BR9808722A - Composições farmacêuticas de tizoxanida e nitazoxanida - Google Patents
Composições farmacêuticas de tizoxanida e nitazoxanidaInfo
- Publication number
- BR9808722A BR9808722A BR9808722-3A BR9808722A BR9808722A BR 9808722 A BR9808722 A BR 9808722A BR 9808722 A BR9808722 A BR 9808722A BR 9808722 A BR9808722 A BR 9808722A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- tizoxanide
- nitazoxanide
- formula
- particle size
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
<B>"COMPOSIçõES FARMACêUTICAS DE TIZOXANIDA E NITAZOXANIDA"<D>. A invenção se refere a uma composição farmacêutica contendo como agente ativo pelo menos um composto selecionado dentre o grupo que consiste dos compostos de fórmula (I) e fórmula (II) abaixo: O agente ativo está preferencialmente na forma de partículas tendo um tamanho de partícula menor que 200 Ám e um tamanho médio de partícula maior que 10 Ám. As composições farmacêuticas são preferencialmente estabilizadas com pelo menos um ácido farmaceuticamente aceitável. As composições são particularmente úteis no tratamento de infecções oportunísticas em pessoas com o sistema de imunidade comprometido ou suprimido e no tratamento de infecções causadas por trematódeos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/852,447 US5968961A (en) | 1997-05-07 | 1997-05-07 | Pharmaceutical compositions of tizoxanide and nitazoxanide |
US08/887,809 US5965590A (en) | 1994-09-08 | 1997-07-03 | Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide |
US08/887,810 US5856348A (en) | 1994-09-08 | 1997-07-03 | Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide |
PCT/US1998/009229 WO1998050035A1 (en) | 1997-05-07 | 1998-05-06 | Pharmaceutical compositions of tizoxanide and nitazoxanide |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808722A true BR9808722A (pt) | 2000-07-11 |
Family
ID=27420362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808722-3A BR9808722A (pt) | 1997-05-07 | 1998-05-06 | Composições farmacêuticas de tizoxanida e nitazoxanida |
Country Status (35)
Country | Link |
---|---|
EP (2) | EP1005342B1 (pt) |
JP (1) | JP3739802B2 (pt) |
KR (2) | KR100576646B1 (pt) |
CN (2) | CN100515420C (pt) |
AP (1) | AP1103A (pt) |
AR (1) | AR057242A2 (pt) |
AT (2) | ATE228839T1 (pt) |
AU (1) | AU740022B2 (pt) |
BG (2) | BG109365A (pt) |
BR (1) | BR9808722A (pt) |
CA (2) | CA2288003C (pt) |
CZ (2) | CZ298269B6 (pt) |
DE (2) | DE69809928T2 (pt) |
DK (2) | DK1005342T3 (pt) |
EA (2) | EA002920B1 (pt) |
EE (1) | EE04870B1 (pt) |
ES (2) | ES2150404T3 (pt) |
GE (1) | GEP20032970B (pt) |
HK (1) | HK1025907A1 (pt) |
HU (1) | HU229641B1 (pt) |
IL (2) | IL155799A (pt) |
IS (1) | IS2087B (pt) |
LV (1) | LV12492B (pt) |
ME (1) | ME00530B (pt) |
NO (2) | NO313983B1 (pt) |
NZ (2) | NZ500149A (pt) |
OA (1) | OA11169A (pt) |
PL (1) | PL193275B1 (pt) |
PT (2) | PT1222921E (pt) |
RO (1) | RO120605B1 (pt) |
SI (1) | SI20149B (pt) |
SK (2) | SK283946B6 (pt) |
TR (1) | TR199902733T2 (pt) |
UA (2) | UA57079C2 (pt) |
WO (1) | WO1998050035A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2467321A1 (en) | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
AU2007204963B2 (en) | 2006-01-09 | 2012-09-27 | Romark Laboratories, L.C. | Viral hepatitis treatment |
HUE049501T2 (hu) * | 2009-02-13 | 2020-09-28 | Romark Laboratories Lc | Nitazoxanidot tartalmazó szabályozott felszabadulású gyógyszerkészítmény |
KR101760956B1 (ko) | 2009-05-12 | 2017-07-24 | 로마크 레버러토리즈, 엘.씨. | 할로알킬 헤테로아릴 벤즈아미드 화합물 |
JP5932640B2 (ja) | 2009-06-26 | 2016-06-08 | ロマーク ラボラトリーズ エル.シー. | インフルエンザを治療するための化合物および方法 |
WO2013110975A1 (es) | 2012-01-27 | 2013-08-01 | Siegfried Rhein S.A. De C.V. | Composición de nitazoxanida mejorada y proceso para prepararla |
BR112017009651A2 (pt) * | 2014-11-11 | 2017-12-19 | Romark Laboratories Lc | composto, composição farmacêutica, e, método para tratamento de uma infecção por protozoário intracelular, uma infecção viral ou um câncer. |
JP7502186B2 (ja) | 2018-02-02 | 2024-06-18 | リップル セラピューティクス コーポレーション | ステロイド二量体を含むガラス製剤およびその使用 |
CN115956083A (zh) | 2020-05-01 | 2023-04-11 | 波纹疗法公司 | 异二聚体组合物及用于治疗眼部病症的方法 |
WO2022130406A1 (en) * | 2020-12-15 | 2022-06-23 | Cipla Limited | Inhalation composition of nitazoxanide or its derivatives for use in coronavirus disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1437800A (en) * | 1973-08-08 | 1976-06-03 | Phavic Sprl | Derivatives of 2-benzamido-5-nitro-thiazoles |
US4315018A (en) * | 1978-12-07 | 1982-02-09 | Rossignol Jean F | Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives |
US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
US5578621A (en) * | 1994-09-08 | 1996-11-26 | Romark Lab Lc | Benzamide derivatives |
-
1998
- 1998-05-06 IL IL15579998A patent/IL155799A/en not_active IP Right Cessation
- 1998-05-06 KR KR1020037011334A patent/KR100576646B1/ko not_active IP Right Cessation
- 1998-05-06 DK DK98920285T patent/DK1005342T3/da active
- 1998-05-06 SI SI9820037A patent/SI20149B/sl not_active IP Right Cessation
- 1998-05-06 EA EA200100956A patent/EA002920B1/ru not_active IP Right Cessation
- 1998-05-06 DK DK02002887T patent/DK1222921T3/da active
- 1998-05-06 CA CA002288003A patent/CA2288003C/en not_active Expired - Fee Related
- 1998-05-06 ME MEP-2008-877A patent/ME00530B/me unknown
- 1998-05-06 WO PCT/US1998/009229 patent/WO1998050035A1/en active IP Right Grant
- 1998-05-06 KR KR10-1999-7009930A patent/KR100426657B1/ko not_active IP Right Cessation
- 1998-05-06 JP JP54843798A patent/JP3739802B2/ja not_active Expired - Fee Related
- 1998-05-06 AU AU72895/98A patent/AU740022B2/en not_active Ceased
- 1998-05-06 DE DE69809928T patent/DE69809928T2/de not_active Expired - Lifetime
- 1998-05-06 IL IL13251698A patent/IL132516A/xx not_active IP Right Cessation
- 1998-05-06 DE DE69827417T patent/DE69827417T2/de not_active Expired - Lifetime
- 1998-05-06 NZ NZ500149A patent/NZ500149A/en not_active IP Right Cessation
- 1998-05-06 PL PL336805A patent/PL193275B1/pl not_active IP Right Cessation
- 1998-05-06 PT PT02002887T patent/PT1222921E/pt unknown
- 1998-05-06 SK SK1511-99A patent/SK283946B6/sk unknown
- 1998-05-06 PT PT98920285T patent/PT1005342E/pt unknown
- 1998-05-06 AT AT98920285T patent/ATE228839T1/de active
- 1998-05-06 AP APAP/P/1999/001675A patent/AP1103A/en active
- 1998-05-06 EA EA199901012A patent/EA002908B1/ru not_active IP Right Cessation
- 1998-05-06 EE EEP199900578A patent/EE04870B1/xx unknown
- 1998-05-06 CZ CZ0391199A patent/CZ298269B6/cs not_active IP Right Cessation
- 1998-05-06 AT AT02002887T patent/ATE281166T1/de active
- 1998-05-06 HU HU0003330A patent/HU229641B1/hu not_active IP Right Cessation
- 1998-05-06 RO RO99-01166A patent/RO120605B1/ro unknown
- 1998-05-06 EP EP98920285A patent/EP1005342B1/en not_active Expired - Lifetime
- 1998-05-06 NZ NZ513881A patent/NZ513881A/xx not_active IP Right Cessation
- 1998-05-06 CN CNB2004100459536A patent/CN100515420C/zh not_active Expired - Fee Related
- 1998-05-06 CN CNB988049007A patent/CN1158074C/zh not_active Expired - Fee Related
- 1998-05-06 TR TR1999/02733T patent/TR199902733T2/xx unknown
- 1998-05-06 GE GEAP19985109A patent/GEP20032970B/en unknown
- 1998-05-06 CZ CZ20060366A patent/CZ298270B6/cs not_active IP Right Cessation
- 1998-05-06 ES ES98920285T patent/ES2150404T3/es not_active Expired - Lifetime
- 1998-05-06 ES ES02002887T patent/ES2232687T3/es not_active Expired - Lifetime
- 1998-05-06 SK SK708-2003A patent/SK283947B6/sk unknown
- 1998-05-06 EP EP02002887A patent/EP1222921B1/en not_active Expired - Lifetime
- 1998-05-06 CA CA002418634A patent/CA2418634C/en not_active Expired - Fee Related
- 1998-05-06 BR BR9808722-3A patent/BR9808722A/pt not_active IP Right Cessation
- 1998-06-05 UA UA99126626A patent/UA57079C2/uk unknown
- 1998-12-06 BG BG109365A patent/BG109365A/en unknown
-
1999
- 1999-10-19 IS IS5223A patent/IS2087B/is unknown
- 1999-10-29 OA OA9900239A patent/OA11169A/en unknown
- 1999-11-04 NO NO19995406A patent/NO313983B1/no not_active IP Right Cessation
- 1999-12-01 LV LVP-99-170A patent/LV12492B/en unknown
- 1999-12-06 BG BG103958A patent/BG64973B1/bg unknown
-
2000
- 2000-08-17 HK HK00105181A patent/HK1025907A1/xx not_active IP Right Cessation
-
2002
- 2002-04-18 NO NO20021832A patent/NO335781B1/no not_active IP Right Cessation
-
2003
- 2003-04-04 UA UA2003042974A patent/UA74388C2/uk unknown
-
2006
- 2006-12-14 AR ARP060105534A patent/AR057242A2/es not_active Application Discontinuation
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Legal Events
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EG | Technical examination (opinion): publication of technical examination (opinion) | ||
FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
HJEG | Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law | ||
FF | Decision: intention to grant | ||
FG9A | Patent or certificate of addition granted | ||
B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent | ||
B19A | Notification of judicial decision: notification of judicial decision | ||
B19A | Notification of judicial decision: notification of judicial decision | ||
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Free format text: PROCESSO INPI NO 52400.183884/2017-76 PROCEDIMENTO COMUM NO 0179027-75.2017.4.02.5101/RJ AUTOR: HYPERA S/A AUTOR: BRAINFARMA INDUSTRIA QUIMICA E FARMACEUTICA S.A. REU: INPI-INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL REU: ROMARK LABORATORIES L.C DECISAO: DESSE MODO, O MEDICAMENTO DO ESTADO DA TECNICA APRESENTADO NAO DEMONSTRA QUE A PATENTE CARECIA DO REQUISITO DE NOVIDADE. JULGO IMPROCEDENTE O PEDIDO, NOS TERMOS DO ART. 487, I, DO CPC. TRANSITADO EM JULGADO EM 23/04/2021 |
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B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 06/05/2018. |