BRPI0506790A - processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepa - Google Patents
processos de preparação de uma cepa de microorganismos evoluìdos e de 1,2-propanodiol, e, cepaInfo
- Publication number
- BRPI0506790A BRPI0506790A BRPI0506790-1A BRPI0506790A BRPI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A BR PI0506790 A BRPI0506790 A BR PI0506790A
- Authority
- BR
- Brazil
- Prior art keywords
- propanediol
- microorganisms
- evolved
- strain
- preparing
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 7
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 title abstract 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 6
- 235000013772 propylene glycol Nutrition 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 229960004063 propylene glycol Drugs 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- GNGACRATGGDKBX-UHFFFAOYSA-N dihydroxyacetone phosphate Chemical compound OCC(=O)COP(O)(O)=O GNGACRATGGDKBX-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 abstract 1
- ABVQGNDUHAQLBS-UHFFFAOYSA-N 2-oxopropanal propanal Chemical compound CCC=O.CC(=O)C=O ABVQGNDUHAQLBS-UHFFFAOYSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004690 coupled electron pair approximation Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 abstract 1
- 101150080369 tpiA gene Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
- C12P7/28—Acetone-containing products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROCESSOS DE PREPARAçãO DE UMA CEPA DE MICROORGANISMOS EVOLUìDOS E DE 1,2-PROPANODIOL, E, CEPA" A invenção refere-se a um novo processo de preparação de um cepa de microorganismos evoluídos para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples, o dito processo compreendendo a cultura sob pressão de seleção em um meio de cultura adequado que compreende uma fonte de carbono simples, de uma cepa bacteriana inicial compreendendo uma deleção do gene tpiA e uma deleção de ao menos um gene implicado na conversão do metil glioxal (propanal) em lactato, a fim de fazer evoluir na dita cepa inicial um mais genes implicados na via de biosíntese do DHAP em metilglioxal e depois em 1,2-propanodiol para os genes evoluídos que têm uma atividade <sym>1,2-propanodiol síntase<sym> melhorada, e depois seleciona-se e isola-se a ou as cepas de microorganismos evoluídos que têm uma atividade <sym>1,2 propanodiol síntase<sym> melhorada. A invenção refere-se igualmente aos microorganismos iniciais e os microorganismos eveoluidos assim obtidos e um processo de preparação de 1,2-propanodiol e eventualmente de acetona por cultura dos microorganismos evoluídos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0400214 | 2004-01-12 | ||
| FR0400214A FR2864967B1 (fr) | 2004-01-12 | 2004-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
| PCT/FR2005/000070 WO2005073364A2 (fr) | 2004-01-12 | 2005-01-12 | Microorganisme evolue pour la production de 1,2-propanediol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0506790A true BRPI0506790A (pt) | 2007-05-22 |
| BRPI0506790B1 BRPI0506790B1 (pt) | 2020-12-22 |
Family
ID=34684930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0506790-1A BRPI0506790B1 (pt) | 2004-01-12 | 2005-01-12 | processo de preparação de uma cepa de escherichia coli evoluída para a produção de 1,2-propanodiol por metabolismo de uma fonte de carbono simples e processo de preparação de 1,2-propanodiol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8252579B2 (pt) |
| EP (2) | EP1704230B1 (pt) |
| JP (1) | JP4613177B2 (pt) |
| KR (1) | KR101229525B1 (pt) |
| CN (1) | CN1910278B (pt) |
| AT (1) | ATE440135T1 (pt) |
| BR (1) | BRPI0506790B1 (pt) |
| CA (1) | CA2547695C (pt) |
| DE (1) | DE602005016073D1 (pt) |
| DK (1) | DK1704230T3 (pt) |
| ES (1) | ES2329914T3 (pt) |
| FR (1) | FR2864967B1 (pt) |
| PL (1) | PL1704230T3 (pt) |
| PT (1) | PT1704230E (pt) |
| RU (1) | RU2407793C2 (pt) |
| SI (1) | SI1704230T1 (pt) |
| WO (1) | WO2005073364A2 (pt) |
| ZA (1) | ZA200605440B (pt) |
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| CN115261292B (zh) * | 2021-04-29 | 2023-06-09 | 中国科学院上海高等研究院 | 改造的克雷伯氏菌属细菌及其生产1,2-丙二醇的应用和方法 |
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|---|---|---|---|---|
| US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| BRPI0013315B8 (pt) * | 1999-08-18 | 2018-02-27 | Du Pont | fragmento de ácido nucleico isolado, polipeptídeo, gene quimérico, microorganismo, microorganismo recombinante , e. coli recombinante, linhagem klp23 de e. coli recombinante, linhagem rj8 de e. coli recombinante, vetor pdt29, vetor pkp32 e processos de bioprodução de 1,3-propanodiol |
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| EP2192180A1 (fr) | 2010-06-02 |
| US8252579B2 (en) | 2012-08-28 |
| WO2005073364A2 (fr) | 2005-08-11 |
| FR2864967B1 (fr) | 2006-05-19 |
| CN1910278A (zh) | 2007-02-07 |
| KR101229525B1 (ko) | 2013-02-04 |
| SI1704230T1 (sl) | 2009-12-31 |
| JP2007517517A (ja) | 2007-07-05 |
| PL1704230T3 (pl) | 2010-01-29 |
| DK1704230T3 (da) | 2009-11-02 |
| FR2864967A1 (fr) | 2005-07-15 |
| ATE440135T1 (de) | 2009-09-15 |
| RU2407793C2 (ru) | 2010-12-27 |
| JP4613177B2 (ja) | 2011-01-12 |
| EP1704230B1 (fr) | 2009-08-19 |
| KR20060123490A (ko) | 2006-12-01 |
| PT1704230E (pt) | 2009-10-14 |
| US20070072279A1 (en) | 2007-03-29 |
| CN1910278B (zh) | 2010-05-26 |
| EP1704230A2 (fr) | 2006-09-27 |
| DE602005016073D1 (de) | 2009-10-01 |
| WO2005073364A3 (fr) | 2005-09-29 |
| ES2329914T3 (es) | 2009-12-02 |
| ZA200605440B (en) | 2007-04-25 |
| RU2006129295A (ru) | 2008-02-20 |
| BRPI0506790B1 (pt) | 2020-12-22 |
| CA2547695A1 (fr) | 2005-08-11 |
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