BR9815409A - Tienopirimidinas - Google Patents
TienopirimidinasInfo
- Publication number
- BR9815409A BR9815409A BR9815409-5A BR9815409A BR9815409A BR 9815409 A BR9815409 A BR 9815409A BR 9815409 A BR9815409 A BR 9815409A BR 9815409 A BR9815409 A BR 9815409A
- Authority
- BR
- Brazil
- Prior art keywords
- thienopyrimidines
- treatment
- thyenopyrimidines
- cardio
- phosphodiesterase
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 230000002425 cardiocirculatory effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção:<B>"TIENOPIRIMIDINAS"<D>. Tienopirimidinas da fórmula (I), bem como seus sais fisiologicamente inofensivos, na qual R^ 1^, R^ 2^, R^ 3^, R^ 4^, X e n têm os significados indicados na reivindicação 1, exibem uma inibição de fosfodiesterase V e podem ser utilizados para o tratamento de enfermidades do sistema cárdio-circulatório e para o tratamento e/ou terapia de distúrbios de potência.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19752952A DE19752952A1 (de) | 1997-11-28 | 1997-11-28 | Thienopyrimidine |
PCT/EP1998/007436 WO1999028325A1 (de) | 1997-11-28 | 1998-11-19 | Thienopyrimidine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9815409A true BR9815409A (pt) | 2000-10-24 |
Family
ID=7850200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9815409-5A BR9815409A (pt) | 1997-11-28 | 1998-11-19 | Tienopirimidinas |
Country Status (24)
Country | Link |
---|---|
US (2) | US6420368B1 (pt) |
EP (1) | EP1036078B1 (pt) |
JP (1) | JP4314341B2 (pt) |
KR (1) | KR20010032445A (pt) |
CN (1) | CN1138780C (pt) |
AR (1) | AR010962A1 (pt) |
AT (1) | ATE361926T1 (pt) |
AU (1) | AU742433B2 (pt) |
BR (1) | BR9815409A (pt) |
CA (1) | CA2311922C (pt) |
CO (1) | CO4980884A1 (pt) |
CZ (1) | CZ291068B6 (pt) |
DE (2) | DE19752952A1 (pt) |
ES (1) | ES2285796T3 (pt) |
HK (1) | HK1038924A1 (pt) |
HU (1) | HUP0100488A3 (pt) |
ID (1) | ID24571A (pt) |
NO (1) | NO20002702L (pt) |
PL (1) | PL341156A1 (pt) |
RU (1) | RU2217431C2 (pt) |
SK (1) | SK7772000A3 (pt) |
TW (1) | TW472059B (pt) |
WO (1) | WO1999028325A1 (pt) |
ZA (1) | ZA9810845B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19819023A1 (de) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidine |
US6482948B1 (en) | 1999-03-30 | 2002-11-19 | Nippon Soda Co., Ltd. | Thienopyrimidine compounds and salts thereof and process for the preparation of the same |
DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
DE60124085D1 (de) | 2000-04-19 | 2006-12-07 | Lilly Icos Llc | Pde-v hemmer zur behandlung von morbus parkinson |
DE10031585A1 (de) * | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 2-Aminoalkyl-thieno[2,3-d]pyrimidine |
DE10031584A1 (de) | 2000-06-29 | 2002-01-10 | Merck Patent Gmbh | 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine |
DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
AU2001290311A1 (en) * | 2000-09-29 | 2002-04-08 | Nippon Soda Co., Ltd. | Thienopyrimidine compounds and their salts and process for preparation of both |
DE10058663A1 (de) * | 2000-11-25 | 2002-05-29 | Merck Patent Gmbh | Verwendung von Thienopyrimidinen |
PL361805A1 (en) * | 2000-12-19 | 2004-10-04 | Merck Patent Gmbh | Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives |
DE10064994A1 (de) * | 2000-12-23 | 2002-07-04 | Merck Patent Gmbh | Sulfamidothienopyrimidine |
DE10103647A1 (de) | 2001-01-27 | 2002-08-01 | Merck Patent Gmbh | Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates |
CN1499969A (zh) * | 2001-01-31 | 2004-05-26 | Ĭ��ר���ɷ�����˾ | 含有吡唑并[4,3-d]嘧啶和硝酸酯或噻吩并嘧啶和硝酸酯的药物组合物 |
CN101100472A (zh) * | 2001-04-30 | 2008-01-09 | 美国拜尔公司 | 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 |
DE10148883A1 (de) | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
WO2003035653A1 (fr) * | 2001-10-26 | 2003-05-01 | Nippon Soda Co.,Ltd. | Compose pyridothienopyrimidine et son sel |
RS20050810A (en) | 2003-04-29 | 2007-08-03 | Pfizer Inc., | 5,7-diaminopyrazolo(4,3-d)pyrimidines useful in the treatment of hypertension |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
DK1742950T3 (da) | 2004-04-07 | 2009-03-16 | Pfizer Ltd | Pyrazolo-[4,3-D]-pyrimidiner |
GB0420719D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
ES2259892B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
ES2259891B1 (es) * | 2004-11-30 | 2007-11-01 | Laboratorios Almirall S.A. | Nuevos derivados de piridotienopirimidina. |
AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
CN109297923A (zh) * | 2018-09-19 | 2019-02-01 | 南通出入境检验检疫局检验检疫综合技术中心 | 纺织品中微量含氟整理剂的测定方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE245666C (pt) | ||||
DD245666A1 (de) * | 1985-09-20 | 1987-05-13 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-aminosubstituierten thieno 2,3-d-pyrimidin-2-ylessigsaeureestern |
GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
DE19644228A1 (de) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
-
1997
- 1997-11-28 DE DE19752952A patent/DE19752952A1/de not_active Withdrawn
-
1998
- 1998-11-19 SK SK777-2000A patent/SK7772000A3/sk unknown
- 1998-11-19 DE DE59814003T patent/DE59814003D1/de not_active Expired - Lifetime
- 1998-11-19 AT AT98964411T patent/ATE361926T1/de not_active IP Right Cessation
- 1998-11-19 JP JP2000523217A patent/JP4314341B2/ja not_active Expired - Fee Related
- 1998-11-19 CN CNB988113767A patent/CN1138780C/zh not_active Expired - Fee Related
- 1998-11-19 PL PL98341156A patent/PL341156A1/xx not_active Application Discontinuation
- 1998-11-19 WO PCT/EP1998/007436 patent/WO1999028325A1/de active IP Right Grant
- 1998-11-19 RU RU2000116899/04A patent/RU2217431C2/ru not_active IP Right Cessation
- 1998-11-19 CZ CZ20001962A patent/CZ291068B6/cs not_active IP Right Cessation
- 1998-11-19 EP EP98964411A patent/EP1036078B1/de not_active Expired - Lifetime
- 1998-11-19 AU AU19625/99A patent/AU742433B2/en not_active Ceased
- 1998-11-19 HU HU0100488A patent/HUP0100488A3/hu unknown
- 1998-11-19 ID IDW20000942A patent/ID24571A/id unknown
- 1998-11-19 KR KR1020007005686A patent/KR20010032445A/ko active IP Right Grant
- 1998-11-19 CA CA002311922A patent/CA2311922C/en not_active Expired - Fee Related
- 1998-11-19 ES ES98964411T patent/ES2285796T3/es not_active Expired - Lifetime
- 1998-11-19 US US09/555,210 patent/US6420368B1/en not_active Expired - Fee Related
- 1998-11-19 BR BR9815409-5A patent/BR9815409A/pt not_active Application Discontinuation
- 1998-11-26 ZA ZA9810845A patent/ZA9810845B/xx unknown
- 1998-11-26 TW TW087119650A patent/TW472059B/zh not_active IP Right Cessation
- 1998-11-27 CO CO98070308A patent/CO4980884A1/es unknown
- 1998-11-27 AR ARP980106028A patent/AR010962A1/es not_active Application Discontinuation
-
2000
- 2000-05-26 NO NO20002702A patent/NO20002702L/no not_active Application Discontinuation
-
2002
- 2002-01-25 HK HK02100600.0A patent/HK1038924A1/zh unknown
- 2002-05-16 US US10/146,028 patent/US6495554B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6420368B1 (en) | 2002-07-16 |
WO1999028325A1 (de) | 1999-06-10 |
PL341156A1 (en) | 2001-03-26 |
ID24571A (id) | 2000-07-27 |
RU2217431C2 (ru) | 2003-11-27 |
AU1962599A (en) | 1999-06-16 |
TW472059B (en) | 2002-01-11 |
US6495554B2 (en) | 2002-12-17 |
EP1036078B1 (de) | 2007-05-09 |
CA2311922A1 (en) | 1999-06-10 |
ATE361926T1 (de) | 2007-06-15 |
CN1306534A (zh) | 2001-08-01 |
US20020132818A1 (en) | 2002-09-19 |
ES2285796T3 (es) | 2007-11-16 |
CZ20001962A3 (cs) | 2002-01-16 |
ZA9810845B (en) | 1999-05-26 |
CN1138780C (zh) | 2004-02-18 |
KR20010032445A (ko) | 2001-04-25 |
CO4980884A1 (es) | 2000-11-27 |
CZ291068B6 (cs) | 2002-12-11 |
HK1038924A1 (zh) | 2002-04-04 |
NO20002702D0 (no) | 2000-05-26 |
CA2311922C (en) | 2009-09-29 |
AR010962A1 (es) | 2000-07-12 |
JP4314341B2 (ja) | 2009-08-12 |
SK7772000A3 (en) | 2000-12-11 |
HUP0100488A2 (hu) | 2001-09-28 |
HUP0100488A3 (en) | 2003-03-28 |
JP2001525325A (ja) | 2001-12-11 |
EP1036078A1 (de) | 2000-09-20 |
DE19752952A1 (de) | 1999-06-02 |
DE59814003D1 (en) | 2007-06-21 |
NO20002702L (no) | 2000-05-26 |
AU742433B2 (en) | 2002-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: C07D 495/04, A61K 31/519, A61P 9/00, A61P 15/10 Ipc: C07D 495/04 (2007.01), A61K 31/519 (2007.01), A61P |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI. |