BRPI0410653A - composto, composição farmacêutica, e, uso de um composto ou um sal, solvato, hidrato ou n-óxido farmaceuticamente aceitável do mesmo - Google Patents

composto, composição farmacêutica, e, uso de um composto ou um sal, solvato, hidrato ou n-óxido farmaceuticamente aceitável do mesmo

Info

Publication number
BRPI0410653A
BRPI0410653A BRPI0410653-9A BRPI0410653A BRPI0410653A BR PI0410653 A BRPI0410653 A BR PI0410653A BR PI0410653 A BRPI0410653 A BR PI0410653A BR PI0410653 A BRPI0410653 A BR PI0410653A
Authority
BR
Brazil
Prior art keywords
compound
solvate
hydrate
oxide
pharmaceutically acceptable
Prior art date
Application number
BRPI0410653-9A
Other languages
English (en)
Inventor
Daniel Christopher Brookings
Jeremy Martin Davis
Barry John Langham
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314492A external-priority patent/GB0314492D0/en
Priority claimed from GB0329485A external-priority patent/GB0329485D0/en
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of BRPI0410653A publication Critical patent/BRPI0410653A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO OU UM SAL, SOLVATO, HIDRATO OU N-óXIDO FARMACEUTICAMENTE ACEITáVEL DO MESMO". Uma série de derivados de tieno¢2,3-b!piridin-6(7H)-ona, substituídos na posição 2 por meio de uma pirrolidin-1-ila ligado a carbonila ou sulfonila ou porção relacionada, que são inibidores de p38 MAP quinase, são usados na medicina, por exemplo, no tratamento e/ou na prevenção de distúrbios imunológicos ou inflamatórios.
BRPI0410653-9A 2003-06-20 2004-06-18 composto, composição farmacêutica, e, uso de um composto ou um sal, solvato, hidrato ou n-óxido farmaceuticamente aceitável do mesmo BRPI0410653A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314492A GB0314492D0 (en) 2003-06-20 2003-06-20 Chemical compounds
GB0329485A GB0329485D0 (en) 2003-12-19 2003-12-19 Chemical compounds
PCT/GB2004/002621 WO2004113347A1 (en) 2003-06-20 2004-06-18 Thienopyridone derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0410653A true BRPI0410653A (pt) 2006-07-04

Family

ID=33542685

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410653-9A BRPI0410653A (pt) 2003-06-20 2004-06-18 composto, composição farmacêutica, e, uso de um composto ou um sal, solvato, hidrato ou n-óxido farmaceuticamente aceitável do mesmo

Country Status (12)

Country Link
US (1) US7521460B2 (pt)
EP (1) EP1641804A1 (pt)
JP (1) JP2007516161A (pt)
KR (1) KR20060021905A (pt)
AU (1) AU2004249495A1 (pt)
BR (1) BRPI0410653A (pt)
CA (1) CA2528602A1 (pt)
EA (1) EA010297B1 (pt)
IL (1) IL172132A0 (pt)
MX (1) MXPA05013227A (pt)
NO (1) NO20060279L (pt)
WO (1) WO2004113347A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
AU2004249498B2 (en) * 2003-06-20 2009-11-19 Ucb Pharma S.A. Thienopyridone derivatives as kinase inhibitors
US7795256B2 (en) * 2003-10-24 2010-09-14 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors
CN103012254A (zh) 2005-05-10 2013-04-03 英特芒尼公司 用于调节应激-活化蛋白激酶***的吡啶酮衍生物
PL1934174T3 (pl) * 2005-10-07 2011-09-30 Exelixis Inc Azetydyny jako inhibitory w leczeniu chorób proliferacyjnych
KR20080076968A (ko) * 2005-11-23 2008-08-20 인터뮨, 인크. 스트레스-활성화 단백질 키나제 시스템을 조절하는 방법
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
AU2007236116A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having MnKl /Mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
EP2099805A2 (en) * 2006-11-30 2009-09-16 UCB Pharma S.A. Novel aminothienopyridinone derivatives processes for preparing them and pharmaceutical compositions thereof
CN101605540A (zh) * 2006-12-14 2009-12-16 埃克塞利希斯股份有限公司 使用mek抑制剂的方法
WO2008124085A2 (en) * 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
CA3034994A1 (en) 2008-06-03 2009-12-10 Intermune, Inc. Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
BRPI0918971A2 (pt) 2008-08-26 2015-12-01 Boehringer Ingelheim Int tienopirimidinas para composições farmacêuticas
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
AR080328A1 (es) 2010-02-26 2012-03-28 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros
TW201141872A (en) 2010-02-26 2011-12-01 Boehringer Ingelheim Int Cycloalkyl containing thienopyrimidines for pharmaceutical compositions
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
NZ706723A (en) 2012-10-12 2018-07-27 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
EP4056572A1 (en) * 2012-11-21 2022-09-14 Zoetis Services LLC Synthesis of spirocyclic isoxazoline derivatives
WO2014100755A2 (en) 2012-12-20 2014-06-26 Biomatrica, Inc. Formulations and methods for stabilizing pcr reagents
CN105491883B (zh) 2013-06-13 2018-11-02 生物马特里卡公司 细胞稳定化
MX2016012808A (es) 2014-04-02 2017-01-05 Intermune Inc Piridinonas anti-fibroticas.
EP3942931A1 (en) 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
JP6827048B2 (ja) 2015-12-08 2021-02-10 バイオマトリカ，インク． 赤血球沈降速度の低下

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048863A (en) * 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
EP1086085A1 (en) * 1998-06-12 2001-03-28 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
AU2004249498B2 (en) * 2003-06-20 2009-11-19 Ucb Pharma S.A. Thienopyridone derivatives as kinase inhibitors
US7795256B2 (en) * 2003-10-24 2010-09-14 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
WO2004113347A1 (en) 2004-12-29
EP1641804A1 (en) 2006-04-05
NO20060279L (no) 2006-03-20
KR20060021905A (ko) 2006-03-08
MXPA05013227A (es) 2006-03-09
EA200600064A1 (ru) 2006-08-25
EA010297B1 (ru) 2008-08-29
JP2007516161A (ja) 2007-06-21
IL172132A0 (en) 2006-04-10
CA2528602A1 (en) 2004-12-29
AU2004249495A1 (en) 2004-12-29
US20070099894A1 (en) 2007-05-03
US7521460B2 (en) 2009-04-21

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: UCB S.A. (BE)

Free format text: TRANSFERIDO DE: CELLTECH RANDD LIMITED

B25A Requested transfer of rights approved

Owner name: UCB PHARMA S.A. (BE)

Free format text: TRANSFERIDO DE: UCB S.A.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2140 DE 10/01/2012.