BRPI0506790A - processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa - Google Patents
processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepaInfo
- Publication number
- BRPI0506790A BRPI0506790A BRPI0506790-1A BRPI0506790A BRPI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A
- Authority
- BR
- Brazil
- Prior art keywords
- propanediol
- microorganisms
- evolved
- strain
- preparing
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 7
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 6
- 235000013772 propylene glycol Nutrition 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 229960004063 propylene glycol Drugs 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 abstract 1
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004690 coupled electron pair approximation Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 101150080369 tpiA gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROCESSOS DE PREPARAçãO DE UMA CEPA DE MICROORGANISMOS EVOLUìDOS E DE 1,2-PROPANODIOL, E, CEPA" A invenção refere-se a um novo processo de preparação de um cepa de microorganismos evoluídos para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples, o dito processo compreendendo a cultura sob pressão de seleção em um meio de cultura adequado que compreende uma fonte de carbono simples, de uma cepa bacteriana inicial compreendendo uma deleção do gene tpiA e uma deleção de ao menos um gene implicado na conversão do metil glioxal (propanal) em lactato, a fim de fazer evoluir na dita cepa inicial um mais genes implicados na via de biosíntese do DHAP em metilglioxal e depois em 1,2-propanodiol para os genes evoluídos que têm uma atividade <sym>1,2-propanodiol síntase<sym> melhorada, e depois seleciona-se e isola-se a ou as cepas de microorganismos evoluídos que têm uma atividade <sym>1,2 propanodiol síntase<sym> melhorada. A invenção refere-se igualmente aos microorganismos iniciais e os microorganismos eveoluidos assim obtidos e um processo de preparação de 1,2-propanodiol e eventualmente de acetona por cultura dos microorganismos evoluídos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0400214 | 2004-01-12 | ||
FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0506790A true BRPI0506790A (pt) | 2007-05-22 |
BRPI0506790B1 BRPI0506790B1 (pt) | 2020-12-22 |
Family
ID=34684930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506790-1A BRPI0506790B1 (pt) | 2004-01-12 | 2005-01-12 | processo de preparação de uma cepa de escherichia coli evoluída para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples e processo de preparação de 1,2-propanodiol |
Country Status (18)
Country | Link |
---|---|
US (1) | US8252579B2 (pt) |
EP (2) | EP1704230B1 (pt) |
JP (1) | JP4613177B2 (pt) |
KR (1) | KR101229525B1 (pt) |
CN (1) | CN1910278B (pt) |
AT (1) | ATE440135T1 (pt) |
BR (1) | BRPI0506790B1 (pt) |
CA (1) | CA2547695C (pt) |
DE (1) | DE602005016073D1 (pt) |
DK (1) | DK1704230T3 (pt) |
ES (1) | ES2329914T3 (pt) |
FR (1) | FR2864967B1 (pt) |
PL (1) | PL1704230T3 (pt) |
PT (1) | PT1704230E (pt) |
RU (1) | RU2407793C2 (pt) |
SI (1) | SI1704230T1 (pt) |
WO (1) | WO2005073364A2 (pt) |
ZA (1) | ZA200605440B (pt) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2041293A4 (en) * | 2006-05-01 | 2011-06-22 | Univ Florida | ETHANOL PRODUCTION IN NON-RECOMBINANT HOST |
BRPI0622099A2 (pt) | 2006-10-31 | 2011-12-27 | Metabolic Explorer Sa | processo para a produÇço biolàgica de 1,3-propanodiol a partir de glicerol com alto rendimento |
KR100971790B1 (ko) * | 2006-12-15 | 2010-07-23 | 바이오퓨얼켐 주식회사 | Butyryl-CoA를 중간체로 하여 부탄올을 생합성하는 능력을가지는 박테리아를 이용하여 부탄올을 제조하는 방법 |
US20100062505A1 (en) * | 2006-12-21 | 2010-03-11 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
US8673601B2 (en) * | 2007-01-22 | 2014-03-18 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
CN101631864A (zh) * | 2007-02-08 | 2010-01-20 | 生物普尔肯株式会社 | 使用酵母菌通过丁酰-CoA作为中间体制备丁醇的方法 |
EP2118266A4 (en) * | 2007-02-09 | 2010-05-19 | Univ California | BIOFUEL PRODUCTION BY RECOMBINANT MICROORGANISMS |
WO2008115840A2 (en) | 2007-03-16 | 2008-09-25 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
EP2570481B1 (en) * | 2007-03-20 | 2014-11-26 | University of Florida Research Foundation, Inc. | Materials and methods for efficient succinate and malate production |
EP2142637A1 (en) * | 2007-03-23 | 2010-01-13 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of acetol |
KR20100015815A (ko) * | 2007-03-23 | 2010-02-12 | 메타볼릭 익스플로러 | 1,2-프로판디올 및 아세톨의 제조를 위한 미생물 및 방법 |
BRPI0808972B1 (pt) * | 2007-03-23 | 2016-11-29 | Metabolic Explorer Sa | método para a preparação de uma cepa de escherichia coli para a produção de 1,2-propanodiol a partir de uma fonte de carbono |
CA2679987A1 (en) * | 2007-03-23 | 2008-10-02 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of 1,2-propanediol |
WO2008116849A1 (en) * | 2007-03-23 | 2008-10-02 | Metabolic Explorer | New micro-organisms for the production of acetol obtained by a combination of evolution and rational design. |
US20090111154A1 (en) * | 2007-04-04 | 2009-04-30 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
EP2188243A2 (en) * | 2007-08-10 | 2010-05-26 | Genomatica, Inc. | Methods for the synthesis of acrylic acid and derivatives from fumaric acid |
US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
US20100221800A1 (en) * | 2007-10-12 | 2010-09-02 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
RU2010129915A (ru) | 2007-12-17 | 2012-01-27 | Университейт Ван Амстердам (Nl) | Стимулируемое светом восстановление co2 до органических соединений, служащих топливами или промышленными полуфабрикатами, в автотрофах, содержащих кассету с генами ферментов |
JP2011509691A (ja) | 2008-01-22 | 2011-03-31 | ジェノマティカ, インコーポレイテッド | 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体 |
WO2009103380A1 (en) * | 2008-02-21 | 2009-08-27 | Takata-Petri Ag | Airbag module for a motor vehicle |
EP2262901B1 (en) * | 2008-03-05 | 2018-11-21 | Genomatica, Inc. | Primary alcohol producing organisms |
WO2009115114A1 (en) * | 2008-03-18 | 2009-09-24 | Metabolic Explorer | Polypeptide having glyoxylase iii activity, polynucleotide encoding the same and uses thereof |
SI2265709T1 (en) * | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
BRPI0911759A2 (pt) * | 2008-05-01 | 2019-09-24 | Genomatica Inc | microorganismo para a produção de ácido metacrílico |
CA2725549A1 (en) * | 2008-06-17 | 2009-12-23 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
US20100021978A1 (en) * | 2008-07-23 | 2010-01-28 | Genomatica, Inc. | Methods and organisms for production of 3-hydroxypropionic acid |
CN102089421B (zh) * | 2008-07-28 | 2013-06-19 | 科莱恩金融(Bvi)有限公司 | 生产方法 |
WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
AU2009291825B2 (en) * | 2008-09-10 | 2016-05-05 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
MY152034A (en) | 2008-10-03 | 2014-08-15 | Metabolic Explorer Sa | Method for purifying an alcohol from a fermentation broth using a falling film, a wiped film, a thin film or a short path evaporator |
ES2429305T3 (es) | 2008-11-07 | 2013-11-14 | Metabolic Explorer | Utilización de la sacarosa como sustrato para la producción fermentativa de 1,2-propanodiol |
US20100184173A1 (en) * | 2008-11-14 | 2010-07-22 | Genomatica, Inc. | Microorganisms for the production of methyl ethyl ketone and 2-butanol |
CN102395671B (zh) * | 2008-12-03 | 2014-06-25 | 韩国生命工学研究院 | 用于制造1,3-丙二醇的丙三醇氧化途径中阻隔的突变体 |
WO2010071697A1 (en) * | 2008-12-16 | 2010-06-24 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
BRPI0923748B1 (pt) | 2008-12-31 | 2019-04-09 | Metabolic Explorer | Método para a preparação de dióis |
WO2010104224A1 (ko) * | 2009-03-12 | 2010-09-16 | 한국생명공학연구원 | 글리세롤 산화대사경로를 차단시킨 재조합 균주를 이용한 1、3-프로판디올의 제조방법 |
KR101711308B1 (ko) | 2009-04-02 | 2017-02-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 석시네이트 생성을 위한 경로의 엔지니어링 |
EP2425006A4 (en) | 2009-04-30 | 2013-01-23 | Genomatica Inc | ORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL, N-BUTANOL AND ISOBUTANOL |
EP3318626B1 (en) * | 2009-04-30 | 2020-01-15 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
KR102099295B1 (ko) | 2009-05-07 | 2020-04-09 | 게노마티카 인코포레이티드 | 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법 |
BRPI1012877A2 (pt) * | 2009-05-15 | 2016-04-05 | Genomatica Inc | organismo para produção de ciclohexanona |
KR102237801B1 (ko) * | 2009-06-04 | 2021-04-07 | 게노마티카 인코포레이티드 | 발효액 성분들의 분리 방법 |
MY195387A (en) | 2009-06-04 | 2023-01-18 | Genomatica Inc | Microorganisms for the Production of 1,4-Butanediol and Related Methods |
US8420375B2 (en) * | 2009-06-10 | 2013-04-16 | Genomatica, Inc. | Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol |
EP2267126A1 (en) | 2009-06-26 | 2010-12-29 | Metabolic Explorer | Process for the stable gene interruption in clostridia |
WO2011012697A2 (en) | 2009-07-30 | 2011-02-03 | Metabolic Explorer | Mutant yqhd enzyme for the production of a biochemical by fermentation |
US8980604B2 (en) | 2009-07-30 | 2015-03-17 | Metabolic Explorer | Mutant glycerol dehydrogenase (GlyDH) for the production of a biochemical by fermentation |
KR101771266B1 (ko) | 2009-07-30 | 2017-08-24 | 메타볼릭 익스플로러 | 발효에 의한 생화학물질의 생산을 위한 돌연변이체 메틸글리옥살 신타제 (mgs) |
EP3190174A1 (en) | 2009-08-05 | 2017-07-12 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
NZ598374A (en) | 2009-08-21 | 2014-10-31 | Mascoma Corp | Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms |
KR20120068021A (ko) | 2009-09-09 | 2012-06-26 | 게노마티카 인코포레이티드 | 아이소프로판올과 1차 알콜, 다이올 및 산과의 공동 생산을 위한 미생물 및 방법 |
KR20120083908A (ko) | 2009-10-13 | 2012-07-26 | 게노마티카 인코포레이티드 | 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-coa, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법 |
US20110097767A1 (en) * | 2009-10-23 | 2011-04-28 | Priti Pharkya | Microorganisms for the production of aniline |
US8530210B2 (en) * | 2009-11-25 | 2013-09-10 | Genomatica, Inc. | Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone |
US8268607B2 (en) | 2009-12-10 | 2012-09-18 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
WO2011094131A1 (en) * | 2010-01-29 | 2011-08-04 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
US8445244B2 (en) * | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
US8048661B2 (en) * | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
KR20190006103A (ko) | 2010-05-05 | 2019-01-16 | 게노마티카 인코포레이티드 | 부타디엔을 생합성하기 위한 미생물 및 방법 |
EP2588598B1 (en) | 2010-07-02 | 2016-03-09 | Metabolic Explorer | Method for the preparation of hydroxy acids |
TWI500768B (zh) | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備1,3-丙二醇之方法 |
CN103025877A (zh) | 2010-07-26 | 2013-04-03 | 基因组股份公司 | 用于生物合成芳族化合物、2,4-戊二烯酸和1,3-丁二烯的微生物和方法 |
KR20140052934A (ko) | 2011-02-22 | 2014-05-07 | 도레이 카부시키가이샤 | 디올 조성물 및 폴리에스테르 |
EP2532751A1 (en) | 2011-06-10 | 2012-12-12 | Metabolic Explorer | Use of inducible promoters in the fermentative production of 1,2-propanediol |
EP2721167A1 (en) | 2011-06-15 | 2014-04-23 | B.R.A.I.N. Biotechnology Research And Information Network AG | New means and methods for producing propanediol |
EP2540834A1 (en) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
US9410164B2 (en) | 2011-10-11 | 2016-08-09 | Metabolic Explorer | Biosynthesis pathway for prenol in a recombinant microorganism |
EP2647718A3 (en) | 2012-04-06 | 2014-12-24 | Metabolic Explorer | Process for producing 5-aminopentanoate empolying a recombinant microorganism |
BR112014030202A2 (pt) | 2012-06-04 | 2017-09-12 | Genomatica Inc | microorganismos e métodos para a produção de 4-hidroxibutirato 1,4-butanodiol e compostos relacionados |
EP2708598A1 (en) * | 2012-09-14 | 2014-03-19 | Basf Se | Serinol production in glycerol catabolism deficient escherichia coli strains |
WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
CN103589756B (zh) * | 2013-11-15 | 2015-12-02 | 中国科学院微生物研究所 | 利用l-乳酸生物合成s-1,2-丙二醇的方法 |
MX2016014821A (es) * | 2014-05-12 | 2017-03-10 | Metabolic Explorer Sa | Microorganismo y metodo nuevos para la produccion de 1,2-propanodiol basada en acetol reductasa dependiente de nadph y suministro mejorado de nadph. |
JP6026494B2 (ja) * | 2014-12-05 | 2016-11-16 | メタボリック エクスプローラー | 1,2−プロパンジオールの発酵製造のための基質としてのスクロースの使用 |
EP3050970B1 (en) | 2015-01-28 | 2019-09-18 | Metabolic Explorer | Modified microorganism for optimized production of 1,4-butanediol |
WO2016162442A1 (en) | 2015-04-07 | 2016-10-13 | Metabolic Explorer | A modified microorganism for the optimized production of 2,4-dihydroxyburyrate with enhanced 2,4-dihydroxybutyrate efflux |
US10415062B2 (en) | 2015-04-07 | 2019-09-17 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxybutyrate |
EP3328997B1 (en) | 2015-07-27 | 2020-12-23 | Institut National Des Sciences Appliquees | New polypeptide having ferredoxin-nadp+ reductase activity, polynucleotide encoding the same and uses thereof |
WO2017025766A1 (en) | 2015-08-07 | 2017-02-16 | Metabolic Explorer | Protein thiocarboxylate-dependent l-methionine production by fermentation |
EP3347478B1 (en) | 2015-09-10 | 2022-09-21 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
US10801050B2 (en) | 2015-10-23 | 2020-10-13 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
RU2729012C2 (ru) | 2015-11-27 | 2020-08-03 | Эвоник Оперейшенс ГмбХ | Способ получения l-метионина |
WO2017211883A1 (en) * | 2016-06-07 | 2017-12-14 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to polyols |
JP7321089B2 (ja) * | 2016-07-08 | 2023-08-04 | メタボリック エクスプローラー | 糖ホスホトランスフェラーゼ系(pts)をコードする遺伝子を含んでなる微生物による目的分子の発酵生産法 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP3342873A1 (en) | 2016-12-29 | 2018-07-04 | Metabolic Explorer | Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof |
EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
WO2019092495A1 (en) * | 2017-11-09 | 2019-05-16 | Braskem S.A. | Process for the recovery of ketones and glycols from fermentation |
CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
CN115125263B (zh) * | 2022-05-31 | 2024-01-23 | 中国科学院天津工业生物技术研究所 | 解除pts依赖碳源对相关启动子阻遏的方法及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
BRPI0013315B8 (pt) * | 1999-08-18 | 2018-02-27 | Du Pont | fragmento de ácido nucleico isolado, polipeptídeo, gene quimérico, microorganismo, microorganismo recombinante , e. coli recombinante, linhagem klp23 de e. coli recombinante, linhagem rj8 de e. coli recombinante, vetor pdt29, vetor pkp32 e processos de bioprodução de 1,3-propanodiol |
-
2004
- 2004-01-12 FR FR0400214A patent/FR2864967B1/fr not_active Expired - Fee Related
-
2005
- 2005-01-12 DK DK05717405T patent/DK1704230T3/da active
- 2005-01-12 BR BRPI0506790-1A patent/BRPI0506790B1/pt active IP Right Grant
- 2005-01-12 EP EP05717405A patent/EP1704230B1/fr active Active
- 2005-01-12 SI SI200530761T patent/SI1704230T1/sl unknown
- 2005-01-12 AT AT05717405T patent/ATE440135T1/de active
- 2005-01-12 PT PT05717405T patent/PT1704230E/pt unknown
- 2005-01-12 EP EP20090167750 patent/EP2192180A1/fr not_active Ceased
- 2005-01-12 RU RU2006129295/10A patent/RU2407793C2/ru active
- 2005-01-12 WO PCT/FR2005/000070 patent/WO2005073364A2/fr active Application Filing
- 2005-01-12 CA CA2547695A patent/CA2547695C/fr active Active
- 2005-01-12 ES ES05717405T patent/ES2329914T3/es active Active
- 2005-01-12 PL PL05717405T patent/PL1704230T3/pl unknown
- 2005-01-12 US US10/585,040 patent/US8252579B2/en active Active
- 2005-01-12 CN CN2005800023110A patent/CN1910278B/zh active Active
- 2005-01-12 JP JP2006548349A patent/JP4613177B2/ja active Active
- 2005-01-12 KR KR1020067014050A patent/KR101229525B1/ko active IP Right Grant
- 2005-01-12 DE DE602005016073T patent/DE602005016073D1/de active Active
-
2006
- 2006-06-30 ZA ZA200605440A patent/ZA200605440B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2547695C (fr) | 2015-03-10 |
EP2192180A1 (fr) | 2010-06-02 |
US8252579B2 (en) | 2012-08-28 |
WO2005073364A2 (fr) | 2005-08-11 |
FR2864967B1 (fr) | 2006-05-19 |
CN1910278A (zh) | 2007-02-07 |
KR101229525B1 (ko) | 2013-02-04 |
SI1704230T1 (sl) | 2009-12-31 |
JP2007517517A (ja) | 2007-07-05 |
PL1704230T3 (pl) | 2010-01-29 |
DK1704230T3 (da) | 2009-11-02 |
FR2864967A1 (fr) | 2005-07-15 |
ATE440135T1 (de) | 2009-09-15 |
RU2407793C2 (ru) | 2010-12-27 |
JP4613177B2 (ja) | 2011-01-12 |
EP1704230B1 (fr) | 2009-08-19 |
KR20060123490A (ko) | 2006-12-01 |
PT1704230E (pt) | 2009-10-14 |
US20070072279A1 (en) | 2007-03-29 |
CN1910278B (zh) | 2010-05-26 |
EP1704230A2 (fr) | 2006-09-27 |
DE602005016073D1 (de) | 2009-10-01 |
WO2005073364A3 (fr) | 2005-09-29 |
ES2329914T3 (es) | 2009-12-02 |
ZA200605440B (en) | 2007-04-25 |
RU2006129295A (ru) | 2008-02-20 |
BRPI0506790B1 (pt) | 2020-12-22 |
CA2547695A1 (fr) | 2005-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0506790A (pt) | processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa | |
Denger et al. | Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle | |
Fesko et al. | Biocatalytic Methods for C C Bond Formation | |
Chan et al. | The rare fluorinated natural products and biotechnological prospects for fluorine enzymology | |
Rodriguez et al. | Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity | |
Kourist et al. | Biocatalytic synthesis of optically active tertiary alcohols | |
Bräutigam et al. | Asymmetric whole cell biotransformations in biphasic ionic liquid/water-systems by use of recombinant Escherichia coli with intracellular cofactor regeneration | |
JP7105783B2 (ja) | 組換え宿主におけるシトロネラール及びシトロネロールの生産 | |
Chen et al. | Mechanism of 2, 3-butanediol stereoisomer formation in Klebsiella pneumoniae | |
Zhao et al. | Exploiting tandem repetitive promoters for high-level production of 3-hydroxypropionic acid | |
CN104946575B (zh) | 一种高产酪醇和/或红景天苷和淫羊藿次苷d2的大肠杆菌表达菌株及其应用 | |
MXPA05008857A (es) | Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas. | |
Czajka et al. | Synthetic biology for manufacturing chemicals: constraints drive the use of non-conventional microbial platforms | |
Wang et al. | Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains | |
WO2009073557A3 (en) | Biological systems for production of commercially valuable compounds | |
BR112020017362A2 (pt) | Método para produzir vanilina | |
CA2987508A1 (en) | Biosynthesis of phenylpropanoids and phenylpropanoid derivatives | |
Gao et al. | Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose | |
Wang et al. | Improvement of NADPH bioavailability in Escherichia coli by replacing NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase GapA with NADP+-dependent GapB from Bacillus subtilis and addition of NAD kinase | |
BR112021011629A2 (pt) | Via de coprodução de derivados de 3-hp e acetil-coa a partir de malonato semialdeído | |
Ménil et al. | Tuning of the enzyme ratio in a neutral redox convergent cascade: A key approach for an efficient one‐pot/two‐step biocatalytic whole‐cell system | |
Bleem et al. | Multiplexed fitness profiling by RB-TnSeq elucidates pathways for lignin-related aromatic catabolism in Sphingobium sp. SYK-6 | |
Wang et al. | Identification of novel knockout and up-regulated targets for improving isoprenoid production in E. coli | |
US20180094281A1 (en) | Production of fragrant compounds | |
Henríquez et al. | Whole cell biosynthetic activity of Komagataella phaffii (Pichia pastoris) GS115 strains engineered with transgenes encoding Chromobacterium violaceum ω‐transaminase alone or combined with native transketolase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |