BRPI0410986A - derivados de estaurosporina para sìndrome hipereosinofìlica - Google Patents
derivados de estaurosporina para sìndrome hipereosinofìlicaInfo
- Publication number
- BRPI0410986A BRPI0410986A BRPI0410986-4A BRPI0410986A BRPI0410986A BR PI0410986 A BRPI0410986 A BR PI0410986A BR PI0410986 A BRPI0410986 A BR PI0410986A BR PI0410986 A BRPI0410986 A BR PI0410986A
- Authority
- BR
- Brazil
- Prior art keywords
- hypereosinophilic syndrome
- pdgfr
- staurosporine derivatives
- derivatives
- fip1l1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/48—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed
- G11B5/4806—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed specially adapted for disk drive assemblies, e.g. assembly prior to operation, hard or flexible disk drives
- G11B5/4813—Mounting or aligning of arm assemblies, e.g. actuator arm supported by bearings, multiple arm assemblies, arm stacks or multiple heads on single arm
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/48—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed
- G11B5/54—Disposition or mounting of heads or head supports relative to record carriers ; arrangements of heads, e.g. for scanning the record carrier to increase the relative speed with provision for moving the head into or out of its operative position or across tracks
- G11B5/55—Track change, selection or acquisition by displacement of the head
- G11B5/5521—Track change, selection or acquisition by displacement of the head across disk tracks
- G11B5/5526—Control therefor; circuits, track configurations or relative disposition of servo-information transducers and servo-information tracks for control thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Moving Of Heads (AREA)
Abstract
"DERIVADOS DE ESTAUROSPORINA PARA SìNDROME HIPEREOSINOFìLICA". A presente invenção refere-se ao uso de derivados de estaurosporina para a preparação de uma droga para o tratamento de doenças mieloproliferativas induzidas por FIP1L1-PDGFR<244>, especialmente para o tratamento curativo e/ou profilático de síndrome hipereosinofílica e síndrome hipereosinofílica com resistência a imatinib, e a um método de tratar síndrome hipereosinofílica e síndrome hipereosinofílica com resistência a imatinib, ou outras doenças associadas a FIP1L1-PDGFR<244> ou mutações similares que ativam PDGFR<244>.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47637603P | 2003-06-06 | 2003-06-06 | |
PCT/EP2004/006070 WO2004108132A1 (en) | 2003-06-06 | 2004-06-04 | Staurosporine derivatives for hypereosinophilic syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0410986A true BRPI0410986A (pt) | 2006-07-04 |
Family
ID=33511782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410986-4A BRPI0410986A (pt) | 2003-06-06 | 2004-06-04 | derivados de estaurosporina para sìndrome hipereosinofìlica |
Country Status (9)
Country | Link |
---|---|
US (2) | US20040246627A1 (pt) |
EP (1) | EP1635819A1 (pt) |
JP (1) | JP2006527181A (pt) |
CN (1) | CN1816333A (pt) |
AU (1) | AU2004244747B2 (pt) |
BR (1) | BRPI0410986A (pt) |
CA (1) | CA2528156A1 (pt) |
MX (1) | MXPA05013200A (pt) |
WO (1) | WO2004108132A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0308957D0 (en) * | 2003-04-17 | 2003-05-28 | Lillishall Plastics And Engine | Tolerance ring assembly |
JP2005339655A (ja) * | 2004-05-26 | 2005-12-08 | Hitachi Global Storage Technologies Netherlands Bv | 回転円板形記憶装置 |
GB0419159D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
GB0425856D0 (en) * | 2004-11-24 | 2004-12-29 | Rencol Tolerance Rings Ltd | Fixing of components |
SG130178A1 (en) * | 2005-08-31 | 2007-03-20 | Samsung Electronics Co Ltd | Actuator and hard disk drive employing the same |
US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
US7554771B2 (en) * | 2006-09-11 | 2009-06-30 | Intri-Plex Technologies, Inc. | Tolerance ring for data storage with overlapping tab feature for mass control |
US20090279211A1 (en) * | 2008-05-07 | 2009-11-12 | Sae Magnetics (Hk) Ltd. | Bearing apparatus for a hard disk drive |
US8944690B2 (en) * | 2009-08-28 | 2015-02-03 | Saint-Gobain Performance Plastics Pampus Gmbh | Corrosion resistant bushing |
TWI487850B (zh) | 2009-09-25 | 2015-06-11 | Saint Gobain Performance Plast | 用於滑移介面滑動力的公差環控制之系統、方法和裝置 |
US8579514B2 (en) * | 2010-04-26 | 2013-11-12 | Seagate Technology Llc | Press fitting a cartridge bearing |
US9293162B1 (en) * | 2014-09-09 | 2016-03-22 | HGST Netherlands B.V. | Actuator comb having a stepped inner bore |
EP3250902B1 (en) * | 2015-01-27 | 2024-05-08 | Ventana Medical Systems, Inc. | Methods for tissue sample fixation using an extended soak in aldehyde-based fixative solutions |
US9620155B2 (en) | 2015-07-23 | 2017-04-11 | Seagate Technology Llc | Disc drive actuator bearing cartridge assembly with temperature induced rotational torque mitigation |
KR102399149B1 (ko) | 2017-12-15 | 2022-05-19 | 생-고뱅 퍼포먼스 플라스틱스 렌콜 리미티드 | 구성 요소 변위 제어를 위한 환형 부재, 방법 및 어셈블리 |
CN115054606B (zh) * | 2022-04-14 | 2023-12-29 | 华中农业大学 | 一种猪链球菌丝氨酸苏氨酸蛋白激酶抑制剂及其应用 |
JP2024046316A (ja) * | 2022-09-22 | 2024-04-03 | 株式会社東芝 | ディスク装置 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
US5315465A (en) * | 1991-07-12 | 1994-05-24 | Seagate Technology, Inc. | Compliant pivot mechanism for a rotary actuator |
GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
JP2675986B2 (ja) * | 1994-02-18 | 1997-11-12 | インターナショナル・ビジネス・マシーンズ・コーポレイション | 複合アクチュエータベアリングシステムを有する直接アクセス記憶装置及びその方法 |
US5524343A (en) * | 1994-03-18 | 1996-06-11 | Seagate Technology, Inc. | Press-fit glueless bearing pivot assembly |
US5654849A (en) * | 1995-10-24 | 1997-08-05 | Western Digital Corporation | Molded swing-type actuator assembly with press-fit pivot and spring-loaded ground conductor elements |
US5666242A (en) * | 1995-11-21 | 1997-09-09 | Western Digital Corporation | Disk drive having elastomeric interface in pivot bearing assembly |
US5757588A (en) * | 1996-06-28 | 1998-05-26 | Western Digital Corporation | Hard disk assembly having a pivot bearing assembly comprising fingers bearing on a shaft |
US5818665A (en) * | 1996-11-26 | 1998-10-06 | Western Digital Corporation | Rotary actuator arrangement and method of manufacture |
US5727882A (en) * | 1997-03-27 | 1998-03-17 | Western Digital Corporation | Pivot bearing assembly providing damping for unit-to-unit consistency |
US5894382A (en) * | 1998-01-05 | 1999-04-13 | Western Digital Corporation | Head stack assembly for a disk drive having a plastic inner sleeve |
US6372314B1 (en) * | 1998-01-07 | 2002-04-16 | Intri-Plex Technologies, Inc. | Base plate with toothed hub for press-in attachment of suspension assembly in hard disk drive |
US6018441A (en) * | 1998-06-08 | 2000-01-25 | Read-Rite Corporation | Disk drive pivot bearing and actuator arm assembly |
SG128410A1 (en) * | 2000-08-23 | 2007-01-30 | Seagate Technology Llc | Actuator pivot assembly |
US6519116B1 (en) * | 2000-11-30 | 2003-02-11 | Western Digital Technologies, Inc. | Actuator arm assembly having bearing gap formed between bearing outer race and pivot sleeve for mitigating torque ripple on actuator arm in a disk drive |
-
2004
- 2004-03-24 US US10/807,892 patent/US20040246627A1/en not_active Abandoned
- 2004-06-04 WO PCT/EP2004/006070 patent/WO2004108132A1/en active Application Filing
- 2004-06-04 US US10/559,502 patent/US20060229290A1/en not_active Abandoned
- 2004-06-04 CN CNA2004800186240A patent/CN1816333A/zh active Pending
- 2004-06-04 CA CA002528156A patent/CA2528156A1/en not_active Abandoned
- 2004-06-04 BR BRPI0410986-4A patent/BRPI0410986A/pt not_active IP Right Cessation
- 2004-06-04 MX MXPA05013200A patent/MXPA05013200A/es unknown
- 2004-06-04 AU AU2004244747A patent/AU2004244747B2/en not_active Ceased
- 2004-06-04 JP JP2006508282A patent/JP2006527181A/ja active Pending
- 2004-06-04 EP EP04739621A patent/EP1635819A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2528156A1 (en) | 2004-12-16 |
WO2004108132A1 (en) | 2004-12-16 |
JP2006527181A (ja) | 2006-11-30 |
EP1635819A1 (en) | 2006-03-22 |
AU2004244747A1 (en) | 2004-12-16 |
AU2004244747B2 (en) | 2008-05-08 |
US20060229290A1 (en) | 2006-10-12 |
MXPA05013200A (es) | 2006-03-09 |
US20040246627A1 (en) | 2004-12-09 |
CN1816333A (zh) | 2006-08-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |