BRPI0407662A - derivados do ácido 1-fenilalcanocarboxìlico para o tratamento de doenças neurodegenerativas - Google Patents

derivados do ácido 1-fenilalcanocarboxìlico para o tratamento de doenças neurodegenerativas

Info

Publication number
BRPI0407662A
BRPI0407662A BRPI0407662-1A BRPI0407662A BRPI0407662A BR PI0407662 A BRPI0407662 A BR PI0407662A BR PI0407662 A BRPI0407662 A BR PI0407662A BR PI0407662 A BRPI0407662 A BR PI0407662A
Authority
BR
Brazil
Prior art keywords
treatment
acid derivatives
neurodegenerative diseases
phenylalkanecarboxylic acid
phenylalkanecarboxylic
Prior art date
Application number
BRPI0407662-1A
Other languages
English (en)
Inventor
Luca Raveglia
Ilaria Peretto
Stefano Radaelli
Bruno Pietro Imbimbo
Andrea Rizzi
Gino Villetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20030311 external-priority patent/ITMI20030311A1/it
Priority claimed from ITMI20032068 external-priority patent/ITMI20032068A1/it
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BRPI0407662A publication Critical patent/BRPI0407662A/pt
Publication of BRPI0407662B1 publication Critical patent/BRPI0407662B1/pt
Publication of BRPI0407662B8 publication Critical patent/BRPI0407662B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/12—Polycyclic non-condensed hydrocarbons
    • C07C15/14—Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

"DERIVADOS DO áCIDO 1-FENILALCANOCARBOXìLICO PARA O TRATAMENTO DE DOENçAS NEURODEGENERATIVAS". Derivados do ácido fenilalcanocarboxílico; processos para seu preparo e sua utilização no tratamento e/ou prevenção de doenças neurodegenerativas tal como a doença de Alzheimer.
BRPI0407662A 2003-02-21 2004-02-19 derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas BRPI0407662B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20030311 ITMI20030311A1 (it) 2003-02-21 2003-02-21 Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
ITMI20032068 ITMI20032068A1 (it) 2003-10-23 2003-10-23 Derivati dell'acido 1-fenilcicloalcancarbossilico per il trattamento delle malattie neurodegenerative.
PCT/EP2004/001596 WO2004074232A1 (en) 2003-02-21 2004-02-19 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

Publications (3)

Publication Number Publication Date
BRPI0407662A true BRPI0407662A (pt) 2006-03-01
BRPI0407662B1 BRPI0407662B1 (pt) 2019-11-12
BRPI0407662B8 BRPI0407662B8 (pt) 2021-05-25

Family

ID=32910543

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407662A BRPI0407662B8 (pt) 2003-02-21 2004-02-19 derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas

Country Status (17)

Country Link
US (3) US7662995B2 (pt)
EP (1) EP1594833B1 (pt)
JP (1) JP4472691B2 (pt)
KR (2) KR101088272B1 (pt)
AT (1) ATE409176T1 (pt)
AU (1) AU2004213145B2 (pt)
BR (1) BRPI0407662B8 (pt)
CA (1) CA2514384C (pt)
CY (1) CY1108514T1 (pt)
DE (1) DE602004016729D1 (pt)
DK (1) DK1594833T3 (pt)
ES (1) ES2312964T3 (pt)
HK (1) HK1087398A1 (pt)
NO (1) NO333118B1 (pt)
PT (1) PT1594833E (pt)
SI (1) SI1594833T1 (pt)
WO (1) WO2004074232A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1284729A4 (en) * 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
JP4472691B2 (ja) * 2003-02-21 2010-06-02 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 神経変性疾患の処置のための１−フェニルアルカンカルボン酸誘導体
US20050042284A1 (en) * 2003-07-11 2005-02-24 Myriad Genetics, Incorporated Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
MXPA06012165A (es) * 2004-04-29 2007-01-17 Keystone Retaining Wall System Chapas para muros, muros de contencion y similares.
DE602005007912D1 (de) 2004-08-03 2008-08-14 Chiesi Farma Spa Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
BRPI0514303A (pt) * 2004-08-11 2008-06-10 Myriad Genetics Inc composição farmacêutica e método para tratar distúrbios neurodegenerativos
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
EP1909777A2 (en) * 2005-07-22 2008-04-16 Myriad Genetics, Inc. High drug load formulations and dosage forms
WO2008006099A2 (en) * 2006-07-07 2008-01-10 Myriad Genetics, Inc. Treatment of psychiatric disorders
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
CN101945848A (zh) 2007-12-20 2011-01-12 英维沃医药有限公司 四取代的苯
EP2133322A1 (en) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
JP5996428B2 (ja) * 2009-08-04 2016-09-21 シエシー ファルマセウティチィ ソシエタ ペル アチオニ １−（２−ハロビフェニル−４−イル）−シクロプロパンカルボン酸の誘導体の調製方法
RU2569061C2 (ru) 2010-02-03 2015-11-20 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
KR20130036210A (ko) 2010-04-01 2013-04-11 키에시 파르마슈티시 엣스. 피. 에이. 신규 다형체 및 염
CN102844290B (zh) * 2010-04-21 2015-06-17 奇斯药制品公司 用于治疗转甲状腺素蛋白淀粉样变性的1-(2-氟联苯-4-基)-烷基羧酸衍生物
EP2575797A1 (en) * 2010-06-04 2013-04-10 Chiesi Farmaceutici S.p.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
CN104169251A (zh) * 2012-04-04 2014-11-26 奇斯药制品公司 用于治疗神经退行性疾病的1-(2-卤代-联苯-4-基)-烷羧酸的衍生物
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
RU2015153818A (ru) 2013-06-24 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Усовершенствованный способ получения производных 1-(2-фтор[1, 1-бифенил]-4-ил)-циклопропанкарбоновой кислоты
EP2818460A1 (en) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US20150320706A1 (en) 2014-05-12 2015-11-12 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
WO2015181094A1 (en) 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
IL310956A (en) 2021-08-31 2024-04-01 Cerespir Incorporated common crystal

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE735385A (pt) 1968-07-04 1969-12-01
JPS4994680A (pt) 1973-01-22 1974-09-09
JPS5046669A (pt) 1973-03-28 1975-04-25
JPS58177977A (ja) 1982-04-09 1983-10-18 Grelan Pharmaceut Co Ltd ４−フエニルピラゾ−ル類
WO1996002529A1 (fr) * 1994-07-13 1996-02-01 Taisho Pharmaceutical Co., Ltd. Derive de l'acide thiophene acetique
JPH0994680A (ja) * 1995-07-24 1997-04-08 Toyota Motor Corp 摩擦圧接装置
US5994379A (en) 1998-02-13 1999-11-30 Merck Frosst Canada, Inc. Bisaryl COX-2 inhibiting compounds, compositions and methods of use
EP1284729A4 (en) 2000-04-13 2007-12-19 Mayo Foundation REDUCTION AGENTS OF A (BETA) 42
EP1587798A4 (en) * 2003-01-14 2007-06-27 Merck & Co Inc NSAID DERIVATIVES WITH GEMINAL DISUBSTITUTION AS ABETA REDUCING AGENTS 42
JP4472691B2 (ja) * 2003-02-21 2010-06-02 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 神経変性疾患の処置のための１−フェニルアルカンカルボン酸誘導体
DE602005007912D1 (de) * 2004-08-03 2008-08-14 Chiesi Farma Spa Derivate von 1-phenylalkancarbonsäuren zur behandlung von neurodegenerativen krankheiten
EP2133322A1 (en) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Also Published As

Publication number Publication date
PT1594833E (pt) 2008-12-03
BRPI0407662B1 (pt) 2019-11-12
US20100099768A1 (en) 2010-04-22
KR20110057227A (ko) 2011-05-31
BRPI0407662B8 (pt) 2021-05-25
CA2514384A1 (en) 2004-09-02
NO20053855D0 (no) 2005-08-18
US7662995B2 (en) 2010-02-16
ATE409176T1 (de) 2008-10-15
WO2004074232A1 (en) 2004-09-02
NO333118B1 (no) 2013-03-04
HK1087398A1 (en) 2006-10-13
US20070060752A1 (en) 2007-03-15
JP4472691B2 (ja) 2010-06-02
DE602004016729D1 (de) 2008-11-06
US8022250B2 (en) 2011-09-20
EP1594833A1 (en) 2005-11-16
DK1594833T3 (da) 2008-12-15
US8314268B2 (en) 2012-11-20
CA2514384C (en) 2012-04-10
KR20050104369A (ko) 2005-11-02
JP2006518351A (ja) 2006-08-10
KR101152448B1 (ko) 2012-07-02
CY1108514T1 (el) 2014-04-09
AU2004213145B2 (en) 2010-05-13
NO20053855L (no) 2005-11-21
AU2004213145A1 (en) 2004-09-02
WO2004074232A8 (en) 2005-09-09
KR101088272B1 (ko) 2011-11-30
SI1594833T1 (sl) 2008-12-31
US20110288175A1 (en) 2011-11-24
ES2312964T3 (es) 2009-03-01
EP1594833B1 (en) 2008-09-24

Similar Documents

Publication Publication Date Title
BRPI0407662B8 (pt) derivados do ácido 1-fenilalcanocarboxílico para o tratamento de doenças neurodegenerativas
DOP2002000429A (es) Imidazotriazinas
WO2007038459A3 (en) Carboxyamine compounds and their use in the treatment of hdac dependent diseases
WO2006035237A3 (en) Methods and compositions relating to alzheimer's disease
ES2414872T8 (es) Terapia combinada para la prevención o tratamiento de la enfermedad de Alzheimer y kit correspondiente
WO2005004803A3 (en) Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
HK1096392A1 (en) Substituted heterocycles
EP2213684A3 (en) Nogo-a antibodies for the treatment of Alzheimer disease
WO2004006858A3 (en) Compounds, compositions, and methods employing same
HK1092467A1 (en) N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n-
WO2005032471A3 (en) Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
WO2004062625A3 (en) Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease
UA85559C2 (en) Aminobenzophenone compounds
UY27993A1 (es) Derivados de 4-pirrolidino-fenil-bencil eter
WO2005018545A3 (en) Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
BR0318278A (pt) compostos de éter aminocicloexìlico e usos dos mesmo
HK1104280A1 (en) Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases
DE60326069D1 (de) 4-(heterocyclyl)-benzenesulfoximin verbindungen zur behandlung entzündlicher erkrankungenen
WO2007017146A3 (en) Use of collismycin and derivatives thereof as oxidative stress inhibitors
WO2005080549A3 (de) Trioxacarcine und deren verwendung gegen infektionskrankheiten
WO2007048034A3 (en) Use of androgens for the treatment of parkinson' s disease
BRPI0509881A (pt) combinação terapêutica para tratamento da doença de alzheimer
UY27348A1 (es) Imidazotriazinas
ITRM20030213A0 (it) Composizione farmaceutica per l'uso nella cura delle malattie psichiche e dei disturbi ad esse correlati.
DOP2003000657A (es) Amidas de acidos 2-heteroarilcarboxilicos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/11/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/11/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/02/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2710 DE 13-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.