BR9916190A - Emprego de inibidores do canal kqt1 para a preparação de um medicamento para o tratamento de doenças, que são provocadas por helmintos e ectoparasitas - Google Patents

Emprego de inibidores do canal kqt1 para a preparação de um medicamento para o tratamento de doenças, que são provocadas por helmintos e ectoparasitas

Info

Publication number
BR9916190A
BR9916190A BR9916190-7A BR9916190A BR9916190A BR 9916190 A BR9916190 A BR 9916190A BR 9916190 A BR9916190 A BR 9916190A BR 9916190 A BR9916190 A BR 9916190A
Authority
BR
Brazil
Prior art keywords
ectoparasites
helminths
kqt1
medicine
preparation
Prior art date
Application number
BR9916190-7A
Other languages
English (en)
Inventor
Uwe Gerlach
Joachim Hofmann
Hans Jochen Lang
Aguan Wei
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR9916190A publication Critical patent/BR9916190A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"EMPREGO DE INIBIDORES DO CANAL KQT1 PARA A PREPARAçãO DE UM MEDICAMENTO PARA O TRATAMENTO DE DOENçAS, QUE SãO PROVOCADAS POR HELMINTOS E ECTOPARASITAS"<D>. A invenção refere-se a inibidores do canal KQT1 que representam um novo princípio letal para helmintos e ectoparasitas. Por isso, utilizam-se bloqueadores do canal KQT1 celular, que aparece em helmintos e ectoparasitas, para preparar um medicamento para o tratamento de animais vertebrados e homem, que são infestados por helmintos ou ectoparasitas. Estes bloqueadores KQT1 são aplicados como medicamentos sozinhos ou em combinação com outros medicamentos e medidas terapêuticas. Inibidores do canal KQT1 representam igualmente um novo mecanismo de ação para as pragas de plantas tais como insetos, tetrânicos, moluscos e nematódios e são empregados, conseq³entemente, para a preparação de um agente de proteção de plantas.
BR9916190-7A 1998-12-17 1999-12-07 Emprego de inibidores do canal kqt1 para a preparação de um medicamento para o tratamento de doenças, que são provocadas por helmintos e ectoparasitas BR9916190A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19858253A DE19858253A1 (de) 1998-12-17 1998-12-17 Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
PCT/EP1999/009547 WO2000035429A1 (de) 1998-12-17 1999-12-07 Verwendung von inhibitoren des kqt1-kanals zur herstellung eines medikaments zur behandlung von krankheiten, die durch helminthen und ektoparasiten hervorgerufen werden

Publications (1)

Publication Number Publication Date
BR9916190A true BR9916190A (pt) 2001-09-11

Family

ID=7891421

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916190-7A BR9916190A (pt) 1998-12-17 1999-12-07 Emprego de inibidores do canal kqt1 para a preparação de um medicamento para o tratamento de doenças, que são provocadas por helmintos e ectoparasitas

Country Status (24)

Country Link
US (2) US6335363B1 (pt)
EP (1) EP1140042B1 (pt)
JP (1) JP2002532412A (pt)
KR (1) KR20010089574A (pt)
CN (1) CN1170528C (pt)
AR (1) AR021690A1 (pt)
AT (1) ATE390130T1 (pt)
AU (1) AU1559500A (pt)
BR (1) BR9916190A (pt)
CA (1) CA2355300A1 (pt)
CZ (1) CZ20012125A3 (pt)
DE (2) DE19858253A1 (pt)
HK (1) HK1041647B (pt)
HR (1) HRPK20010442B1 (pt)
HU (1) HUP0200152A3 (pt)
IL (1) IL143717A0 (pt)
NO (1) NO20012976L (pt)
NZ (1) NZ512408A (pt)
PL (1) PL349511A1 (pt)
RU (1) RU2238090C2 (pt)
SK (1) SK8562001A3 (pt)
TR (1) TR200101750T2 (pt)
WO (1) WO2000035429A1 (pt)
ZA (1) ZA200103620B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1718677T3 (pl) * 2003-12-19 2012-09-28 Genentech Inc Jednowartościowe fragmenty przeciwciała stosowane jako środki lecznicze
CN104804095A (zh) * 2004-08-05 2015-07-29 健泰科生物技术公司 人源化抗c-met 拮抗剂
AU2008261822B2 (en) 2007-06-07 2014-07-03 Bayer Animal Health Gmbh Control of ectoparasites
US8859003B2 (en) * 2009-06-05 2014-10-14 Intercontinental Great Brands Llc Preparation of an enteric release system
US20100307542A1 (en) * 2009-06-05 2010-12-09 Kraft Foods Global Brands Llc Method of Reducing Surface Oil on Encapsulated Material
US20100310726A1 (en) 2009-06-05 2010-12-09 Kraft Foods Global Brands Llc Novel Preparation of an Enteric Release System
US9968564B2 (en) * 2009-06-05 2018-05-15 Intercontinental Great Brands Llc Delivery of functional compounds
CA2835242A1 (en) 2011-06-30 2013-01-03 Genentech, Inc. Anti-c-met antibody formulations
US8859005B2 (en) 2012-12-03 2014-10-14 Intercontinental Great Brands Llc Enteric delivery of functional ingredients suitable for hot comestible applications
JP2017516458A (ja) 2014-03-24 2017-06-22 ジェネンテック， インコーポレイテッド ｃ−ｍｅｔ拮抗剤による癌治療及びｃ−ｍｅｔ拮抗剤のＨＧＦ発現との相関
EP2957557A1 (en) * 2014-06-17 2015-12-23 Novartis Tiergesundheit AG New compounds
KR20180114910A (ko) 2016-02-05 2018-10-19 데날리 테라퓨틱스 인크. 수용체-상호작용 단백질 키나제 1의 억제제
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
JP7210483B2 (ja) * 2017-06-30 2023-01-23 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規アザキノリン誘導体
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
WO1995014669A1 (en) * 1993-11-29 1995-06-01 Merrell Pharmaceuticals Inc. Novel benzenesulfonylimine derivatives as inhibitors of il-1 action
US5559026A (en) * 1994-10-31 1996-09-24 American Cyanamid Company Genes encoding a novel family of potassium channels
DE19504379A1 (de) * 1995-02-10 1996-08-14 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
EP0807629B1 (de) 1996-05-15 2004-03-03 Aventis Pharma Deutschland GmbH Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19706675A1 (de) 1997-02-20 1998-08-27 Hoechst Ag Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19707656A1 (de) * 1997-02-26 1998-08-27 Hoechst Ag Sulfonamid-substituierte anellierte 7-Ring-Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19742509A1 (de) * 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19742508A1 (de) 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19748469A1 (de) * 1997-11-03 1999-05-06 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen

Also Published As

Publication number Publication date
CN1330540A (zh) 2002-01-09
KR20010089574A (ko) 2001-10-06
DE59914712D1 (de) 2008-05-08
CA2355300A1 (en) 2000-06-22
US6335363B1 (en) 2002-01-01
NO20012976L (no) 2001-08-06
HRP20010442A2 (en) 2002-06-30
CN1170528C (zh) 2004-10-13
JP2002532412A (ja) 2002-10-02
HUP0200152A2 (hu) 2002-05-29
NZ512408A (en) 2003-10-31
NO20012976D0 (no) 2001-06-15
EP1140042A1 (de) 2001-10-10
IL143717A0 (en) 2002-04-21
ATE390130T1 (de) 2008-04-15
PL349511A1 (en) 2002-07-29
EP1140042B1 (de) 2008-03-26
US20020055537A1 (en) 2002-05-09
RU2238090C2 (ru) 2004-10-20
TR200101750T2 (tr) 2002-01-21
AU1559500A (en) 2000-07-03
HK1041647A1 (en) 2002-07-19
CZ20012125A3 (cs) 2001-09-12
DE19858253A1 (de) 2000-06-21
HUP0200152A3 (en) 2003-01-28
SK8562001A3 (en) 2001-12-03
AR021690A1 (es) 2002-07-31
WO2000035429A1 (de) 2000-06-22
HK1041647B (zh) 2005-04-01
ZA200103620B (en) 2002-06-04
HRPK20010442B1 (en) 2003-10-31

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM O ARTIGO 22 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.