BRPI0411721A - derivados de tiazolilpiperidina como inibidores de mtp - Google Patents
derivados de tiazolilpiperidina como inibidores de mtpInfo
- Publication number
- BRPI0411721A BRPI0411721A BRPI0411721-2A BRPI0411721A BRPI0411721A BR PI0411721 A BRPI0411721 A BR PI0411721A BR PI0411721 A BRPI0411721 A BR PI0411721A BR PI0411721 A BRPI0411721 A BR PI0411721A
- Authority
- BR
- Brazil
- Prior art keywords
- mtp inhibitors
- thiazolylpiperidine derivatives
- thiazolylpiperidine
- derivatives
- radical selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
"DERIVADOS DE TIAZOLILPIPERIDINA COMO INIBIDORES DE MTP". A presente invenção refere-se aos derivados de tiazolilpiperidina da fórmula geral (1): em que: A representa um radical selecionado dos radicais a1 e a2 abaixo: G representa uma ligação ou um radical divalente selecionado dos grupos g¬ 1¬, g¬ 2¬ e g¬ 3¬ abaixo: e R¬ 1¬, R¬ 2¬, R¬ 2¬<39>, R¬ 3¬, R¬ 4¬, R¬ 5¬, Y e Z são como definidos na descrição. Aplicação dos compostos da fórmula (1) para o tratamento de hipertrigliceridemia, hi-percolesterolemia e dislipidemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0307670A FR2856685B1 (fr) | 2003-06-25 | 2003-06-25 | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
PCT/EP2004/005931 WO2005003128A1 (en) | 2003-06-25 | 2004-06-02 | Thiazolylpiperidine derivatives as mtp inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0411721A true BRPI0411721A (pt) | 2006-05-23 |
Family
ID=33515396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411721-2A BRPI0411721A (pt) | 2003-06-25 | 2004-06-02 | derivados de tiazolilpiperidina como inibidores de mtp |
Country Status (18)
Country | Link |
---|---|
US (1) | US7674803B2 (pt) |
EP (1) | EP1636218B1 (pt) |
JP (1) | JP4629666B2 (pt) |
KR (1) | KR20060024812A (pt) |
CN (1) | CN1809560A (pt) |
AR (1) | AR044909A1 (pt) |
AT (1) | ATE426599T1 (pt) |
AU (1) | AU2004253649B2 (pt) |
BR (1) | BRPI0411721A (pt) |
CA (1) | CA2531011C (pt) |
DE (1) | DE602004020223D1 (pt) |
ES (1) | ES2323463T3 (pt) |
FR (1) | FR2856685B1 (pt) |
MX (1) | MXPA05013521A (pt) |
RU (1) | RU2006101890A (pt) |
TW (1) | TW200518751A (pt) |
WO (1) | WO2005003128A1 (pt) |
ZA (1) | ZA200600690B (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2865733B1 (fr) * | 2004-02-04 | 2007-10-12 | Merck Sante Sas | Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine |
CA2580725A1 (en) * | 2004-09-20 | 2006-03-30 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
US20100267717A1 (en) * | 2005-07-29 | 2010-10-21 | 4Sc Ag | Novel Heterocyclic NF-kB Inhibitors |
US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
NZ565470A (en) * | 2005-07-29 | 2010-11-26 | 4Sc Ag | Novel heterocyclic NF-kB inhibitors |
ATE430744T1 (de) * | 2005-08-18 | 2009-05-15 | Hoffmann La Roche | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren |
EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
JP2009529555A (ja) * | 2006-03-15 | 2009-08-20 | 4エスツェー アクチェンゲゼルシャフト | 新規複素環式NF−κB阻害薬 |
EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
WO2007115805A2 (en) * | 2006-04-05 | 2007-10-18 | European Molecular Biology Laboratory (Embl) | Aurora kinase inhibitors |
MX2008013400A (es) | 2006-04-19 | 2008-11-10 | Astellas Pharma Inc | Derivado de azolcarboxamida. |
EP2043655A2 (en) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
US8318735B2 (en) * | 2006-10-31 | 2012-11-27 | Merck Sharp & Dohme Corp. | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
WO2008054702A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
JP5337711B2 (ja) * | 2007-01-25 | 2013-11-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺菌性アミド |
DE102007047735A1 (de) | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Thiazolderivate |
KR101494734B1 (ko) | 2007-10-11 | 2015-02-26 | 아스트라제네카 아베 | 단백질 키나제 b 억제제로서 피롤로[2,3-d]피리미딘 유도체 |
TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
BRPI0818201B8 (pt) | 2007-10-24 | 2021-05-25 | Astellas Pharma Inc | composto de azolcarboxamida ou sal do mesmo e uso do mesmo para o tratamento de frequência urinária, urgência urinária, incontinência urinária e dores do trato urinário inferior associadas com várias doenças do trato urinário inferior, e várias doenças acompanhadas de dor |
CN101910165A (zh) * | 2007-10-29 | 2010-12-08 | 先灵公司 | 作为蛋白质激酶抑制剂的噻唑衍生物 |
EP2402332A3 (en) | 2008-01-25 | 2014-10-29 | E.I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
BRPI0910837B1 (pt) | 2008-04-30 | 2017-03-07 | Bayer Cropscience Ag | ésteres e tioésteres tiazol-4-carboxílicos, seus usos, e método e composição para controlar fungos fitopatogênicos prejudiciais |
WO2010037479A1 (de) * | 2008-10-01 | 2010-04-08 | Bayer Cropscience Ag | Heterocyclyl substituierte thiazole als pflanzenschutzmittel |
EP2358709B1 (en) | 2008-12-02 | 2014-01-22 | E. I. du Pont de Nemours and Company | Fungicidal heterocyclic compounds |
US8889674B2 (en) * | 2009-03-05 | 2014-11-18 | Shionogi & Co., Ltd. | Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism |
EP2272846A1 (de) * | 2009-06-23 | 2011-01-12 | Bayer CropScience AG | Thiazolylpiperidin Derivate als Fungizide |
GEP20146079B (en) * | 2009-08-12 | 2014-04-25 | Syngenta Participations Ag | Microbiocidal heterocycles |
WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
MX2012005067A (es) | 2009-10-30 | 2012-06-13 | Bayer Cropscience Ag | Derivados de heteroarilpiperidina y heteroarilpiperazina. |
EP2516424B1 (en) * | 2009-12-22 | 2013-12-18 | Syngenta Participations AG | Pyrazole derivatives |
EP2563786B1 (de) * | 2010-04-28 | 2016-11-02 | Bayer Intellectual Property GmbH | Ketoheteroarylpiperidin und -piperazin Derivate als Fungizide |
EP2595989B1 (en) | 2010-05-06 | 2016-07-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
US8815775B2 (en) * | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
BR112013019667B1 (pt) * | 2011-02-01 | 2019-07-02 | Bayer Intellectual Property Gmbh | Compostos derivados de heteroaril-piperidina e -piperazina, seus usos, composição, processos de produção de compostos e de composições, método para o controle de fungos fitopatogênicos prejudiciais |
EP2670752B1 (en) | 2011-02-02 | 2016-03-16 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
AR085333A1 (es) * | 2011-02-10 | 2013-09-25 | Syngenta Participations Ag | Derivados de pirazol microbicidas |
WO2012112743A1 (en) * | 2011-02-18 | 2012-08-23 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
SI2694056T1 (sl) | 2011-04-01 | 2019-12-31 | Astrazeneca Ab | Terapevtsko zdravljenje |
PL2785349T5 (pl) | 2011-11-30 | 2023-01-30 | Astrazeneca Ab | Kombinacja do leczenia nowotworu |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
EP3573619A4 (en) * | 2017-01-27 | 2020-10-28 | SignalRX Pharmaceuticals, Inc. | THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN AND CHECKPOINT INHIBITORS |
US11312685B2 (en) * | 2017-04-28 | 2022-04-26 | Texas Heart Institute | Targeting nanoparticles |
CN111196805A (zh) * | 2018-11-17 | 2020-05-26 | 曲阜德禄生物科技有限公司 | 哌啶基噻唑甲酰胺类化合物合成方法与用途 |
CA3183111A1 (en) * | 2020-05-12 | 2021-11-18 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of nmda receptor, and pharmaceutical composition and use thereof |
WO2024155864A1 (en) * | 2023-01-20 | 2024-07-25 | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. | Sprk1 inhibitors and methods of use |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 5員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
CN1210267C (zh) * | 2000-04-04 | 2005-07-13 | 史密斯克莱·比奇曼公司 | 用于抗菌的2-羟基-姆替林氨基甲酸酯衍生物 |
FR2816940A1 (fr) * | 2000-11-23 | 2002-05-24 | Lipha | Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation |
GB0129013D0 (en) * | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
-
2003
- 2003-06-25 FR FR0307670A patent/FR2856685B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-02 RU RU2006101890/04A patent/RU2006101890A/ru unknown
- 2004-06-02 CA CA2531011A patent/CA2531011C/en not_active Expired - Fee Related
- 2004-06-02 DE DE602004020223T patent/DE602004020223D1/de not_active Expired - Lifetime
- 2004-06-02 MX MXPA05013521A patent/MXPA05013521A/es unknown
- 2004-06-02 EP EP04735742A patent/EP1636218B1/en not_active Expired - Lifetime
- 2004-06-02 WO PCT/EP2004/005931 patent/WO2005003128A1/en active Application Filing
- 2004-06-02 KR KR1020057024663A patent/KR20060024812A/ko not_active Application Discontinuation
- 2004-06-02 CN CNA2004800157394A patent/CN1809560A/zh active Pending
- 2004-06-02 US US10/561,989 patent/US7674803B2/en not_active Expired - Fee Related
- 2004-06-02 AU AU2004253649A patent/AU2004253649B2/en not_active Ceased
- 2004-06-02 BR BRPI0411721-2A patent/BRPI0411721A/pt not_active IP Right Cessation
- 2004-06-02 ES ES04735742T patent/ES2323463T3/es not_active Expired - Lifetime
- 2004-06-02 JP JP2006515818A patent/JP4629666B2/ja not_active Expired - Fee Related
- 2004-06-02 AT AT04735742T patent/ATE426599T1/de not_active IP Right Cessation
- 2004-06-21 TW TW093117985A patent/TW200518751A/zh unknown
- 2004-06-25 AR ARP040102230A patent/AR044909A1/es unknown
-
2006
- 2006-01-24 ZA ZA200600690A patent/ZA200600690B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2323463T3 (es) | 2009-07-16 |
ATE426599T1 (de) | 2009-04-15 |
JP4629666B2 (ja) | 2011-02-09 |
US20070054939A1 (en) | 2007-03-08 |
RU2006101890A (ru) | 2007-07-27 |
ZA200600690B (en) | 2007-05-30 |
EP1636218B1 (en) | 2009-03-25 |
FR2856685B1 (fr) | 2005-09-23 |
AR044909A1 (es) | 2005-10-05 |
JP2007506651A (ja) | 2007-03-22 |
CA2531011C (en) | 2012-10-09 |
WO2005003128A1 (en) | 2005-01-13 |
CA2531011A1 (en) | 2005-01-13 |
AU2004253649B2 (en) | 2009-09-24 |
KR20060024812A (ko) | 2006-03-17 |
US7674803B2 (en) | 2010-03-09 |
EP1636218A1 (en) | 2006-03-22 |
FR2856685A1 (fr) | 2004-12-31 |
MXPA05013521A (es) | 2006-03-09 |
DE602004020223D1 (de) | 2009-05-07 |
TW200518751A (en) | 2005-06-16 |
CN1809560A (zh) | 2006-07-26 |
AU2004253649A1 (en) | 2005-01-13 |
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