AR023482A1 - Acidos nucleicos que codifican polipeptidos quimericos cd40/cd4ol, metodos para su produccion y usos de los mismos - Google Patents
Acidos nucleicos que codifican polipeptidos quimericos cd40/cd4ol, metodos para su produccion y usos de los mismosInfo
- Publication number
- AR023482A1 AR023482A1 ARP000101716A ARP000101716A AR023482A1 AR 023482 A1 AR023482 A1 AR 023482A1 AR P000101716 A ARP000101716 A AR P000101716A AR P000101716 A ARP000101716 A AR P000101716A AR 023482 A1 AR023482 A1 AR 023482A1
- Authority
- AR
- Argentina
- Prior art keywords
- cd4ol
- production
- methods
- nucleic acids
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un ácido nucleico que codifica un polipéptido quimérico que comprende fragmentos de ácido nucleico que codifican: i) un péptido senal mamífero, ycorriente abajo del mismo: ii) el dominio de vinculacion y de trimerizacion del CD40L, y, corriente abajodel mismo: iii) un separador de 50 a 100 amino ácidosy, corriente abajo del mismo: iv) los dominios transmembranal y de transduccion de las senales, del CD40, es util como agente de terapia de genes para eltratamiento localizado de los tumores solidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99107611A EP1067194A1 (en) | 1999-04-16 | 1999-04-16 | Vectors containing a gene coding for CD40 and/or CD40L under the control of a cytokine-inducible promoter which is a human acute phase amyloid A gene promoter. Methods for their production and uses thereof |
| EP99113967 | 1999-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023482A1 true AR023482A1 (es) | 2002-09-04 |
Family
ID=26152970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101716A AR023482A1 (es) | 1999-04-16 | 2000-04-13 | Acidos nucleicos que codifican polipeptidos quimericos cd40/cd4ol, metodos para su produccion y usos de los mismos |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1173589A1 (es) |
| JP (1) | JP2003508016A (es) |
| AR (1) | AR023482A1 (es) |
| AU (1) | AU3966200A (es) |
| CA (1) | CA2369820A1 (es) |
| IL (1) | IL144952A0 (es) |
| NO (1) | NO20015003D0 (es) |
| WO (1) | WO2000063395A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002028480A2 (en) | 2000-10-02 | 2002-04-11 | Chiron Corporation | Methods of therapy for b-cell malignancies |
| WO2002036769A2 (en) * | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| EP2243492A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
| PT1680141E (pt) | 2003-11-04 | 2010-12-20 | Novartis Vaccines & Diagnostic | Métodos terapêuticos para tumores sólidos que expressam o antigénio de superfície celular cd40 |
| PT1682177E (pt) | 2003-11-04 | 2010-11-29 | Xoma Technology Lt | Utilização de anticorpos antagonistas anti-cd40 para o tratamento da leucemia linfocítica crónica |
| EP1682178B8 (en) | 2003-11-04 | 2010-09-01 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for cancers expressing the cd40 antigen |
| CA2544368C (en) | 2003-11-04 | 2014-04-01 | Chiron Corporation | Methods of therapy for b cell-related cancers |
| WO2006125117A2 (en) | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
| NZ571757A (en) | 2006-04-21 | 2012-01-12 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer |
| ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
| JP2011502165A (ja) | 2007-10-30 | 2011-01-20 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 鞭毛細菌に対する免疫応答を強化する組成物および方法 |
| ES2599905T3 (es) | 2007-11-01 | 2017-02-06 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para aumentar las respuestas inmunitarias a Eimeria |
| JP5568807B2 (ja) * | 2008-06-06 | 2014-08-13 | 静岡県 | プロテオミクス解析を用いたメラノーママーカーの同定 |
| HUE037157T2 (hu) | 2010-01-21 | 2018-08-28 | Univ Arkansas | Vakcinavektorok, és eljárások immunválaszok fokozására |
| MX350306B (es) | 2010-06-09 | 2017-09-04 | Univ Arkansas | Vacuna y metodos para reducir una infeccion por campylobacter. |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| PL2956165T3 (pl) | 2013-02-14 | 2020-04-30 | The Board Of Trustees Of The University Of Arkansas | Kompozycje i sposoby wzmacniania odpowiedzi immunologicznych na Eimeria lub ograniczania infekcji Eimeria |
| EP3578190A1 (en) | 2013-03-15 | 2019-12-11 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
| TWI758288B (zh) | 2016-05-03 | 2022-03-21 | 阿肯色州大學董事會 | 包含免疫刺激性及抗原性多肽的酵母菌疫苗載體以及其使用方法 |
| US11564944B2 (en) | 2016-11-21 | 2023-01-31 | Nant Holdings Ip, Llc | Fractal combination therapy |
| US20200024326A1 (en) * | 2018-06-14 | 2020-01-23 | Nantbio, Inc. | Tnf-type receptor-ligand fusion proteins and methods |
| WO2020073045A1 (en) * | 2018-10-05 | 2020-04-09 | Nantcell, Inc. | Cd40 and cd40l combo in an adenovirus vaccine vehicle |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0897983B1 (en) * | 1991-10-25 | 2003-05-07 | Immunex Corporation | Antibody against CD40-L |
| US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
-
2000
- 2000-04-13 AU AU39662/00A patent/AU3966200A/en not_active Abandoned
- 2000-04-13 JP JP2000612474A patent/JP2003508016A/ja active Pending
- 2000-04-13 AR ARP000101716A patent/AR023482A1/es unknown
- 2000-04-13 WO PCT/EP2000/003318 patent/WO2000063395A1/en not_active Application Discontinuation
- 2000-04-13 CA CA002369820A patent/CA2369820A1/en not_active Abandoned
- 2000-04-13 IL IL14495200A patent/IL144952A0/xx unknown
- 2000-04-13 EP EP00918873A patent/EP1173589A1/en not_active Withdrawn
-
2001
- 2001-10-15 NO NO20015003A patent/NO20015003D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2369820A1 (en) | 2000-10-26 |
| NO20015003L (no) | 2001-10-15 |
| JP2003508016A (ja) | 2003-03-04 |
| AU3966200A (en) | 2000-11-02 |
| WO2000063395A1 (en) | 2000-10-26 |
| IL144952A0 (en) | 2002-06-30 |
| NO20015003D0 (no) | 2001-10-15 |
| EP1173589A1 (en) | 2002-01-23 |
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