FR2872159B1 - Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete - Google Patents

Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete

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Publication number
FR2872159B1
FR2872159B1 FR0407076A FR0407076A FR2872159B1 FR 2872159 B1 FR2872159 B1 FR 2872159B1 FR 0407076 A FR0407076 A FR 0407076A FR 0407076 A FR0407076 A FR 0407076A FR 2872159 B1 FR2872159 B1 FR 2872159B1
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France
Prior art keywords
diabetes
treatment
carboxylic acid
acid derivatives
phenyl carboxylic
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Expired - Fee Related
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FR0407076A
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English (en)
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FR2872159A1 (fr
Inventor
Gerard Moinet
Gerard Botton
Micheline Kergoat
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Merck Sante SAS
Original Assignee
Merck Sante SAS
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Priority to FR0407076A priority Critical patent/FR2872159B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to PCT/EP2005/005868 priority patent/WO2006000288A1/fr
Priority to US11/630,892 priority patent/US7816397B2/en
Priority to JP2007518474A priority patent/JP2008504312A/ja
Priority to AU2005256359A priority patent/AU2005256359B2/en
Priority to EP05749839A priority patent/EP1761486A1/fr
Priority to CA2572153A priority patent/CA2572153C/fr
Priority to ARP050102600A priority patent/AR055219A1/es
Publication of FR2872159A1 publication Critical patent/FR2872159A1/fr
Application granted granted Critical
Publication of FR2872159B1 publication Critical patent/FR2872159B1/fr
Expired - Fee Related legal-status Critical Current
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    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
FR0407076A 2004-06-28 2004-06-28 Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete Expired - Fee Related FR2872159B1 (fr)

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FR0407076A FR2872159B1 (fr) 2004-06-28 2004-06-28 Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete
US11/630,892 US7816397B2 (en) 2004-06-28 2005-06-01 Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes
JP2007518474A JP2008504312A (ja) 2004-06-28 2005-06-01 フェニルカルボン酸誘導体および糖尿病の処置のためのその使用
AU2005256359A AU2005256359B2 (en) 2004-06-28 2005-06-01 Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes
PCT/EP2005/005868 WO2006000288A1 (fr) 2004-06-28 2005-06-01 Derives d'acide phenylcarboxylique, et leur utilisation pour traiter le diabete
EP05749839A EP1761486A1 (fr) 2004-06-28 2005-06-01 Derives d'acide phenylcarboxylique, et leur utilisation pour traiter le diabete
CA2572153A CA2572153C (fr) 2004-06-28 2005-06-01 Derives d'acide phenylcarboxylique, et leur utilisation pour traiter le diabete
ARP050102600A AR055219A1 (es) 2004-06-28 2005-06-24 Derivados de acido fenilcarboxilico y su uso para el tratamiento de diabetes

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US20110053995A1 (en) * 2006-11-16 2011-03-03 The Regents Of The University Of California Benzenesulfonanilide compound inhibitors of urea transporters
TWI594975B (zh) 2013-04-24 2017-08-11 第一三共股份有限公司 二羧酸化合物
US11261154B2 (en) 2018-07-31 2022-03-01 Ono Pharmaceutical Co., Ltd. Benzene derivative
JP7384179B2 (ja) 2020-01-29 2023-11-21 小野薬品工業株式会社 ベンゼン誘導体を含有する医薬組成物

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AU2005256359B2 (en) 2011-05-12
AR055219A1 (es) 2007-08-15
US7816397B2 (en) 2010-10-19
AU2005256359A1 (en) 2006-01-05
WO2006000288A1 (fr) 2006-01-05
CA2572153C (fr) 2013-09-03
FR2872159A1 (fr) 2005-12-30
EP1761486A1 (fr) 2007-03-14
CA2572153A1 (fr) 2006-01-05
JP2008504312A (ja) 2008-02-14

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