/sr unknown
- 2005-05-02 PL PL05763706T patent/PL1745123T3/pl unknown
- 2005-05-02 AU AU2005252401A patent/AU2005252401B2/en active Active
- 2005-05-02 CA CA2562773A patent/CA2562773C/fr active Active
- 2005-05-02 ZA ZA200609162A patent/ZA200609162B/xx unknown
- 2005-05-02 EP EP05763706A patent/EP1745123B1/fr active Active
- 2005-05-02 SG SG2011083565A patent/SG185179A1/en unknown
- 2005-05-02 WO PCT/FR2005/001090 patent/WO2005121315A1/fr active Application Filing
- 2005-05-02 LT LTEP10186024.5T patent/LT2354218T/lt unknown
- 2005-05-02 PT PT05763706T patent/PT1745123E/pt unknown
- 2005-05-02 RU RU2006143060/13A patent/RU2397245C2/ru active
- 2005-05-02 ES ES10186024.5T patent/ES2662971T3/es active Active
- 2005-05-02 EP EP10186024.5A patent/EP2354218B1/fr active Active
- 2005-05-02 SG SG10201501156WA patent/SG10201501156WA/en unknown
- 2005-05-02 US US11/568,572 patent/US8211676B2/en active Active
- 2005-05-02 KR KR1020067023167A patent/KR101252304B1/ko active IP Right Grant
- 2005-05-02 PT PT101860245T patent/PT2354218T/pt unknown
- 2005-05-02 JP JP2007512255A patent/JP5053838B2/ja active Active
- 2005-05-02 SG SG200706409-0A patent/SG150408A1/en unknown
- 2005-05-02 DK DK05763706.8T patent/DK1745123T3/da active
- 2005-05-02 MX MXPA06012840A patent/MXPA06012840A/es active IP Right Grant
- 2005-05-02 CN CN2005800227391A patent/CN1981029B/zh active Active
- 2005-05-02 PL PL10186024T patent/PL2354218T3/pl unknown
- 2005-05-02 ES ES05763706T patent/ES2390588T3/es active Active
- 2005-05-02 RS RS20120413A patent/RS52444B/en unknown
- 2005-05-02 DK DK10186024.5T patent/DK2354218T3/en active
- 2005-05-02 NZ NZ551057A patent/NZ551057A/en unknown
- 2005-05-05 AR ARP050101823A patent/AR048938A1/es not_active Application Discontinuation
-
2006
- 2006-10-19 IL IL178741A patent/IL178741A/en not_active IP Right Cessation
- 2006-11-02 MA MA29434A patent/MA28570B1/fr unknown
- 2006-11-23 NO NO20065402A patent/NO341207B1/no unknown
-
2007
- 2007-11-15 HK HK07112490.3A patent/HK1107117A1/xx unknown
-
2011
- 2011-12-21 JP JP2011279322A patent/JP5670310B2/ja active Active
-
2012
- 2012-05-24 US US13/479,355 patent/US8685705B2/en active Active
- 2012-10-04 CY CY20121100926T patent/CY1113174T1/el unknown
- 2012-10-09 HR HRP20120806TT patent/HRP20120806T1/hr unknown
-
2015
- 2015-04-19 IL IL238365A patent/IL238365B/en active IP Right Grant
-
2017
- 2017-08-29 NO NO20171396A patent/NO343427B1/no unknown
-
2018
- 2018-03-13 HR HRP20180433TT patent/HRP20180433T1/hr unknown
- 2018-03-13 CY CY20181100308T patent/CY1120394T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/12/2016, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/05/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B25D | Requested change of name of applicant approved | ||
| B25G | Requested change of headquarter approved | ||
| B25A | Requested transfer of rights approved |