BR9808059A - Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica - Google Patents

Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica

Info

Publication number
BR9808059A
BR9808059A BR9808059-8A BR9808059A BR9808059A BR 9808059 A BR9808059 A BR 9808059A BR 9808059 A BR9808059 A BR 9808059A BR 9808059 A BR9808059 A BR 9808059A
Authority
BR
Brazil
Prior art keywords
polypeptide
isolated
processes
antibody
pharmaceutical composition
Prior art date
Application number
BR9808059-8A
Other languages
English (en)
Inventor
Paul O Sheppard
Theresa A Deisher
Original Assignee
Zimogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/822,897 external-priority patent/US6380158B1/en
Application filed by Zimogenetics Inc filed Critical Zimogenetics Inc
Publication of BR9808059A publication Critical patent/BR9808059A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MOLéCULAS DE POLINUCLEOTìDEO ISOLADA CODIFICANDO UM POLIPEPTìDEO, POLINUCLEOTìDEO, VETOR DE EXPRESSãO, CéLULA CULTIVADA, POLIPEPTìDEO ISOLADO, COMPOSIçãO FARMACêUTICA, ANTICORPO, PROCESSOS PARA PRODUZIR POLIPEPTìDEO ZSIG33, E, PARA ESTIMULAR A MOTILIDADE GáSTRICA". A presente invenção é dirigida a polinucleotídeos, polipeptídeos e fragmentos de peptídeos dos mesmos, e usos dos mesmos para uma nova sequência de cDNA que tem homologia para motilina. A distribuição de tecido de mRNA para o novo polipeptídeo é específica para o estómago, intestino delgado e pâncreas. A presente invenção ainda inclui agonistas, antagonistas, anticorpos, células hospedeitas, expressando o cDNA codificando os novos homólogos de motilina e processos para aumentar a motilidade gástrica usando as novas moléculas.
BR9808059-8A 1997-03-24 1998-03-23 Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica BR9808059A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4110297P 1997-03-24 1997-03-24
US08/822,897 US6380158B1 (en) 1997-03-24 1997-03-24 Motilin homologs
PCT/US1998/005620 WO1998042840A1 (en) 1997-03-24 1998-03-23 Motilin homologs

Publications (1)

Publication Number Publication Date
BR9808059A true BR9808059A (pt) 2000-03-08

Family

ID=26717805

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808059-8A BR9808059A (pt) 1997-03-24 1998-03-23 Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica

Country Status (9)

Country Link
JP (1) JP4335318B2 (pt)
KR (1) KR20010005701A (pt)
CN (1) CN1170933C (pt)
AU (1) AU726423B2 (pt)
BR (1) BR9808059A (pt)
CA (1) CA2284733C (pt)
NO (1) NO994614L (pt)
NZ (1) NZ337958A (pt)
WO (1) WO1998042840A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627729B1 (en) 1997-03-24 2003-09-30 Zymogenetics, Inc. TML peptides
EP1190059A1 (en) * 1999-06-30 2002-03-27 ZymoGenetics, Inc. Sgip peptides
US6420521B1 (en) 1999-06-30 2002-07-16 Zymogenetics, Inc. Short gastrointestinal peptides
CA2380058C (en) * 1999-07-23 2011-08-09 Kenji Kangawa Novel peptides
ATE435871T1 (de) 1999-11-22 2009-07-15 Zymogenetics Inc Methode zur bildung einen peptid-rezeptor komplex mit zsig33 polypeptiden.
US6897286B2 (en) 2000-05-11 2005-05-24 Zymogenetics, Inc. Zsig33-like peptides
DE60142511D1 (de) * 2000-05-11 2010-08-19 Zymogenetics Inc Zsig33-ähnliche peptide
CA2411667A1 (en) 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
ES2338789T3 (es) 2003-06-18 2010-05-12 Tranzyme Pharma Inc. Antagonistas macrociclicos del receptor de motilina.
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
MX2012001193A (es) * 2009-07-29 2012-03-14 Daiichi Sankyo Co Ltd Compuesto peptidico similar a motilina con capacidad de absorcion transmucosa impartida al mismo.
JP7049775B2 (ja) 2017-04-03 2022-04-07 リンナイ株式会社 表示装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5006469A (en) * 1988-02-09 1991-04-09 Oregon Health Sciences University Vectors and host cells expressing prepromotilin and motilin-associated peptide (MAP)
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
JPH04299990A (ja) * 1991-03-27 1992-10-23 Sanwa Kagaku Kenkyusho Co Ltd モチリンアナログの精製方法

Also Published As

Publication number Publication date
WO1998042840A1 (en) 1998-10-01
CA2284733C (en) 2010-10-26
CA2284733A1 (en) 1998-10-01
CN1170933C (zh) 2004-10-13
NO994614L (no) 1999-11-23
AU726423B2 (en) 2000-11-09
CN1254375A (zh) 2000-05-24
JP4335318B2 (ja) 2009-09-30
JP2001513651A (ja) 2001-09-04
NO994614D0 (no) 1999-09-23
AU6576998A (en) 1998-10-20
NZ337958A (en) 2001-03-30
KR20010005701A (ko) 2001-01-15

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