CU22737A1 - Proteínas de fusión recombinantes basadas en adhesinas bacterianas para el desarrollo de ensayos diagnóstico - Google Patents
Proteínas de fusión recombinantes basadas en adhesinas bacterianas para el desarrollo de ensayos diagnósticoInfo
- Publication number
- CU22737A1 CU22737A1 CU1997047A CU1997047A CU22737A1 CU 22737 A1 CU22737 A1 CU 22737A1 CU 1997047 A CU1997047 A CU 1997047A CU 1997047 A CU1997047 A CU 1997047A CU 22737 A1 CU22737 A1 CU 22737A1
- Authority
- CU
- Cuba
- Prior art keywords
- fusion proteins
- recombinant fusion
- development
- bacterial
- diagnostic tests
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
- G01N33/555—Red blood cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención está relacionada con el campo de la biotecnología, en particular con el desarrollo de proteinas de fusión recombinantes basadas en adhesinas bacterianas y su uso en ensayos diagnósticos de hemaglutinación para la detección específica de anticuerpos o antígenos en sangre y otras muestras biológicas. Su objetivo técnico es obtener proteínas de fusión recombinantes, o conjugados bioquímicos, útiles para el desarrollo de sistemas simples de ensayo diagnóstico, basados en adhesinas bacterianas o sus dominios de interacción molecular con las células rojas. El uso de proteínas de adhesión de E. coli como base de proteínas recombinantes de fusión con actividad de unión a eritrocitos humanos, favorece las características de expresión en este hospedero, eliminando problemas potenciales en los rendimientos de producción asociados a la toxicidad bacteriana.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1997047A CU22737A1 (es) | 1997-04-28 | 1997-04-28 | Proteínas de fusión recombinantes basadas en adhesinas bacterianas para el desarrollo de ensayos diagnóstico |
PCT/CU1998/000005 WO1998049327A1 (es) | 1997-04-28 | 1998-04-27 | Proteinas de fusion recombinantes basadas en adhesinas bacterianas para el desarollo de ensayos diagnosticos |
CA002288348A CA2288348A1 (en) | 1997-04-28 | 1998-04-27 | Recombinant fusion proteines based on bacterial adhesines for diagnostic assays |
AU70277/98A AU741043B2 (en) | 1997-04-28 | 1998-04-27 | Recombinant fusion proteins based on bacterial adhesins for diagnostic assays |
EP98916797A EP0978564A1 (en) | 1997-04-28 | 1998-04-27 | Recombinant fusion proteines based on bacterial adhesines for diagnostic assays |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1997047A CU22737A1 (es) | 1997-04-28 | 1997-04-28 | Proteínas de fusión recombinantes basadas en adhesinas bacterianas para el desarrollo de ensayos diagnóstico |
Publications (1)
Publication Number | Publication Date |
---|---|
CU22737A1 true CU22737A1 (es) | 2002-02-28 |
Family
ID=5459262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU1997047A CU22737A1 (es) | 1997-04-28 | 1997-04-28 | Proteínas de fusión recombinantes basadas en adhesinas bacterianas para el desarrollo de ensayos diagnóstico |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0978564A1 (es) |
AU (1) | AU741043B2 (es) |
CA (1) | CA2288348A1 (es) |
CU (1) | CU22737A1 (es) |
WO (1) | WO1998049327A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
EP3909603A1 (en) | 2014-02-21 | 2021-11-17 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Glycotargeting therapeutics |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL87768A (en) * | 1987-09-17 | 1994-12-29 | Agen Ltd | Blood assay including erythrocyte agglutination and reagent for the assay comprising conjugate of erythrocyte binding molecule and analyte binding molecule |
EP0646173A4 (en) * | 1992-05-22 | 1997-02-26 | Agen Ltd | REAGENT FOR MEASURING AGGLUTINATION. |
-
1997
- 1997-04-28 CU CU1997047A patent/CU22737A1/es unknown
-
1998
- 1998-04-27 AU AU70277/98A patent/AU741043B2/en not_active Ceased
- 1998-04-27 WO PCT/CU1998/000005 patent/WO1998049327A1/es not_active Application Discontinuation
- 1998-04-27 EP EP98916797A patent/EP0978564A1/en not_active Withdrawn
- 1998-04-27 CA CA002288348A patent/CA2288348A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU7027798A (en) | 1998-11-24 |
WO1998049327A1 (es) | 1998-11-05 |
CA2288348A1 (en) | 1998-11-05 |
EP0978564A1 (en) | 2000-02-09 |
AU741043B2 (en) | 2001-11-22 |
WO1998049327A8 (es) | 2000-03-16 |
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