BR9915129A - Antagonistas do receptor de crf e processos relacionados aos mesmos - Google Patents
Antagonistas do receptor de crf e processos relacionados aos mesmosInfo
- Publication number
- BR9915129A BR9915129A BR9915129-4A BR9915129A BR9915129A BR 9915129 A BR9915129 A BR 9915129A BR 9915129 A BR9915129 A BR 9915129A BR 9915129 A BR9915129 A BR 9915129A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- related processes
- crf receptor
- compounds
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
Abstract
"ANTAGONISTAS DO RECEPTOR DE CRF E PROCESSOS RELACIONADOS AOS MESMOS" compostos são descritos que tem utilidade no tratamento de vários distúrbios, incluindo o tratamento de distúrbios manifestando hipersecreção de CRF em animais de sangue quente, incluindo ataques. Os compostos desta invenção tem estruturas (I) : (a) em que n, m, R, R1, R2, X e Ar são como aqui definidos, incluindo estereoisómeros e sais farmaceuticamente aceitáveis dos mesmos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19095898A | 1998-11-12 | 1998-11-12 | |
US40074499A | 1999-09-21 | 1999-09-21 | |
PCT/US1999/026984 WO2000027850A2 (en) | 1998-11-12 | 1999-11-12 | Crf receptor antagonists and methods relating thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915129A true BR9915129A (pt) | 2001-08-07 |
Family
ID=26886600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915129-4A BR9915129A (pt) | 1998-11-12 | 1999-11-12 | Antagonistas do receptor de crf e processos relacionados aos mesmos |
Country Status (19)
Country | Link |
---|---|
US (3) | US6348466B1 (pt) |
EP (1) | EP1129096B1 (pt) |
JP (1) | JP2002529469A (pt) |
KR (1) | KR20010080402A (pt) |
CN (1) | CN1178941C (pt) |
AT (1) | ATE240958T1 (pt) |
AU (1) | AU755997B2 (pt) |
BR (1) | BR9915129A (pt) |
CA (1) | CA2349904A1 (pt) |
DE (1) | DE69908173T2 (pt) |
DK (1) | DK1129096T3 (pt) |
ES (1) | ES2196898T3 (pt) |
HK (1) | HK1038925B (pt) |
IL (1) | IL143105A0 (pt) |
NO (1) | NO20012228D0 (pt) |
NZ (1) | NZ511267A (pt) |
PT (1) | PT1129096E (pt) |
TR (1) | TR200102178T2 (pt) |
WO (1) | WO2000027850A2 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2398956A1 (en) * | 2000-02-14 | 2001-08-16 | Japan Tobacco Inc. | A pharmaceutical composition for prophylaxis or therapy of a postoperative stress |
EP1278751A1 (en) * | 2000-05-01 | 2003-01-29 | Bristol-Myers Squibb Pharma Company | Tricyclic fused pyridine and pyrimidine derivatives as crf receptor antagonists |
ES2207614T3 (es) * | 2000-05-18 | 2004-06-01 | Neurocrine Biosciences, Inc. | Antagonistas del receptor de crf y metodos relacionados con estos. |
DE60102231T2 (de) | 2000-05-18 | 2005-04-14 | Neurocrine Biosciences, Inc., San Diego | Crf rezeptor-antagonisten und darauf bezogene methoden |
JP2004529075A (ja) * | 2000-11-03 | 2004-09-24 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニストおよびそれに関する方法 |
WO2002064592A1 (en) * | 2000-12-28 | 2002-08-22 | Neurocrine Biosciences, Inc. | Tricyclic crf receptor antagonists |
ATE375345T1 (de) | 2000-12-28 | 2007-10-15 | Ono Pharmaceutical Co | Cyclopenta(d)pyrazolo(1,5-a)pyrimidin-verbindun als crf-rezeptor antagonist |
IL158063A0 (en) | 2001-04-30 | 2004-03-28 | Glaxo Group Ltd | Crf receptor antagonists |
GB0117395D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
US7273871B2 (en) | 2001-07-17 | 2007-09-25 | Sb Pharmco Puerto Rico Inc. | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists |
NZ544301A (en) | 2003-06-25 | 2008-08-29 | Ono Pharmaceutical Co | Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same |
US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
DE602004012318T2 (de) * | 2003-12-22 | 2009-03-12 | Sb Pharmco Puerto Rico Inc. | Crf-rezeptorantagonisten und diese betreffende verfahren |
EP2527446A1 (en) | 2004-06-03 | 2012-11-28 | Athlomics Pty Ltd | Agents and methods for diagnosing stress |
US7869958B2 (en) * | 2004-08-09 | 2011-01-11 | Research Development Foundation | Structure-based modulators of B1 G-protein coupled receptors |
WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
ES2380604T3 (es) | 2004-08-25 | 2012-05-16 | Ardea Biosciences, Inc. | S-triazolil alfa-mercaptoacetanilidas como inhibidores de la transcriptasa inversa del VIH |
EP1877411B9 (en) | 2005-05-05 | 2012-08-29 | Ardea Biosciences, Inc. | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv |
MX2009005009A (es) | 2006-11-09 | 2009-09-22 | Ardea Biosciences Inc | Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. |
EP2842948A1 (en) | 2007-11-27 | 2015-03-04 | Ardea Biosciences, Inc. | Novel compounds and compositions and methods of use |
WO2009079412A2 (en) | 2007-12-14 | 2009-06-25 | Ardea Biosciences Inc. | Reverse transcriptase inhibitors |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
DE69323212T2 (de) | 1992-12-17 | 1999-05-27 | Pfizer | Pyrazole mit crf antagonistischer aktivität |
TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
RU2130453C1 (ru) | 1992-12-17 | 1999-05-20 | Пфайзер Инк. | Замещенные пиразолы, фармацевтическая композиция на их основе, способ лечения, промежуточный продукт |
DK0674641T3 (da) * | 1992-12-17 | 1999-09-27 | Pfizer | Pyrrolopyrimidiner som CRF-antagonister |
TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
RU2153494C2 (ru) | 1993-10-12 | 2000-07-27 | Дзе Дюпон Мерк Фармасьютикал Компани | 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция |
TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
CN1056611C (zh) | 1994-06-16 | 2000-09-20 | 美国辉瑞有限公司 | 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体 |
AU716993B2 (en) | 1995-05-12 | 2000-03-16 | Neurogen Corporation | Novel deazapurine derivatives; a new class of CRF1 specific ligands |
FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
JP2000507552A (ja) | 1996-03-26 | 2000-06-20 | デュポン ファーマシューティカルズ カンパニー | アリールオキシおよびアリールチオ縮合ピリジン、アリールオキシおよびアリールチオ縮合ピリミジン、およびそれらの誘導体 |
US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
US6326368B1 (en) | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
RO121272B1 (ro) | 1996-07-24 | 2007-02-28 | The Du Pont Merck Pharmaceutical Company | Azolotriazine şi pirimidine |
KR20000029843A (ko) | 1996-08-06 | 2000-05-25 | 디. 제이. 우드;스피겔 알렌 제이 | 치환된피리도-또는피리미도-함유6,6-또는6,7-비시클릭유도체 |
TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
CZ68199A3 (cs) * | 1996-08-28 | 1999-11-17 | Pfizer Inc. | 6,5-Heterobicyklické deriváty, farmaceutická kompozice na jejich bázi a způsob léčení chorob |
ATE213495T1 (de) | 1996-09-16 | 2002-03-15 | Du Pont Pharm Co | Eine resorbierbare röntgenopake markierung enthaltendes chirurgisches implantat und verfahren zum verriegeln desselben in einem körper |
FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
-
1999
- 1999-11-12 WO PCT/US1999/026984 patent/WO2000027850A2/en not_active Application Discontinuation
- 1999-11-12 CA CA002349904A patent/CA2349904A1/en not_active Abandoned
- 1999-11-12 CN CNB998131725A patent/CN1178941C/zh not_active Expired - Fee Related
- 1999-11-12 AT AT99961675T patent/ATE240958T1/de not_active IP Right Cessation
- 1999-11-12 KR KR1020017005818A patent/KR20010080402A/ko not_active Application Discontinuation
- 1999-11-12 EP EP99961675A patent/EP1129096B1/en not_active Expired - Lifetime
- 1999-11-12 AU AU18199/00A patent/AU755997B2/en not_active Ceased
- 1999-11-12 JP JP2000581028A patent/JP2002529469A/ja active Pending
- 1999-11-12 NZ NZ511267A patent/NZ511267A/xx unknown
- 1999-11-12 BR BR9915129-4A patent/BR9915129A/pt not_active IP Right Cessation
- 1999-11-12 PT PT99961675T patent/PT1129096E/pt unknown
- 1999-11-12 DE DE69908173T patent/DE69908173T2/de not_active Expired - Lifetime
- 1999-11-12 DK DK99961675T patent/DK1129096T3/da active
- 1999-11-12 TR TR2001/02178T patent/TR200102178T2/xx unknown
- 1999-11-12 US US09/439,841 patent/US6348466B1/en not_active Expired - Fee Related
- 1999-11-12 IL IL14310599A patent/IL143105A0/xx unknown
- 1999-11-12 ES ES99961675T patent/ES2196898T3/es not_active Expired - Lifetime
-
2001
- 2001-05-04 NO NO20012228A patent/NO20012228D0/no not_active Application Discontinuation
- 2001-12-20 US US10/027,789 patent/US6723721B2/en not_active Expired - Lifetime
-
2002
- 2002-01-29 HK HK02100689.4A patent/HK1038925B/zh not_active IP Right Cessation
-
2004
- 2004-02-23 US US10/785,386 patent/US20040229879A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20010080402A (ko) | 2001-08-22 |
AU755997B2 (en) | 2003-01-02 |
NZ511267A (en) | 2002-12-20 |
US6723721B2 (en) | 2004-04-20 |
IL143105A0 (en) | 2002-04-21 |
EP1129096A2 (en) | 2001-09-05 |
US6348466B1 (en) | 2002-02-19 |
WO2000027850A3 (en) | 2000-08-03 |
DK1129096T3 (da) | 2003-09-15 |
US20040229879A1 (en) | 2004-11-18 |
EP1129096B1 (en) | 2003-05-21 |
JP2002529469A (ja) | 2002-09-10 |
DE69908173T2 (de) | 2004-08-19 |
NO20012228L (no) | 2001-05-04 |
WO2000027850A2 (en) | 2000-05-18 |
CN1326458A (zh) | 2001-12-12 |
AU1819900A (en) | 2000-05-29 |
CN1178941C (zh) | 2004-12-08 |
HK1038925A1 (en) | 2002-04-04 |
HK1038925B (zh) | 2003-12-05 |
US20020143008A1 (en) | 2002-10-03 |
TR200102178T2 (tr) | 2002-01-21 |
PT1129096E (pt) | 2003-09-30 |
CA2349904A1 (en) | 2000-05-18 |
NO20012228D0 (no) | 2001-05-04 |
ES2196898T3 (es) | 2003-12-16 |
ATE240958T1 (de) | 2003-06-15 |
DE69908173D1 (de) | 2003-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA(S) 7A, 8A E 9A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009. |