BR9814415A - "método para desenvolver, testar e utilizar associados de macromoléculas e agregados de complexos para carga útil aumentada e velocidades de desassociação controláveis" - Google Patents
"método para desenvolver, testar e utilizar associados de macromoléculas e agregados de complexos para carga útil aumentada e velocidades de desassociação controláveis"Info
- Publication number
- BR9814415A BR9814415A BR9814415-4A BR9814415A BR9814415A BR 9814415 A BR9814415 A BR 9814415A BR 9814415 A BR9814415 A BR 9814415A BR 9814415 A BR9814415 A BR 9814415A
- Authority
- BR
- Brazil
- Prior art keywords
- aggregates
- testing
- associates
- charged
- macromolecule
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229920002521 macromolecule Polymers 0.000 title abstract 3
- 238000012360 testing method Methods 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 1
- 102000015336 Nerve Growth Factor Human genes 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000011161 development Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940053128 nerve growth factor Drugs 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
Patente de Invenção: <B>"MéTODO PARA DESENVOLVER, TESTAR E UTILIZAR ASSOCIADOS DE MACROMOLéCULAS E AGREGADOS DE COMPLEXOS PARA CARGA úTIL AUMENTADA E VELOCIDADES DE DESASSOCIAçãO CONTROLáVEIS"<D>. A invenção descreve os princípios e os procedimentos adequados para o desenvolvimento, teste, fabricação e utilização de combinações de diversas macromoléculas anfipáticas, se necessário modificadas (tais como polipeptídios, proteínas, etc.) ou outras moléculas de cadeia (tais como adequadas, por exemplo, polinucleotídeos ou polissacarídeos parcialmente tornados hidrófobos) com agregados que compreende uma mistura de anfipatos polares e ou carregados e formam superfícies prolongadas que podem ser livremente suspensas ou sustentadas. Os métodos descritos podem ser utilizados para a otimização de agregados que, depois da associação com moléculas de cadeia que exercem alguma atividade ou uma função útil, são adequados para a aplicação in vitro ou in vivo, por exemplo, nos campos de transferência de drogas, diagnósticos ou catálise biológica. Como exemplos especiais, são descritas misturas de gotículas vesiculares que consistem em lipídios carregados (associados) com insulina, interferon, interleucina, fator de crescimento de nervo, calcitonina e uma imunoglobulina, etc.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1998/006750 WO2000024377A1 (en) | 1998-10-23 | 1998-10-23 | Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814415A true BR9814415A (pt) | 2000-10-10 |
Family
ID=8167110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814415-4A BR9814415A (pt) | 1998-10-23 | 1998-10-23 | "método para desenvolver, testar e utilizar associados de macromoléculas e agregados de complexos para carga útil aumentada e velocidades de desassociação controláveis" |
Country Status (13)
Country | Link |
---|---|
US (2) | US20080311184A1 (pt) |
EP (1) | EP1039880A1 (pt) |
JP (1) | JP4838936B2 (pt) |
KR (1) | KR100464601B1 (pt) |
CN (1) | CN1192766C (pt) |
AU (1) | AU765385C (pt) |
BR (1) | BR9814415A (pt) |
CA (1) | CA2309633C (pt) |
HK (1) | HK1032745A1 (pt) |
HU (1) | HUP0102741A3 (pt) |
MX (1) | MXPA00006196A (pt) |
NO (1) | NO20003287L (pt) |
WO (1) | WO2000024377A1 (pt) |
Families Citing this family (17)
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SI1031347T1 (en) | 1999-01-27 | 2002-10-31 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
DK1031346T3 (da) | 1999-01-27 | 2002-08-12 | Idea Ag | Ikke-invasiv vaccination gennem huden |
US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
GB2398495B (en) * | 2003-01-23 | 2007-08-22 | Kent G Lau | A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug |
UA75030C2 (en) * | 2005-11-30 | 2006-03-15 | Viktor Oleksandrovych Bykov | Method for obtaining stable aqueous solutions of drugs |
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
US8962015B2 (en) | 2007-09-28 | 2015-02-24 | Sdg, Inc. | Orally bioavailable lipid-based constructs |
JP6051157B2 (ja) | 2010-07-14 | 2016-12-27 | 中国医学科学院▲薬▼物研究所 | 一種インスリンの脂質複合物及び作製方法や製剤 |
US8422540B1 (en) | 2012-06-21 | 2013-04-16 | CBF Networks, Inc. | Intelligent backhaul radio with zero division duplexing |
KR101849441B1 (ko) | 2015-03-19 | 2018-04-16 | 김태구 | 캔 오프너 |
KR20160112915A (ko) | 2015-10-23 | 2016-09-28 | 김태구 | 캔 오프너 |
WO2017087685A1 (en) * | 2015-11-20 | 2017-05-26 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
SG11201908052PA (en) * | 2017-03-13 | 2019-09-27 | Sdg Inc | Lipid-based nanoparticles with enhanced stability |
AU2018331357A1 (en) | 2017-09-18 | 2020-04-02 | Bayer Healthcare Llc | Methods of inactivation of viruses using N-methylglucamides and its Derivatives |
US20220030860A1 (en) * | 2018-08-08 | 2022-02-03 | 3M Innovative Properties Company | Therapeutic composition and related methods |
KR20220118210A (ko) * | 2021-02-18 | 2022-08-25 | (주)아모레퍼시픽 | 트랜스퍼좀을 포함하는 난용성 효능물질 전달체 |
CN115350330B (zh) * | 2022-09-01 | 2023-10-20 | 北京化工大学 | 一种负电性小分子调控的表面在蛋白差异性黏附上的应用 |
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IL64397A0 (en) * | 1981-01-07 | 1982-02-28 | Weder Hans G | Process for the preparation of liposomal medicaments |
US5008050A (en) * | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
US4897269A (en) * | 1984-09-24 | 1990-01-30 | Mezei Associates Limited | Administration of drugs with multiphase liposomal delivery system |
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US5244678A (en) * | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
CA1308025C (en) * | 1986-11-28 | 1992-09-29 | Paul A. Tremblay | Phospholipid composition |
US4849224A (en) * | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US5043165A (en) * | 1988-12-14 | 1991-08-27 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs |
US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
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CN1320880C (zh) * | 1998-12-23 | 2007-06-13 | 伊迪亚股份公司 | 改进的体内局部无创伤用制剂 |
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US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
GB0417494D0 (en) * | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
-
1998
- 1998-10-23 BR BR9814415-4A patent/BR9814415A/pt not_active Application Discontinuation
- 1998-10-23 AU AU14350/99A patent/AU765385C/en not_active Ceased
- 1998-10-23 EP EP98958234A patent/EP1039880A1/en not_active Ceased
- 1998-10-23 CA CA2309633A patent/CA2309633C/en not_active Expired - Fee Related
- 1998-10-23 KR KR10-2000-7007020A patent/KR100464601B1/ko not_active IP Right Cessation
- 1998-10-23 JP JP2000577988A patent/JP4838936B2/ja not_active Expired - Fee Related
- 1998-10-23 MX MXPA00006196A patent/MXPA00006196A/es active IP Right Grant
- 1998-10-23 CN CNB988126605A patent/CN1192766C/zh not_active Expired - Fee Related
- 1998-10-23 HU HU0102741A patent/HUP0102741A3/hu unknown
- 1998-10-23 WO PCT/EP1998/006750 patent/WO2000024377A1/en active IP Right Grant
-
2000
- 2000-06-22 NO NO20003287A patent/NO20003287L/no not_active Application Discontinuation
-
2001
- 2001-05-15 HK HK01103359A patent/HK1032745A1/xx not_active IP Right Cessation
-
2007
- 2007-10-30 US US11/929,544 patent/US20080311184A1/en not_active Abandoned
- 2007-10-30 US US11/929,480 patent/US20080279815A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1192766C (zh) | 2005-03-16 |
KR100464601B1 (ko) | 2004-12-31 |
HUP0102741A3 (en) | 2002-12-28 |
NO20003287D0 (no) | 2000-06-22 |
HUP0102741A2 (hu) | 2002-03-28 |
AU1435099A (en) | 2000-05-15 |
AU765385B2 (en) | 2003-09-18 |
JP2002528406A (ja) | 2002-09-03 |
US20080311184A1 (en) | 2008-12-18 |
HK1032745A1 (en) | 2001-08-03 |
KR20010033518A (ko) | 2001-04-25 |
AU765385C (en) | 2004-05-20 |
NO20003287L (no) | 2000-08-23 |
EP1039880A1 (en) | 2000-10-04 |
WO2000024377A1 (en) | 2000-05-04 |
CA2309633A1 (en) | 2000-05-04 |
US20080279815A1 (en) | 2008-11-13 |
CA2309633C (en) | 2010-12-14 |
CN1283107A (zh) | 2001-02-07 |
JP4838936B2 (ja) | 2011-12-14 |
MXPA00006196A (es) | 2003-07-21 |
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