BRPI0412404A - uso de rapamicina e de derivado da rapamicina para o tratamento da perda óssea - Google Patents
uso de rapamicina e de derivado da rapamicina para o tratamento da perda ósseaInfo
- Publication number
- BRPI0412404A BRPI0412404A BRPI0412404-9A BRPI0412404A BRPI0412404A BR PI0412404 A BRPI0412404 A BR PI0412404A BR PI0412404 A BRPI0412404 A BR PI0412404A BR PI0412404 A BRPI0412404 A BR PI0412404A
- Authority
- BR
- Brazil
- Prior art keywords
- rapamycin
- treatment
- bone loss
- derivative
- rapamycin derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"USO DA RAPAMICINA E DE DERIVADO DA RAPAMICINA PARA O TRATAMENTO DA PERDA óSSEA". A presente invenção refere-se a um novo uso da rapamicina e de derivados da rapamicina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0315965A GB0315965D0 (en) | 2003-07-08 | 2003-07-08 | Organic compounds |
GB0315963A GB0315963D0 (en) | 2003-07-08 | 2003-07-08 | Organic compounds |
PCT/EP2004/007437 WO2005005434A1 (en) | 2003-07-08 | 2004-07-07 | Use of rapamycin and rapamycin derivatives for the treatment of bone loss |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412404A true BRPI0412404A (pt) | 2006-09-05 |
Family
ID=34066609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412404-9A BRPI0412404A (pt) | 2003-07-08 | 2004-07-07 | uso de rapamicina e de derivado da rapamicina para o tratamento da perda óssea |
Country Status (13)
Country | Link |
---|---|
US (3) | US20060173033A1 (pt) |
EP (1) | EP1646634B1 (pt) |
JP (1) | JP4755981B2 (pt) |
AT (1) | ATE414089T1 (pt) |
AU (1) | AU2004255340B2 (pt) |
BR (1) | BRPI0412404A (pt) |
CA (1) | CA2531454C (pt) |
DE (1) | DE602004017736D1 (pt) |
ES (1) | ES2316995T3 (pt) |
MX (1) | MXPA06000117A (pt) |
PL (1) | PL1646634T3 (pt) |
PT (1) | PT1646634E (pt) |
WO (1) | WO2005005434A1 (pt) |
Families Citing this family (86)
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EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
DK1636585T3 (da) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurinstoffer med kinasehæmmende aktivitet |
CL2004001834A1 (es) | 2003-07-23 | 2005-06-03 | Bayer Pharmaceuticals Corp | Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol |
CA2637255C (en) * | 2006-02-02 | 2018-06-12 | Novartis Ag | 40-o-(2-hydroxyethyl)-rapamycin for treating tuberous sclerosis disorders |
WO2008022256A2 (en) * | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
KR100937456B1 (ko) | 2007-08-01 | 2010-01-19 | 한국생명공학연구원 | 인간배아줄기세포를 조골세포 직계열로 분화시키는 방법 |
CN104997774A (zh) | 2009-04-10 | 2015-10-28 | 齐海燕 | 新的抗衰老试剂及其鉴别方法 |
US20140248372A1 (en) | 2011-09-19 | 2014-09-04 | Emory University | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CA2856520C (en) | 2011-11-23 | 2021-04-06 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
PT2974728T (pt) | 2013-03-13 | 2020-07-21 | Santen Pharmaceutical Co Ltd | Agente terapêutico para a disfunção meibomiana |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
JP6709493B2 (ja) * | 2015-01-26 | 2020-06-17 | 国立大学法人京都大学 | 進行性骨化性線維異形成症治療剤 |
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CA3020153A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
CN110366550A (zh) | 2016-12-22 | 2019-10-22 | 美国安进公司 | 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物 |
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JP2022542319A (ja) | 2019-08-02 | 2022-09-30 | アムジエン・インコーポレーテツド | Kif18a阻害剤 |
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TW202216151A (zh) | 2020-07-15 | 2022-05-01 | 日商大鵬藥品工業股份有限公司 | 含有使用於腫瘤之治療之嘧啶化合物之組合 |
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GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
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US20030220297A1 (en) * | 2002-02-01 | 2003-11-27 | Berstein David L. | Phosphorus-containing compounds and uses thereof |
-
2004
- 2004-07-07 MX MXPA06000117A patent/MXPA06000117A/es active IP Right Grant
- 2004-07-07 JP JP2006518133A patent/JP4755981B2/ja not_active Expired - Fee Related
- 2004-07-07 ES ES04740750T patent/ES2316995T3/es active Active
- 2004-07-07 AT AT04740750T patent/ATE414089T1/de active
- 2004-07-07 EP EP04740750A patent/EP1646634B1/en not_active Not-in-force
- 2004-07-07 AU AU2004255340A patent/AU2004255340B2/en not_active Ceased
- 2004-07-07 US US10/563,707 patent/US20060173033A1/en not_active Abandoned
- 2004-07-07 PL PL04740750T patent/PL1646634T3/pl unknown
- 2004-07-07 BR BRPI0412404-9A patent/BRPI0412404A/pt not_active IP Right Cessation
- 2004-07-07 WO PCT/EP2004/007437 patent/WO2005005434A1/en active Search and Examination
- 2004-07-07 PT PT04740750T patent/PT1646634E/pt unknown
- 2004-07-07 CA CA2531454A patent/CA2531454C/en not_active Expired - Fee Related
- 2004-07-07 DE DE602004017736T patent/DE602004017736D1/de active Active
-
2009
- 2009-03-05 US US12/398,225 patent/US20090221503A1/en not_active Abandoned
-
2012
- 2012-05-18 US US13/475,044 patent/US20120232011A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE414089T1 (de) | 2008-11-15 |
PT1646634E (pt) | 2009-02-16 |
AU2004255340A1 (en) | 2005-01-20 |
AU2004255340B2 (en) | 2008-05-01 |
JP2009513522A (ja) | 2009-04-02 |
DE602004017736D1 (de) | 2008-12-24 |
WO2005005434A1 (en) | 2005-01-20 |
CA2531454A1 (en) | 2005-01-20 |
US20120232011A1 (en) | 2012-09-13 |
US20090221503A1 (en) | 2009-09-03 |
PL1646634T3 (pl) | 2009-04-30 |
EP1646634B1 (en) | 2008-11-12 |
CA2531454C (en) | 2011-10-25 |
EP1646634A1 (en) | 2006-04-19 |
ES2316995T3 (es) | 2009-04-16 |
JP4755981B2 (ja) | 2011-08-24 |
MXPA06000117A (es) | 2006-04-27 |
US20060173033A1 (en) | 2006-08-03 |
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