BRPI0413215A - peptìdeos com capacidade de ligar-se a um fator de crescimento transformador beta 1(tgf-beta) - Google Patents
peptìdeos com capacidade de ligar-se a um fator de crescimento transformador beta 1(tgf-beta)Info
- Publication number
- BRPI0413215A BRPI0413215A BRPI0413215-7A BRPI0413215A BRPI0413215A BR PI0413215 A BRPI0413215 A BR PI0413215A BR PI0413215 A BRPI0413215 A BR PI0413215A BR PI0413215 A BRPI0413215 A BR PI0413215A
- Authority
- BR
- Brazil
- Prior art keywords
- tgf
- beta
- growth factor
- transforming growth
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PEPTìDEOS COM A CAPACIDADE PARA LIGAREM-SE A FATOR DE CRESCIMENTO TRANSFORMADOR BETA 1 (TGF-BETA 1) Os peptídeos descritos possuem a capacidade para ligarem-se a Fator de Crescimento Transformador TGF-beta 1 (TGF-beta1), e são potenciais inibidores da atividades biológica de TGF-beta 1 através da ligação direta a esta citoquina. Estes peptídeos podem ser usados no tratamento de doenças ou alterações patológicas baseadas na expressão TGF-beta 1 desregulada ou excessiva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200302020A ES2304069B1 (es) | 2003-08-22 | 2003-08-22 | Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1). |
PCT/ES2004/000320 WO2005019244A1 (es) | 2003-08-22 | 2004-07-05 | Péptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-beta1) |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413215A true BRPI0413215A (pt) | 2007-06-19 |
Family
ID=34203356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413215-7A BRPI0413215A (pt) | 2003-08-22 | 2004-07-05 | peptìdeos com capacidade de ligar-se a um fator de crescimento transformador beta 1(tgf-beta) |
Country Status (18)
Country | Link |
---|---|
US (1) | US7666841B2 (pt) |
EP (1) | EP1669367B1 (pt) |
JP (1) | JP4902352B2 (pt) |
CN (1) | CN100424093C (pt) |
AT (1) | ATE479702T1 (pt) |
AU (2) | AU2004266856A1 (pt) |
BR (1) | BRPI0413215A (pt) |
CA (1) | CA2535807A1 (pt) |
CY (1) | CY1110885T1 (pt) |
DE (1) | DE602004028949D1 (pt) |
DK (1) | DK1669367T3 (pt) |
ES (2) | ES2304069B1 (pt) |
HR (1) | HRP20100637T1 (pt) |
PL (1) | PL1669367T3 (pt) |
PT (1) | PT1669367E (pt) |
RU (2) | RU2333917C2 (pt) |
SI (1) | SI1669367T1 (pt) |
WO (1) | WO2005019244A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8158589B2 (en) * | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
AU2005337776B2 (en) * | 2005-10-24 | 2013-01-31 | Proyecto De Biomedicina Cima, S.L. | Use of TGF-Beta1 inhibitor peptides in the preparation of an immune response modulating agent |
ES2327088B1 (es) * | 2007-08-20 | 2010-07-26 | Proyecto De Biomedicina Cima S.L. | Combinaciones terapeuticas para el tratamiento de las metastasis. |
ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
CN102123737B (zh) | 2008-06-13 | 2014-01-01 | 西马生物医学计划公司 | 用于生物活性化合物施用的轭合物 |
AU2010210033A1 (en) * | 2009-02-05 | 2011-08-04 | Digna Biotech, S.L. | Pharmaceutical compositions comprising TGF- beta1 inhibitor peptides |
RU2012123145A (ru) | 2009-11-05 | 2013-12-10 | Проекто Де Биомедисина Сима, С.Л. | Генный конструкт (варианты), вектор и рекомбинантный вирусный геном на его основе, вирион, их фармацевтическая композиция, способ in vitro экспрессии полинуклеотида в клетке печеночной природы, лекарственное средство, способ лечения заболевания печени (варианты), индуцируемый двунаправленный оператор-промотор |
WO2012001196A2 (es) | 2010-06-28 | 2012-01-05 | Proyecto De Biomedicina Cima, S.L. | Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos |
KR101029705B1 (ko) * | 2010-06-30 | 2011-04-18 | (주)엔솔테크 | 신규 펩타이드 및 그 용도 |
EP2407534A1 (en) | 2010-07-14 | 2012-01-18 | Neo Virnatech, S.L. | Methods and reagents for obtaining transcriptionally active virus-like particles and recombinant virions |
CA2857073A1 (en) | 2011-11-28 | 2013-06-06 | Institucio Catalana De Recerca I Estudis Avancats | Methods and kits for the prognosis of colorectal cancer |
WO2013113755A1 (en) | 2012-01-30 | 2013-08-08 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Reagents and methods for the treatment of diseases based on the inhibition of calcineurin - nfat signalling pathway |
ES2791627T3 (es) | 2012-11-12 | 2020-11-05 | Inst Catalana Recerca Estudis Avancats | Métodos y kits para el pronóstico del cáncer colorrectal |
US20140170158A1 (en) * | 2012-12-17 | 2014-06-19 | The Johns Hopkins University | Compositions and methods for treating or preventing lung diseases |
ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
EP3069732B1 (en) | 2013-11-14 | 2023-07-12 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
US20170121685A1 (en) | 2015-11-02 | 2017-05-04 | Tigenix S.A.U. | Mesenchymal stem cell-derived exosomes and their uses |
WO2017110093A1 (ja) | 2015-12-24 | 2017-06-29 | 学校法人同志社 | TGF-βシグナルに起因する障害を治療または予防するための医薬およびその応用 |
GB201707561D0 (en) * | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
JPWO2019022152A1 (ja) | 2017-07-26 | 2020-07-27 | 学校法人同志社 | TGF−βシグナルに起因する障害を治療または予防するための医薬およびその応用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08151396A (ja) * | 1994-11-28 | 1996-06-11 | Teijin Ltd | Hla結合性オリゴペプチド及びそれを含有する免疫調節剤 |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
ES2146552B1 (es) * | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
US6509318B1 (en) * | 2000-09-29 | 2003-01-21 | The Regents Of The University Of California | TGF-B inhibitors and methods |
CN1826137A (zh) * | 2002-11-01 | 2006-08-30 | 博伊斯镇国家研究医院 | α1β1整联蛋白的可诱导的配体和用途 |
-
2003
- 2003-08-22 ES ES200302020A patent/ES2304069B1/es not_active Expired - Fee Related
-
2004
- 2004-07-05 WO PCT/ES2004/000320 patent/WO2005019244A1/es active Application Filing
- 2004-07-05 DE DE602004028949T patent/DE602004028949D1/de not_active Expired - Lifetime
- 2004-07-05 CA CA002535807A patent/CA2535807A1/en not_active Abandoned
- 2004-07-05 PL PL04742049T patent/PL1669367T3/pl unknown
- 2004-07-05 EP EP04742049A patent/EP1669367B1/en not_active Expired - Lifetime
- 2004-07-05 DK DK04742049.2T patent/DK1669367T3/da active
- 2004-07-05 ES ES04742049T patent/ES2351865T3/es not_active Expired - Lifetime
- 2004-07-05 SI SI200431516T patent/SI1669367T1/sl unknown
- 2004-07-05 JP JP2006524375A patent/JP4902352B2/ja not_active Expired - Fee Related
- 2004-07-05 AT AT04742049T patent/ATE479702T1/de active
- 2004-07-05 US US10/569,012 patent/US7666841B2/en not_active Expired - Fee Related
- 2004-07-05 PT PT04742049T patent/PT1669367E/pt unknown
- 2004-07-05 RU RU2006109011/13A patent/RU2333917C2/ru not_active IP Right Cessation
- 2004-07-05 BR BRPI0413215-7A patent/BRPI0413215A/pt not_active IP Right Cessation
- 2004-07-05 CN CNB200480024201XA patent/CN100424093C/zh not_active Expired - Fee Related
- 2004-07-05 AU AU2004266856A patent/AU2004266856A1/en not_active Abandoned
-
2008
- 2008-04-21 RU RU2008115678/10A patent/RU2455358C2/ru not_active IP Right Cessation
-
2010
- 2010-08-20 AU AU2010212466A patent/AU2010212466B2/en not_active Ceased
- 2010-11-12 CY CY20101101024T patent/CY1110885T1/el unknown
- 2010-11-24 HR HR20100637T patent/HRP20100637T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
ATE479702T1 (de) | 2010-09-15 |
CN100424093C (zh) | 2008-10-08 |
HRP20100637T1 (hr) | 2010-12-31 |
RU2333917C2 (ru) | 2008-09-20 |
DE602004028949D1 (en) | 2010-10-14 |
US20070142275A1 (en) | 2007-06-21 |
AU2010212466B2 (en) | 2012-07-19 |
SI1669367T1 (sl) | 2010-11-30 |
AU2004266856A1 (en) | 2005-03-03 |
DK1669367T3 (da) | 2010-11-08 |
EP1669367B1 (en) | 2010-09-01 |
CA2535807A1 (en) | 2005-03-03 |
JP2007525204A (ja) | 2007-09-06 |
RU2006109011A (ru) | 2006-07-27 |
ES2304069B1 (es) | 2009-08-12 |
CY1110885T1 (el) | 2015-06-10 |
JP4902352B2 (ja) | 2012-03-21 |
PL1669367T3 (pl) | 2011-02-28 |
RU2008115678A (ru) | 2009-10-27 |
US7666841B2 (en) | 2010-02-23 |
AU2010212466A1 (en) | 2010-09-09 |
CN1839149A (zh) | 2006-09-27 |
WO2005019244A1 (es) | 2005-03-03 |
PT1669367E (pt) | 2010-12-07 |
ES2304069A1 (es) | 2008-09-01 |
EP1669367A1 (en) | 2006-06-14 |
ES2351865T3 (es) | 2011-02-11 |
RU2455358C2 (ru) | 2012-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2261 DE 06/05/2014. |