BRPI0114870B8 - uso de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-amino)fenil]-benzamida para a fabricação de composições farmacêuticas para tratamento de tumores estromais gastrointestinais - Google Patents
uso de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-amino)fenil]-benzamida para a fabricação de composições farmacêuticas para tratamento de tumores estromais gastrointestinaisInfo
- Publication number
- BRPI0114870B8 BRPI0114870B8 BRPI0114870A BRPI0114870B8 BR PI0114870 B8 BRPI0114870 B8 BR PI0114870B8 BR PI0114870 A BRPI0114870 A BR PI0114870A BR PI0114870 B8 BRPI0114870 B8 BR PI0114870B8
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- methylpiperazin
- benzamide
- pyrimidin
- ylmethyl
- Prior art date
Links
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 title abstract 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 title abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24381000P | 2000-10-27 | 2000-10-27 | |
US60/243,810 | 2000-10-27 | ||
PCT/EP2001/012442 WO2002034727A2 (en) | 2000-10-27 | 2001-10-26 | Treatment of gastrointestinal stromal tumors |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0114870A BR0114870A (pt) | 2004-02-17 |
BRPI0114870B1 BRPI0114870B1 (pt) | 2020-06-16 |
BRPI0114870B8 true BRPI0114870B8 (pt) | 2021-05-25 |
Family
ID=22920224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0114870-2 BRPI0114870B8 (pt) | 2000-10-27 | 2001-10-26 | uso de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-amino)fenil]-benzamida para a fabricação de composições farmacêuticas para tratamento de tumores estromais gastrointestinais |
Country Status (26)
Country | Link |
---|---|
US (1) | US6958335B2 (pt) |
EP (1) | EP1332137B1 (pt) |
JP (1) | JP4386635B2 (pt) |
KR (1) | KR100885129B1 (pt) |
CN (1) | CN1276754C (pt) |
AT (1) | ATE321556T1 (pt) |
AU (2) | AU2002218262B2 (pt) |
BR (1) | BRPI0114870B8 (pt) |
CA (1) | CA2424470C (pt) |
CY (1) | CY1105055T1 (pt) |
CZ (1) | CZ303944B6 (pt) |
DE (1) | DE60118430T2 (pt) |
DK (1) | DK1332137T3 (pt) |
ES (1) | ES2260317T3 (pt) |
HK (1) | HK1058193A1 (pt) |
HU (1) | HU229106B1 (pt) |
IL (2) | IL155029A0 (pt) |
MX (1) | MXPA03003703A (pt) |
NO (1) | NO324948B1 (pt) |
NZ (1) | NZ525254A (pt) |
PL (1) | PL209733B1 (pt) |
PT (1) | PT1332137E (pt) |
RU (1) | RU2301066C2 (pt) |
SK (1) | SK287335B6 (pt) |
WO (1) | WO2002034727A2 (pt) |
ZA (1) | ZA200302155B (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60219617T2 (de) * | 2001-05-16 | 2008-01-03 | Novartis Ag | Kombination von n- 5- 4-(4-methyl-piperazino-methyl)-benzoylamido -2-methylphenyl -4-(3-pyridil)-2pyrimidine-amin mit einem biphosphonat |
JP2004537537A (ja) * | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性疾患を治療するためのチロシンキナーゼ阻害剤の使用法 |
US7678805B2 (en) * | 2001-06-29 | 2010-03-16 | Ab Science | Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD) |
ATE376182T1 (de) * | 2001-06-29 | 2007-11-15 | Ab Science | C-kit inhibitoren |
US7700610B2 (en) * | 2001-06-29 | 2010-04-20 | Ab Science | Use of tyrosine kinase inhibitors for treating allergic diseases |
JP2004530730A (ja) * | 2001-06-29 | 2004-10-07 | アブ サイエンス | 腫瘍の血管新生を治療するための強力で選択的かつ非毒性のc−kit阻害剤の使用法 |
US20040242612A1 (en) * | 2001-09-20 | 2004-12-02 | Alain Moussy | Use of tyrosine kinase inhibitors for promoting hair growth |
DE60228278D1 (de) * | 2001-09-20 | 2008-09-25 | Ab Science | Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung |
WO2003072090A2 (en) * | 2002-02-27 | 2003-09-04 | Ab Science | Use of tyrosine kinase inhibitors for treating cns disorders |
FR2844452A1 (fr) * | 2002-09-18 | 2004-03-19 | Inst Gustave Roussy Igr | Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation |
US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
CA2538523A1 (en) * | 2003-09-19 | 2005-03-31 | Novartis Ag | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin |
US20100210596A1 (en) * | 2006-02-01 | 2010-08-19 | Bluestone Jeffrey A | Use of aminopyrimidine compounds in the treatment of immune disorders |
EP2061468A4 (en) * | 2006-09-11 | 2011-05-04 | Curis Inc | TYROSINE KINASE INHIBITORS CONTAINING ZINC BINDING CHARACTERISTIC GROUP |
SG174772A1 (en) * | 2006-09-11 | 2011-10-28 | Curis Inc | Multi-functional small molecules as anti-proliferative agents |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
US20090082361A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched imatinib |
CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
US8530492B2 (en) | 2009-04-17 | 2013-09-10 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
KR102061743B1 (ko) | 2011-03-04 | 2020-01-03 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
AU2013223749A1 (en) | 2012-02-21 | 2014-09-11 | Sun Pharmaceutical Industries Limited | Stable dosage forms of imatinib mesylate |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
ES2656091T3 (es) | 2012-07-27 | 2018-02-23 | Izumi Technology, Llc. | Composiciones de inhibidores de eflujo y métodos de tratamiento que las utilizan |
WO2015017728A1 (en) | 2013-07-31 | 2015-02-05 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
WO2019016673A2 (en) | 2017-07-20 | 2019-01-24 | Kashiv Pharma Llc | STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION OF IMATINIB |
WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
MX2022001863A (es) | 2019-08-12 | 2022-05-30 | Deciphera Pharmaceuticals Llc | Metodos para tratar los tumores del estroma gastrointestinal. |
BR112022013169A2 (pt) | 2019-12-30 | 2022-09-13 | Deciphera Pharmaceuticals Llc | Composições de 1-(4-bromo-5-(1-etil-7-(metilamino)-2-oxo-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofeil)-3-fenilurea |
RS65058B1 (sr) | 2019-12-30 | 2024-02-29 | Deciphera Pharmaceuticals Llc | Formulacije inhibitora amorfne kinaze i postupci njihove primene |
KR102535840B1 (ko) | 2020-07-31 | 2023-05-23 | (주)파로스아이바이오 | 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도 |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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TW225528B (pt) * | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
EP1117397A1 (en) * | 1998-08-31 | 2001-07-25 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
-
2001
- 2001-10-26 RU RU2003114752/15A patent/RU2301066C2/ru not_active IP Right Cessation
- 2001-10-26 WO PCT/EP2001/012442 patent/WO2002034727A2/en active IP Right Grant
- 2001-10-26 KR KR1020037003903A patent/KR100885129B1/ko active IP Right Review Request
- 2001-10-26 CZ CZ20031152A patent/CZ303944B6/cs not_active IP Right Cessation
- 2001-10-26 MX MXPA03003703A patent/MXPA03003703A/es active IP Right Grant
- 2001-10-26 US US10/415,015 patent/US6958335B2/en not_active Expired - Lifetime
- 2001-10-26 EP EP01988712A patent/EP1332137B1/en not_active Expired - Lifetime
- 2001-10-26 SK SK518-2003A patent/SK287335B6/sk not_active IP Right Cessation
- 2001-10-26 CA CA002424470A patent/CA2424470C/en not_active Expired - Lifetime
- 2001-10-26 DK DK01988712T patent/DK1332137T3/da active
- 2001-10-26 HU HU0301512A patent/HU229106B1/hu unknown
- 2001-10-26 NZ NZ525254A patent/NZ525254A/en not_active IP Right Cessation
- 2001-10-26 PT PT01988712T patent/PT1332137E/pt unknown
- 2001-10-26 CN CNB018178952A patent/CN1276754C/zh not_active Ceased
- 2001-10-26 PL PL362148A patent/PL209733B1/pl unknown
- 2001-10-26 AT AT01988712T patent/ATE321556T1/de active
- 2001-10-26 AU AU2002218262A patent/AU2002218262B2/en not_active Expired
- 2001-10-26 AU AU1826202A patent/AU1826202A/xx active Pending
- 2001-10-26 JP JP2002537718A patent/JP4386635B2/ja not_active Expired - Lifetime
- 2001-10-26 IL IL15502901A patent/IL155029A0/xx unknown
- 2001-10-26 ES ES01988712T patent/ES2260317T3/es not_active Expired - Lifetime
- 2001-10-26 DE DE60118430T patent/DE60118430T2/de not_active Expired - Lifetime
- 2001-10-26 BR BRPI0114870-2 patent/BRPI0114870B8/pt active IP Right Grant
-
2003
- 2003-03-18 ZA ZA200302155A patent/ZA200302155B/en unknown
- 2003-03-20 IL IL155029A patent/IL155029A/en active IP Right Grant
- 2003-04-24 NO NO20031833A patent/NO324948B1/no not_active IP Right Cessation
- 2003-12-29 HK HK03109439A patent/HK1058193A1/xx not_active IP Right Cessation
-
2006
- 2006-06-21 CY CY20061100839T patent/CY1105055T1/el unknown
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Legal Events
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: C07D 241/00 Ipc: A61K 31/506 (2011.01), A61P 35/00 (2011.01) |
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B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
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Free format text: INPI NO 52402.005155/2020-65 ORIGEM: JUIZO FEDERAL DA 31A VF DO RIO DE JANEIRO (TRF2) PROCESSO NO: 5034049-12.2020.4.02.5101 NULIDADE DE ATO ADMINISTRATIVO COM PEDIDO DE ANTECIPACAO DE TUTELA AUTOR: CRISTALIA PRODUTOS QUIMICOS FARMACEUTICOS LTDA. REU(S): NOVARTIS AG E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL (INPI) |
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