BR9809481A - Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente - Google Patents
Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um pacienteInfo
- Publication number
- BR9809481A BR9809481A BR9809481-5A BR9809481A BR9809481A BR 9809481 A BR9809481 A BR 9809481A BR 9809481 A BR9809481 A BR 9809481A BR 9809481 A BR9809481 A BR 9809481A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- compound
- treat
- risk
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 206010062016 Immunosuppression Diseases 0.000 title abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 title abstract 2
- 230000000414 obstructive effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000023504 respiratory system disease Diseases 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Liquid Crystal (AREA)
- Valve-Gear Or Valve Arrangements (AREA)
Abstract
"COMPOSTO, PROCESSO PARA SUA PREPARAçãO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA SUA PREPARAçãO, PARA EFETUAR A IMUNOSSUPRESSãO E PARA TRATAR OU REDUZIR O RISCO DE UMA DOENçA OBSTRUTIVA REVERSìVEL DAS VIAS AéREAS EM UM PACIENTE". Composto de fórmula (I) em que R, R^ 1^, R^ 2^ e R^ 3^ têm os significados dados na descrição. O composto (I) é útil no tratamento (profilático) de doenças autoimunes, inflamatórias, proliferativas e hiperproliferativas e de doenças mediadas imunologicamente, incluindo a rejeição de órgãos ou tecidos transplantados e a síndrome da imunodeficiência adquirida (AIDS).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702001A SE9702001D0 (sv) | 1997-05-28 | 1997-05-28 | Novel compounds |
PCT/SE1998/000935 WO1998054190A1 (en) | 1997-05-28 | 1998-05-18 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809481A true BR9809481A (pt) | 2000-06-20 |
Family
ID=20407123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809481-5A BR9809481A (pt) | 1997-05-28 | 1998-05-18 | Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente |
Country Status (28)
Country | Link |
---|---|
US (2) | US6180635B1 (pt) |
EP (1) | EP0991653B1 (pt) |
JP (1) | JP2002500666A (pt) |
KR (1) | KR100561988B1 (pt) |
CN (1) | CN1122037C (pt) |
AT (1) | ATE226205T1 (pt) |
AU (1) | AU723708B2 (pt) |
BR (1) | BR9809481A (pt) |
CA (1) | CA2289509C (pt) |
CZ (1) | CZ297536B6 (pt) |
DE (1) | DE69808765T2 (pt) |
DK (1) | DK0991653T3 (pt) |
EE (1) | EE04018B1 (pt) |
ES (1) | ES2184270T3 (pt) |
HU (1) | HU226627B1 (pt) |
ID (1) | ID28432A (pt) |
IL (2) | IL132763A0 (pt) |
IS (1) | IS1983B (pt) |
NO (1) | NO323752B1 (pt) |
NZ (1) | NZ500853A (pt) |
PL (1) | PL199567B1 (pt) |
PT (1) | PT991653E (pt) |
RU (1) | RU2225410C2 (pt) |
SE (1) | SE9702001D0 (pt) |
SK (1) | SK283589B6 (pt) |
TR (1) | TR199902904T2 (pt) |
UA (1) | UA61111C2 (pt) |
WO (1) | WO1998054190A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9801399D0 (sv) | 1998-04-21 | 1998-04-21 | Astra Pharma Prod | Method and apparatus for filling containers |
GB9819384D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
GB9819382D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
GB2361917A (en) * | 2000-05-04 | 2001-11-07 | Astrazeneca Ab | Novel thieno[2,3-d]pyrimidinediones |
EP1280806B1 (en) * | 2000-05-04 | 2004-08-04 | AstraZeneca AB | THIENO 2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS |
GB2363377B (en) * | 2000-06-14 | 2004-06-09 | Astrazeneca Ab | Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof |
BR0207216A (pt) * | 2001-02-14 | 2004-03-09 | Warner Lambert Co | Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz |
GB0117583D0 (en) * | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
PL370989A1 (en) * | 2001-12-21 | 2005-06-13 | Novo Nordisk A/S | Amide derivatives as gk activators |
PL215132B1 (pl) * | 2002-06-27 | 2013-10-31 | Novo Nordisk As | Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca |
US6890923B2 (en) * | 2002-12-16 | 2005-05-10 | Astrazeneca Ab | Compounds |
SE0300117D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel Compounds |
JP2006515880A (ja) | 2003-01-17 | 2006-06-08 | アストラゼネカ・アクチエボラーグ | 自己免疫疾患の調節におけるチエノピリダジノンとその使用 |
SE0300119D0 (sv) * | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300120D0 (sv) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
KR101126225B1 (ko) * | 2004-01-06 | 2012-04-12 | 노보 노르디스크 에이/에스 | 헤테로아릴-유리아 및 글루코키나아제 활성제로서의 그들의 사용 |
ATE547396T1 (de) * | 2005-07-08 | 2012-03-15 | Novo Nordisk As | Dicycloalkylcarbamoyl-harnstoffe als glucokinase- aktivatoren |
KR20080024211A (ko) * | 2005-07-08 | 2008-03-17 | 노보 노르디스크 에이/에스 | 디시클로알킬 우레아 글루코키나제 활성제 |
US7884210B2 (en) * | 2005-07-14 | 2011-02-08 | Novo Nordisk A/S | Ureido-thiazole glucokinase activators |
WO2007103776A2 (en) * | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
CN101186612B (zh) * | 2006-11-15 | 2012-10-03 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用 |
WO2008070529A2 (en) * | 2006-12-01 | 2008-06-12 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
JP5226008B2 (ja) | 2007-01-11 | 2013-07-03 | ノボ・ノルデイスク・エー/エス | ウレアグルコキナーゼアクチベーター |
EP2008656A1 (en) | 2007-06-28 | 2008-12-31 | Bergen Teknologioverforing AS | Compositions for the treatment of hyperphenylalaninemia |
EA201190138A1 (ru) * | 2009-03-23 | 2013-05-30 | Гленмарк Фармасьютикалс, С.А. | Производные фуропиримидиндиона в качестве модуляторов trpa1 |
CN106905346B (zh) | 2011-11-11 | 2019-05-28 | 吉利德阿波罗公司 | Acc抑制剂和其用途 |
JP6268093B2 (ja) * | 2012-09-14 | 2018-01-24 | キッセイ薬品工業株式会社 | 縮合複素環誘導体の製造方法およびその製造中間体 |
AU2014334040A1 (en) | 2013-10-07 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | Cyclic thienouracil-carboxamides and use thereof |
UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
EP3380479B1 (en) | 2015-11-25 | 2022-12-07 | Gilead Apollo, LLC | Triazole acc inhibitors and uses thereof |
JP2019502660A (ja) | 2015-11-25 | 2019-01-31 | ギリアド アポロ, エルエルシー | ピラゾールacc阻害剤およびその使用 |
AU2016361414A1 (en) | 2015-11-25 | 2018-05-24 | Gilead Apollo, Llc | Ester ACC inhibitors and uses thereof |
BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
BR112018067408A2 (pt) | 2016-03-02 | 2018-12-26 | Gilead Apollo Llc | formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas |
WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
RU2019111357A (ru) * | 2016-09-23 | 2020-10-23 | Байер Акциенгезельшафт | N3-циклически замещенные тиеноурацилы и их применение |
PT4122464T (pt) | 2017-03-28 | 2024-06-27 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças do fígado |
CA3093025A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU599515B2 (en) * | 1987-09-16 | 1990-07-19 | Taiho Pharmaceutical Co., Ltd. | Thienopyrimidine derivatives |
TW276256B (pt) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
FR2750862B1 (fr) * | 1996-07-12 | 1998-10-16 | Dupin Jean Pierre | Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques |
-
1997
- 1997-05-28 SE SE9702001A patent/SE9702001D0/xx unknown
-
1998
- 1998-05-18 US US09/117,426 patent/US6180635B1/en not_active Expired - Fee Related
- 1998-05-18 EE EEP199900539A patent/EE04018B1/xx not_active IP Right Cessation
- 1998-05-18 RU RU99128111/04A patent/RU2225410C2/ru not_active IP Right Cessation
- 1998-05-18 IL IL13276398A patent/IL132763A0/xx active IP Right Grant
- 1998-05-18 DE DE69808765T patent/DE69808765T2/de not_active Expired - Fee Related
- 1998-05-18 SK SK1513-99A patent/SK283589B6/sk not_active IP Right Cessation
- 1998-05-18 JP JP50056599A patent/JP2002500666A/ja not_active Ceased
- 1998-05-18 CN CN98807378A patent/CN1122037C/zh not_active Expired - Fee Related
- 1998-05-18 ES ES98924705T patent/ES2184270T3/es not_active Expired - Lifetime
- 1998-05-18 PT PT98924705T patent/PT991653E/pt unknown
- 1998-05-18 BR BR9809481-5A patent/BR9809481A/pt not_active Application Discontinuation
- 1998-05-18 EP EP98924705A patent/EP0991653B1/en not_active Expired - Lifetime
- 1998-05-18 AT AT98924705T patent/ATE226205T1/de not_active IP Right Cessation
- 1998-05-18 KR KR1019997011086A patent/KR100561988B1/ko not_active IP Right Cessation
- 1998-05-18 DK DK98924705T patent/DK0991653T3/da active
- 1998-05-18 NZ NZ500853A patent/NZ500853A/en unknown
- 1998-05-18 WO PCT/SE1998/000935 patent/WO1998054190A1/en active IP Right Grant
- 1998-05-18 ID IDW991450A patent/ID28432A/id unknown
- 1998-05-18 AU AU76808/98A patent/AU723708B2/en not_active Ceased
- 1998-05-18 TR TR1999/02904T patent/TR199902904T2/xx unknown
- 1998-05-18 CZ CZ0420199A patent/CZ297536B6/cs not_active IP Right Cessation
- 1998-05-18 CA CA002289509A patent/CA2289509C/en not_active Expired - Fee Related
- 1998-05-18 PL PL337126A patent/PL199567B1/pl not_active IP Right Cessation
- 1998-05-18 UA UA99127140A patent/UA61111C2/uk unknown
- 1998-05-18 HU HU0003355A patent/HU226627B1/hu not_active IP Right Cessation
-
1999
- 1999-11-04 IL IL132763A patent/IL132763A/en not_active IP Right Cessation
- 1999-11-23 IS IS5264A patent/IS1983B/is unknown
- 1999-11-26 NO NO19995810A patent/NO323752B1/no unknown
-
2000
- 2000-10-23 US US09/693,896 patent/US6342502B1/en not_active Expired - Fee Related
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