BR9910913A - Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com resistência a insulina - Google Patents
Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com resistência a insulinaInfo
- Publication number
- BR9910913A BR9910913A BR9910913-1A BR9910913A BR9910913A BR 9910913 A BR9910913 A BR 9910913A BR 9910913 A BR9910913 A BR 9910913A BR 9910913 A BR9910913 A BR 9910913A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- insulin resistance
- conditions associated
- clinical conditions
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C271/38—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"COMPOSTO, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA A PROFILAXIA E/OU TRATAMENTO DE CONDIçõES CLìNICAS ASSOCIADAS COM RESISTêNCIA A INSULINA" Um novo composto de ácido 3-{4-[2-(4-terc-butoxicarbonilaminofenila)etóxi]fenila}-(S)-2-etóxi propanóico, tendo a fórmula (I) e sais, solvatos e formas cristalinas farmaceuticamente aceitáveis deste, um processo e intermediários para a sua fabricação, preparações farmacêuticas contendo-o e o uso do composto em condições clínicas associadas com a resistência a insulina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801990A SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | New 3-aryl propionic acid derivatives and analogs |
PCT/SE1999/000940 WO1999062870A1 (en) | 1998-06-04 | 1999-05-31 | New 3-aryl-2-hydroxypropionic acid derivative iii |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9910913A true BR9910913A (pt) | 2001-03-06 |
Family
ID=20411585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9910913-1A BR9910913A (pt) | 1998-06-04 | 1999-05-31 | Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com resistência a insulina |
Country Status (28)
Country | Link |
---|---|
US (1) | US6362360B1 (pt) |
EP (1) | EP1084101B1 (pt) |
JP (2) | JP3568897B2 (pt) |
KR (1) | KR20010052522A (pt) |
CN (1) | CN1311769A (pt) |
AR (1) | AR019853A1 (pt) |
AT (1) | ATE261429T1 (pt) |
AU (1) | AU4667099A (pt) |
BR (1) | BR9910913A (pt) |
CA (1) | CA2334107A1 (pt) |
DE (1) | DE69915470T2 (pt) |
DK (1) | DK1084101T3 (pt) |
EE (1) | EE200000717A (pt) |
ES (1) | ES2216527T3 (pt) |
ID (1) | ID28164A (pt) |
IL (1) | IL139942A0 (pt) |
IS (1) | IS5735A (pt) |
MA (1) | MA26637A1 (pt) |
NO (1) | NO20006114L (pt) |
PL (1) | PL344682A1 (pt) |
PT (1) | PT1084101E (pt) |
SE (1) | SE9801990D0 (pt) |
SK (1) | SK17672000A3 (pt) |
TN (1) | TNSN99107A1 (pt) |
TR (1) | TR200003543T2 (pt) |
TW (1) | TW446694B (pt) |
WO (1) | WO1999062870A1 (pt) |
ZA (2) | ZA200006771B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999016758A1 (en) * | 1997-10-27 | 1999-04-08 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
MA26634A1 (fr) | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
AU2034601A (en) * | 1999-12-03 | 2001-06-12 | Astrazeneca Ab | Crystalline form of 3-(4-(2-(4-tert-butoxycarbonylaminophenyl)ethoxy)phenyl)-(s) 2-ethoxy propanoic acid |
SE9904412D0 (sv) * | 1999-12-03 | 1999-12-03 | Astra Ab | Comminuted form |
SE9904421D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | New compounds |
ES2215769T3 (es) * | 1999-12-03 | 2004-10-16 | Astrazeneca Ab | Forma cristalina de acido (s)-2-etoxi-3-(4-(2-(4-metanosulfoniloxifenil)etoxi)fenil)propanoico. |
TW574193B (en) * | 1999-12-03 | 2004-02-01 | Astrazeneca Ab | Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses |
SE9904415D0 (sv) * | 1999-12-03 | 1999-12-03 | Astra Ab | New process |
US6559335B2 (en) | 2000-09-22 | 2003-05-06 | Dr. Reddy's Laboratories Limited | Process for the preparation of 3-aryl-2-hydroxy propanoic acid |
SE0101386D0 (sv) | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | New compounds |
SE0101978D0 (sv) | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | New compounds |
SE0101981D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
SE0101980D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
PL368051A1 (en) | 2001-06-07 | 2005-03-21 | Eli Lilly And Company | Modulators of peroxisome proliferator activated receptors |
WO2003008362A1 (en) * | 2001-06-28 | 2003-01-30 | Dr. Reddy's Laboratories Ltd | Novel 3-aryl-2-hydroxy propanol derivatives and a process for their preparation |
WO2003002508A1 (en) * | 2001-06-28 | 2003-01-09 | Dr. Reddy's Research Foundation | Derivatives of para-ethoxy-phenillactic acid |
US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
UA82835C2 (en) * | 2001-12-03 | 2008-05-26 | Reddys Lab Ltd Dr | ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon |
WO2003051841A2 (en) | 2001-12-14 | 2003-06-26 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0314075D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
FR2872159B1 (fr) * | 2004-06-28 | 2007-10-05 | Merck Sante Soc Par Actions Si | Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete |
FR2917086B1 (fr) * | 2007-06-05 | 2009-07-17 | Galderma Res & Dev | Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques. |
CN103260625B (zh) | 2010-11-08 | 2016-01-06 | 阿尔比里奥公司 | 用于治疗肝脏疾病的ibat抑制剂 |
PL2637646T3 (pl) | 2010-11-08 | 2017-01-31 | Albireo Ab | Kombinacja farmaceutyczna zawierająca inhibitor ibat i środek wiążący kwasy żółciowe |
WO2012177956A1 (en) * | 2011-06-23 | 2012-12-27 | Metabolic Solutions Development Comapny, Llc | Ppar-sparing compounds for use in the treatment of diabetes and other metabolic diseases |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL77843A (en) | 1985-02-11 | 1989-07-31 | Syntex Inc | Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them |
ZA9610738B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
RU2169141C2 (ru) * | 1996-04-04 | 2001-06-20 | Санкио Компани Лимитед | Производные фенилалкилкарбоновой кислоты и фармацевтическая композиция на их основе |
FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
SE9702305D0 (sv) * | 1997-06-17 | 1997-06-17 | Astra Ab | New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives |
CN1137120C (zh) | 1997-09-10 | 2004-02-04 | 味之素株式会社 | 5,11-二氢二苯并[b,e][1,4]氧氮杂�衍生物和含有相同物质的药用组合物 |
-
1998
- 1998-06-04 SE SE9801990A patent/SE9801990D0/xx unknown
-
1999
- 1999-05-25 TW TW088108575A patent/TW446694B/zh not_active IP Right Cessation
- 1999-05-28 MA MA25601A patent/MA26637A1/fr unknown
- 1999-05-31 SK SK1767-2000A patent/SK17672000A3/sk unknown
- 1999-05-31 AU AU46670/99A patent/AU4667099A/en not_active Abandoned
- 1999-05-31 CA CA002334107A patent/CA2334107A1/en not_active Abandoned
- 1999-05-31 US US09/341,935 patent/US6362360B1/en not_active Expired - Fee Related
- 1999-05-31 KR KR1020007013663A patent/KR20010052522A/ko not_active Application Discontinuation
- 1999-05-31 CN CN99809355A patent/CN1311769A/zh active Pending
- 1999-05-31 WO PCT/SE1999/000940 patent/WO1999062870A1/en not_active Application Discontinuation
- 1999-05-31 EE EEP200000717A patent/EE200000717A/xx unknown
- 1999-05-31 IL IL13994299A patent/IL139942A0/xx unknown
- 1999-05-31 BR BR9910913-1A patent/BR9910913A/pt not_active IP Right Cessation
- 1999-05-31 ID IDW20002584A patent/ID28164A/id unknown
- 1999-05-31 JP JP2000552083A patent/JP3568897B2/ja not_active Expired - Fee Related
- 1999-05-31 ES ES99930058T patent/ES2216527T3/es not_active Expired - Lifetime
- 1999-05-31 TR TR2000/03543T patent/TR200003543T2/xx unknown
- 1999-05-31 AT AT99930058T patent/ATE261429T1/de not_active IP Right Cessation
- 1999-05-31 PL PL99344682A patent/PL344682A1/xx not_active Application Discontinuation
- 1999-05-31 PT PT99930058T patent/PT1084101E/pt unknown
- 1999-05-31 EP EP99930058A patent/EP1084101B1/en not_active Expired - Lifetime
- 1999-05-31 DK DK99930058T patent/DK1084101T3/da active
- 1999-05-31 DE DE69915470T patent/DE69915470T2/de not_active Expired - Fee Related
- 1999-06-02 TN TNTNSN99107A patent/TNSN99107A1/fr unknown
- 1999-06-03 AR ARP990102636A patent/AR019853A1/es not_active Application Discontinuation
-
2000
- 2000-11-20 ZA ZA200006771A patent/ZA200006771B/en unknown
- 2000-11-20 ZA ZA200006773A patent/ZA200006773B/en unknown
- 2000-11-28 IS IS5735A patent/IS5735A/is unknown
- 2000-12-01 NO NO20006114A patent/NO20006114L/no not_active Application Discontinuation
-
2004
- 2004-04-14 JP JP2004118663A patent/JP2004256548A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TNSN99107A1 (fr) | 2005-11-10 |
PT1084101E (pt) | 2004-07-30 |
IS5735A (is) | 2000-11-28 |
DE69915470D1 (en) | 2004-04-15 |
JP2002516898A (ja) | 2002-06-11 |
JP3568897B2 (ja) | 2004-09-22 |
ZA200006771B (en) | 2002-05-20 |
PL344682A1 (en) | 2001-11-19 |
MA26637A1 (fr) | 2004-12-20 |
EP1084101A1 (en) | 2001-03-21 |
US6362360B1 (en) | 2002-03-26 |
ATE261429T1 (de) | 2004-03-15 |
KR20010052522A (ko) | 2001-06-25 |
AU4667099A (en) | 1999-12-20 |
NO20006114D0 (no) | 2000-12-01 |
NO20006114L (no) | 2001-02-02 |
AR019853A1 (es) | 2002-03-20 |
EE200000717A (et) | 2001-08-15 |
IL139942A0 (en) | 2002-02-10 |
SE9801990D0 (sv) | 1998-06-04 |
JP2004256548A (ja) | 2004-09-16 |
EP1084101B1 (en) | 2004-03-10 |
TR200003543T2 (tr) | 2001-04-20 |
DE69915470T2 (de) | 2005-02-24 |
ZA200006773B (en) | 2002-02-20 |
SK17672000A3 (sk) | 2001-08-06 |
TW446694B (en) | 2001-07-21 |
CA2334107A1 (en) | 1999-12-09 |
WO1999062870A1 (en) | 1999-12-09 |
ID28164A (id) | 2001-05-10 |
DK1084101T3 (da) | 2004-06-14 |
ES2216527T3 (es) | 2004-10-16 |
CN1311769A (zh) | 2001-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9910913A (pt) | Composto, processo para a preparação de um composto, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com resistência a insulina | |
BR9910928A (pt) | Composto, processo para a prepará-lo, uso do mesmo, formulação, e, processo para a profilaxia e/ou tratamento de condições clinicas associadas com resistência a insulina | |
BR9910921A (pt) | Composto, processo para preparar o mesmo, formulação farmacêutica, uso de um composto, e, processo para a profilaxia e/ou tratamento de condições clìnicas associadas com a resistência à insulina | |
BR0108870A (pt) | Sais cloridrato de 5-[4-[2-(n-metil-n-(2-piridil) amino) etoxi] benzil] tiazolidino-2,4-diona | |
AR016351A1 (es) | FORMA CRISTALINA BETA DE LA SAL DE ADICIoN DE ÁCIDO METANSULFoNICO DE 4-(4-METILPIPERAZIN-1-ILMETIL)-N-[4-METIL-3-(4-PIRIDIN-3-IL) PIRIMIDIN-2-ILAMINO) FENIL] BENZAMIDA, COMPOSICIoN FARMACÉUTICA, USO DE LA FORMA CRISTALINA PARA LA PREPARACIoN DE UN AGENTE FARMACOLoGICO, Y PROCESOS PARA LA PREPARACIo | |
BR9307408A (pt) | Novo derivado arilpropi nico processo para a prepara-Æo do mesmo e seu uso como agente analgesico | |
RU93043528A (ru) | Моногидрат 5-(2-(4-(1,2-бензотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-он хлоргидрата, способ его получения, фармацевтическая композиция, способ лечения | |
PT82610B (pt) | Processo para a preparacao de tiazolidino-dionas hipoglicemicas | |
PL334773A1 (en) | Endothelin antagonists: n-[[2'-[[4,5-dimethyl-3-isoxazolyl)amino]sulphonyl]-4-(oxazoyl)[1,1'diphenyl]-ilyl-2]methyl]-n,3,3-trimethylabutane amide and n-(4,5-dimethyl-3-isoxazoyl)-2'-[3,3-dimethyl-2-oxo-1-pyrollydinyl)methyl]-4.-(2-oxazolyl)[1,1'-diphenyl]-2-sulphonamide and their salts | |
BR0214988A (pt) | S-enanciÈmero de um composto, composto, formulação farmacêutica, método de tratamento ou prevenção de distúrbios de lipìdeo, uso de um composto, método de tratamento ou prevenção de diabetes tipo 2, processo para a preparação de um composto, e, composição farmacêutica | |
BR0111913A (pt) | Análogos de gabapentina para distúrbios do sono | |
BR0108604A (pt) | Forma cristalina de ácido n-[4-[2-(2-amino-4,7 -diidro-4-oxo-3hpirrolo[2-3-d]pirimidin-5-il)etil]benzoi l]-l-glutâmico e processo para sua preparação | |
TR200401333T4 (tr) | (S)-2 Etoksi -3-4- (2-4-Metansulfoniloksifenil Etoksi) Fenil] Propanoik Asidin Kristal Formu | |
PT82480B (pt) | Processo para a preparacao de 2-amino tiazois n- substituidos e das correspondentes composicoes farmaceuticas | |
BR0314844A (pt) | Novo composto | |
BR0314843A (pt) | Novo composto | |
BR0101230A (pt) | Processo para a preparação de11-amino-3-cloro-6,11-diidro-5-5-dioxo-6-metil-dibenzo[c,f][1,2]tiazepina e aplicação para a sìntese detianeptina | |
BR0209206A (pt) | Clatrato de hidrato de azitromicina com 1,2-propileno glicol, processo para a sua preparação e composição farmacêutica compreendendo o mesmo | |
BR0113713A (pt) | Sal de cloridrato de 5-[4-[2-(metil-n-(2-piridil)amino)etóxi]benzil]tiazolidina -2,4-diona | |
ES2165410T3 (es) | Nuevas 5-(ariloxi-metil)-oxazolinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. | |
BR9712033A (pt) | Composição farmacêutica para tratamento de doenças virais. | |
HUP0003710A2 (hu) | 2-[3-{4-[2-terc-Butil-6-(trifluor-metil)-4-pirimidinil]-1-piperazinil}-propil-tio]-4-pirimidinol-fumarát, valamint ezt a vegyületet tartalmazó gyógyászati készítmény | |
AR026704A1 (es) | Forma cristalina | |
BR0112981A (pt) | Sais tartarato de derivado de tiazolidinadiona | |
BR9915835A (pt) | Composição farmacêutica, e, processo para a preparação de uma composição |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |