BR9811845A - Análogos do ácido antranìlico - Google Patents
Análogos do ácido antranìlicoInfo
- Publication number
- BR9811845A BR9811845A BR9811845-5A BR9811845A BR9811845A BR 9811845 A BR9811845 A BR 9811845A BR 9811845 A BR9811845 A BR 9811845A BR 9811845 A BR9811845 A BR 9811845A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- haloalkyl
- alkyl
- coor
- proviso
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Patente de Invenção: <B>"ANáLOGOS DO áCIDO ANTRANìLICO"<D>. Compostos da fórmula (I) na qual: R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 7~, e R~ 8~ são, independentemente, hidrogênio, COOR~ 15~, halogênio, nitro, ciano, C~ 1-10~ alcóxi, C~ 1-10~ haloalcóxi, ácido sulfónico, C~ 1-10~ alquilsulfonila, C~ 6-12~ arilsulfonila, C~ 6-12~ aralquilsulfonila, C~ 1-10~ alquilsufinila, C~ 6-12~ arilsufinila, C~ 6-12~ aralquilsufinila, sulfamoíla, C~ 1-10~ alquilsulfamida, C~ 6-12~ arilsulfamida, C~ 1-10~ alcanoíla, C~ 6-12~ ariloíla, C~ 6-12~ aralcanoil, amina, C~ 1-10~ alquilamino, C~ 2-10~ dialquilamino, C~ 6-12~ araquilamino, C~ 6-12~ arilamino, carboxamida, C~ 1-10~ alquilcarboxamida, C~ 6-12~ arilcarboxamida, C~ 1-10~ haloalquila, C~ 1-10~ alquila, C~ 2-12~ alquenila, C~ 6-12~ arila, C~ 6-12~ aralquila; com a condição de que pelo menos um de R~ 4~ e R~ 5~ seja COOR~ 15~; R~ 9~ é hidrogênio, C~ 1-10~ alquila e C~ 1-10~ haloalquila; R~ 10~ é hidrogênio, C~ 1-10~ alquila, C~ 1-10~ haloalquila, ou C~ 2-12~ alquilideno; R~ 15~ é hidrogênio, cátion de metal, acetilamida, alcoxiacetoíla ou uma porção relacionada que fornece o carboxilato in vivo; a linha pontilhada é uma dupla união opcional; com a condição de que quando R~ 10~ é uma porção de alquilideno, a dupla união esteja ausente; e W é nitrogênio ou carbono conduzindo um hidrogênio, ou R~ 4~, R~ 5~ ou R~ 6~ como aqui anteriormente definidos; ou sais farmacêuticos destes, são úteis no tratamento de distúrbios associados com a contração dos músculos lisos via canal de potássio e modulação do canal de cloreto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90668397A | 1997-08-05 | 1997-08-05 | |
PCT/US1998/016099 WO1999007669A1 (en) | 1997-08-05 | 1998-08-03 | Anthranilic acid analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811845A true BR9811845A (pt) | 2000-08-08 |
Family
ID=25422806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811845-5A BR9811845A (pt) | 1997-08-05 | 1998-08-03 | Análogos do ácido antranìlico |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003712A1 (pt) |
JP (1) | JP2001513526A (pt) |
CN (1) | CN1273579A (pt) |
AU (1) | AU8684598A (pt) |
BR (1) | BR9811845A (pt) |
CA (1) | CA2297412A1 (pt) |
WO (1) | WO1999007669A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19929076A1 (de) * | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
DE19935219A1 (de) | 1999-07-27 | 2001-02-01 | Boehringer Ingelheim Pharma | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
DE10065042A1 (de) * | 2000-12-23 | 2002-06-27 | Boehringer Ingelheim Pharma | Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
US7429593B2 (en) | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
AU2003258491A1 (en) * | 2002-09-05 | 2004-03-29 | Neurosearch A/S | Amide derivatives and their use as chloride channel blockers |
US7144881B2 (en) * | 2002-11-22 | 2006-12-05 | Bristol-Myers Squibb Company | Arylcyclopropylcarboxylic amides as potassium channel openers |
GB0319124D0 (en) * | 2003-08-14 | 2003-09-17 | Smithkline Beecham Corp | Chemical compounds |
CN110357789B (zh) * | 2018-04-11 | 2022-09-30 | 华东理工大学 | 作为dhodh抑制剂的n-取代丙烯酰胺衍生物及其制备和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5970654A (ja) * | 1982-10-15 | 1984-04-21 | Nippon Redarii Kk | アントラニル酸誘導体 |
JPS6097946A (ja) * | 1983-11-01 | 1985-05-31 | Ono Pharmaceut Co Ltd | カルボキサミド誘導体 |
GB9214120D0 (en) * | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
-
1998
- 1998-08-03 WO PCT/US1998/016099 patent/WO1999007669A1/en not_active Application Discontinuation
- 1998-08-03 CN CN98809866A patent/CN1273579A/zh active Pending
- 1998-08-03 CA CA002297412A patent/CA2297412A1/en not_active Abandoned
- 1998-08-03 EP EP98938288A patent/EP1003712A1/en not_active Withdrawn
- 1998-08-03 JP JP2000507205A patent/JP2001513526A/ja active Pending
- 1998-08-03 AU AU86845/98A patent/AU8684598A/en not_active Abandoned
- 1998-08-03 BR BR9811845-5A patent/BR9811845A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999007669A1 (en) | 1999-02-18 |
CA2297412A1 (en) | 1999-02-18 |
AU8684598A (en) | 1999-03-01 |
JP2001513526A (ja) | 2001-09-04 |
CN1273579A (zh) | 2000-11-15 |
EP1003712A1 (en) | 2000-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |