BR9808059A - Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica - Google Patents
Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástricaInfo
- Publication number
- BR9808059A BR9808059A BR9808059-8A BR9808059A BR9808059A BR 9808059 A BR9808059 A BR 9808059A BR 9808059 A BR9808059 A BR 9808059A BR 9808059 A BR9808059 A BR 9808059A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- isolated
- processes
- antibody
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"MOLéCULAS DE POLINUCLEOTìDEO ISOLADA CODIFICANDO UM POLIPEPTìDEO, POLINUCLEOTìDEO, VETOR DE EXPRESSãO, CéLULA CULTIVADA, POLIPEPTìDEO ISOLADO, COMPOSIçãO FARMACêUTICA, ANTICORPO, PROCESSOS PARA PRODUZIR POLIPEPTìDEO ZSIG33, E, PARA ESTIMULAR A MOTILIDADE GáSTRICA". A presente invenção é dirigida a polinucleotídeos, polipeptídeos e fragmentos de peptídeos dos mesmos, e usos dos mesmos para uma nova sequência de cDNA que tem homologia para motilina. A distribuição de tecido de mRNA para o novo polipeptídeo é específica para o estómago, intestino delgado e pâncreas. A presente invenção ainda inclui agonistas, antagonistas, anticorpos, células hospedeitas, expressando o cDNA codificando os novos homólogos de motilina e processos para aumentar a motilidade gástrica usando as novas moléculas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4110297P | 1997-03-24 | 1997-03-24 | |
US08/822,897 US6380158B1 (en) | 1997-03-24 | 1997-03-24 | Motilin homologs |
PCT/US1998/005620 WO1998042840A1 (en) | 1997-03-24 | 1998-03-23 | Motilin homologs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808059A true BR9808059A (pt) | 2000-03-08 |
Family
ID=26717805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808059-8A BR9808059A (pt) | 1997-03-24 | 1998-03-23 | Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica |
Country Status (9)
Country | Link |
---|---|
JP (1) | JP4335318B2 (pt) |
KR (1) | KR20010005701A (pt) |
CN (1) | CN1170933C (pt) |
AU (1) | AU726423B2 (pt) |
BR (1) | BR9808059A (pt) |
CA (1) | CA2284733C (pt) |
NO (1) | NO994614L (pt) |
NZ (1) | NZ337958A (pt) |
WO (1) | WO1998042840A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6627729B1 (en) | 1997-03-24 | 2003-09-30 | Zymogenetics, Inc. | TML peptides |
EP1190059A1 (en) * | 1999-06-30 | 2002-03-27 | ZymoGenetics, Inc. | Sgip peptides |
US6420521B1 (en) | 1999-06-30 | 2002-07-16 | Zymogenetics, Inc. | Short gastrointestinal peptides |
CA2380058C (en) * | 1999-07-23 | 2011-08-09 | Kenji Kangawa | Novel peptides |
ATE435871T1 (de) | 1999-11-22 | 2009-07-15 | Zymogenetics Inc | Methode zur bildung einen peptid-rezeptor komplex mit zsig33 polypeptiden. |
US6897286B2 (en) | 2000-05-11 | 2005-05-24 | Zymogenetics, Inc. | Zsig33-like peptides |
DE60142511D1 (de) * | 2000-05-11 | 2010-08-19 | Zymogenetics Inc | Zsig33-ähnliche peptide |
CA2411667A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co. Inc. | Ghrelin analogs |
ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
JP5684474B2 (ja) | 2006-09-11 | 2015-03-11 | オセラ セラピューティクス, インコーポレイテッド | 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト |
MX2012001193A (es) * | 2009-07-29 | 2012-03-14 | Daiichi Sankyo Co Ltd | Compuesto peptidico similar a motilina con capacidad de absorcion transmucosa impartida al mismo. |
JP7049775B2 (ja) | 2017-04-03 | 2022-04-07 | リンナイ株式会社 | 表示装置 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
US5006469A (en) * | 1988-02-09 | 1991-04-09 | Oregon Health Sciences University | Vectors and host cells expressing prepromotilin and motilin-associated peptide (MAP) |
US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
JPH04299990A (ja) * | 1991-03-27 | 1992-10-23 | Sanwa Kagaku Kenkyusho Co Ltd | モチリンアナログの精製方法 |
-
1998
- 1998-03-23 NZ NZ337958A patent/NZ337958A/xx not_active IP Right Cessation
- 1998-03-23 KR KR1019997008769A patent/KR20010005701A/ko not_active Application Discontinuation
- 1998-03-23 AU AU65769/98A patent/AU726423B2/en not_active Ceased
- 1998-03-23 WO PCT/US1998/005620 patent/WO1998042840A1/en not_active Application Discontinuation
- 1998-03-23 CA CA2284733A patent/CA2284733C/en not_active Expired - Fee Related
- 1998-03-23 BR BR9808059-8A patent/BR9808059A/pt not_active Application Discontinuation
- 1998-03-23 JP JP54327698A patent/JP4335318B2/ja not_active Expired - Fee Related
- 1998-03-23 CN CNB988046822A patent/CN1170933C/zh not_active Expired - Fee Related
-
1999
- 1999-09-23 NO NO994614A patent/NO994614L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998042840A1 (en) | 1998-10-01 |
CA2284733C (en) | 2010-10-26 |
CA2284733A1 (en) | 1998-10-01 |
CN1170933C (zh) | 2004-10-13 |
NO994614L (no) | 1999-11-23 |
AU726423B2 (en) | 2000-11-09 |
CN1254375A (zh) | 2000-05-24 |
JP4335318B2 (ja) | 2009-09-30 |
JP2001513651A (ja) | 2001-09-04 |
NO994614D0 (no) | 1999-09-23 |
AU6576998A (en) | 1998-10-20 |
NZ337958A (en) | 2001-03-30 |
KR20010005701A (ko) | 2001-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9808059A (pt) | Molécula de plinucleotìdeo isolada codificando um polipeptìdeo, polinucleotìdeo, vetor de expressão, célula cultivada, polipeptìdeo isolado, composição farmacêutica, anticorpo, processos para produzir polipeptìdeo zsig33, e, para estimular a motilidde gástrica | |
AU683234B2 (en) | Peptide inhibitors of fibronectin and related collagen-binding proteins | |
Bisello et al. | Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies | |
Curnis et al. | Spontaneous formation of L-isoaspartate and gain of function in fibronectin | |
Reinhard et al. | VASP interaction with vinculin: a recurring theme of interactions with proline‐rich motifs | |
Sakata et al. | Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms: heparan sulfate glycosaminoglycan requirement for Met binding and signaling | |
Lavorgna et al. | FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu | |
Canalis et al. | A bone-derived growth factor isolated from rat calvariae is beta2 microglobulin | |
Cruz et al. | . mu.-Conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling and receptor characterization | |
Kao et al. | A peptide derived from the amino terminus of endothelial-monocyte-activating polypeptide II modulates mononuclear and polymorphonuclear leukocyte functions, defines an apparently novel cellular interaction site, and induces an acute inflammatory response | |
Koc et al. | Regulation of mammalian mitochondrial translation by post-translational modifications | |
Gasparri et al. | Chromogranin A fragments modulate cell adhesion: identification and characterization of a pro-adhesive domain | |
KR870004143A (ko) | Dna서열, 재조합 dna분자 및 뮬레리안억제 물질류 폴리펩티드의 생산 방법 | |
WO1997033995A3 (en) | Extracellular matrix signalling molecules | |
BR0008772A (pt) | Polipeptìdeo isolado, proteìna de fusão, molécula de polinucleotìdeo isolado, vetor de expressão, célula cultivada, anticorpo, processos para produzir uma proteìna e um anticorpo para um polipeptìdeo, para estimular uma resposta imunológica em um mamìfero, para expandir células hematopoiéticas e progenitores de células hematopoiéticas, para reduzir a proliferação de células b ou t neoplásicas e para detectar a presença de rna de ligando zalfa11 e de ligando zalfal11 em uma amostra biológica | |
PT861261E (pt) | Sequências nucleotídicas e proteicas de genes delta de vertebrado e métodos nelas baseados | |
BR9813296A (pt) | Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula | |
Abramson et al. | Initiation factors that bind mRNA. A comparison of mammalian factors with wheat germ factors. | |
EP2357195B1 (en) | Growth factor complexes and modulation of cell migration and growth | |
DE69637874D1 (de) | C-C CHEMOKIN REZEPTOR 3: CKR-3 ODER Eos-L2 | |
AR023482A1 (es) | Acidos nucleicos que codifican polipeptidos quimericos cd40/cd4ol, metodos para su produccion y usos de los mismos | |
Okazaki et al. | Identification of biologically active sequences in the laminin α4 chain G domain | |
BR9913942A (pt) | Polinucleotìdeo e polipeptìdeo isolado, vetor de expressão, célula cultivada, constructo de dna codificador de uma proteìna de fusão, processos de produção de uma proteìna, de fusão de um polipeptìdeo e de um anticorpo para o polipeptìdeo e de detecção, em uma amostra de teste, da presença de um modulador da atividade da proteìna zalpha11 e de um ligante de receptor zalpha11 dentro de uma amostra de teste, e, anticorpo | |
IL150885A0 (en) | Cyr61 compositions and methods | |
Schwanbeck et al. | Cdc2 and Mitogen-activated Protein Kinases Modulate DNA Binding Properties of the Putative Transcriptional RegulatorChironomus High Mobility Group Protein I |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART. 37, INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE NAO PREENCHE O DISPOSTO NO ART. 8O COMBINADO COM O ART. 13 DA LPI, ALEM DE REIVINDICAR MATERIA QUE NAO E PASSIVEL DE PRIVILEGIO DE ACORDO COM O DISPOSTO NO ARTIGO 10 (IX) DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |